Tissue Rejection

ABSTRACT

This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No.11/434,711, filed May 15, 2006, which claims priority from U.S.Provisional Application Ser. No. 60/683,737, filed May 23, 2005. Thedisclosures of the prior applications are considered part of (and areincorporated by reference in) the disclosure of this application.

TECHNICAL FIELD

This document relates to methods and materials involved in tissuerejection (e.g., organ rejection) and detecting tissue rejection.

BACKGROUND

The transplantation of tissue from one mammal to another has been usedfor years to save lives and to improve the quality of lives. Forexample, the first successful kidney transplant was performed in themid-1950s between identical twin brothers. Since then, donors have grownto include not only close relatives but also distant relatives, friends,and total strangers. In some cases, the recipient may reject thetransplanted tissue. Thus, tissue rejection is a concern for anyrecipient of transplanted tissue. If a doctor is able to recognize earlysigns of tissue rejection, anti-rejection medication often can be usedto reverse tissue rejection.

SUMMARY

This document relates to methods and materials involved in detectingtissue rejection (e.g., organ rejection). More particularly, thisdocument relates to methods and materials involved in the earlydetection of tissue rejection (e.g., kidney rejection) and theassessment of a mammal's probability of rejecting tissue such as atransplanted organ. For example, this document provides nucleic acidarrays that can be used to diagnose tissue rejection in a mammal. Sucharrays can allow clinicians to diagnose tissue rejection early based ona determination of the expression levels of nucleic acids that aredifferentially expressed in tissue being rejected as compared to controltissue not being rejected. The differential expression of such nucleicacids can be detected in tissue being rejected prior to the emergence ofvisually-observable, histological signs of tissue rejection. Earlydiagnosis of patients rejecting transplanted tissue (e.g., a kidney) canhelp clinicians determine appropriate treatments for those patients. Forexample, a clinician who diagnoses a patient as rejecting transplantedtissue can treat that patient with medication that suppresses tissuerejection (e.g., immunosuppressants).

The description provided herein is based, in part, on the discovery ofnucleic acids that are differentially expressed in tissue being rejectedas compared to control tissue that is not being rejected. Such nucleicacids can be nucleic acids that are induced by, for example, gammainterferon (IFN-γ). The term “gamma interferon induced transcripts” or“GITs” as used herein refers to transcripts that are expressed inkidneys of mammals treated with IFN-γ at a level at least 2-fold greaterthan the level of expression in normal kidney tissue. In someembodiments, a “GIT” is identified based expression that is increased atleast two-fold in response to IFN-γ in normal kidneys of one or moreparticular strains (e.g., B6, CBA, and/or BALB/c) as compared to thelevel of expression in untreated normal kidney. The term “rejectioninduced transcripts” or “RITs” as used herein refers to transcripts thatare elevated at least 2-fold in WT kidney allografts at day 5 posttransplant in WT hosts vs. normal kidneys. In some embodiments, a “RIT”is identified based on expression that is increased at least two-fold inWT allografts from one or more particular strains (e.g., B6, CBA, and/orBALB/c) as compared to the level of expression in normal kidney. Theterm “injury and repair-induced transcripts” or “IRITs” refers totranscripts that are increased at least two-fold in isografts at leastonce between day 1 and day 21, as compared to normal kidney, and alsoare increased at least two-fold in CBA allografts at day 5 as comparedto normal kidneys.

The term “gamma interferon and rejection induced transcripts” or “GRITs”as used herein refers to IFN-γ and rejection-inducible transcripts.These transcripts are (a) expressed at a level at least 2-fold greaterin kidney tissue of mammals treated with IFN-γ than in kidney tissue ofuntreated mammals, (b) elevated at least 2-fold in tissue from WT kidneyallografts at day 5 post transplant in WT hosts as compared to normalkidney tissue, and (c) expressed at levels at least 2-fold lower inkidney tissue from IFN-γ-deficient (GKO) D5 allografts as compared to WTD5 allografts. Thus, the expression of GRITs is affected by the presenceor absence of IFN-γ in allografts. The term “GRIT-like” transcripts asused herein refers to transcripts that are (a) expressed at a level atleast 2-fold greater in kidney tissue of mammals treated with IFN-γ thanin kidney tissue of untreated mammals, (b) elevated at least 2-fold intissue from WT kidney allografts at day 5 post transplant in WT hosts ascompared to normal kidney tissue, and (c) not lower or even increasedwhen IFN-γ is absent in GKO D5 allografts compared to WT D5 allografts.GRIT-like transcripts, despite being inducible by rIFN-γ, are increasedin allografts by mechanisms largely independent of IFN-γ.

The term “transcript” as used herein refers to an mRNA identified by oneor more numbered Affymetrix probe sets, while a “unique transcript” isan mRNA identified by only one probe set. The term “true interferongamma dependent and rejection-induced transcripts” or “tGRITs” refers torejection-induced transcripts that are IFN-γ-dependent in rejection, andalso are unique transcripts that are increased at least 2-fold byrIFN-γ. The term “occult interferon gamma dependent andrejection-induced transcripts” or “oGRITs” refers to GRITs that areunique transcripts, but that are not 2-fold induced by rIFN-γ in normalkidneys.

The description provided herein also is based, in part, on the discoverythat the expression levels of RITs can be used to distinguishtransplanted tissue that is being rejected from transplanted tissue thatis not being rejected. For example, the expression levels of nucleicacids listed in Table 2, Table 7, and/or Table 11 can be assessed intransplanted tissue to determine whether or not that transplanted tissueis being rejected. In addition, the description provided herein isbased, in part, on the discovery that the expression levels of RITs(e.g., those listed in Table 2, Table 7, and/or Table 11) can be used todistinguish transplanted tissue that is being rejected from transplantedtissue that is not being rejected at a time point prior to the emergenceof any visually-observable, histological sign of tissue rejection (e.g.,tubulitis for kidney rejection). In some embodiments, expression levelsof GRITs or GRIT-like transcripts, including, for example, those listedin Tables 4, 5, and 9 can be assessed to determine whether or nottransplanted tissue is being rejected or to distinguish transplantedtissue that is being rejected from transplanted tissue that is not beingrejected.

In one aspect, this document features a method for detecting tissuerejection. The method can include determining whether or not tissuetransplanted into a mammal contains cells that express at least two ofthe nucleic acids listed in Table 2 or Table 11 at elevated levels,wherein the presence of the cells indicates that the tissue is beingrejected. The mammal can be a human. The tissue can be kidney tissue ora kidney. The method can include determining whether or not the tissuecontains cells that express at least five of the nucleic acids, at leastten of the nucleic acids, or at least twenty of the nucleic acids. Thedetermining step can include measuring the level of mRNA expressed fromthe at least two nucleic acids or measuring the level of polypeptideexpressed from the at least two nucleic acids. The method can includedetermining whether or not the tissue contains cells that express atleast two of the nucleic acids at a level greater than the average levelof expression exhibited in cells from control tissue that has not beentransplanted.

In another aspect, this document features a method for detecting tissuerejection. The method can include determining whether or not a samplecontains cells that express at least two of the nucleic acids listed inTable 2 or Table 11 at elevated levels, wherein the sample containscells, was obtained from tissue that was transplanted into a mammal, andwas obtained from the tissue within fifteen days of the tissue beingtransplanted into the mammal, and wherein the presence of the cellsindicates that the tissue is being rejected. The mammal can be a human.The tissue can be kidney tissue or a kidney. The method can includedetermining whether or not the sample contains cells that express atleast five of the nucleic acids, at least ten of the nucleic acids, orat least twenty of the nucleic acids. The determining step can includemeasuring the level of mRNA expressed from the at least two nucleicacids or measuring the level of polypeptide expressed from the at leasttwo nucleic acids. The sample can be obtained from the tissue within tendays of the tissue being transplanted into the mammal or within fivedays of the tissue being transplanted into the mammal. The method caninclude determining whether or not the sample contains cells thatexpress at least two of the nucleic acids at a level greater than theaverage level of expression exhibited in cells from control tissue thathas not been transplanted.

In another aspect, this document features a nucleic acid arraycontaining at least 20 nucleic acid molecules, wherein each of the atleast 20 nucleic acid molecules has a different nucleic acid sequence,and wherein at least 50 percent of the nucleic acid molecules of thearray contain a sequence from nucleic acid selected from the groupconsisting of the nucleic acids listed in Table 2 and Table 11. Thearray can contain at least 50 nucleic acid molecules, wherein each ofthe at least 50 nucleic acid molecules has a different nucleic acidsequence. The array can contain at least 100 nucleic acid molecules,wherein each of the at least 100 nucleic acid molecules has a differentnucleic acid sequence. Each of the nucleic acid molecules that contain asequence from a nucleic acid selected from the group can contain no morethan three mismatches. At least 75 percent of the nucleic acid moleculesof the array can contain a sequence from nucleic acid selected from thegroup. At least 95 percent of the nucleic acid molecules of the arraycan contain a sequence from nucleic acid selected from the group. Thearray can include glass. The at least 20 nucleic acid molecules cancontain a sequence present in a human.

In another aspect, this document features a computer-readable storagemedium having instructions stored thereon for causing a programmableprocessor to determine whether one or more nucleic acids listed in Table2 or Table 11 are detected in a sample, wherein the sample is from atransplanted tissue. The computer-readable storage medium can furtherhave instructions stored thereon for causing a programmable processor todetermine whether one or more of the nucleic acids listed in Table 2 orTable 11 is expressed at a greater level in the sample than in a controlsample of non-transplanted tissue.

This document also features an apparatus for determining whether atransplanted tissue is being rejected. The apparatus can include one ormore collectors for obtaining signals representative of the presence ofone or more nucleic acids listed in Table 2 or Table 11 in a sample fromthe transplanted tissue, and a processor for analyzing the signals anddetermining whether the tissue is being rejected. The one or morecollectors can be configured to obtain further signals representative ofthe presence of the one or more nucleic acids in a control sample fromnon-transplanted tissue.

Unless otherwise defined, all technical and scientific terms used hereinhave the same meaning as commonly understood by one of ordinary skill inthe art to which this invention pertains. Although methods and materialssimilar or equivalent to those described herein can be used in thepractice or testing of the present invention, suitable methods andmaterials are described below. All publications, patent applications,patents, and other references mentioned herein are incorporated byreference in their entirety. In case of conflict, the presentspecification, including definitions, will control. In addition, thematerials, methods, and examples are illustrative only and not intendedto be limiting.

The details of one or more embodiments of the invention are set forth inthe accompanying drawings and the description below. Other features,objects, and advantages of the invention will be apparent from thedescription and drawings, and from the claims.

DESCRIPTION OF DRAWINGS

FIG. 1 is a depiction of selection criteria used for identification ofGRITs and GRIT-like transcripts. WT D5—wild type allografts, GKOD5—IFN-γ-deficient allografts.

FIG. 2A is a depiction of an unsupervised hierarchical clustering ofGRITs. FIG. 2B is a graph showing an expression time course of GRITs ininjury and rejection. FIG. 2C is a graph showing the signal strength ofIFN-γ over the time course of in injury and rejection. Clustering wasbased on distance as the similarity measure. ISO—isografts,WT—allografts, NCBA—control kidneys.

FIG. 3A is a depiction of an unsupervised hierarchical clustering ofGRIT-like transcripts. FIG. 3B is a graph showing an expression timecourse of GRIT-like transcripts in injury and rejection. Normalizedvalues are shown. Clustering was based on distance as the similaritymeasure. ISO—isografts, WT—allografts, NCBA—control kidneys.

FIGS. 4A, 4B, and 4C are graphs showing expression profiles of IFN-γ,GRITs, and GRIT-like transcripts, respectively, early aftertransplantation. ISO—isografts, WT—allografts, GKO D5—IFN-γ deficientgrafts, NCBA—control kidneys.

FIG. 5A is a depiction of an unsupervised hierarchical clustering ofinjury-induced RIT. FIG. 5B is a graph showing an expression time courseof RIT in injury and rejection. Normalized values are shown. Clusteringwas based on distance as the similarity measure. ISO—isografts,WT—allografts, NCBA—control kidneys.

FIG. 6A is a graph showing expression profiles of acute phase markers inisografts and allografts. FIG. 6B is a graph showing the expressionprofiles of Tgfbi and the average expression profile of injury-inducedRIT in isografts and allografts. Normalized values are shown in bothgraphs. ISO—isografts, WT—allografts, NCBA—control kidneys.

FIG. 7A is a graph showing an expression profile of Tgfbi superimposedon that for injury-induced RIT. FIG. 7B is a graph showing an expressionprofile of STAT-1 superimposed on that for injury-induced RIT.

FIG. 8A is a diagram of an algorithm for identifying GRITs. FIG. 8B is adiagram of an algorithm for identifying RITs. FIG. 8C is a diagram of analgorithm for identifying tGRITs and oGRITs.

FIG. 9 is a diagram of an algorithm for identifying IRITs.

DETAILED DESCRIPTION

This description provides methods and materials involved in detectingtissue rejection (e.g., organ rejection). For example, this descriptionprovides methods and materials that can be used to diagnose a mammal(e.g., a human) as having transplanted tissue that is being rejected. Amammal can be diagnosed as having transplanted tissue that is beingrejected if it is determined that the tissue contains cells that expresselevated levels of one or more RITs or that express elevated levels oneor more of the nucleic acids listed in Table 2, Table 7, or Table 11. Insome embodiments, a mammal can be diagnosed as having transplantedtissue that is being rejected if it is determined that the tissuecontains cells that express elevated levels of one or more GRITs,GRIT-like, true GRIT, or occult GRIT transcripts including, withoutlimitation, those listed in Tables 4, 5, 9, or 10, respectively.

The methods and materials provided herein can be used to detect tissuerejection in any mammal such as a human, monkey, horse, dog, cat, cow,pig, mouse, or rat. In addition, the methods and materials providedherein can be used to detect rejection of any type of transplantedtissue including, without limitation, kidney, heart, liver, pancreas,and lung tissue. For example, the methods and materials provided hereincan be used to determine whether or not a human who received a kidneytransplant is rejecting that transplanted kidney.

Any type of sample containing cells can be used to determine whether ornot transplanted tissue contains cells that express one or more RITs orthat express one or more of the nucleic acids listed in Table 2, Table7, or Table 11 at elevated levels. Similarly, any type of samplecontaining cells can be used to determine whether or not transplantedtissue contains cells that express one or more GRITs, GRIT-like, trueGRIT, or occult GRIT transcripts, or that express one or more of thenucleic acids listed in Table 4, Table 5, Table 9, or Table 10 atelevated levels. For example, biopsy (e.g., punch biopsy, aspirationbiopsy, excision biopsy, needle biopsy, or shave biopsy), tissuesection, lymph fluid, blood, and synovial fluid samples can be used. Insome embodiments, a tissue biopsy sample can be obtained directly fromthe transplanted tissue. In some embodiments, a lymph fluid sample canbe obtained from one or more lymph vessels that drain from thetransplanted tissue. A sample can contain any type of cell including,without limitation, cytotoxic T lymphocytes, CD4 T cells, B cells,peripheral blood mononuclear cells, macrophages, kidney cells, lymphnode cells, or endothelial cells.

As explained herein, a RIT refers to a transcript that is elevated atleast 2-fold in WT kidney allografts at day 5 post transplant in WThosts vs. normal kidneys. Examples of RITs include, without limitation,those listed in Tables 2, 7, and 11. A GRIT refers to an IFN-γ andrejection induced transcript that is (a) expressed at a level at least2-fold greater in kidney tissue of mammals treated with IFN-γ than inkidney tissue of untreated mammals, (b) elevated at least 2-fold intissue from WT kidney allografts at day 5 post transplant in WT hosts ascompared to normal kidney tissue, and (c) expressed at levels at least2-fold lower in kidney tissue from IFN-γ-deficient (GKO) D5 allograftsas compared to WT D5 allografts. Examples of GRITs include, withoutlimitation, the nucleic acids listed in Table 4. A GRIT-like transcriptrefers to a transcript that is (a) expressed at a level at least 2-foldgreater in kidney tissue of mammals treated with IFN-γ than in kidneytissue of untreated mammals, (b) elevated at least 2-fold in tissue fromWT kidney allografts at day 5 post transplant in WT hosts as compared tonormal kidney tissue, and (c) not lower or even increased when IFN-γ isabsent in GKO D5 allografts compared to WT D5 allografts. Examples ofGRIT-like transcripts include, without limitation, those listed in Table5. Additional examples of RITs, GRITs, and GRIT-like transcripts can beidentified using the procedures described herein. For example, theprocedures described in Example 1 can be used to identify RITs, GRITs,and GRIT-like transcripts other than those listed in Tables 2, 4, 5, and7.

A tGRIT refers to a unique transcript that is rejection-induced andIFN-γ-dependent in rejection, and also is increased at least two-fold byrIFN-γ. Examples of tGRITs include, without limitation, those listed inTable 9. An oGRIT refers to a GRIT that is a unique transcript, but thatis not induced at least 2-fold by rIFN-γ in normal kidneys. Examples ofoGRITs include, without limitation, those listed in Table 10. An IRITrefers to a transcript that is increased at least two-fold in isograftsat least once between day 1 and day 21, as compared to normal kidney,and also increased at least two-fold in CBA allografts at day 5 ascompared to normal kidneys. Examples of IRITs include, withoutlimitation, those listed in Table 11. The procedures described inExample 2 can be used to identify RITs, IRITs, GRITs, true GRITs, andoccult GRITs other than those listed in Tables 9, 10, and 11.

The expression of any number of RITs, IRITs, GRITs, GRIT-liketranscripts, tGRITs, oGRITs, or nucleic acids listed in Tables 2, 4, 5,7, 9, 10, and/or 11 can be evaluated to determine whether or nottransplanted tissue will be rejected. For example, the expression of oneor more than one (e.g., two, three, four, five, six, seven, eight, nine,ten, 15, 20, 25, 30, 40, 50, 75, 100, or more than 100) of the nucleicacids listed in Table 2 can be used. In some embodiments, determiningthat a nucleic acid listed in Table 2 is expressed in a sample at adetectable level can indicate that the transplanted tissue will berejected. In some embodiments, transplanted tissue can be evaluated bydetermining whether or not the tissue contains cells that express anucleic acid listed in Table 2 at an elevated level, i.e., a level thatis greater than the average expression level observed in control cellsobtained from tissue that has not been transplanted. Typically, anucleic acid can be classified as being expressed at a level that isgreater than the average level observed in control cells if theexpression levels differ by at least 1-fold (e.g., 1.5-fold, 2-fold,3-fold, or more than 3-fold). Control cells typically are the same typeof cells as those being evaluated. In some cases, the control cells canbe isolated from kidney tissue that has not been transplanted into amammal. Any number of tissues can be used to obtain control cells. Forexample, control cells can be obtained from one or more tissue samples(e.g., at least 5, 6, 7, 8, 9, 10, or more tissue samples) obtained fromone or more healthy mammals (e.g., at least 5, 6, 7, 8, 9, 10, or morehealthy mammals).

Any suitable method can be used to determine whether or not a particularnucleic acid is expressed at a detectable level or at a level that isgreater than the average level of expression observed in control cells.For example, expression of a particular nucleic acid can be measured byassessing mRNA expression. mRNA expression can be evaluated using, forexample, northern blotting, slot blotting, quantitative reversetranscriptase polymerase chain reaction (RT-PCR), real-time RT-PCR, orchip hybridization techniques. Methods for chip hybridization assaysinclude, without limitation, those described herein. Such methods can beused to determine simultaneously the relative expression levels ofmultiple mRNAs. Alternatively, expression of a particular nucleic acidcan be measured by assessing polypeptide levels. For example,polypeptide levels can be measured using any method such as immuno-basedassays (e.g., ELISA), western blotting, or silver staining.

The methods and materials provided herein can be used at any timefollowing a tissue transplantation to determine whether or not thetransplanted tissue will be rejected. For example, a sample obtainedfrom transplanted tissue at any time following the tissuetransplantation can be assessed for the presence of cells expressingelevated levels of a nucleic acid listed in Table 2. In some cases, asample can be obtained from transplanted tissue 1, 2, 3, 4, 5, 6, 7, 8,or more hours after the transplanted tissue was transplanted. In somecases, a sample can be obtained from transplanted tissue one or moredays (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, or moredays) after the transplanted tissue was transplanted. Typically, asample can be obtained from transplanted tissue 2 to 7 days (e.g., 5 to7 days) after transplantation and assessed for the presence of cellsexpressing elevated levels of one or more RITs or expressing elevatedlevels of one or more nucleic acids listed in Table 2.

This description also provides nucleic acid arrays. The arrays providedherein can be two-dimensional arrays, and can contain at least 10different nucleic acid molecules (e.g., at least 20, at least 30, atleast 50, at least 100, or at least 200 different nucleic acidmolecules). Each nucleic acid molecule can have any length. For example,each nucleic acid molecule can be between 10 and 250 nucleotides (e.g.,between 12 and 200, 14 and 175, 15 and 150, 16 and 125, 18 and 100, 20and 75, or 25 and 50 nucleotides) in length. In addition, each nucleicacid molecule can have any sequence. For example, the nucleic acidmolecules of the arrays provided herein can contain sequences that arepresent within the nucleic acids listed in Table 2, Table 4, Table 5,Table 7, Table 9, Table 10, and/or Table 11. For the purpose of thisdocument, a sequence is considered present within a nucleic acid listedin, for example, Table 2 when the sequence is present within either thecoding or non-coding strand. For example, both sense and anti-senseoligonucleotides designed to human Abp1 nucleic acid are consideredpresent within Abp1 nucleic acid.

Typically, at least 25% (e.g., at least 30%, at least 40%, at least 50%,at least 60%, at least 75%, at least 80%, at least 90%, at least 95%, or100%) of the nucleic acid molecules of an array provided herein containa sequence that is (1) at least 10 nucleotides (e.g., at least 11, 12,13, 14, 15, 16, 17, 18, 19, 20, 25, or more nucleotides) in length and(2) at least about 95 percent (e.g., at least about 96, 97, 98, 99, or100) percent identical, over that length, to a sequence present within anucleic acid listed in Table 2, Table 4, Table 5, Table 7, Table 9,Table 10, or Table 11. For example, an array can contain 100 nucleicacid molecules located in known positions, where each of the 100 nucleicacid molecules is 100 nucleotides in length while containing a sequencethat is (1) 30 nucleotides in length, and (2) 100 percent identical,over that 30 nucleotide length, to a sequence of one of the nucleicacids listed in Table 2. A nucleic acid molecule of an array providedherein can contain a sequence present within a nucleic acid listed inTable 2, where that sequence contains one or more (e.g., one, two,three, four, or more) mismatches.

The nucleic acid arrays provided herein can contain nucleic acidmolecules attached to any suitable surface (e.g., plastic or glass). Inaddition, any method can be use to make a nucleic acid array. Forexample, spotting techniques and in situ synthesis techniques can beused to make nucleic acid arrays. Further, the methods disclosed in U.S.Pat. Nos. 5,744,305 and 5,143,854 can be used to make nucleic acidarrays.

Computer-Readable Medium and an Apparatus for Predicting Rejection

This disclosure further provides a computer-readable storage mediumconfigured with instructions for causing a programmable processor todetermine whether a transplanted tissue is being or is likely to berejected. The determination of whether a transplanted tissue is being orwill be rejected can be carried out as described herein; that is, bydetermining whether one or more of the nucleic acids listed in Table 2or Table 11 is detected in a sample (e.g., a sample of the tissue), oris expressed at a level that is greater than the level of expression ina corresponding tissue that is not transplanted. The processor also canbe designed to perform functions such as removing baseline noise fromdetection signals.

Instructions carried on a computer-readable storage medium (e.g., fordetecting signals) can be implemented in a high level procedural orobject oriented programming language to communicate with a computersystem. Alternatively, such instructions can be implemented in assemblyor machine language. The language further can be compiled or interpretedlanguage.

The nucleic acid detection signals can be obtained using an apparatus(e.g., a chip reader) and a determination of tissue rejection can begenerated using a separate processor (e.g., a computer). Alternatively,a single apparatus having a programmable processor can both obtain thedetection signals and process the signals to generate a determination ofwhether rejection is occurring or is likely to occur. In addition, theprocessing step can be performed simultaneously with the step ofcollecting the detection signals (e.g., “real-time”).

Any suitable process can be used to determine whether a transplantedtissue is being or is likely to be rejected. In some embodiments, forexample, a process can include determining whether a pre-determinednumber (e.g., one, two, three, four, five, six, seven, eight, nine, ten,15, 20, 25, 30, 40, 50, 75, 100, or more than 100) of the nucleic acidslisted in Table 2 or Table 11 is expressed in a sample (e.g., a sampleof transplanted tissue) at a detectable level. If the number of nucleicacids that are expressed in the sample is equal to or exceeds thepre-determined number, the transplanted tissue can be predicted to berejected. If the number of nucleic acids that are expressed in thesample is less than the pre-determined number, the transplanted tissuecan be predicted to not be rejected. The steps of this process (e.g.,the detection, or non-detection, of each of the nucleic acids listed inTable 2 or Table 11) can be carried out in any suitable order. In someembodiments, a process can include determining whether a pre-determinednumber of the nucleic acids listed in Table 2 or Table 11 is expressedin a sample at a level that is greater than the average level observedin control cells (e.g., cells obtained from tissue that has not beentransplanted. If the number of nucleic acids having increased levels ofexpression in the sample is equal to or exceeds the pre-determinednumber, the transplanted tissue can be predicted to be rejected. If thenumber of nucleic acids having increased expression levels in the sampleis less than the pre-determined number, the transplanted tissue can bepredicted to not be rejected. Again, the steps of this process can becarried out in any suitable order.

Also provided herein, therefore, is an apparatus for determining whethera transplanted tissue is being or is likely to be rejected. An apparatusfor determining whether tissue rejection will occur can include one ormore collectors for obtaining signals from a sample (e.g., a sample ofnucleic acids hybridized to nucleic acid probes on a substrate such as achip) and a processor for analyzing the signals and determining whetherrejection will occur. By way of example, the collectors can includecollection optics for collecting signals (e.g., fluorescence) emittedfrom the surface of the substrate, separation optics for separating thesignal from background focusing the signal, and a recorder responsive tothe signal, for recording the amount of signal. The collector can obtainsignals representative of the presence of one or more nucleic acidslisted in Table 2 or Table 11 (e.g., in samples from transplanted and/ornon-transplanted tissue). The apparatus further can generate a visual orgraphical display of the signals, such as a digitized representation.The apparatus further can include a display. In some embodiments, theapparatus can be portable.

The invention will be further described in the following examples, whichdo not limit the scope of the invention described in the claims.

EXAMPLES Example 1 Interactions Between IFN-γ-Induced Transcripts andInjury Effects

The roles of IFN-γ were investigated in a mouse kidney allograft modelthat develops the pathologic lesions that are diagnostic in human graftrejection. Basically, a comparison of mouse kidney pathology to themouse transcriptome was used to guide understanding of the relationshipof lesions to transcriptome changes in human rejection. RecombinantIFN-γ (rIFN-γ) was administered to WT mice to identify the GITs in thekidney and examined how the GITs changed during graft rejection,comparing WT to IFN-γ deficient grafts. These experiments have providedinsight into some of the complex relationships between IFN-γinducibility during rejection and in tissue injury and regulation ofGITs by non IFN-γ dependent factors during kidney transplantation.

Materials and Methods

Mice: Male CBA/J (CBA) and C57B1/6 (B6) mice were obtained from theJackson Laboratory (Bar Harbor, Me.). IFN-γ deficient mice (BALB/c.GKO)and (B6.129S7-IFNg^(tm1Ts); B6.GKO) were bred in the Health SciencesLaboratory Animal Services at the University of Alberta. Micemaintenance and experiments were in conformity with approved animal careprotocols. CBA (H-2K, I-A^(k)) into C57B1/6 (B6; H-2K^(b)D^(b), I-A^(b))mice strain combinations, BALB/c.GKO into B6.GKO were studied acrossfull MHC and non-MHC disparities.

Renal transplantation: Renal transplantation was performed as a nonlife-supporting transplant model. Recovered mice were killed at day 5,7, 14, 21 or 42 post-transplant. Kidneys were removed, snap frozen inliquid nitrogen and stored at −70° C. No mice received immunosuppressivetherapy. Kidneys with technical complications or infection at the timeof harvesting were removed from the study.

Treatment with recombinant IFN-γ: CBA mice were injected i.p with300,000 I.U. of recombinant INF-γ at 0 and 24 hours. rIFN-γ was agenerous gift from Dr. T. Stewart at Genentech (South San Francisco,Calif.). Mice were sacrificed after 48 hours.

Microarrays: High-density oligonucleotide Genechip 430A and 430 2.0arrays, GeneChip T7-Oligo(dT) Promotor Primer Kit, Enzo BioArrayHighYield RNA Transcript Labeling Kit, IVT Labeling KIT, GeneChip SampleCleanup Module, IVT cRNA Cleanup Kit were purchased from Affymetrix(Santa Clara, Calif.). RNeasy Mini Kit was from Qiagen (Ont, Canada),Superscript II, E. coli DNA ligase, E. coli DNA polymerase I, E. coliRnase H, T4 DNA polymerase, 5× second strand buffer, and dNTPs were fromInvitrogen Life Technologies.

RNA preparation and hybridization: Total RNA was extracted fromindividual kidneys using the guanidinium-cesium chloride method andpurified RNA using the RNeasy Mini Kit (Quiagen, Ont. Canada). RNAyields were measured by UV absorbance. The quality was assessed bycalculating the absorbance ratio at 260 nm and 280 nm, as well as byusing an Agilent BioAnalyzer to evaluate 18S and 28S RNA integrity.

For each array, RNA from 3 mice was pooled. RNA processing, labeling andhybridization to MOE430A or MOE430 2.0 arrays was carried out accordingto the protocols included in the Affymetrix GeneChip Expression AnalysisTechnical Manual (available on the World Wide Web at affymetrix.com).cRNA used for Moe 430 2.0 arrays was labeled and fragmented using an IVTLabeling Kit and IVT cRNA Cleanup Kit.

Sample designation: Normal control kidneys were obtained from CBA miceand designated as NCBA. Allografts rejecting in wild type hosts (B6) atday 5 through day 42 post transplant were designated as WT D5, D7, D14,D21 and D42, respectively. Corresponding isografts were designated IsoD5, D7 and D21. Kidneys from mice treated with recombinant IFN-γ andharvested after 48 h were designated rIFN-γ. BALB/c-GKO kidneys(deficient in IFN-γ) rejecting in IFN-γ-deficient B6 hosts at day 5 weredesignated as GKO D5 and corresponding isografts were designated ISO.GKOD5. The following samples (each consisting of RNA pooled from 3 mice)were analyzed by the Moe 430A arrays: two biological replicates of IsoD7, WT (D7, D14, D21 and D42); three replicates for NCBA and WT D5,single samples for Iso D5 and D21. Samples analyzed by the Moe 430 2.0were NCBA (three replicates), WT D5, GKO D5, ISO.GKO D5 and rIFN-γ (tworeplicates each).

Sample analysis: Microarray Suite Expression Analysis 5.0 software wasused for analysis of Moe 430A arrays (MAS 5.0, Affymetrix), and GeneChip Operating software (GCOS 2.0, Affymetrix) was used for analysis ofMoe 430 2.0 arrays to calculate absolute signal strength and transcriptsflagging. Normalization per chip and per gene (GeneSpring™ 7.2, Agilent,Palo Alto Calif.) and to the control samples (NCBA) were describedpreviously. The mean normalized value for further analysis of replicatesamples.

Transcripts of interest were selected based on 2-fold differences andsignificance by Welch's t-test (Anova parametric test, variances notassumed equal). Groups of selected transcripts were then compared forindividual time points using the univariate analysis of variance(Unianova with Bonferroni post hoc tests, for log transformed normalizeddata, SSPS 11.0 statistical package).

Hierarchical cluster analysis was performed using GeneSpring 7.2. Datawere log transformed and similarity of transcript expression betweenexperimental groups and between individual transcripts was visualized bya condition and gene tree diagram. Similarity measurements were based ondistance. Trajectory clustering (expression pattern comparison, 0.95correlation coefficient) was performed using the “find similar gene”feature in GeneSpring package.

Results

Terminology: rIFN-γ induced transcripts (GITs) were identified as thoseincreased 48 hours after two injections of rIFN-γ, spaced 24 hoursapart. Rejection induced transcripts (RITs) were identified as thoseincreased in allografts at day 5. Injury-induced transcripts wereidentified as those induced in isografts at days 5 and/or 7. Therejection induced transcripts thus include effects of transplant-relatedstress as well as alloimmune related changes.

Identification of transcripts induced by IFN-γ in vivo in rejectingkidney allografts: Identification of IFN-γ induced transcripts in kidneyallografts was based on data obtained from the Moe 430 2.0 arrays, withcytotoxic T lymphocyte associated transcripts (CATs) deleted from alllists to avoid overlap. First, the rIFN-γ-induced transcripts wereidentified: 342 transcripts flagged present and increased 2-fold innormal kidneys from mice treated with rIFN-γ (significant by ANOVA)(Table 1). RITs were then selected, defined as transcripts that wereelevated 2-fold in WT allografts at day 5 post transplant in WT hostsvs. normal kidneys (significant by Anova). 2040 transcripts, flaggedpresent in the allografts, fulfilled these criteria (Table 2). Todetermine how many of these transcripts were IFN-γ inducible, they werecompared to the GITs. This comparison yielded 163 common transcriptsthat were induced by rIFN-γ treatment and increased in rejecting kidneysat day 5. Thus, 179 GITs were not significantly induced in rejectingkidneys by these criteria, in spite of the strong IFN-γ response in theallograft.

Validation of IFN-γ induced transcripts in mouse kidney allografts: Toverify that the increased expression of 163 transcripts in day 5allografts was at least partially dependent on IFN-γ, IFN-γ-deficientkidney allografts grafted into IFN-γ-deficient hosts were studied. Inthese grafts, neither the donor nor the host cells can make IFN-γ. Afterremoving CATs, 570 transcripts were expressed at least 2-fold lower inGKO D5 compared to WT D5 (significant by ANOVA), indicating that theexpression of these transcripts was affected by the presence or absenceof IFN-γ in allografts (Table 3). Of the 163 previously defined rIFN-γ-and rejection-induced transcripts, 74 were decreased in GKO D5,indicating that they were at least partially dependent on IFN-γ in WT D5allografts. These were termed IFN-γ and rejection-inducible transcripts(GRITs). On the other hand, 89 transcripts, despite beingrIFN-γ-inducible, were not lower or were even increased when IFN-γ wasabsent in GKO D5 allografts compared to WT D5 allografts. These weretermed GRIT-like transcripts. Thus, the GRIT-like transcripts, despitebeing inducible by rIFN-γ, were increased in allografts by mechanismslargely independent of IFN-γ. The algorithm used for transcriptselection is shown in FIG. 1.

Functional classification of GRIT and GRIT-like: The list of GRITs(Table 4) summarizes local effects of IFN-γ on transcription in theisografts and the allografts, as well as systemic effects on the normalrejecting kidney. The transcripts represent genes for several majorclasses of proteins: (a) MHCs and their related factors (B2m Psmb8-9,Tapbp) and other ubiquitination/proteolysis-related factors (Parp14,Psmb10, Ubd, Ub11); (b) guanylate binding proteins (Gbp2),interferon-induced GTPases (Igtp, Iigp1, Tgtp) and other so calledIFN-γ-induced proteins (Ifi1 and Ifi47); (c) cytokines and chemokinesCc15, Cc18, Cxcl 9, Cxc110, interleukin-18 binding protein (II18 bp),Artsl; (d) other immune functions: complement components (C1r, C1s, C2);and (e) transcription factors and activators: Irf7 (ISRE sites), Stat1(GAS sites), class II transactivator C2ta.

The list of GRIT-like transcripts (Table 5) includes complementcomponents (C1qb, C1qg, Serping1); cytokine, chemokine and receptorrelated transcripts (Tnfsf13b, Ccr5, Cxcl14, Socs2); someinterferon-induced transcripts (Ifi27, Ifitm1, Ifitm6); and Tgfbi, atranscript whose expression is regulated by Tgfb1.

Expression profiles of GRIT and GRIT-like in the isografts and theallografts: The time course of changes in these transcripts posttransplant was studied by querying a previously established databasefrom MOE 430A arrays containing the expression values of all transcriptsin isografts and allografts, at different times post transplant.Previously identified GRITs were “translated” (using the GeneSpringtranslation feature) to Moe 430A arrays, and these increased at least 2fold (significant by Anova) in WT D5 allografts vs NCBA were selected.This permitted creation of a final list of 59 GRITs (Table 4) and 42GRIT-like transcripts (Table 5). The lower number of transcripts was dueto a lack of certain probe sets interrogating Riken sequences in Moe430A arrays, and perhaps also to the lower sensitivity of the M430Aarrays.

Analysis of the expression time course of GRITs and GRIT-liketranscripts in isografts and allografts permitted comparison of theimpact of transplant-related stress and/or injury on rejection. First,unsupervised clustering of all isografts and allografts was performedbased on GRITs and GRIT-like lists (FIG. 2 and FIG. 3). Kidney sampleswere grouped into two clusters. One powerful cluster included all of theallografts, indicating strong and consistent expression of the GRITs andGRIT-like transcripts in all allografts at all times tested.Surprisingly, ISO D5 clustered with all allografts for the GRITs (FIG.2). ISO D21 co-clustered with NCBA, indicating recovery of kidneys frominjury. ISO D7 was more similar to this group. On the other hand,GRIT-like list yielded good separation of the all isografts from theallografts, clustering ISO D5 and ISO D7 in one subgroup (FIG. 3). Thisindicated a stronger relation of GRIT expression in ISO D5 to rejectingallografts, compared to GRIT-like expression.

Time course of GRIT expression parallels IFN-γ expression: The timecourse of GRIT expression supported the cluster organization and theconclusion that there were differences in regulation of GRITs (FIG. 2)versus GRIT-like transcripts (FIG. 3). In the isografts, expression ofmany GRITs peaked at D5 post transplant and sharply declined at D7 andD21. Thirty-nine and 11 GRITs were increased at least 2-fold at ISO D5and ISO D7, respectively. Mean expression of GRITs in ISO D5 samples washigher than in ISO D7 and D21 (p<0.01). GRIT expression in theallografts, however, was sustained throughout the observation period,with no significant differences among the samples except for a smallpeak at D14 (p<0.05). In addition, GRIT expression in the allograftsshowed 4-fold higher mean expression compared to ISO D5 (p<0.02,corrected for multiple comparisons).

For the comparison, FIG. 2A demonstrates the time course of IFN-γexpression in the isografts D5 throughout D21 and the allografts day 5throughout day 42. Isograft IFN-γ transcript levels peaked at D5 anddeclined from D7 on (FIGS. 2B and 2C). However, IFN-γ transcript levelswere 5-fold higher in WT D5 allografts compared to ISO D5, and remainedhigh at all allograft time points, with some increase at day 14. ThusGRIT expression parallels that of IFN-γ.

IFN-γ expression also was assessed in WT allografts at early times posttransplant. IFN-γ signal strength increased about 8 fold in D5 comparedto D3 allografts (FIG. 4A), indicating that the IFN-γ expression wasestablished at D5 post transplant.

Time course of GRIT-like transcripts parallels TGF-β1 expression:GRIT-like transcripts were analyzed over the time course shown in FIG.3A, and showed consistent expression in all allografts. However, theydiffered in isografts: there was no statistically significant differencebetween their mean expression at ISO D5 and ISO D7 (FIG. 3B). 17GRIT-like allografts were increased at least 2-fold either in ISO D5 orISO D7 samples. Mean GRIT-like expression was 2 fold higher compared toISO D5 or ISO D7 (p<0.02, corrected for multiple comparisons). However,GRIT-like mean expression in the isografts and the allografts was lowerby 2-fold compared to GRITs.

The appearance of Tgfbi in the GRIT-like list suggests that Tgfb1 may beplaying a role in the regulation of some of these transcripts. Moreover,the GRIT-like transcripts, by definition, are not significantly reducedin the absence of IFN-γ, indicating that they are induced by otherfactors, one candidate being Tgf-β1. The expression profile of Tgfbi wasreminiscent of Tgfb1, i.e., it demonstrated a similar peak in ISO D7 andstrong increase in the allografts, like many of the GRIT-liketranscripts.

The expression time course of GRIT/GRIT-like in WT allografts at earlytimes post transplant demonstrated a step-wise increase from day 3 today 4 to day 5 post transplant (FIGS. 4B and 4C).

Expression of GRITs and GRIT-like in the isografts differ in response toIFN-γ. To confirm that the elevated expression of GRIT in wild typeisografts is dependent on IFN-γ, the expression of GRITs was assessed inthe IFN-γ-deficient D5 isografts (ISO.GKO D5) by Moe 430 2.0 arrays andcompared to GRIT expression in wild type isografts D5. Transcripts thatwere increased at least 2-fold in WT D5 vs to ISO.GKO D5 were translatedto Moe 430A arrays. It was observed that 36 out of 59 GRITs (Table 4)were expressed at least 2-fold higher in WT D5 isografts compared toISO.GKO D5. Notably, only 10 GRIT-like transcripts fulfilled thesecriteria (Table 5). Thus, the majority (66%) of GRITs and only afraction (25%) of GRIT-like transcripts seemed to be dependent on IFN-γproduced in the isografts.

Regulation of the expression of injury and rejection induced transcriptsthat are not IFN-γ regulated by these criteria: Due to the uniformitywith which the GRITs and GRIT-like transcripts were increased in theisografts (albeit to a varying degree in ISO D5 and ISO D7 samples), theanalysis of transplant stress/injury to rejection was extended byanalyzing all transcripts flagged present and elevated 2-fold either inisografts at days 5 or 7 and increased 2-fold in WT D5 (significant byAnova). GRITs, GRIT-like and CATs were eliminated from this list.Moreover, transcripts were detected that were decreased 2-fold or morein GKO D5 compared to WT D5, but were not affected by rIFNγadministration. One hundred ten of these transcripts translated to Moe430A arrays (Table 6) and were eliminated from the RIT list.

The analysis yielded many transcripts that behaved like the GRIT-liketranscripts, with a peak at day 7 and consistent high expression in allallografts. As listed in Table 7, 147 injury-induced RITs met theseconditions in Moe 430A database. Unsupervised clustering based on thislist grouped ISO D7 samples with the allografts (FIG. 5A). Expressionpattern of these transcripts confirmed the clustering result.Injury-induced RITs peaked in ISO D7 isografts rather than ISO D5 (FIG.5B; significant by Anova). One hundred forty RITs were increased 2-foldor more at ISO D7, including the acute-phase response markers: serumamyloids 1-3 and ceruloplasmin, while 54 were increased at ISO D5. Themean expression of RITs was more elevated and sustained in theallografts compared to ISO D7 and ISO D5, with a peak in WT D14allografts (FIG. 5B, significant by Anova). A Medline-assistedliterature search revealed that expression of the injury-induced RITstranscripts could be dependent on either IFN-γ or Tgfb1, or both. IFN-γcontrol was reported for Vim, Cc12, Arrb2 (also reported as a possiblemarker of human heart rejection), ceruloplasmin, Fnl, Fos, Socs3, Timp1,Ncf2, Fcgr3, Plek, and Casp12. Tgfb1 control was reported fortranscripts Tgfbi, collagen type 1a2 and 3a1, Socs3, Lox, Cspg2, Fnl,Postn (periostin, homologous to Tgfbi) (Table 8).

The expression profiles of these transcripts were then analyzed, and itwas observed that the average expression pattern of injury-induced RITswas significantly similar to the Tgfbi expression profile, as assessedby the trajectory profiling i.e. “find similar gene(s)” feature ofGeneSpring (FIGS. 6A and 6B). Next, the expression profiles of aselected prototypic GRIT (Stat1, which was elevated in isografts) and aprototypic GRIT-like transcript (Tgfbi) were compared to the expressionprofiles of injury-induced RITs. Using the trajectory clustering, 50transcripts were found with patterns similar to that of Tgfbi (FIG. 7A),and 43 transcripts were found with patterns similar to that of STAT-1(FIG. 7B). RITs showing Stat-1-like profiles had substantial overlap (39transcripts) with Tgfbi-like profiles.

TABLE 1 rIFN-γ-induced transcripts (GITs) rIFNg Gene Symbol NCBA vsAffymetrix Gene Title Affymetrix Raw NCBA Genbank — — 1241 3.2 AV290571— — 855 3.0 AV227574 — — 12 2.2 BB416480 — — 127 2.0 BB291656 — — 2193.0 BB533460 — — 25 2.8 AW554440 — — 83 2.3 BB308208 Oasl2 2′-5′oligoadenylate synthetase-like 2 209 2.2 BQ033138 Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A 291 2.8 BB123978 reductase Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A 83 5.8 BC014714 synthase 2 Arf3ADP-ribosylation factor 3 107 2.6 BQ175059 Akr1c18 aldo-keto reductasefamily 1, member C18 314 7.9 NM_134066 Akr1c20 aldo-keto reductasefamily 1, member C20 28 15.8 BC021607 Angptl3 angiopoietin-like 3 2533.7 BC019491 Arg2 arginase type II 85 9.3 AV002218 Arvcf armadillorepeat gene deleted in velo- 153 2.0 BE947943 cardio-facial syndromeAstn1 astrotactin 1 21 2.7 NM_007495 Atp8a1 ATPase, aminophospholipidtransporter 150 2.1 BQ176779 (APLT), class I, type 8A, member 1 Atp1a2ATPase, Na+/K+ transporting, alpha 2 33 3.3 AV325919 polypeptide Abcb1aATP-binding cassette, sub-family B 40 3.9 M30697 (MDR/TAP), member 1AAbcb1a ATP-binding cassette, sub-family B 142 3.8 M30697 (MDR/TAP),member 1A Abcc3 ATP-binding cassette, sub-family C 130 17.7 AK006128(CFTR/MRP), member 3 Bhlhb5 basic helix-loop-helix domain containing,113 2.0 NM_021560 class B5 B2m beta-2 microglobulin 9650 2.6 AI099111B2m beta-2 microglobulin 71 3.5 AA170322 B2m beta-2 microglobulin 134692.0 BF715219 Bhmt betaine-homocysteine methyltransferase 331 9.6NM_016668 Bace beta-site APP cleaving enzyme 152 4.1 BB114336 Baat bileacid-Coenzyme A: amino acid N- 17 11.2 NM_007519 acyltransferase Cdh11cadherin 11 381 2.0 NM_009866 Car5a carbonic anhydrase 5a, mitochondrial98 2.2 NM_007608 Cart1 cartilage homeo protein 1 57 2.4 BB366930 Ctsscathepsin S 838 2.6 NM_021281 BC011209 cDNA sequence BC011209 437 2.0BC011209 BC021340 cDNA sequence BC021340 256 2.2 BC021340 BC060267 cDNAsequence BC060267 59 2.2 BB124106 Ceacam1 CEA-related cell adhesionmolecule 1 296 3.0 M77196 Ceacam1 CEA-related cell adhesion molecule 1377 2.3 BC016891 Ceacam1 CEA-related cell adhesion molecule 1 670 2.5NM_011926 Ceacam2 CEA-related cell adhesion molecule 2 100 3.1 NM_007543Ceacam2 CEA-related cell adhesion molecule 2 733 2.6 BC024320 Cpceruloplasmin 232 2.1 BB332449 Ccl21a chemokine (C-C motif) ligand 21a(serine) 368 2.0 NM_011335 Ccl5 chemokine (C-C motif) ligand 5 34 6.0NM_013653 Ccl8 chemokine (C-C motif) ligand 8 115 2.3 NM_021443 Ccr5chemokine (C-C motif) receptor 5 73 2.6 D83648 Cxcl10 chemokine (C—X—Cmotif) ligand 10 162 2.2 NM_021274 Cxcl12 chemokine (C—X—C motif) ligand12 1335 2.2 NM_013655 Cxcl14 chemokine (C—X—C motif) ligand 14 260 2.1AF252873 Cxcl14 chemokine (C—X—C motif) ligand 14 124 2.4 AF252873 Cxcl9chemokine (C—X—C motif) ligand 9 125 6.5 NM_008599 CRAD-Lcis-retinol/3alpha hydroxysterol short-chain 2243 4.5 BC018263dehydrogenase-like C2ta class II transactivator 89 2.0 AF042158 C1qbcomplement component 1, q 363 2.8 NM_009777 subcomponent, betapolypeptide C1qg complement component 1, q 185 4.0 NM_007574subcomponent, gamma polypeptide C1r complement component 1, r 148 2.8BB558917 subcomponent C1r complement component 1, r 382 3.1 NM_023143subcomponent C1s complement component 1, s 395 2.3 BC022123 subcomponentC2 complement component 2 (within H-2S) 1215 2.6 NM_013484 Coro1acoronin, actin binding protein 1A 168 2.2 BB740218 Coro1a coronin, actinbinding protein 1A 239 2.2 BC002136 Cugbp2 CUG triplet repeat, RNAbinding protein 2 161 2.1 BB644164 Cdkn1c cyclin-dependent kinaseinhibitor 1C (P57) 367 2.1 NM_009876 Cox8b cytochrome c oxidase, subunitVIIIb 47 6.0 NM_007751 Cyp4a10 cytochrome P450, family 4, subfamily a,573 2.0 BC013476 polypeptide 10 Cyp4a14 cytochrome P450, family 4,subfamily a, 47 148.5 AI327006 polypeptide 14 Dach1 dachshund 1(Drosophila) 91 2.0 BB522228 Dock10 dedicator of cytokinesis 10 145 2.6BF715043 D10Bwg1379e DNA segment, Chr 10, Brigham & 25 3.9 BB125269Women's Genetics 1379 expressed D12Ertd647e DNA segment, Chr 12, ERATODoi 647, 953 4.9 AW554405 expressed D12Ertd647e DNA segment, Chr 12,ERATO Doi 647, 1414 3.4 BI655075 expressed D3Bwg0562e DNA segment, Chr3, Brigham & Women's 52 2.4 BQ175587 Genetics 0562 expressed D3Bwg0562eDNA segment, Chr 3, Brigham & Women's 178 3.1 BB238462 Genetics 0562expressed D7Bwg0421e DNA segment, Chr 7, Brigham & Women's 64 2.0AK017222 Genetics 0421 expressed Duf6 DUF6 containing protein 112 2.2BB758319 Edaradd EDAR (ectodysplasin-A receptor)- 28 3.1 NM_133643associated death domain Emr4 EGF-like module containing, mucin-like, 203.5 AF396935 hormone receptor-like sequence 4 Elovl2 elongation of verylong chain fatty acids 951 2.3 NM_019423 (FEN1/Elo2, SUR4/Elo3,yeast)-like 2 Elovl6 ELOVL family member 6, elongation of 323 3.2NM_130450 long chain fatty acids (yeast) Enah enabled homolog(Drosophila) 81 2.1 AV329519 Ednra endothelin receptor type A 18 3.6BC008277 Eva epithelial V-like antigen 371 2.0 BC015076 Eva epithelialV-like antigen 490 2.0 BC015076 AI481100 expressed sequence AI481100 3655.2 NM_019440 AI788959 expressed sequence AI788959 914 2.8 BC028826AI789751 expressed sequence AI789751 326 9.9 AI789751 AI987712 expressedsequence AI987712 92 28.2 AW554594 AU040377 expressed sequence AU040377141 2.1 AV024806 AW111922 expressed sequence AW111922 361 8.0 BM239828AW111922 expressed sequence AW111922 885 7.5 BM239828 AW413625 expressedsequence AW413625 80 2.7 NM_026640 Fabp7 fatty acid binding protein 7,brain 795 2.1 NM_021272 Facl2 fatty acid Coenzyme A ligase, long chain 25896 2.3 BC006692 Facl2 fatty acid Coenzyme A ligase, long chain 2 14172.1 BI413218 Fer1l3 fer-1-like 3, myoferlin (C. elegans) 208 1.9BI555209 Fgl2 fibrinogen-like protein 2 114 2.5 BF136544 Foxd1 forkheadbox D1 36 2.8 BB662927 Foxq1 forkhead box Q1 219 2.5 NM_008239 Foxq1forkhead box Q1 142 3.8 AV009267 Gpr135 G protein-coupled receptor 13545 2.9 AV221890 Gsto1 glutathione S-transferase omega 1 1328 2.1AV003026 Gpm6b glycoprotein m6b 232 2.2 AK016567 Gzma granzyme A 68 3.6NM_010370 Gc group specific component 554 6.0 AI195150 Gbp2 guanylatenucleotide binding protein 2 321 23.0 NM_010260 Gbp2 guanylatenucleotide binding protein 2 272 22.9 BE197524 Hck hemopoietic cellkinase 117 2.1 NM_010407 Hdgfrp3 hepatoma-derived growth factor, related93 2.6 BB291880 protein 3 H2-Aa histocompatibility 2, class II antigenA, 2137 4.3 AF119253 alpha H2-Aa histocompatibility 2, class II antigenA, 3501 4.3 BE688749 alpha H2-Ab1 histocompatibility 2, class II antigenA, 421 8.2 M15848 beta 1 H2-Ab1 histocompatibility 2, class II antigenA, 950 7.9 NM_010379 beta 1 H2-Ab1 histocompatibility 2, class IIantigen A, 659 10.9 M15848 beta 1 H2-Eb1 histocompatibility 2, class IIantigen E beta 1760 3.7 NM_010382 H2-DMa histocompatibility 2, class II,locus DMa 261 9.0 NM_010386 H2-DMb1 histocompatibility 2, class II,locus Mb1 121 14.5 NM_010388 H2-DMb1 histocompatibility 2, class II,locus Mb1 159 15.2 BB734586 H2-DMb1 histocompatibility 2, class II,locus Mb1 116 8.9 NM_010387 H2-DMb1 histocompatibility 2, class II,locus Mb1 87 20.1 BB734586 H2-DMb1 histocompatibility 2, class II, locusMb1 347 7.4 NM_010388 H2-K histocompatibility 2, K region 626 10.3L23495 H2-T10 histocompatibility 2, T region locus 10 2355 2.3 NM_010395associated — Mus musculus 0 day neonate head cDNA, 420 2.5 BB109391RIKEN full-length enriched library, clone: 4833430O13 product: unknownEST, full insert sequence — Mus musculus 0 day neonate kidney 39 2.3BB500101 cDNA, RIKEN full-length enriched library, clone: D630024M22product: unclassifiable, full insert sequence — Mus musculus 0 dayneonate kidney 153 2.1 BB820846 cDNA, RIKEN full-length enrichedlibrary, clone: D630033M22 product: hypothetical protein, full insertsequence — Mus musculus 0 day neonate kidney 54 2.9 BB504342 cDNA, RIKENfull-length enriched library, clone: D630047M14 product: unclassifiable,full insert sequence — Mus musculus 0 day neonate lung cDNA, 70 2.0BI452538 RIKEN full-length enriched library, clone: E030022N22 product:unclassifiable, full insert sequence — Mus musculus 0 day neonate thymus112 2.7 AK020789 cDNA, RIKEN full-length enriched library, clone:A430110A21 product: unclassifiable, full insert sequence — Mus musculus10 days neonate 38 2.7 BM201103 cerebellum cDNA, RIKEN full-lengthenriched library, clone: B930059K21 product: unknown EST, full insertsequence — Mus musculus 12 days embryo spinal 56 2.0 BB454099 ganglioncDNA, RIKEN full-length enriched library, clone: D130028L22 product:unclassifiable, full insert sequence — Mus musculus 16 days embryo head110 2.3 BB208251 cDNA, RIKEN full-length enriched library, clone:C130051K14 product: unknown EST, full insert sequence — Mus musculus 16days embryo head 71 2.6 BB374879 cDNA, RIKEN full-length enrichedlibrary, clone: C130077H22 product: unclassifiable, full insert sequence— Mus musculus 16 days neonate 128 2.1 AV118079 cerebellum cDNA, RIKENfull-length enriched library, clone: 9630032E14 product: unknown EST,full insert sequence — Mus musculus 16 days neonate thymus 56 2.4BB162048 cDNA, RIKEN full-length enriched library, clone: A130086M19product: unknown EST, full insert sequence — Mus musculus 18-day embryowhole body 157 2.2 BM730637 cDNA, RIKEN full-length enriched library,clone: 1110059G02 product: unclassifiable, full insert sequence — Musmusculus 2 days pregnant adult 55 2.2 BB053468 female oviduct cDNA,RIKEN full-length enriched library, clone: E230038I17 product: unknownEST, full insert sequence — Mus musculus 3 days neonate thymus 172 2.8BI151331 cDNA, RIKEN full-length enriched library, clone: A630040D01product: unknown EST, full insert sequence — Mus musculus 4 days neonatemale 87 2.0 BB326079 adipose cDNA, RIKEN full-length enriched library,clone: B430203I24 product: unknown EST, full insert sequence — Musmusculus 6 days neonate head 85 2.1 AK017417 cDNA, RIKEN full-lengthenriched library, clone: 5430440L12 product: unknown EST, full insertsequence — Mus musculus 7 days embryo whole body 124 2.2 BB408240 cDNA,RIKEN full-length enriched library, clone: C430005H19 product: unknownEST, full insert sequence — Mus musculus adult male bone cDNA, 55 2.3BB134628 RIKEN full-length enriched library, clone: 9830116N24 product:unclassifiable, full insert sequence — Mus musculus adult male corpora64 2.6 AI323288 quadrigemina cDNA, RIKEN full-length enriched library,clone: B230339M22 product: inhibitor of DNA binding 4, full insertsequence — Mus musculus adult male medulla 26 2.2 AV332226 oblongatacDNA, RIKEN full-length enriched library, clone: 6330531L09 product:unknown EST, full insert sequence — Mus musculus adult male olfactorybrain 26 1.9 AV237721 cDNA, RIKEN full-length enriched library, clone:6430566E03 product: unknown EST, full insert sequence — Mus musculusCorpos mRNA, 3′ 59 2.2 BM220939 untranslated region — Mus musculusNOD-derived CD11c +ve 223 2.1 AK004894 dendritic cells cDNA, RIKENfull-length enriched library, clone: F630107D10 product: similar toUBIQUITIN- ACTIVATING ENZYME E1 [Homo sapiens], full insert sequence —Mus musculus similar to Aldo-keto 907 2.1 BG073853 reductase family 1member C13 (LOC238465), mRNA — Mus musculus similar to hypothetical 7162.5 BM243674 protein (LOC243374), mRNA — Mus musculus similar tohypothetical 25 2.4 BE197771 protein FLJ31208 (LOC225602), mRNA — Musmusculus transcribed sequence 31 3.5 AI790337 — Mus musculus transcribedsequence with 47 3.3 BG063622 strong similarity to protein sp: P00722(E. coli) BGAL_ECOLI Beta-galactosidase (Lactase) — Mus musculustranscribed sequence with 44 4.7 BB210623 weak similarity to proteinref: NP_036400.1 (H. sapiens) similar to vaccinia virus HindIII K4L ORF[Homo sapiens] — Mus musculus transcribed sequence with 191 45.8BM241485 weak similarity to protein sp: P32456 (H. sapiens) GBP2_HUMANInterferon- induced guanylate-binding protein 2 (Guaninenucleotide-binding protein 2) — Mus musculus transcribed sequences 352.5 BB460538 — Mus musculus transcribed sequences 90 2.1 BB485280 — Musmusculus transcribed sequences 46 2.0 BM218007 — Mus musculustranscribed sequences 87 3.4 AV277444 — Mus musculus transcribedsequences 438 4.5 BE688358 — Mus musculus transcribed sequences 182 2.1AW492955 — Mus musculus transcribed sequences 58 4.5 BI134319 — Musmusculus transcribed sequences 91 2.0 BB497148 — Mus musculustranscribed sequences 63 2.4 BG069383 — Mus musculus transcribedsequences 67 2.1 BM220820 — Mus musculus transcribed sequences 25 2.2BB553888 — Mus musculus transcribed sequences 18 2.2 BB767194 — Musmusculus transcribed sequences 44 2.0 BM730703 — Mus musculustranscribed sequences 102 1.9 BG068971 — Mus musculus transcribedsequences 339 27.6 BG092512 — Mus musculus transcribed sequences 130 2.0AW546127 — Mus musculus transcribed sequences 72 2.3 AW543171 — Musmusculus transcribed sequences 150 2.1 BI664122 — Mus musculustranscribed sequences 193 2.0 AV291009 — Mus musculus transcribedsequences 54 2.0 AU041975 — Mus musculus transcribed sequences 95 2.0AV352204 — Mus musculus transcribed sequences 20 2.1 BB043509 — Musmusculus transcribed sequences 217 2.0 BM119402 — Mus musculustranscribed sequences 32 2.5 AV300631 — Mus musculus transcribedsequences 82 4.6 BG067157 — Mus musculus transcribed sequences 115 2.2AW111920 — Mus musculus transcribed sequences 35 3.5 BM225081 — Musmusculus transcribed sequences 133 2.0 AW556334 — Mus musculustranscribed sequences 27 3.0 AI118114 — Mus musculus transcribedsequences 18 3.1 BB520952 — Mus musculus transcribed sequences 142 2.2AV264768 — Mus musculus, clone IMAGE: 4507681, 32 3.0 BG071655 mRNA Mllmyeloid/lymphoid or mixed-lineage 128 2.1 AK017541 leukemia Npntnephronectin 1459 2.0 AA223007 Npnt nephronectin BB433705 Ntf3neurotrophin 3 49 3.3 NM_008742 Odz3 odd Oz/ten-m homolog 3 (Drosophila)9 3.2 BB472509 Olfr56 olfactory receptor 56 336 3.4 NM_008330 Padi2peptidyl arginine deiminase, type II 110 3.0 NM_008812 Ppicappeptidylprolyl isomerase C-associated 1079 3.2 NM_011150 protein Pte2aperoxisomal acyl-CoA thioesterase 2A 780 2.7 NM_134246 Pck1phosphoenolpyruvate carboxykinase 1, 46 6.8 BB225177 cytosolic Pik3ap1phosphoinositide-3-kinase adaptor protein 1 64 3.0 BI684288 Pigrpolymeric immunoglobulin receptor 3030 2.1 AV027632 Kcnk1 potassiumchannel, subfamily K, member 1 708 4.0 AU043100 Prickle1 prickle like 1(Drosophila) 144 2.3 BC022643 Prickle1 prickle like 1 (Drosophila) 402.9 BE992966 Pdcd1lg1 programmed cell death 1 ligand 1 73 4.4 NM_021893Prom1 prominin 1 2598 2.7 NM_008935 Psmb10 proteasome (prosome,macropain) 525 3.2 NM_013640 subunit, beta type 10 Psmb8 proteosome(prosome, macropain) 17 5.1 AV068122 subunit, beta type 8 (largemultifunctional protease 7) Psmb8 proteosome (prosome, macropain) 4619.9 NM_010724 subunit, beta type 8 (large multifunctional protease 7)Psmb9 proteosome (prosome, macropain) 298 4.5 NM_013585 subunit, betatype 9 (large multifunctional protease 2) Arhgef6 Rac/Cdc42 guaninenucleotide exchange 142 2.8 BM246754 factor (GEF) 6 Rai2 retinoic acidinduced 2 59 2.0 BB770528 1110004C05Rik RIKEN cDNA 1110004C05 gene 37012.3 BC010291 1110036C17Rik RIKEN cDNA 1110036C17 gene 622 2.7 BC0272851110036O03Rik RIKEN cDNA 1110036O03 gene 115 2.0 BE951265 1110063G11RikRIKEN cDNA 1110063G11 gene 81 2.0 AK004359 1190005J19Rik RIKEN cDNA1190005J19 gene 31 2.0 NM_007819 1200015N20Rik RIKEN cDNA 1200015N20gene 39 2.2 BB461323 1600020H07Rik RIKEN cDNA 1600020H07 gene 1301 2.7NM_019975 1700003F17Rik RIKEN cDNA 1700003F17 gene 64 2.9 AV2202131700007J06Rik RIKEN cDNA 1700007J06 gene 27 2.2 AK005720 1700019D03RikRIKEN cDNA 1700019D03 gene 20 2.4 AK006110 1810037B05Rik RIKEN cDNA1810037B05 gene 50 3.0 AK007714 2010204K13Rik RIKEN cDNA 2010204K13 gene249 2.3 NM_023450 2310007B03Rik RIKEN cDNA 2310007B03 gene 78 2.3AK009193 2310008H04Rik RIKEN cDNA 2310008H04 gene 246 5.7 BC0268772310015I10Rik RIKEN cDNA 2310015I10 gene 269 5.7 BC008532 2310022A04RikRIKEN cDNA 2310022A04 gene 327 2.0 AK007542 2310035M22Rik RIKEN cDNA2310035M22 gene 44 2.2 NM_025863 2310046K10Rik RIKEN cDNA 2310046K10gene 63 2.2 AK017174 2310046K10Rik RIKEN cDNA 2310046K10 gene 106 2.1BF020640 2310061N23Rik RIKEN cDNA 2310061N23 gene 219 4.2 AY0900982410041A17Rik RIKEN cDNA 2410041A17 gene 556 3.4 NM_133348 2510038N07RikRIKEN cDNA 2510038N07 gene 161 2.5 AW208668 2610030H06Rik RIKEN cDNA2610030H06 gene 510 2.3 BB429625 2700038M07Rik RIKEN cDNA 2700038M07gene 786 2.0 BC019601 2810002E22Rik RIKEN cDNA 2810002E22 gene 543 2.2NM_133859 2810030E01Rik RIKEN cDNA 2810030E01 gene 76 2.1 BB2559993300001H21Rik RIKEN cDNA 3300001H21 gene 106 2.3 NM_027334 4631422C05RikRIKEN cDNA 4631422C05 gene 716 1.9 BI648645 4930513H15Rik RIKEN cDNA4930513H15 gene 49 2.4 AK017117 4931406H21Rik RIKEN cDNA 4931406H21 gene75 2.0 BG076071 4931408A02Rik RIKEN cDNA 4931408A02 gene 58 3.7 AK0164434933402B14Rik RIKEN cDNA 4933402B14 gene 45 2.2 AV278444 5430425C04RikRIKEN cDNA 5430425C04 gene 44 2.9 AK017334 5830458K16Rik RIKEN cDNA5830458K16 gene 525 2.6 BC024872 6330407A03Rik RIKEN cDNA 6330407A03gene 60 2.2 AW519657 6720477E09Rik RIKEN cDNA 6720477E09 gene 132 2.3BB053506 9230117N10Rik RIKEN cDNA 9230117N10 gene 222 2.2 NM_1337759330174J19Rik RIKEN cDNA 9330174J19 gene 39 4.4 BE687891 A330021E22RikRIKEN cDNA A330021E22 gene 52 2.0 BB561281 A830021K08Rik RIKEN cDNAA830021K08 gene 825 2.4 BB291885 A930021H16Rik RIKEN cDNA A930021H16gene 54 2.1 BB513585 B830010L13Rik RIKEN cDNA B830010L13 gene 144 2.6BB333374 C330012H03Rik RIKEN cDNA C330012H03 gene 69 2.0 BB098431D430019H16Rik RIKEN cDNA D430019H16 gene 57 2.5 BM116882 D730043B02RikRIKEN cDNA D730043B02 gene 104 2.2 AK021336 E530005C20Rik RIKEN cDNAE530005C20 gene 56 2.0 BB662566 Robo2 roundabout homolog 2 (Drosophila)22 2.3 BB366379 Sall1 sal-like 1 (Drosophila) 687 2.1 BB739342 Sema3esema domain, immunoglobulin domain 60 2.0 NM_011348 (Ig), short basicdomain, secreted, (semaphorin) 3E Serpina10 serine (or cysteine)proteinase inhibitor, 211 7.6 BC018416 clade A (alpha-1 antiproteinase,antitrypsin), member 10 Serpina3g serine (or cysteine) proteinaseinhibitor, 92 4.5 BC002065 clade A, member 3G Serpinb9 serine (orcysteine) proteinase inhibitor, 323 2.1 BE686716 clade B, member 9Serping1 serine (or cysteine) proteinase inhibitor, 2372 3.8 NM_009776clade G, member 1 Stard13 serologically defined colon cancer antigen 1512.0 BB667840 13 Stat1 signal transducer and activator of 171 3.8AW214029 transcription 1 Stat1 signal transducer and activator of 9152.7 AW214029 transcription 1 Stat1 signal transducer and activator of808 2.8 AW214029 transcription 1 Slamf8 SLAM family member 8 27 3.3BC024587 Slc7a12 solute carrier family 7 (cationic amino acid 290 29.4NM_080852 transporter, y+ system), member 12 Slco2a1 solute carrierorganic anion transporter 349 2.1 NM_033314 family, member 2a1 Stab2stabilin 2 230 1.9 NM_138673 Scd1 stearoyl-Coenzyme A desaturase 1 22555.6 NM_009127 Scd1 stearoyl-Coenzyme A desaturase 1 389 3.5 NM_009127Socs2 suppressor of cytokine signaling 2 478 3.7 NM_007706 Socs2suppressor of cytokine signaling 2 354 4.7 NM_007706 Syt13 synaptotagmin13 37 3.3 BB244585 Tapbp TAP binding protein 2304 3.5 AF043943 Tbx3T-box 3 58 2.1 BB728182 Tgtp T-cell specific GTPase 1220 8.9 NM_011579Thoc1 THO complex 1 33 2.2 BB647938 Thbs1 thrombospondin 1 727 2.1AI385532 Tmsb10 thymosin, beta 10 941 2.4 NM_025284 Top2a topoisomerase(DNA) II alpha 142 2.0 BM211413 Tle2 transducin-like enhancer of split2, 150 2.1 AU067681 homolog of Drosophila E(spl) Tgfbi transforminggrowth factor, beta induced 294 2.3 NM_009369 Tgfbi transforming growthfactor, beta induced 229 2.5 NM_009369 Tm4sf3 transmembrane 4superfamily member 3 124 2.1 C76990 Tap1 transporter 1, ATP-bindingcassette, sub- 127 5.7 AW048052 family B (MDR/TAP) Tmlhe trimethyllysinehydroxylase, epsilon 66 1.9 BC005497 Tpm2 tropomyosin 2, beta 307 2.1BC024358 Tubb2 tubulin, beta 2 969 2.3 BC003475 Tnfsf13b tumor necrosisfactor (ligand) superfamily, 101 2.4 NM_033622 member 13b Arts1 type 1tumor necrosis factor receptor 444 2.3 NM_030711 shedding aminopeptidaseregulator Arts1 type 1 tumor necrosis factor receptor 221 2.8 AV287655shedding aminopeptidase regulator Ubd ubiquitin D 121 11.5 NM_023137 Utxubiquitously transcribed tetratricopeptide 22 2.6 BB306686 repeat gene,X chromosome Vcam1 vascular cell adhesion molecule 1 268 2.6 BB250384Was Wiskott-Aldrich syndrome homolog 25 3.8 NM_009515 (human) Xdhxanthine dehydrogenase 167 4.7 AV286265 Zbp1 Z-DNA binding protein 1 495.1 AK008179 Zdhhc6 zinc finger, DHHC domain containing 6 70 2.0BB251023

TABLE 2 Rejection-induced transcripts (RITs) WT D5 Gene Symbol NCBA vsAffymetrix Common Gene Title Affymetrix Raw NCBA Genbank 0610009C03Rik0610009C03Rik RIKEN cDNA 0610009C03 gene 538 2.0 AK002371 0610025L06Rik0610025L06Rik RIKEN cDNA 0610025L06 gene 277 5.2 AK012581 0610033I05Rik0610033I05Rik RIKEN cDNA 0610033I05 gene 407 3.0 BC003333 0610037M15Rik0610037M15Rik RIKEN cDNA 0610037M15 gene 169 15.6 BG916808 0610039P13Rik0610039P13Rik RIKEN cDNA 0610039P13 gene 141 3.4 BC021548 —0910001A06Rik Mus musculus 3 days neonate thymus 60 4.2 BB229269 cDNA,RIKEN full-length enriched library, clone: A630020J17 product: unknownEST, full insert sequence 0910001A06Rik 0910001A06Rik RIKEN cDNA0910001A06 gene 663 6.7 BC011343 0910001A06Rik 0910001A06Rik RIKEN cDNA0910001A06 gene 63 2.3 AV033641 1100001H23Rik 1100001H23Rik RIKEN cDNA1100001H23 gene 988 4.4 NM_025806 1100001I19Rik 1100001I19Rik RIKEN cDNA1100001I19 gene 288 2.1 BM119324 1100001I19Rik 1100001I19Rik RIKEN cDNA1100001I19 gene 219 2.8 BE949451 1110006O17Rik 1110006O17Rik RIKEN cDNA1110006O17 gene 199 5.1 BB736636 1110007F12Rik 1110007F12Rik RIKEN cDNA1110007F12 gene 30 4.0 BB765808 1110007F12Rik 1110007F12Rik RIKEN cDNA1110007F12 gene 1154 3.0 BC020080 — 1110007H17Rik Mus musculus 0 dayneonate lung cDNA, 97 2.1 BI466783 RIKEN full-length enriched library,clone: E030022F06 product: inferred: exchange factor for ARF6 {Rattusnorvegicus}, full insert sequence 1110008F13Rik 1110008F13Rik RIKEN cDNA1110008F13 gene 16 6.7 AV316605 1110013L07Rik 1110013L07Rik RIKEN cDNA1110013L07 gene 165 3.0 BB765852 — 1110033M05Rik Mus musculustranscribed sequences 34 2.1 BM220862 1200002N14Rik 1200002N14Rik RIKENcDNA 1200002N14 gene 470 4.3 BC021433 1200008O12Rik 1200008O12Rik RIKENcDNA 1200008O12 gene 44 16.3 AK004655 1200009I06Rik 1200009I06Rik RIKENcDNA 1200009I06 gene 270 2.0 AK005443 1200013B08Rik 1200013B08Rik RIKENcDNA 1200013B08 gene 183 8.3 AK004734 1300002K09Rik 1300002K09Rik RIKENcDNA 1300002K09 gene 141 3.6 AV222559 1500001L15Rik 1500001L15Rik RIKENcDNA 1500001L15 gene 921 2.1 BB559925 1500002B03Rik 1500002B03Rik RIKENcDNA 1500002B03 gene 175 2.4 AK005105 1500004A08Rik 1500004A08Rik RIKENcDNA 1500004A08 gene 219 2.3 BB030508 1500031M22Rik 1500031M22Rik RIKENcDNA 1500031M22 gene 119 2.1 AK015145 1700013H19Rik 1700013H19Rik RIKENcDNA 1700013H19 gene 144 2.3 AK005954 1700022C02Rik 1700022C02Rik RIKENcDNA 1700022C02 gene 24 3.9 AK014919 1700025G04Rik 1700025G04Rik RIKENcDNA 1700025G04 gene 110 2.0 AW557527 1700001M19Rik 1700029K01Rik RIKENcDNA 1700001M19 gene 59 2.0 BG075808 1700047I17Rik 1700047I17Rik RIKENcDNA 1700047I17 gene 65 3.8 BB824055 1700061I17Rik 1700061I17Rik RIKENcDNA 1700061I17 gene 27 2.5 AK006854 — 1700091G21Rik Mus musculus 16days neonate thymus 97 4.3 BG075562 cDNA, RIKEN full-length enrichedlibrary, clone: A130042K22 product: unknown EST, full insert sequence1700095N21Rik 1700095N21Rik RIKEN cDNA 1700095N21 gene 151 2.3 NM_029682— 1700097N02Rik Mus musculus adult male testis cDNA, 16 5.0 AA266367RIKEN full-length enriched library, clone: 1700122G02 product: unknownEST, full insert sequence 1810019A08Rik 1810019A08Rik RIKEN cDNA1810019A08 gene 80 5.1 AK007540 1810033B17Rik 1810033B17Rik RIKEN cDNA1810033B17 gene 38 6.4 BB533148 1810037B05Rik 1810037B05Rik RIKEN cDNA1810037B05 gene 50 3.1 AK007714 1810049K24Rik 1810049K24Rik RIKEN cDNA1810049K24 gene 484 2.4 BB558800 1810054D07Rik 1810054D07Rik RIKEN cDNA1810054D07 gene 40 5.0 AK007856 1810054D07Rik 1810054D07Rik RIKEN cDNA1810054D07 gene 45 5.4 BB397062 1810054D07Rik 1810054D07Rik RIKEN cDNA1810054D07 gene 99 4.5 BB259628 — 1810057P16Rik Mus musculus 10 daysneonate cortex 94 2.6 BB275943 cDNA, RIKEN full-length enriched library,clone: A830095F23 product: unknown EST, full insert sequence1810062O14Rik 1810062O14Rik RIKEN cDNA 1810062O14 gene 99 7.4 AV0604172010012C16Rik 2010012C16Rik RIKEN cDNA 2010012C16 gene 187 3.0 AK006303— 2010012F05Rik Mus musculus adult male colon cDNA, 54 2.2 AK018542RIKEN full-length enriched library, clone: 9030607L20 product: weaklysimilar to MHC CLASS I T7 ANTIGEN (FRAGMENT) [Mus musculus], full insertsequence 2010106G01Rik 2010106G01Rik RIKEN cDNA 2010106G01 gene 1397 2.0NM_023220 2010109K11Rik 2010109K11Rik RIKEN cDNA 2010109K11 gene 256 3.2BB174749 2010308M01Rik 2010308M01Rik RIKEN cDNA 2010308M01 gene 163 2.3BC008266 A430106J12Rik 2010316F05Rik RIKEN cDNA A430106J12 gene 41 3.5BB228331 2200002D01Rik 2200002D01Rik RIKEN cDNA 2200002D01 gene 189 2.3AK008617 2210421G13Rik 2210421G13Rik RIKEN cDNA 2210421G13 gene 19 9.3AV081797 2310014H01Rik 2310014H01Rik RIKEN cDNA 2310014H01 gene 331 3.3AK009340 2310015N21Rik 2310015N21Rik RIKEN cDNA 2310015N21 gene 300 2.9AK009372 2310031L18Rik 2310031L18Rik RIKEN cDNA 2310031L18 gene 76 3.4BC027435 2310032F03Rik 2310032F03Rik RIKEN cDNA 2310032F03 gene 36 7.7BE633038 2310043D08Rik 2310043D08Rik RIKEN cDNA 2310043D08 gene 28 5.6BF021255 — 2310047A01Rik Mus musculus similar to hypothetical 81 2.0BB813478 protein FLJ90798 (LOC382857), mRNA 2310047O13Rik 2310047O13RikRIKEN cDNA 2310047O13 gene 18 2.9 AW554864 2310061F22Rik 2310061F22RikRIKEN cDNA 2310061F22 gene 734 2.1 BB253397 2310067E08Rik 2310067E08RikRIKEN cDNA 2310067E08 gene 246 2.5 BF168366 2310075C12Rik 2310075C12RikRIKEN cDNA 2310075C12 gene 850 2.2 NM_133739 2400006A19Rik 2400006A19RikRIKEN cDNA 2400006A19 gene 288 7.5 BC006869 2410002M20Rik 2410002M20RikRIKEN cDNA 2410002M20 gene 637 2.2 BM209793 2410002O22Rik 2410002O22RikRIKEN cDNA 2410002O22 gene 48 2.4 AK012141 2410004I17Rik 2410004I17RikRIKEN cDNA 2410004I17 gene 26 6.8 AK010391 — 2410006H16Rik Mus musculusES cells cDNA, RIKEN 359 2.3 AA939619 full-length enriched library,clone: 2410006H16 product: unknown EST, full insert sequence2410012M04Rik 2410012M04Rik RIKEN cDNA 2410012M04 gene 58 2.0 BG229936B230342M21Rik 2410024N18Rik RIKEN cDNA B230342M21 gene 40 3.2 AK0105872410030K01Rik 2410030K01Rik RIKEN cDNA 2410030K01 gene 130 2.4 BF577722— 2410129E14Rik Mus musculus transcribed sequence with 374 3.2 AA986082strong similarity to protein ref: NP_001060.1 (H. sapiens) tubulin, betapolypeptide [Homo sapiens] 2600005O03Rik 2600005O03Rik RIKEN cDNA2600005O03 gene 22 5.5 AK011162 — 2610002F03Rik Mus musculus ES cellscDNA, RIKEN 24 3.7 AV011566 full-length enriched library, clone:2410046H18 product: unknown EST, full insert sequence 2610028H07Rik2610028H07Rik RIKEN cDNA 2610028H07 gene 365 2.9 BC006738 2610029G23Rik2610029G23Rik RIKEN cDNA 2610029G23 gene 582 2.0 NM_026312 —2610036L11Rik Mus musculus adult male testis cDNA, 68 3.7 BF453953 RIKENfull-length enriched library, clone: 1700015C21 product: unknown EST,full insert sequence 2610039C10Rik 2610039C10Rik RIKEN cDNA 2610039C10gene 153 3.9 AK012533 2610040C18Rik 2610040C18Rik RIKEN cDNA 2610040C18gene 25 4.3 AU043467 2610042L04Rik 2610042L04Rik RIKEN cDNA 2610042L04gene 203 5.0 BM195235 2610042L04Rik 2610042L04Rik RIKEN cDNA 2610042L04gene 337 4.9 BM195235 2610206B13Rik 2610206B13Rik RIKEN cDNA 2610206B13gene 105 2.6 AK011896 2610208M17Rik 2610208M17Rik RIKEN cDNA 2610208M17gene 227 2.8 BI104583 2610208M17Rik 2610208M17Rik RIKEN cDNA 2610208M17gene 610 3.5 BI104583 2610208M17Rik 2610208M17Rik RIKEN cDNA 2610208M17gene 114 3.1 BQ129438 2610300B10Rik 2610300B10Rik RIKEN cDNA 2610300B10gene 87 2.6 BB538449 — 2610307O08Rik — 47 18.7 AV300716 2610307O08Rik2610307O08Rik RIKEN cDNA 2610307O08 gene 246 6.8 AK012006 —2610318C08Rik Mus musculus adult male small intestine 156 2.5 AA197362cDNA, RIKEN full-length enriched library, clone: 2010016H04 product:unknown EST, full insert sequence 2610318N02Rik 2610318N02Rik RIKEN cDNA2610318N02 gene 21 7.0 AK012048 2610510H01Rik 2610510H01Rik RIKEN cDNA2610510H01 gene 214 2.1 AV122997 2610510H01Rik 2610510H01Rik RIKEN cDNA2610510H01 gene 253 2.4 AV122997 2610510J17Rik 2610510J17Rik RIKEN cDNA2610510J17 gene 155 3.0 BM230253 2700019D07Rik 2700019D07Rik RIKEN cDNA2700019D07 gene 369 2.7 BM937429 — 2700038G22Rik Mus musculus adultretina cDNA, RIKEN 141 2.3 AK012332 full-length enriched library, clone:A930033E24 product: unclassifiable, full insert sequence 2700049P18Rik2700049P18Rik RIKEN cDNA 2700049P18 gene 73 2.4 AV127670 2810026P18Rik2810026P18Rik RIKEN cDNA 2810026P18 gene 209 3.1 AK012825 2810047L02Rik2810047L02Rik RIKEN cDNA 2810047L02 gene 19 8.8 AV270035 2810052M02Rik2810052M02Rik RIKEN cDNA 2810052M02 gene 99 4.6 NM_023320 2810406C15Rik2810406C15Rik RIKEN cDNA 2810406C15 gene 103 5.4 BC025460 2810417H13Rik2810417H13Rik RIKEN cDNA 2810417H13 gene 165 23.4 AK017673 2810417H13Rik2810417H13Rik RIKEN cDNA 2810417H13 gene 44 17.7 AK017673 2810418N01Rik2810418N01Rik RIKEN cDNA 2810418N01 gene 115 3.2 AK013116 A330067P212810453L12Rik hypothetical protein A330067P21 65 2.2 BG0858122810457I06Rik 2810457I06Rik RIKEN cDNA 2810457I06 gene 186 2.6 AK0133612810457I06Rik 2810457I06Rik RIKEN cDNA 2810457I06 gene 180 3.0 AW0459476720435I21Rik 2810474O19Rik RIKEN cDNA 6720435I21 gene 860 2.2 AA5098702900024D24Rik 2900024D24Rik RIKEN cDNA 2900024D24 gene 48 10.4 BB1346962900024D24Rik 2900024D24Rik RIKEN cDNA 2900024D24 gene 82 4.3 AI449126Krc 2900056N03Rik kappa B and Rss recognition component 88 5.0 BB1641273110010F15Rik 3110010F15Rik RIKEN cDNA 3110010F15 gene 173 2.6 BF3207553110010F15Rik 3110010F15Rik RIKEN cDNA 3110010F15 gene 307 2.0 BF3207553110037K17Rik 3110037K17Rik RIKEN cDNA 3110037K17 gene 58 21.7 AK0141353300001P08Rik 3300001P08Rik RIKEN cDNA 3300001P08 gene 64 2.4 BM2138514432406C08Rik 4432406C08Rik RIKEN cDNA 4432406C08 gene 16 10.0 BM2474654631422C13Rik 4631422C13Rik RIKEN cDNA 4631422C13 gene 27 2.8 BB154962AW413625 4632417K18Rik expressed sequence AW413625 80 15.2 NM_0266404632428N05Rik 4632428N05Rik RIKEN cDNA 4632428N05 gene 139 2.6 BC0039674632434I11Rik 4632434I11Rik RIKEN cDNA 4632434I11 gene 20 2.8 BB4636104732429D16Rik 4732429D16Rik RIKEN cDNA 4732429D16 gene 130 2.0 BC0198144732490P18Rik 4732490P18Rik RIKEN cDNA 4732490P18 gene 31 2.1 BB009703 —4833403J16Rik Mus musculus 0 day neonate head 41 2.5 AK014653 cDNA,RIKEN full-length enriched library, clone: 4833403J16 product: unknownEST, full insert sequence 4833427B12Rik 4833427B12Rik RIKEN cDNA4833427B12 gene 24 7.7 AW488914 4921501M20Rik 4921501M20Rik RIKEN cDNA4921501M20 gene 46 3.5 AF361364 — 4921511E18Rik Mus musculus adult maletestis cDNA, 107 2.2 AK014868 RIKEN full-length enriched library, clone:4921511E18 product: unclassifiable, full insert sequence 4930427A07Rik4930427A07Rik RIKEN cDNA 4930427A07 gene 58 2.9 BE951637 4930477M194930477M19 hypothetical protein 4930477M19 66 2.4 BB017021 4930503L19Rik4930503L19Rik RIKEN cDNA 4930503L19 gene 42 3.5 AI450962 4930503L19Rik4930503L19Rik RIKEN cDNA 4930503L19 gene 27 6.4 AI450962 4930547N16Rik4930547N16Rik RIKEN cDNA 4930547N16 gene 10 6.9 BM205349 4930547N16Rik4930547N16Rik RIKEN cDNA 4930547N16 gene 25 3.5 BM877490 4930553M18Rik4930553M18Rik RIKEN cDNA 4930553M18 gene 83 2.1 BG065617 — 4930571N24RikMus musculus transcribed sequence with 20 3.5 BE687174 moderatesimilarity to protein sp: P00722 (E. coli) BGAL_ECOLI Beta-galactosidase (Lactase) 4930579G24Rik 4930579G24Rik RIKEN cDNA4930579G24 gene 99 3.0 BB821996 4931400A14Rik 4931400A14Rik RIKEN cDNA4931400A14 gene 533 2.8 AK016419 — 4933412E12Rik Mus musculus 13 daysembryo heart 197 2.2 AK016788 cDNA, RIKEN full-length enriched library,clone: D330011B05 product: unknown EST, full insert sequence4933426L22Rik 4933426L22Rik RIKEN cDNA 4933426L22 gene 88 3.8 BB3614364933426L22Rik 4933426L22Rik RIKEN cDNA 4933426L22 gene 40 5.6 BB6672474933430F08Rik 4933430F08Rik RIKEN cDNA 4933430F08 gene 31 37.4 AK0169904933431N12Rik 4933431N12Rik RIKEN cDNA 4933431N12 gene 38 4.1 BE8532765033406L14Rik 5033406L14Rik RIKEN cDNA 5033406L14 gene 101 3.1 BB667600— 5033413D16Rik Mus musculus 0 day neonate eyeball 144 2.4 AK017164cDNA, RIKEN full-length enriched library, clone: E130011D04 product:unknown EST, full insert sequence — 5230400M03Rik Mus musculus adultmale xiphoid 57 2.9 BB312292 cartilage cDNA, RIKEN full-length enrichedlibrary, clone: 5230400M03 product: unclassifiable, full insert sequenceA630029F06 5330417K06Rik hypothetical protein A630029F06 182 3.0BB023868 5430427O19Rik 5430427O19Rik RIKEN cDNA 5430427O19 gene 23 7.3AI645098 5430435G22Rik 5430435G22Rik RIKEN cDNA 5430435G22 gene 53 7.4BB128517 — 5430437J10Rik Mus musculus, clone IMAGE: 5356629, 12 4.9BF227338 mRNA — 5730405O12Rik Mus musculus 0 day neonate eyeball 19 3.1AK017499 cDNA, RIKEN full-length enriched library, clone: E130007N07product: unclassifiable, full insert sequence 5730466H23Rik5730466H23Rik RIKEN cDNA 5730466H23 gene 26 2.1 BB079695 — 5730507H05RikMus musculus adult male hypothalamus 25 10.1 BB702347 cDNA, RIKENfull-length enriched library, clone: A230105F24 product: hypotheticalprotein, full insert sequence 5730508B09Rik 5730508B09Rik RIKEN cDNA5730508809 gene 179 3.5 AK017758 5730508B09Rik 5730508B09Rik RIKEN cDNA5730508809 gene 47 11.2 C80506 — 5730601F06Rik Mus musculus 16 daysembryo head 71 2.2 BB374879 cDNA, RIKEN full-length enriched library,clone: C130077H22 product: unclassifiable, full insert sequence5830405N20Rik 5830405N20Rik RIKEN cDNA 5830405N20 gene 49 2.5 BB2028485830405N20Rik 5830405N20Rik RIKEN cDNA 5830405N20 gene 19 5.9 AK0179009630005B12Rik 5830411O09Rik RIKEN cDNA 9630005B12 gene 139 2.4 BB4316549630005B12Rik 5830411O09Rik RIKEN cDNA 9630005B12 gene 114 2.7 BB4316545830426I05Rik 5830426I05Rik RIKEN cDNA 5830426I05 gene 102 6.9 NM_133762AI595338 5830443L24Rik expressed sequence AI595338 174 75.0 NM_0295095830458K16Rik 5830458K16Rik RIKEN cDNA 5830458K16 gene 23 4.8 BC0248725830458K16Rik 5830458K16Rik RIKEN cDNA 5830458K16 gene 525 9.1 BC0248725830482F20Rik 5830482F20Rik RIKEN cDNA 5830482F20 gene 122 3.6 AW4935835830484A20Rik 5830484A20Rik RIKEN cDNA 5830484A20 gene 99 4.8 AW909306 —6030405P05Rik Mus musculus 13 days embryo male 125 7.5 BM244999 testiscDNA, RIKEN full-length enriched library, clone: 6030405P05 product:unclassifiable, full insert sequence 6030423D04Rik 6030423D04Rik RIKENcDNA 6030423D04 gene 48 6.1 BE986588 6230416J20Rik 6230416J20Rik RIKENcDNA 6230416J20 gene 37 2.2 BB794620 6330406L22Rik 6330406L22Rik RIKENcDNA 6330406L22 gene 56 7.7 AK018130 6330407A03Rik 6330407A03Rik RIKENcDNA 6330407A03 gene 60 3.3 AW519657 6330412F12Rik 6330412F12Rik RIKENcDNA 6330412F12 gene 303 2.0 BG066220 6330442E10Rik 6330442E10Rik RIKENcDNA 6330442E10 gene 22 7.5 AV328515 — 6330442E10Rik — 82 4.2 BB3021036330500D04Rik 6330500D04Rik RIKEN cDNA 6330500D04 gene 87 2.8 BB8676666330500D04Rik 6330500D04Rik RIKEN cDNA 6330500D04 gene 104 3.9 BM2422946330500D04Rik 6330500D04Rik RIKEN cDNA 6330500D04 gene 66 2.3 AV3290706330503K22Rik 6330503K22Rik RIKEN cDNA 6330503K22 gene 182 2.3 BG0708356330583I20Rik 6330583I20Rik RIKEN cDNA 6330583I20 gene 43 2.5 BM248637 —6430570G24 Mus musculus adult male olfactory brain 241 3.1 BG069663cDNA, RIKEN full-length enriched library, clone: 6430570G24 product:unknown EST, full insert sequence — 6430570G24 Mus musculus adult maleolfactory brain 606 3.8 BG069663 cDNA, RIKEN full-length enrichedlibrary, clone: 6430570G24 product: unknown EST, full insert sequenceMGC66590 6430706D22Rik Unknown (protein for MGC: 66590) 24 2.3 BC004768MGC66590 6430706D22Rik Unknown (protein for MGC: 66590) 271 2.3 BM2482256530401D17Rik 6530401D17Rik RIKEN cDNA 6530401D17 gene 34 2.7 AK0137406820428D13 6820428D13 hypothetical protein 6820428D13 39 2.7 BG064903 —8030448K23Rik Mus musculus transcribed sequences 98 2.1 BM2045798430437G11Rik 8430437G11Rik RIKEN cDNA 8430437G11 gene 271 2.2 BC0071609030408N13Rik 9030408N13Rik RIKEN cDNA 9030408N13 gene 66 7.0 NM_0257799030625A04Rik 9030625A04Rik RIKEN cDNA 9030625A04 gene 217 2.0 AV3736069130002C22Rik 9130002C22Rik RIKEN cDNA 9130002C22 gene 476 24.4 BM2435719130017N09Rik 9130017N09Rik RIKEN cDNA 9130017N09 gene 339 2.5 BQ0308759130019I15Rik 9130019I15Rik RIKEN cDNA 9130019I15 gene 16 46.3 AK0186369130022K13Rik 9130022K13Rik RIKEN cDNA 9130022K13 gene 65 5.6 AK018646 —9130211I03Rik Mus musculus similar to Jun dimerization 64 4.9 AK020278protein 1 gene (LOC381319), mRNA 9130422G05Rik 9130422G05Rik RIKEN cDNA9130422G05 gene 177 5.0 AK018685 9130422G05Rik 9130422G05Rik RIKEN cDNA9130422G05 gene 195 4.4 AK018685 9230105E10Rik 9230105E10Rik RIKEN cDNA9230105E10 gene 108 3.6 BB433710 — 9230110J10 Mus musculus transcribedsequences 58 4.4 BG967674 9230117N10Rik 9230117N10Rik RIKEN cDNA9230117N10 gene 222 7.6 NM_133775 9330132E09Rik 9330132E09Rik RIKEN cDNA9330132E09 gene 189 2.3 AV336691 9330175E14Rik 9330175E14Rik RIKEN cDNA9330175E14 gene 11 8.0 BB082472 MGC6357 9430034N14Rik hypotheticalprotein MGC6357 68 2.2 BB667558 — 9430065F17Rik Mus musculus 12 daysembryo 30 2.1 AK021377 embryonic body between diaphragm region and neckcDNA, RIKEN full-length enriched library, clone: 9430065F17 product:unclassifiable, full insert sequence 9430077D24Rik 9430077D24Rik RIKENcDNA 9430077D24 gene 559 2.0 BG865652 — 9530028C05 Mus musculus adultmale testis cDNA, 278 3.9 BQ175154 RIKEN full-length enriched library,clone: 4921508F21 product: similar to HISTOCOMPATIBILITY 2, CLASS IIANTIGEN E BETA [Mus musculus], full insert sequence — 9530028C05 Musmusculus adult male testis cDNA, 228 4.6 BQ175154 RIKEN full-lengthenriched library, clone: 4921508F21 product: similar toHISTOCOMPATIBILITY 2, CLASS II ANTIGEN E BETA [Mus musculus], fullinsert sequence — 9530053H05Rik — 108 4.5 AK020608 9630044O09Rik9630044O09Rik RIKEN cDNA 9630044O09 gene 71 3.0 BB704967 AI6457209630054F20Rik expressed sequence AI645720 106 2.1 BB131620 —9630055N22Rik Mus musculus adult retina cDNA, RIKEN 523 1.9 BB276950full-length enriched library, clone: A930001C09 product: TAIL FIBROBLASTRECEPTOR FOR FELINE LEUKEMIA VIRUS SUBGROUP C homolog [Mus dunni], fullinsert sequence 9830147J24Rik 9830147J24Rik RIKEN cDNA 9830147J24 gene83 38.2 BC010229 — A130052D22 Mus musculus transcribed sequence with 4482.1 BB194075 strong similarity to protein ref: NP_057365.1 (H. sapiens)STE20-like kinase; STE2-like kinase [Homo sapiens] A130092J06RikA130092J06Rik RIKEN cDNA A130092J06 gene 141 3.6 BI111848 A130096K20A130096K20 hypothetical protein A130096K20 576 2.5 AV256780 —A230061C15Rik Mus musculus adult male hypothalamus 112 3.2 BB153043cDNA, RIKEN full-length enriched library, clone: A230061C15 product:unknown EST, full insert sequence A330021E22Rik A330021E22Rik RIKEN cDNAA330021E22 gene 52 2.2 BB561281 A330042H22 A330042H22 hypotheticalprotein A330042H22 87 11.3 AW743924 — A330042I21Rik Mus musculus adultmale spinal cord 1523 3.6 AI645293 cDNA, RIKEN full-length enrichedlibrary, clone: A330042I21 product: unknown EST, full insert sequenceA330102K04 A330102K04Rik hypothetical protein A330102K04 35 5.5 AA214835— A430093F15Rik Mus musculus 0 day neonate thymus 54 4.9 BB209605 cDNA,RIKEN full-length enriched library, clone: A430093F15 product:hypothetical protein, full insert sequence A430106J12Rik A430106J12RikRIKEN cDNA A430106J12 gene 140 2.1 BB498608 A430107D22Rik A430107D22RikRIKEN cDNA A430107D22 gene 68 4.8 AI481597 A430107D22Rik A430107D22RikRIKEN cDNA A430107D22 gene 26 16.4 AV312663 — A530052I06Rik Mus musculusadult male aorta and vein 14 3.3 BM239855 cDNA, RIKEN full-lengthenriched library, clone: A530052I06 product: unknown EST, full insertsequence A630077B13Rik A630077B13Rik RIKEN cDNA A630077B13 gene 5 183.1BB239429 Znfn1a2 A730095J18Rik zinc finger protein, subfamily 1A, 2 593.6 BB291816 (Helios) Znfn1a2 A730095J18Rik zinc finger protein,subfamily 1A, 2 273 2.4 BB319935 (Helios) — AA536717 Mus musculus 3 daysneonate thymus 31 3.2 BB201845 cDNA, RIKEN full-length enriched library,clone: A630021I17 product: unknown EST, full insert sequence AA536743AA536743 expressed sequence AA536743 368 2.6 BI248354 AA536743 AA536743expressed sequence AA536743 543 3.0 BI248354 AA589481 AA589481 expressedsequence AA589481 123 2.1 BB826899 — AB124611 Mus musculus 13 daysembryo male 65 10.6 BM246462 testis cDNA, RIKEN full-length enrichedlibrary, clone: 6030438F01 product: unclassifiable, full insert sequenceAbp1 Abp1 amiloride binding protein 1 (amine 188 8.7 BC021880 oxidase,copper-containing) Facl4 Acsl4 fatty acid-Coenzyme A ligase, long chain4 174 2.2 AB033886 Facl5 Acsl5; ACS2; fatty acid Coenzyme A ligase, longchain 5 2295 2.1 AK006541 ACS5; Facl5; 1700030F05Rik Strm Actn1 striamin153 2.0 BC003232 Actr3 Actr3 ARP3 actin-related protein 3 homolog 43392.2 BE372352 (yeast) Actr3 Actr3 ARP3 actin-related protein 3 homolog3734 2.2 BE372352 (yeast) Adam12 Adam12 a disintegrin andmetalloproteinase 141 2.4 NM_007400 domain 12 (meltrin alpha) Adam8Adam8 a disintegrin and metalloprotease domain 8 54 4.4 NM_007403Adamts1 Adamts1 a disintegrin-like and metalloprotease 863 4.5 D67076(reprolysin type) with thrombospondin type 1 motif, 1 Adamts2 Adamts2 adisintegrin-like and metalloprotease 139 2.3 BM125019 (reprolysin type)with thrombospondin type 1 motif, 2 Adamts4 Adamts4 a disintegrin-likeand metalloprotease 60 5.6 BB443585 (reprolysin type) withthrombospondin type 1 motif, 4 Adamts6 Adamts6 a disintegrin-like andmetalloprotease 22 3.0 BB227648 (reprolysin type) with thrombospondintype 1 motif, 6 — Adar Mus musculus transcribed sequence with 103 3.5BB308291 weak similarity to protein ref: NP_081764.1 (M. musculus) RIKENcDNA 5730493B19 [Mus musculus] Adcy7 Adcy7 adenylate cyclase 7 118 17.3BB746807 Adfp Adfp adipose differentiation related protein 1090 2.7NM_007408 Adrbk1 Adrbk1 adrenergic receptor kinase, beta 1 490 2.1AF333028 4833444A01Rik Adrbk2 RIKEN cDNA 4833444A01 gene 235 2.0BG073639 Agpat4 Agpat4 1-acylglycerol-3-phosphate O- 241 2.5 BE994529acyltransferase 1 (lysophosphatidic acid acyltransferase, delta)AI114950 AI114950 expressed sequence AI114950 244 2.7 BB224153 —AI132321 Mus musculus transcribed sequence with 44 27.8 BB210623 weaksimilarity to protein ref: NP_036400.1 (H. sapiens) similar to vacciniavirus HindIII K4L ORF [Homo sapiens] AI854251 AI413582 expressedsequence AI854251 116 2.4 AV039444 — AI426953 Mus musculus 2 daysneonate thymus 38 2.4 BE632903 thymic cells cDNA, RIKEN full-lengthenriched library, clone: E430023L24 product: unknown EST, full insertsequence — AI447881 Mus musculus transcribed sequences 102 2.7 AI447881AI447904 AI447904 expressed sequence AI447904 59 26.2 BM241008 AI447904AI447904 expressed sequence AI447904 7 70.3 BM241008 — AI449310 Musmusculus transcribed sequences 72 2.4 AW552116 AI449441 AI449441expressed sequence AI449441 91 2.5 AV094878 — AI451557 Mus musculustranscribed sequences 87 24.1 AV277444 AI452102 AI452102 expressedsequence AI452102 45 3.3 BB312740 AI467606 AI467606 expressed sequenceAI467606 168 10.2 BB234337 AI467606 AI467606 expressed sequence AI46760625 9.5 BB234337 — AI504062 Mus musculus 9 days embryo whole 415 2.7BM238926 body cDNA, RIKEN full-length enriched library, clone:D030050E20 product: unclassifiable, full insert sequence AI504432AI504432 expressed sequence AI504432 30 15.1 BB202185 Kcna3 AI504432potassium voltage-gated channel, 23 18.8 AI323624 shaker-relatedsubfamily, member 3 AI597013 AI597013 expressed sequence AI597013 47 6.1BB014626 AI597013 AI597013 expressed sequence AI597013 77 7.9 BB014626LOC226691 AI607873 interferon-activatable protein 15 28.9 AI607873AI661017 AI661017 expressed sequence AI661017 21 15.4 AV173260 —AI661384 Mus musculus transcribed sequences 11 14.9 BB034038 — AI848100Mus musculus transcribed sequences 128 2.2 BB538816 Aif1 Aif1 allograftinflammatory factor 1 71 36.5 NM_019467 Aim1 Aim1 absent in melanoma 1294 2.8 BM233292 Akr1c20 Akr1c20 aldo-keto reductase family 1, member 288.0 BC021607 C20 Akt3 Akt3 thymoma viral proto-oncogene 3 60 3.2AF124142 Akt3 Akt3 thymoma viral proto-oncogene 3 47 4.1 AF124142Sdccag8 Akt3 serologically defined colon cancer 171 3.6 BB521695 antigen8 AL024069 AL024069 expressed sequence AL024069 314 2.8 AI504908 Aldh1a2Aldh1a2 aldehyde dehydrogenase family 1, 303 5.9 NM_009022 subfamily A2Aldh1b1 Aldh1b1 aldehyde dehydrogenase 1 family, 115 2.7 BC020001 memberB1 Alox5ap Alox5ap arachidonate 5-lipoxygenase activating 181 13.7BC026209 protein Ankrd1 Ankrd1 ankyrin repeat domain 1 (cardiac muscle)44 5.7 AK009959 2900037I21Rik Anln RIKEN cDNA 2900037I21 gene 62 7.4BI690018 Anp32b Anp32b acidic nuclear phosphoprotein 32 family, 1716 2.1NM_130889 member B Anxa1 Anxa1 annexin A1 878 2.9 NM_010730 Anxa2 Anxa2annexin A2 2454 2.9 NM_007585 Ap1s2 Ap1s2 adaptor-related proteincomplex 1, sigma 188 2.0 BE655707 2 subunit Ap1s2 Ap1s2; EST1;adaptor-related protein complex 1, sigma 151 6.4 AK005223 1500012A13Rik2 subunit Apaf1 Apaf1 apoptotic protease activating factor 1 274 2.1AK018076 Apob48r Apob48r apolipoprotein B48 receptor 95 3.6 NM_138310Apobec1 Apobec1 apolipoprotein B editing complex 1 235 3.2 BC003792 AppApp amyloid beta (A4) precursor protein 26 2.3 AV348729 Arf3 Arf3ADP-ribosylation factor 3 107 2.4 BQ175059 Arf6 Arf6 ADP-ribosylationfactor 6 3548 2.1 BI248938 Arg2 Arg2 arginase type II 85 4.3 AV002218Arg2 Arg2 arginase type II 145 4.3 NM_009705 6530401L14Rik Arhgap11aRIKEN cDNA 6530401L14 gene 62 8.0 AV349116 — Arhgap15 Mus musculus 16days neonate thymus 38 5.4 BB234837 cDNA, RIKEN full-length enrichedlibrary, clone: A130024J05 product: hypothetical protein, full insertsequence — Arhgap15 Mus musculus 16 days neonate thymus 58 3.1 BB234837cDNA, RIKEN full-length enriched library, clone: A130024J05 product:hypothetical protein, full insert sequence 4933411B03Rik Arhgap19 RIKENcDNA 4933411B03 gene 35 4.1 BG072763 A130039I20Rik Arhgap25 RIKEN cDNAA130039I20 gene 84 3.7 BM241218 Arhgap4 Arhgap4 Rho GTPase activatingprotein 4 117 2.6 NM_138630 AU043488 Arhgap9 expressed sequence AU04348884 8.7 BB327418 Gli Arhgap9 GLI-Kruppel family member GLI 24 11.5AU043488 Gli Arhgap9 GLI-Kruppel family member GLI 12 14.6 AU043488Arhgdib Arhgdib Rho, GDP dissociation inhibitor (GDI) 1160 7.7 AK002516beta Arhgef6 Arhgef6 Rac/Cdc42 guanine nucleotide exchange 142 4.5BM246754 factor (GEF) 6 D430024K22Rik Arid5a RIKEN cDNA D430024K22 gene56 8.3 BC027152 Desrt Arid5b developmentally and sexually retarded 192.7 BB257077 with transient immune abnormalities A630084M22Rik Arl7RIKEN cDNA A630084M22 gene 254 2.8 BQ176306 1200015K23Rik Armc8 RIKENcDNA 1200015K23 gene 115 2.2 BE995635 Arrb2 Arrb2 arrestin, beta 2 2403.5 BC016642 Arts1 Arts1 type 1 tumor necrosis factor receptor 444 4.8NM_030711 shedding aminopeptidase regulator Arts1 Arts1 type 1 tumornecrosis factor receptor 221 4.1 AV287655 shedding aminopeptidaseregulator Asf1b Asf1b ASF1 anti-silencing function 1 homolog B 111 5.0BC003428 (S. cerevisiae) Asns Asns asparagine synthetase 329 2.3BC005552 Asns Asns asparagine synthetase 103 4.0 AV212753 2610509G12RikAtad2 RIKEN cDNA 2610509G12 gene 127 6.0 BM206009 Atf3 Atf3 activatingtranscription factor 3 109 6.6 BC019946 Atp10a Atp10a ATPase, class V,type 10A 37 5.7 BB487289 Atp10a Atp10a ATPase, class V, type 10A 26 3.5BM249532 Atp8b2 Atp8b2 Atpase, class I, type 8B, member 2 248 2.6BQ178970 — Atr Mus musculus 16 days neonate thymus 33 2.3 BM197239 cDNA,RIKEN full-length enriched library, clone: A130049K15 product:unclassifiable, full insert sequence — AU020206 Mus musculus 3 daysneonate thymus 172 10.7 BI151331 cDNA, RIKEN full-length enrichedlibrary, clone: A630040D01 product: unknown EST, full insert sequenceAurkb Aurkb aurora kinase B 21 9.6 BC003261 Aurkb Aurkb aurora kinase B30 11.7 BC003261 — AW049306 Mus musculus transcribed sequences 20 3.9BE457612 — AW112010 Mus musculus transcribed sequences 438 32.5 BE688358— AW121567 Mus musculus 12 days embryo spinal 33 2.9 BB461295 ganglioncDNA, RIKEN full-length enriched library, clone: D130071A17 product:unknown EST, full insert sequence AW212607 AW212607 expressed sequenceAW212607 64 3.1 AV325152 AW212607 AW212607 expressed sequence AW21260774 5.9 BB308532 1810048P08Rik AW490415 RIKEN cDNA 1810048P08 gene 49 3.2AK010874 — AW492955 Mus musculus transcribed sequences 182 2.1 AW492955— AW547186 Mus musculus 13 days embryo male 47 3.4 BB044338 testis cDNA,RIKEN full-length enriched library, clone: 6030487A22 product:unclassifiable, full insert sequence Srr AW550801 serine racemase 1912.3 BM213835 Axud1 Axud1 AXIN1 up-regulated 1 100 4.5 BG070296 IkappaBNSAY078069 NF-kappa B inhibitor 26 9.0 AW495632 B230217C12RikB230217C12Rik RIKEN cDNA B230217C12 gene 24 6.2 BB376573 Cugbp2B230218O03 CUG triplet repeat, RNA binding protein 2 91 8.2 BB644164Cugbp2 B230218O03 CUG triplet repeat, RNA binding protein 2 161 7.9BB644164 B230315M08Rik B230315M08Rik RIKEN cDNA B230315M08 gene 113 2.8AI536469 B2m B2m beta-2 microglobulin 71 11.6 AA170322 B2m B2m beta-2microglobulin 9650 2.7 AI099111 B3gnt5 B3gnt5 UDP-GlcNAc: betaGalbeta-1,3-N- 40 3.7 BM214359 acetylglucosaminyltransferase 5 Bak1 Bak1BCL2-antagonist/killer 1 113 2.1 AF402617 Bak1 Bak1BCL2-antagonist/killer 1 93 5.6 NM_007523 A530094C12Rik Bank1 RIKEN cDNAA530094C12 gene 74 2.0 AI451642 — Basp1 Mus musculus 10 days neonatemedulla 143 9.4 AK011545 oblongata cDNA, RIKEN full-length enrichedlibrary, clone: B830039F09 product: BRAIN ACID SOLUBLE PROTEIN 1 (BASP1PROTEIN) (NEURONAL AXONAL MEMBRANE PROTEIN NAP-22) homolog [Rattusnorvegicus], full insert sequence BB146404 BB146404 expressed sequenceBB146404 17 4.5 BC025893 — BB220380 Mus musculus adult male bone cDNA,33 3.7 AV281292 RIKEN full-length enriched library, clone: 9830142N16product: unclassifiable, full insert sequence BC003236 BC003236 cDNAsequence BC003236 999 2.4 BB231897 BC004701 BC004701 cDNA sequenceBC004701 41 5.9 BC004701 BC006779 BC006779 cDNA sequence BC006779 2963.8 BE853170 BC010462 BC010462 cDNA sequence BC010462 208 3.5 BC010462A530020G20Rik BC010552 RIKEN cDNA A530020G20 gene 21 3.3 AV256906BC010552 BC010552 cDNA sequence BC010552 133 3.6 BC025548 BC013672BC013672 cDNA sequence BC013672 9 8.7 BC013672 BC013712 BC013712 cDNAsequence BC013712 130 12.3 BB262491 BC023105 BC023105 cDNA sequenceBC023105 46 70.3 BC023105 BC023179 BC023179 cDNA sequence BC023179 392.0 BC023179 BC023741 BC023741 cDNA sequence BC023741 208 11.7 BB705351BC023882 BC023882 cDNA sequence BC023882 238 2.8 BC027393 BC027057BC027057 cDNA sequence BC027057 80 3.1 BE133443 BC027057 BC027057 cDNAsequence BC027057 33 8.4 BB040051 L259 BC028528 L259 146 4.1 BC028528BC031748 BC031748 cDNA sequence BC031748 46 2.5 BB709811 — BC031781 —246 2.0 AV312901 BC032204 BC032204 cDNA sequence BC032204 91 9.3BG066664 — BC033596 Mus musculus 16 days neonate thymus 56 2.6 BB162048cDNA, RIKEN full-length enriched library, clone: A130086M19 product:unknown EST, full insert sequence BC037703 BC037703 cDNA sequenceBC037703 87 2.5 AV231983 9830126M18 BC052328 hypothetical protein9830126M18 113 6.4 BM224662 B930060C03 BC065123 hypothetical proteinB930060C03 354 3.9 BM239162 Baz1a BC065123 bromodomain adjacent to zincfinger 340 2.5 AV357135 domain 1A 4732427B05 BC066140 hypotheticalprotein 4732427B05 68 2.3 AV114409 — BC067047 Mus musculus adult maletestis cDNA, 142 3.6 BB794978 RIKEN full-length enriched library, clone:4930413J11 product: mitochondria located 1 homolog (human), full insertsequence — BC068171 Mus musculus similar to DYSKERIN 501 2.2 BG068512(LOC245474), mRNA Bcl11b Bcl11b B-cell leukemia/lymphoma 11B 160 2.2BM117007 Bcl2l11 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 62 2.6BB667581 Bcl2l11 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 114 3.4BM120925 Bcl2l11 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 481 2.5BM120925 Bcl2l11 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 401 3.9BB667581 Bcl3 Bcl3 B-cell leukemia/lymphoma 3 203 3.8 NM_033601 BcorBcor Bcl6 interacting corepressor 181 2.2 AK018370 Bgn Bgn biglycan 20403.2 AI931862 Bgn Bgn biglycan 2268 2.8 BC019502 Birc1b Birc1bbaculoviral IAP repeat-containing 1b 148 2.3 NM_010872 Birc1e Birc1ebaculoviral IAP repeat-containing 1e 59 2.2 NM_010870 Birc1f Birc1fbaculoviral IAP repeat-containing 1f 79 2.5 AI451585 Birc3 Birc2baculoviral IAP repeat-containing 3 824 2.3 NM_007465 Birc2 Birc3baculoviral IAP repeat-containing 2 628 5.7 NM_007464 Birc5 Birc5baculoviral IAP repeat-containing 5 58 18.6 BC004702 Bnip2 Bnip2BCL2/adenovirus E1B 19 kDa-interacting 724 2.4 AV144704 protein 1, NIP2Bnip2 Bnip2; Nip21; BCL2/adenovirus E1B 19 kDa-interacting 667 2.2AK014659 BNIP2beta; protein 1, NIP2 5730523P12Rik 2310015I10Rik Brd4RIKEN cDNA 2310015I10 gene 269 13.8 BC008532 A730011O11Rik Brrn1 RIKENcDNA A730011O11 gene 204 4.6 BB725358 A730011O11Rik Brrn1 RIKEN cDNAA730011O11 gene 81 3.6 BC021499 Bspry Bspry B-box and SPRY domaincontaining 552 3.3 NM_138653 Bst1 Bst1 bone marrow stromal cell antigen1 167 4.5 AI647987 Btg1 Btg1 B-cell translocation gene 1, anti- 3872 2.3L16846 proliferative Btk Btk Bruton agammaglobulinemia tyrosine 26 8.8NM_013482 kinase Btla Btla B and T lymphocyte associated 91 7.9 BM240873Bub1b Bub1b budding uninhibited by benzimidazoles 1 6 12.3 AU045529homolog, beta (S. cerevisiae) Bub3 Bub3 budding uninhibited bybenzimidazoles 3 20 3.6 BB449877 homolog (S. cerevisiae) Bzrp Bzrpbenzodiazepine receptor, peripheral 1248 2.1 BB132602 — C030046G05 Musmusculus adult male corpus striatum 89 3.4 BE691546 cDNA, RIKENfull-length enriched library, clone: C030046G05 product: unknown EST,full insert sequence C130032J12Rik C130032J12Rik RIKEN cDNA C130032J12gene 202 2.0 BB192700 C130036J11 C130036J11 hypothetical proteinC130036J11 8 8.1 BB072624 C1qa C1qa complement component 1, q 489 8.8NM_007572 subcomponent, alpha polypeptide C1qb C1qb complement component1, q 147 34.3 BB111335 subcomponent, beta polypeptide C1qb C1qbcomplement component 1, q 420 6.7 AW227993 subcomponent, betapolypeptide C1qb C1qb complement component 1, q 363 14.1 NM_009777subcomponent, beta polypeptide C1qg C1qg complement component 1, q 18520.8 NM_007574 subcomponent, gamma polypeptide C1r C1r complementcomponent 1, r 382 9.4 NM_023143 subcomponent C1s C1s complementcomponent 1, s 395 12.7 BC022123 subcomponent C2 C2 complement component2 (within H-2S) 1215 3.5 NM_013484 — C2 — 1241 4.6 AV290571 — C2 — 8554.4 AV227574 C2ta C2ta class II transactivator 43 13.2 AF042158 C2taC2ta class II transactivator 89 10.8 AF042158 C3 C3 complement component3 437 29.7 K02782 C330012H03Rik C330012H03Rik RIKEN cDNA C330012H03 gene69 2.8 BB098431 C330027C09Rik C330027C09Rik RIKEN cDNA C330027C09 gene53 5.5 AU018569 C3ar1 C3ar1 complement component 3a receptor 1 113 3.5NM_009779 C3ar1 C3ar1 complement component 3a receptor 1 38 10.2BB333624 C3ar1 C3ar1 complement component 3a receptor 1 50 10.0NM_009779 C4 C4 complement component 4 (within H-2S) 894 8.4 NM_009780C5r1 C5r1; C5aR; complement component 5, receptor 1 41 3.4 NM_007577Cd88 C630016B22Rik C630016B22Rik RIKEN cDNA C630016B22 gene 523 2.0BB711990 C630016B22Rik C630016B22Rik RIKEN cDNA C630016B22 gene 786 2.3BB771888 — C730049O14Rik Mus musculus adult male liver tumor 167 4.8BB200607 cDNA, RIKEN full-length enriched library, clone: C730049O14product: unknown EST, full insert sequence C79407 C79407 expressedsequence C79407 51 3.3 BB540053 C79407 C79407 expressed sequence C7940745 6.4 BE951628 — C79445 Mus musculus 18-day embryo whole 166 3.7 C79445body cDNA, RIKEN full-length enriched library, clone: 1100001P14product: TUBULIN, BETA 5 homolog [Homo sapiens], full insert sequenceC80638 C80638 expressed sequence C80638 38 3.5 AV251613 B130036O03C86302 hypothetical protein B130036O03 256 2.6 BB295220 — C86813; FM2; —45 3.0 C86813 lerepo1 — C86813; FM2; — 284 5.6 C86813 lerepo1 — Cacnb2Mus musculus adult male hippocampus 7 2.8 AV154947 cDNA, RIKENfull-length enriched library, clone: 2900072G11 product: unknown EST,full insert sequence Calm1 Calm1 calmodulin 1 2311 2.2 AU079514 Calmbp1Calmbp1 calmodulin binding protein 1 21 4.2 BB648052 E030025C11RikCamk1d RIKEN cDNA E030025C11 gene 47 4.7 BG071931 Camk2d Camk2dcalcium/calmodulin-dependent protein 69 2.0 BB373572 kinase II, deltaCapg Capg capping protein (actin filament), gelsolin- 221 7.7 NM_007599like Capg Capg capping protein (actin filament), gelsolin- 77 2.1BB136012 like Cappa1 Capza1 capping protein alpha 1 2195 2.5 AV267494 —Capza1 — 2695 2.2 AI463215 Car13 Car13 carbonic anhydrase 13 132 2.3AK010166 Card11 Card11 caspase recruitment domain family, 24 4.6AV095659 member 11 Card4 Card4 caspase recruitment domain 4 228 3.2BB138330 Casp1 Casp1 caspase 1 94 9.4 BC008152 Casp12 Casp12 caspase 12122 3.6 NM_009808 Casp12 Casp12 caspase 12 145 6.8 NM_009808 Casp3 Casp3caspase 3, apoptosis related cysteine 312 2.2 D86352 protease Casp3Casp3 caspase 3, apoptosis related cysteine 707 2.6 BG070529 proteaseCasp4 Casp4 caspase 4, apoptosis-related cysteine 82 13.6 NM_007609protease Casp7 Casp7 caspase 7 234 3.7 U67321 Casp7 Casp7 caspase 7 5282.8 NM_007611 Cbfb Cbfb core binding factor beta 1387 2.3 NM_022309 —Cblb Mus musculus transcribed sequences 134 3.5 BB205662 Cblb CblbCasitas B-lineage lymphoma b 258 2.1 AW545867 Ccl11 Ccl11 smallchemokine (C-C motif) ligand 11 21 4.7 NM_011330 Ccl12 Ccl12 chemokine(C-C motif) ligand 12 11 49.6 U50712 Ccl2 Ccl2 chemokine (C-C motif)ligand 2 43 28.9 AF065933 Ccl4 Ccl4 chemokine (C-C motif) ligand 4 954.5 AF128218 Ccl5 Ccl5 chemokine (C-C motif) ligand 5 34 140.5 NM_013653Ccl6 Ccl6 chemokine (C-C motif) ligand 6 85 8.9 BC002073 Ccl7 Ccl7chemokine (C-C motif) ligand 7 54 6.2 AF128193 Ccl8 Ccl8 chemokine (C-Cmotif) ligand 8 115 16.0 NM_021443 Ccl9 Ccl9 chemokine (C-C motif)ligand 9 25 15.6 AF128196 Ccl9 Ccl9 chemokine (C-C motif) ligand 9 709.8 AF128196 Ccnb1 Ccnb1 cyclin B1 102 7.1 NM_007629 Ccnb1 Ccnb1 cyclinB1 55 12.1 NM_007629 Ccnb1 Ccnb1 cyclin B1 14 22.1 AU015121 Ccnd2 Ccnd2cyclin D2 420 2.3 BQ175880 — Ccne1 — 70 3.9 BB293079 Ccne2 Ccne2 cyclinE2 47 4.5 AF091432 Ccnf Ccnf cyclin F 11 9.5 NM_007634 Ccr1 Ccr1chemokine (C-C motif) receptor 1 81 9.2 AV231648 Ccr2 Ccr2 chemokine(C-C) receptor 2 123 23.0 BB148128 Ccr2 Ccr2 chemokine (C-C) receptor 287 7.6 BB148128 Ccr2 Ccr2 chemokine (C-C) receptor 2 70 24.5 BB148128Ccr5 Ccr5 chemokine (C-C motif) receptor 5 41 16.8 X94151 Ccr5 Ccr5chemokine (C-C motif) receptor 5 31 7.6 X94151 Ccr5 Ccr5 chemokine (C-Cmotif) receptor 5 73 18.6 D83648 Ccr9 Ccr9 chemokine (C-C motif)receptor 9 30 4.6 AJ131357 Ccrl2 Ccrl2 chemokine (C-C motif)receptor-like 2 138 2.5 AJ318863 Cd14 Cd14 CD14 antigen 359 16.5NM_009841 Cd160 Cd160 CD160 antigen 121 2.4 NM_018767 Cd160 Cd160 CD160antigen 16 9.7 AU045688 Cd1d1 Cd1d1 CD1d1 antigen 67 4.1 NM_007639 Mox2Cd200 antigen identified by monoclonal antibody 591 2.2 AF004023 MRCOX-2 F630003A18Rik Cd200r1 RIKEN cDNA F630003A18 gene 21 5.2 BB770873Cd22 Cd22 CD22 antigen 97 2.0 AF102134 Cd244 Cd244 CD244 natural killercell receptor 2B4 14 7.0 NM_018729 Cd28 Cd28 CD28 antigen 16 26.5AV313615 Cd28 Cd28 CD28 antigen 43 22.1 NM_007642 Cd38 Cd38 CD38 antigen191 2.7 NM_007646 Cd38 Cd38 CD38 antigen 455 3.7 BB256012 Cd3e Cd3e CD3antigen, epsilon polypeptide 31 27.4 NM_007648 Cd44 Cd44 CD44 antigen117 15.9 AW146109 Cd47 Cd47 CD47 antigen (Rh-related antigen, 1584 2.1NM_010581 integrin-associated signal transducer) Cd47 Cd47 CD47 antigen(Rh-related antigen, 2922 2.4 NM_010581 integrin-associated signaltransducer) Cd48 Cd48 CD48 antigen 82 20.7 BE634960 Cd5 Cd5 CD5 antigen77 6.3 NM_007650 Cd52 Cd52 CD52 antigen 474 28.2 NM_013706 — Cd53 Musmusculus transcribed sequences 13 7.7 BM239715 Cd6 Cd6 CD6 antigen 1811.9 U12434 Cd68 Cd68 CD68 antigen 189 7.9 BC021637 Cd69 Cd69 CD69antigen 22 13.0 AK017979 Cd72 Cd72 CD72 antigen 51 10.7 BC003824 Cd79bCd79b CD79B antigen 54 2.7 NM_008339 Cd83 Cd83 CD83 antigen 94 7.4NM_009856 Cd84 Cd84 CD84 antigen 44 8.2 NM_013489 Cd86 Cd86 CD86 antigen53 10.4 NM_019388 Cd86 Cd86 CD86 antigen 38 11.2 NM_019388 Cd8a Cd8a CD8antigen, alpha chain 96 11.3 BB154331 Cd8a Cd8a CD8 antigen, alpha chain71 18.2 M12825 Cd8a Cd8a CD8 antigen, alpha chain 60 31.2 M128251700109I12Rik Cd96 RIKEN cDNA 1700109I12 gene 99 2.9 NM_032465 Elovl1Cdc20 elongation of very long chain fatty acids 307 5.7 BB041150(FEN1/Elo2, SUR4/Elo3, yeast)-like 1 Cdc20 Cdc20 cell division cycle 20homolog (S. cerevisiae) 302 3.1 NM_023223 Cdc25b Cdc25b cell divisioncycle 25 homolog B (S. cerevisiae) 110 2.8 NM_023117 Cdc2a Cdc2a celldivision cycle 2 homolog A (S. pombe) 170 5.9 NM_007659 Cdc45l Cdc45lcell division cycle 45 homolog (S. cerevisiae)- 104 2.8 NM_009862 likeCdc7 Cdc7 cell division cycle 7 (S. cerevisiae) 45 5.1 AB0185742610311M19Rik Cdca2 RIKEN cDNA 2610311M19 gene 58 5.2 BG0650562610311M19Rik Cdca2 RIKEN cDNA 2610311M19 gene 27 6.7 BG065056 Cdca3Cdca3 cell division cycle associated 3 200 3.4 BI081061 Cdca4 Cdca4 celldivision cycle associated 4 200 2.1 BB329505 Cdca4 Cdca4 cell divisioncycle associated 4 280 3.2 AF322238 D4Ertd421e Cdca8 DNA segment, Chr 4,ERATO Doi 421, 57 12.2 AV307110 expressed D4Ertd421e Cdca8 DNA segment,Chr 4, ERATO Doi 421, 105 8.3 BB702047 expressed D4Ertd421e Cdca8 DNAsegment, Chr 4, ERATO Doi 421, 67 4.8 AV307110 expressed Cdh11 Cdh11cadherin 11 381 2.8 NM_009866 Cdk6 Cdk6 cyclin-dependent kinase 6 16 3.0NM_009873 Cdkn1a Cdkn1a cyclin-dependent kinase inhibitor 1A 231 3.9AK007630 (P21) Cds1 Cds1 CDP-diacylglycerol synthase 1 324 2.0 BI152841Cdyl Cdyl chromodomain protein, Y chromosome- 188 2.1 AF081260 likeCebpb Cebpb CCAAT/enhancer binding protein 672 3.6 NM_009883 (C/EBP),beta Cebpb Cebpb CCAAT/enhancer binding protein 214 2.9 AB012278(C/EBP), beta Cebpd Cebpd CCAAT/enhancer binding protein 236 5.5BB831146 (C/EBP), delta Cenpa Cenpa centromere autoantigen A 75 8.8AV132173 BC049989 Cenpe cDNA sequence BC049989 13 2.3 BG068387 BC049989Cenpe cDNA sequence BC049989 136 3.1 BG916502 Lek1 Cenpf leucine,glutamic acid, lysine family 1 89 3.4 BE848253 protein Cenph Cenphcentromere autoantigen H 22 5.1 BC025084 Centb1 Centb1 centaurin, beta 1228 2.4 BB757196 Kctd11 Centb1 potassium channel tetramerisation 110 5.9BB115902 domain containing 11 AA968343 Cep1 expressed sequence AA968343166 2.2 BB466021 Cfi Cfi complement component factor i 364 3.3 NM_007686Ch25h Ch25h cholesterol 25-hydroxylase 90 17.6 NM_009890 Chaf1b Chaf1bchromatin assembly factor 1, subunit B 81 3.3 BC013532 (p60) Chek1 Chek1checkpoint kinase 1 homolog (S. pombe) 29 4.7 NM_007691 Chi3l3 Chi3l3chitinase 3-like 3 15 64.7 NM_009892 Chi3l4 Chi3l4 chitinase 3-like 4 7613.4 AY065557 Chsy1 Chsy1 carbohydrate (chondroitin) synthase 1 640 2.0BQ174991 Ckap2 Ckap2 cytoskeleton associated protein 2 121 2.8 BM2081031700001C14Rik Cklf RIKEN cDNA 1700001C14 gene 169 2.1 AY047360 Cklfsf7Cklfsf7 chemokine-like factor super family 7 48 3.2 BC026773 Cks1 Cks1bCDC28 protein kinase 1 181 4.6 NM_016904 Cks1 Cks1b CDC28 protein kinase1 323 6.2 NM_016904 Clca2 Clca2 chloride channel calcium activated 2 393.1 AF108501 Cldn1 Cldn1 claudin 1 471 3.0 AV227581 Clecsf10 Clecsf10C-type (calcium dependent, carbohydrate 68 6.8 NM_020001 recognitiondomain) lectin, superfamily member 10 Clecsf10 Clecsf10 C-type (calciumdependent, carbohydrate 16 11.7 AF240358 recognition domain) lectin,superfamily member 10 Clecsf12 Clecsf12 C-type (calcium dependent,carbohydrate 197 9.5 NM_020008 recognition domain) lectin, superfamilymember 12 Clecsf5 Clecsf5 C-type (calcium dependent, 56 10.9 NM_021364carbohydrate-recognition domain) lectin, superfamily member 51810046I24Rik Clecsf6 RIKEN cDNA 1810046I24 gene 29 7.2 BC006623 Clecsf6Clecsf6 C-type (calcium dependent, carbohydrate 65 4.6 NM_011999recognition domain) lectin, superfamily member 6 Clecsf8 Clecsf8 C-type(calcium dependent, carbohydrate 25 4.5 NM_010819 recognition domain)lectin, superfamily member 8 Clecsf9 Clecsf9 C-type (calcium dependent,carbohydrate 38 3.4 NM_019948 recognition domain) lectin, superfamilymember 9 Clecsf9 Clecsf9 C-type (calcium dependent, carbohydrate 17 30.6NM_019948 recognition domain) lectin, superfamily member 9 Clic1 Clic1chloride intracellular channel 1 3468 2.6 NM_033444 E130314M08Rik ClspnRIKEN cDNA E130314M08 gene 40 7.0 BG067086 Cnn2 Cnn2 calponin 2 626 3.8BI663014 4932442K20Rik Cnot6l RIKEN cDNA 4932442K20 gene 322 2.0BC018506 Cnp1 Cnp1 cyclic nucleotide phosphodiesterase 1 113 2.5 M58045Col15a1 Col15a1 procollagen, type XV 247 2.1 AF011450 Col1a2 Col1a2procollagen, type I, alpha 2 1460 4.5 BF227507 Col1a2 Col1a2procollagen, type I, alpha 2 392 8.6 BF227507 Col3a1 Col3a1 procollagen,type III, alpha 1 165 7.9 AW550625 Col3a1 Col3a1 procollagen, type III,alpha 1 1468 5.7 AW550625 Col5a1 Col5a1 procollagen, type V, alpha 1 2423.6 AW744319 Col5a2 Col5a2 procollagen, type V, alpha 2 65 3.8 AV229424Col5a2 Col5a2 procollagen, type V, alpha 2 150 6.7 AV229424 Col6a2Col6a2 procollagen, type VI, alpha 2 363 3.4 BI455189 Col6a3 Col6a3procollagen, type VI, alpha 3 657 2.6 AF064749 — Col8a1 Mus musculus 6days neonate head 211 4.4 AV292255 cDNA, RIKEN full-length enrichedlibrary, clone: 5430419M07 product: unknown EST, full insert sequenceColec12 Colec12 collectin sub-family member 12 134 2.4 NM_130449 CopebCopeb core promoter element binding protein 198 4.4 AF072403 Copeb Copebcore promoter element binding protein 501 6.3 AV025472 Copeb Copeb corepromoter element binding protein 298 5.5 NM_011803 Coro1a Coro1acoronin, actin binding protein 1A 26 3.9 BB740218 Coro1a Coro1a coronin,actin binding protein 1A 168 24.0 BB740218 5830400N10Rik Coro2a RIKENcDNA 5830400N10 gene 69 4.1 AU042532 5830400N10Rik Coro2a RIKEN cDNA5830400N10 gene 68 4.2 AI316747 Cp Cp ceruloplasmin 727 3.9 BB009037Cpne2 Cpne2 copine II 100 1.9 BC023348 Crem Crem cAMP responsive elementmodulator 373 3.3 AI467599 Crem Crem cAMP responsive element modulator221 3.3 AI467599 Crip1 Crip1 cysteine-rich protein 1 (intestinal) 11913.7 NM_007763 Crlf1 Crlf1 cytokine receptor-like factor 1 63 10.0NM_018827 — Crlf3 Mus musculus transcribed sequences 110 2.8 BG094104Crlf3 Crlf3 cytokine receptor-like factor 3 426 2.4 BB161253 Crtam Crtamcytotoxic and regulatory T cell molecule 54 5.0 NM_019465 Csf1 Csf1colony stimulating factor 1 (macrophage) 138 2.9 BM233698 Csf1 Csf1colony stimulating factor 1 (macrophage) 73 3.2 M21149 Csf1 Csf1 colonystimulating factor 1 (macrophage) 213 5.5 BM233698 Csf2rb1 Csf2rb1colony stimulating factor 2 receptor, beta 7 11.5 NM_007780 1,low-affinity (granulocyte-macrophage) Csf2rb1 Csf2rb1 colony stimulatingfactor 2 receptor, beta 68 14.7 BB769628 1, low-affinity(granulocyte-macrophage) Csf2rb2 Csf2rb2 colony stimulating factor 2receptor, beta 43 11.4 NM_007781 2, low-affinity(granulocyte-macrophage) Csf3r Csf3r colony stimulating factor 3receptor 26 12.4 NM_007782 (granulocyte) Cspg2 Cspg2 chondroitin sulfateproteoglycan 2 42 7.2 NM_019389 Cspg2 Cspg2 chondroitin sulfateproteoglycan 2 59 8.2 BM251152 Cstb Cstb cystatin B 5561 2.3 NM_007793Cstb Cstb cystatin B 2587 2.9 NM_007793 Cstf3 Cstf3 cleavage stimulationfactor, 3′ pre-RNA, 51 2.5 BM218423 subunit 3 Tpbpb Ctla2a trophoblastspecific protein beta 81 2.9 BG064656 Ctla4 Ctla4 cytotoxicT-lymphocyte-associated 26 21.0 NM_009843 protein 4 — Ctsc Mus musculustranscribed sequences 11 14.6 BG070233 Ctsc Ctsc cathepsin C 1593 8.7NM_009982 — Ctsc Mus musculus transcribed sequences 32 5.3 AV367948 —Ctsc Mus musculus transcribed sequences 98 6.5 BM237633 Ctss Ctsscathepsin S 838 16.7 NM_021281 Cx3cl1 Cx3cl1 chemokine (C—X3—C motif)ligand 1 705 2.4 AF010586 Cx3cr1 Cx3cr1 chemokine (C—X3—C) receptor 1139 2.4 BC012653 Cxcl1 Cxcl1 chemokine (C—X—C motif) ligand 1 177 2.7BB554288 Cxcl1 Cxcl1 chemokine (C—X—C motif) ligand 1 74 6.2 NM_008176Cxcl10 Cxcl10 chemokine (C—X—C motif) ligand 10 162 81.6 NM_021274Cxcl11 Cxcl11 chemokine (C—X—C motif) ligand 11 46 10.5 NM_019494 Cxcl11Cxcl11 chemokine (C—X—C motif) ligand 11 144 99.2 NM_019494 Cxcl13Cxcl13 chemokine (C—X—C motif) ligand 13 68 4.4 AF030636 Cxcl14 Cxcl14chemokine (C—X—C motif) ligand 14 260 3.1 AF252873 Cxcl14 Cxcl14chemokine (C—X—C motif) ligand 14 124 9.2 AF252873 Cxcl16 Cxcl16chemokine (C—X—C motif) ligand 16 1027 2.9 BC019961 Cxcl16 Cxcl16chemokine (C—X—C motif) ligand 16 1429 3.7 BC019961 Cxcl16 Cxcl16chemokine (C—X—C motif) ligand 16 199 2.9 AI662455 Cxcl9 Cxcl9 chemokine(C—X—C motif) ligand 9 125 176.4 NM_008599 Cxcr3 Cxcr3 chemokine (C—X—Cmotif) receptor 3 137 10.2 NM_009910 Cxcr4 Cxcr4 chemokine (C—X—C motif)receptor 4 133 3.6 D87747 Cybb Cybb cytochrome b-245, beta polypeptide283 21.3 AV373944 Cybb Cybb cytochrome b-245, beta polypeptide 153 14.2NM_007807 Cybb Cybb cytochrome b-245, beta polypeptide 161 9.1 AV373944Cyp1b1 Cyp1b1 cytochrome P450, family 1, subfamily b, 259 3.4 BI251808polypeptide 1 Cyp4f18 Cyp4f18 cytochrome P450, family 4, subfamily f, 1926.1 NM_024444 polypeptide 18 Cyp4v3 Cyp4v3 cytochrome P450, family 4,subfamily v, 300 3.1 NM_133969 polypeptide 3 Cyp4v3 Cyp4v3 cytochromeP450, family 4, subfamily v, 137 3.9 NM_133969 polypeptide 3 Cyr61 Cyr61cysteine rich protein 61 384 2.5 BM202770 Cysltr1 Cysltr1 cysteinylleukotriene receptor 1 13 4.8 BC027102 Cysltr1 Cysltr1 cysteinylleukotriene receptor 1 12 4.9 BC027102 — D030064D06Rik Mus musculus 9days embryo whole 92 2.3 AW987520 body cDNA, RIKEN full-length enrichedlibrary, clone: D030064D06 product: unknown EST, full insert sequenceD11Ertd461e D11Ertd461e DNA segment, Chr 11, ERATO Doi 461, 26 5.5C87579 expressed D11Ertd759e D11Ertd759e DNA segment, Chr 11, ERATO Doi759, 922 4.9 AW556558 expressed D11Lgp2e D11Lgp2e DNA segment, Chr 11,Lothar 27 6.1 NM_030150 Hennighausen 2, expressed D11Lgp2e D11Lgp2e DNAsegment, Chr 11, Lothar 55 10.0 AF316999 Hennighausen 2, expressedD11Wsu99e D11Wsu99e DNA segment, Chr 11, Wayne State 232 2.6 AV225714University 99, expressed D12Ertd551e D12Ertd551e DNA segment, Chr 12,ERATO Doi 551, 660 2.1 BI102044 expressed — D12Ertd551e Mus musculusadult male tongue cDNA, 20 5.5 BQ175646 RIKEN full-length enrichedlibrary, clone: 2310058N22 product: unknown EST, full insert sequenceD12Ertd647e D12Ertd647e DNA segment, Chr 12, ERATO Doi 647, 953 5.8AW554405 expressed D12Ertd647e D12Ertd647e DNA segment, Chr 12, ERATODoi 647, 1414 4.1 BI655075 expressed 4930513H15Rik D14Ertd581e RIKENcDNA 4930513H15 gene 49 2.1 AK017117 D16Ertd472e D16Ertd472e DNAsegment, Chr 16, ERATO Doi 472, 105 4.2 AV381575 expressed D17H6S56E-5D17H6S56E-5 DNA segment, Chr 17, human D6S56E 5 381 5.9 NM_033075D17H6S56E-5 D17H6S56E-5 DNA segment, Chr 17, human D6S56E 5 195 9.2NM_033075 D2Ertd750e D2Ertd750e DNA segment, Chr 2, ERATO Doi 750, 437.9 AU019491 expressed — D330027G24Rik Mus musculus 13 days embryo heart48 4.3 BB449568 cDNA, RIKEN full-length enriched library, clone:D330027G24 product: unclassifiable, full insert sequence Mecp2D630021H01Rik methyl CpG binding protein 2 55 2.0 BB499491 D730019B10D730019B10 hypothetical protein D730019B10 23 12.8 BB508669 Rpl30D730044K07Rik ribosomal protein L30 13 2.0 BB283415 D7Bwg0421eD7Bwg0421e DNA segment, Chr 7, Brigham & 31 8.1 BB667693 Women'sGenetics 0421 expressed D7Bwg0421e D7Bwg0421e DNA segment, Chr 7,Brigham & 59 8.4 AV370380 Women's Genetics 0421 expressed Atp8a1D830007B15Rik ATPase, aminophospholipid transporter 124 2.7 BB303874(APLT), class I, type 8A, member 1 Atp8a1 D830007B15Rik ATPase,aminophospholipid transporter 164 4.3 BB303874 (APLT), class I, type 8A,member 1 Atp8a1 D830007B15Rik ATPase, aminophospholipid transporter 1845.6 AW610650 (APLT), class I, type 8A, member 1 Atp8a1 D830007B15RikATPase, aminophospholipid transporter 150 2.9 BQ176779 (APLT), class I,type 8A, member 1 Atp8a1 D830007B15Rik ATPase, aminophospholipidtransporter 213 4.3 AW610650 (APLT), class I, type 8A, member 1 Dapp1Dapp1 dual adaptor for phosphotyrosine and 3- 91 3.9 NM_011932phosphoinositides 1 Dapp1 Dapp1 dual adaptor for phosphotyrosine and 3-54 4.4 NM_011932 phosphoinositides 1 Dcamkl1 Dcamkl1 double cortin andcalcium/calmodulin- 3 4.7 AW105916 dependent protein kinase-like 1Dcamkl1 Dcamkl1 double cortin and calcium/calmodulin- 27 5.4 AW105916dependent protein kinase-like 1 Dcamkl1 Dcamkl1 double cortin andcalcium/calmodulin- 18 9.8 AW105916 dependent protein kinase-like 1Dcamkl1 Dcamkl1 double cortin and calcium/calmodulin- 12 19.7 BB757120dependent protein kinase-like 1 Dck Dck deoxycytidine kinase 54 5.3BE630687 Dck Dck deoxycytidine kinase 103 12.6 BB030204 Dck Dckdeoxycytidine kinase 105 5.1 NM_007832 Dcn Dcn decorin 2578 2.7NM_007833 — Ddef1 Mus musculus transcribed sequences 29 3.6 BG064109Ddx21 Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 293 2.1 BM246099 21Ddx39 Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 940 2.6 BC020134 39Ddx39 Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1433 2.3 AV214253 396430573D20Rik Ddx58 RIKEN cDNA 6430573D20 gene 505 3.9 BG063981 Def6Def6 differentially expressed in FDCP 6 54 4.9 AK010356 5830484J08RikDepdc1a RIKEN cDNA 5830484J08 gene 14 8.5 BC005799 — Diap1 Mus musculus7 days embryo whole 124 2.1 BB408240 body cDNA, RIKEN full-lengthenriched library, clone: C430005H19 product: unknown EST, full insertsequence Dkk3 Dkk3 dickkopf homolog 3 (Xenopus laevis) 354 2.5 AK004853Dkk3 Dkk3 dickkopf homolog 3 (Xenopus laevis) 293 2.3 AK004853 Hurp Dlg7hepatoma up-regulated protein 24 3.2 BB132734 Hurp Dlg7 hepatomaup-regulated protein 34 4.5 BM250919 E130315B21Rik Dna2l RIKEN cDNAE130315B21 gene 363 2.0 BB546985 5330419I01Rik Dnajc9 RIKEN cDNA5330419I01 gene 626 2.1 BM942465 Dnase1l3 Dnase1l3 deoxyribonuclease1-like 3 47 6.4 BC012671 Dnase1l3 Dnase1l3 deoxyribonuclease 1-like 3 128.8 BC012671 Npn1 Dnm3 neoplastic progression 1 86 2.5 BB542096 Dnmt1Dnmt1 DNA methyltransferase (cytosine-5) 1 308 2.9 BB165431 — Dock10 Musmusculus transcribed sequences 49 2.3 BB211894 Dock10 Dock10 dedicatorof cytokinesis 10 17 3.0 BB763030 Dock10 Dock10 dedicator of cytokinesis10 145 8.8 BF715043 — Dock11 Mus musculus 11 days pregnant adult 10611.1 AK017170 female ovary and uterus cDNA, RIKEN full-length enrichedlibrary, clone: 5033414A21 product: inferred: human CLASP-4 {Homosapiens}, full insert sequence Dok1 Dok1 downstream of tyrosine kinase 1169 2.1 BC013066 Donson Donson downstream neighbor of SON 150 2.7BQ174742 Dpt Dpt dermatopontin 246 2.4 NM_019759 Dpysl2 Dpysl2dihydropyrimidinase-like 2 1968 2.0 BQ174209 — Dpysl3 Mus musculustranscribed sequence with 78 3.7 AV161550 strong similarity to proteinsp: Q14195 (H. sapiens) DPY3_HUMAN Dihydropyrimidinase related protein-3(DRP-3) (Unc-33-like phosphoprotein) (ULIP protein) (Collapsin responsemediator protein 4) (CRMP-4) Dsg2 Dsg2 desmoglein 2 693 2.1 BG092030 —Dtx3l Mus musculus transcribed sequence with 460 9.1 AV327407 weaksimilarity to protein ref: NP_081764.1 (M. musculus) RIKEN cDNA5730493B19 [Mus musculus] BC044798 Dtx4 cDNA sequence BC044798 589 2.5AV017487 2610016C23Rik Dufd1 RIKEN cDNA 2610016C23 gene 53 3.7 AK016786Dusp10 Dusp10 dual specificity phosphatase 10 41 4.8 NM_022019 Dusp2Dusp2 dual specificity phosphatase 2 54 5.0 L11330 Dutp Dut deoxyuridinetriphosphatase 289 2.7 AF091101 — E030018N11Rik Mus musculus 0 dayneonate lung cDNA, 314 3.4 BB794845 RIKEN full-length enriched library,clone: E030018N11 product: hypothetical protein, full insert sequenceE030024M05Rik E030024M05Rik RIKEN cDNA E030024M05 gene 259 2.1 BC025220— E130113K08Rik Mus musculus transcribed sequences 31 4.5 BB491630E130201N16Rik E130201N16Rik RIKEN cDNA E130201N16 gene 285 4.4 AJ132433E2f1 E2f1 E2F transcription factor 1 80 2.3 AK017841 E2f2 E2f2 E2Ftranscription factor 2 22 4.3 BB543028 E2f7 E2f7 E2F transcriptionfactor 7 33 3.5 BG069355 E330016A19Rik E330016A19Rik RIKEN cDNAE330016A19 gene 40 5.4 BB073366 E430004N04Rik E430004N04Rik RIKEN cDNAE430004N04 gene 65 7.1 BE628523 E430004N04Rik E430004N04Rik RIKEN cDNAE430004N04 gene 21 3.4 BB201286 E430019B13Rik E430019B13Rik RIKEN cDNAE430019B13 gene 51 2.2 BE630983 Ebi2 Ebi2 Epstein-Barr virus inducedgene 2 51 4.5 BM242490 Ebi3 Ebi3 Epstein-Barr virus induced gene 3 702.9 NM_015766 Edg5 Edg5 endothelial differentiation, sphingolipid G- 1522.5 AK003144 protein-coupled receptor, 5 Edg6 Edg6 endothelialdifferentiation, G-protein- 87 3.1 AV081616 coupled receptor 6 EdnraEdnra endothelin receptor type A 18 4.0 BC008277 D4Wsu27e Efhd2 DNAsegment, Chr 4, Wayne State 163 52.1 AA409309 University 27, expressedEgr1 Egr1 early growth response 1 317 5.3 NM_007913 Egr2 Egr2 earlygrowth response 2 3 19.6 X06746 Egr2 Egr2 early growth response 2 3516.7 X06746 Egr3 Egr3 early growth response 3 27 10.5 AV346607 Eif1aEif1a eukaryotic translation initiation factor 1A 923 2.3 BM200591 Eif1aEif1a eukaryotic translation initiation factor 1A 1090 2.4 BM2005911300018P11Rik Eif4e3 RIKEN cDNA 1300018P11 gene 370 4.7 BC0270141300018P11Rik Eif4e3 RIKEN cDNA 1300018P11 gene 464 5.1 BC027014 Pctk2Elk3 PCTAIRE-motif protein kinase 2 465 2.5 BM243464 Elk3 Elk3 ELK3,member of ETS oncogene family 425 2.0 BC005686 Elmo1 Elmo1 engulfmentand cell motility 1, ced-12 36 3.4 NM_080288 homolog (C. elegans) Elmo1Elmo1 engulfment and cell motility 1, ced-12 79 3.7 BC024727 homolog (C.elegans) Emb Emb embigin 402 2.3 BG064842 Emb Emb embigin 609 2.7BG064842 Emilin1 Emilin1 elastin microfibril interface located protein 1179 2.7 NM_133918 Emilin2 Emilin2 elastin microfibril interface locatedprotein 2 92 3.8 BB811788 Emp1 Emp1 epithelial membrane protein 1 10722.0 U25633 Emp3 Emp3 epithelial membrane protein 3 299 5.4 BC001999 Emr1Emr1 EGF-like module containing, mucin-like, 227 3.9 U66888 hormonereceptor-like sequence 1 Emr4 Emr4 EGF-like module containing,mucin-like, 20 14.8 AF396935 hormone receptor-like sequence 4 Emr4 Emr4EGF-like module containing, mucin-like, 27 10.3 AF396935 hormonereceptor-like sequence 4 Enc1 Enc1 ectodermal-neural cortex 1 264 6.4BM120053 Enc1 Enc1 ectodermal-neural cortex 1 175 4.0 BM120053 Enpp4Enpp4 ectonucleotide 657 2.2 AV280361 pyrophosphatase/phosphodiesterase4 Entpd1 Entpd1 ectonucleoside triphosphate 160 3.4 BI151440diphosphohydrolase 1 Entpd1 Entpd1 ectonucleoside triphosphate 89 2.4BI151440 diphosphohydrolase 1 Eomes Eomes eomesodermin homolog (Xenopuslaevis) 69 2.1 BB128925 Epb4.1l2 Epb4.1l2 erythrocyte protein band4.1-like 2 528 2.0 BE951907 Eppk1 Eppk1 epiplakin 1 74 2.1 BC0263872310046K10Rik Epsti1 RIKEN cDNA 2310046K10 gene 63 13.4 AK0171742310046K10Rik Epsti1 RIKEN cDNA 2310046K10 gene 106 14.2 BF020640 —Espl1 Mus musculus 10 days neonate skin 91 2.7 BM200578 cDNA, RIKENfull-length enriched library, clone: 4732457F20 product: unknown EST,full insert sequence Ets1 Ets1 E26 avian leukemia oncogene 1, 5′ 82 2.6BC010588 domain Ets1 Ets1 E26 avian leukemia oncogene 1, 5′ 564 3.2BB151715 domain Ets1 Ets1 E26 avian leukemia oncogene 1, 5′ 556 5.1BB151715 domain Etv3 Etv3 ets variant gene 3 88 2.0 BM932547 — Etv6 Musmusculus transcribed sequence with 73 2.4 BB735884 strong similarity toprotein sp: P00722 (E. coli) BGAL_ECOLI Beta-galactosidase (Lactase)Evi2a Evi2a ecotropic viral integration site 2a 54 7.7 BB236216 Evi2aEvi2a ecotropic viral integration site 2a 19 35.2 AI122415 Evl EvlEna-vasodilator stimulated 96 2.5 AW546029 phosphoprotein Evl EvlEna-vasodilator stimulated 205 4.7 AW553781 phosphoprotein Evl EvlEna-vasodilator stimulated 159 3.7 NM_007965 phosphoprotein Exo1 Exo1exonuclease 1 65 2.4 BE986864 Exo1 Exo1 exonuclease 1 46 2.0 BE9868642310032N20Rik Exosc8 RIKEN cDNA 2310032N20 gene 433 3.7 AK009584 Ezh2Ezh2 enhancer of zeste homolog 2 256 4.0 NM_007971 (Drosophila) F10 F10coagulation factor X 75 2.5 NM_007972 F13a F13a1 coagulation factorXIII, alpha subunit 64 4.5 NM_028784 F2r F2r coagulation factor II(thrombin) receptor 1067 3.0 BQ173958 F2r F2r coagulation factor II(thrombin) receptor 2532 2.3 AV024285 F3 F3 coagulation factor III 5422.8 BC024886 F730004D16Rik F730004D16Rik RIKEN cDNA F730004D16 gene 1005.4 BM230330 — F730047E07Rik Mus musculus hypothetical LOC269515 37 4.7BG071041 (LOC269515), mRNA Fabp5 Fabp5 fatty acid binding protein 5,epidermal 504 3.0 BC002008 Fabp5 Fabp5 fatty acid binding protein 5,epidermal 150 3.5 BC002008 Fabp7 Fabp7 fatty acid binding protein 7,brain 795 5.2 NM_021272 Tnfrsf6 Fas tumor necrosis factor receptor 1206.0 NM_007987 superfamily, member 6 Fbn1 Fbn1 fibrillin 1 269 3.3AF007248 Fbn1 Fbn1 fibrillin 1 494 3.0 NM_007993 Fbxo5 Fbxo5 F-box onlyprotein 5 119 5.0 AK011820 Fbxo6b Fbxo6b F-box only protein 6b 455 3.0NM_015797 1110064L07Rik Fbxw17 RIKEN cDNA 1110064L07 gene 339 4.8AV016303 Fcer1g Fcer1g Fc receptor, IgE, high affinity I, gamma 225 21.7NM_010185 polypeptide Fcgr1 Fcgr1 Fc receptor, IgG, high affinity I 1234.8 BB075261 Fcgr1 Fcgr1 Fc receptor, IgG, high affinity I 74 21.0AF143181 Fcgr2b Fcgr3 Fc receptor, IgG, low affinity IIb 161 11.4NM_010188 Fcrl3 Fcrl3 Fc receptor-like 3 114 20.5 BC027310 Fen1 Fen1flap structure specific endonuclease 1 262 3.1 NM_007999 Fer1l3 Fer1l3fer-1-like 3, myoferlin (C. elegans) 208 4.0 BI555209 Fes Fes felinesarcoma oncogene 105 3.0 BG867327 Fes Fes feline sarcoma oncogene 1013.8 BG867327 Fga Fga fibrinogen, alpha polypeptide 605 6.1 BC005467 Fgd2Fgd2 FYVE, RhoGEF and PH domain 109 2.2 NM_013710 containing 2 Fgd3 Fgd3FYVE, RhoGEF and PH domain 66 2.7 AK018025 containing 3 1500031J01RikFgfr1op2 RIKEN cDNA 1500031J01 gene 82 2.2 AB041650 Fgl2 Fgl2fibrinogen-like protein 2 56 46.7 BF136544 Fgl2 Fgl2 fibrinogen-likeprotein 2 114 28.1 BF136544 Fgr Fgr Gardner-Rasheed feline sarcoma viral120 5.4 NM_010208 (Fgr) oncogene homolog Fgr Fgr Gardner-Rasheed felinesarcoma viral 105 4.3 BB165085 (Fgr) oncogene homolog — Fkbp10 — 84 2.3AI325255 Fli1 Fli1 Friend leukemia integration 1 228 3.5 BB138212 Fli1Fli1 Friend leukemia integration 1 75 5.1 NM_008026 1110008K06Rik Fln29RIKEN cDNA 1110008K06 gene 464 4.0 AK003586 5430425K04Rik Fmnl2 RIKENcDNA 5430425K04 gene 576 2.3 AK017338 Fnbp1 Fnbp1 formin binding protein1 211 2.3 BM244005 Fos Fos FBJ osteosarcoma oncogene 119 9.1 AV026617Fosl2 Fosl2 fos-like antigen 2 247 4.1 BM245170 Foxa1 Foxa1 forkhead boxA1 46 2.3 NM_008259 Foxj1 Foxj1 forkhead box J1 53 2.1 L13204 Foxp1Foxp1 forkhead box P1 120 2.2 BG962849 Fprl1 Fprl1 formyl peptidereceptor-like 1 30 48.3 NM_008039 Frk Frk fyn-related kinase 193 2.2BB787292 Fscn1 Fscn1 fascin homolog 1, actin bundling protein 820 3.1NM_007984 (Strongylocentrotus) purpuratus) Fshprh1 Fshprh1 FSH primaryresponse 1 8 6.8 BB258991 Fstl1 Fstl1 follistatin-like 1 469 4.4BI452727 Fstl1 Fstl1 follistatin-like 1 73 2.2 BB540658 Fstl1 Fstl1follistatin-like 1 739 4.0 BI452727 Fthfsdc1 Fthfsdc1formyltetrahydrofolate synthetase domain 145 3.2 AV095209 containing 1Fus Fus fusion, derived from t(12; 16) malignant 1474 2.6 AF224264liposarcoma (human) Fut4 Fut4 fucosyltransferase 4 16 6.5 AV309809 Fxyd5Fxyd5 FXYD domain-containing ion transport 491 7.4 NM_008761 regulator 5Fyb Fyb FYN binding protein 73 3.8 BE853428 Fyb Fyb FYN binding protein64 18.3 BM243379 Fyb Fyb FYN binding protein 70 19.2 BB157866 Fyn FynFyn proto-oncogene 217 3.1 NM_008054 Fyn Fyn Fyn proto-oncogene 369 2.9NM_008054 G430022H21Rik G430022H21Rik RIKEN cDNA G430022H21 gene 108 2.6BM247306 G430041M01Rik G430041M01Rik RIKEN cDNA G430041M01 gene 602 2.1BG069073 — G430041M01Rik Mus musculus adult male corpora 36 6.9 BM211445quadrigemina cDNA, RIKEN full-length enriched library, clone: B230214O09product: unknown EST, full insert sequence Gab3 Gab3 growth factorreceptor bound protein 2- 35 2.5 BB037935 associated protein 3 — Gadd45b— 152 2.5 AI323528 Galgt1 Galgt1 UDP-N-acetyl-alpha-D-galactosamine: (N-99 8.2 U18975 acetylneuraminyl)- galactosylglucosylceramide-beta-1,4-N-acetylgalactosaminyltransferase Galnt12 Galnt12 UDP-N-acetyl-alpha-D- 922.6 AV376137 galactosamine: polypeptide N-acetylgalactosaminyltransferase 12 Galnt6 Galnt6 UDP-N-acetyl-alpha-D- 711.2 AV231866 galactosamine: polypeptide N-acetylgalactosaminyltransferase 6 — Gas2l3 Mus musculus hypotheticalLOC237436 59 3.3 BB770972 (LOC237436), mRNA — Gas2l3 Mus musculushypothetical LOC237436 52 3.7 BB770972 (LOC237436), mRNA Gas5 Gas5growth arrest specific 5 2282 2.0 NM_013525 Gas5 Gas5 growth arrestspecific 5 288 3.0 BI650268 Gas5 Gas5 growth arrest specific 5 121 5.2AW547050 Gas5 Gas5 growth arrest specific 5 220 4.3 BC004622 Gbp1 Gbp1guanylate nucleotide binding protein 1 9 54.5 NM_010259 Gbp2 Gbp2guanylate nucleotide binding protein 2 272 53.4 BE197524 Gbp2 Gbp2guanylate nucleotide binding protein 2 321 100.2 NM_010260 Gbp3 Gbp4guanylate nucleotide binding protein 3 184 42.9 NM_018734 Gch Gch1 GTPcyclohydrolase 1 54 3.3 NM_008102 Gcnt1 Gcnt1 glucosaminyl (N-acetyl)transferase 1, 26 6.9 AK017462 core 2 Gda Gda guanine deaminase 106 11.9AW911807 Gda Gda guanine deaminase 33 5.4 NM_010266 Gda Gda guaninedeaminase 81 12.1 AW911807 1110035O14Rik Gdap10 RIKEN cDNA 1110035O14gene 329 4.0 NM_010268 Gfpt1 Gfpt1 glutamine fructose-6-phosphate 74 2.7AF334736 transaminase 1 Ggta1 Ggta1 glycoprotein galactosyltransferasealpha 42 3.2 M26925 1, 3 Ggta1 Ggta1 glycoprotein galactosyltransferasealpha 232 3.3 AF297615 1, 3 Ian1 Gimap4 immune associated nucleotide 12439 3.0 BC005577 Ian1 Gimap4 immune associated nucleotide 1 1384 2.4BC005577 Ian3 Gimap7 immune associated nucleotide 3 52 14.1 BC026200Ian3 Gimap7 immune associated nucleotide 3 9 7.7 BB223831 — Gimap8 Musmusculus similar to hypothetical 716 3.2 BM243674 protein (LOC243374),mRNA — Gimap8 — 22 7.8 BB236014 Glipr1 Glipr1 GLI pathogenesis-related 1(glioma) 144 14.8 BC025083 Glipr2 Glipr2 GLI pathogenesis-related 2 3612.8 BM208214 Glipr2 Glipr2 GLI pathogenesis-related 2 49 8.2 BM208214 —Gls Mus musculus transcribed sequences 190 2.7 BM239869 Gmfg Gmfg gliamaturation factor, gamma 310 5.7 NM_022024 Gmfg Gmfg glia maturationfactor, gamma 76 5.9 NM_022024 — Gna13 Mus musculus transcribedsequences 227 2.0 BI180797 Gna13 Gna13 guanine nucleotide bindingprotein, alpha 1712 2.7 BG073165 13 Gnb4 Gnb4 guanine nucleotide bindingprotein, beta 4 290 2.1 BI713933 Gnb4 Gnb4 guanine nucleotide bindingprotein, beta 4 204 3.4 BI713933 Gng10 Gng10 guanine nucleotide bindingprotein (G 619 2.4 NM_025277 protein), gamma 10 — Gng2 Mus musculus 15days embryo male 224 2.3 AV021455 testis cDNA, RIKEN full-lengthenriched library, clone: 8030491K24 product: unknown EST, full insertsequence Gng2 Gng2 guanine nucleotide binding protein (G 91 7.8 BB522409protein), gamma 2 subunit — Gng2 Mus musculus 15 days embryo male 1112.6 AV021455 testis cDNA, RIKEN full-length enriched library, clone:8030491K24 product: unknown EST, full insert sequence Gp38 Gp38glycoprotein 38 383 2.6 NM_010329 Gpm6b Gpm6b glycoprotein m6b 249 3.0AF254879 Gpm6b Gpm6b glycoprotein m6b 232 4.4 AK016567 Gpr132 Gpr132 Gprotein-coupled receptor 132 47 3.8 BB208670 F730001G15Rik Gpr171 RIKENcDNA F730001G15 gene 17 17.5 BB229616 Gpr18 Gpr18 G protein-coupledreceptor 18 100 9.9 BG145550 Gpr35 Gpr35 G protein-coupled receptor 3515 14.0 NM_022320 Gpr43 Gpr43 G protein-coupled receptor 43 17 2.6AV370830 Gpr64 Gpr64 G protein-coupled receptor 64 79 2.2 AV242919Gpcr25 Gpr65 G-protein coupled receptor 25 50 13.6 NM_008152 Gpr68 Gpr68G protein-coupled receptor 68 24 10.0 BB538372 Gpr84 Gpr84 Gprotein-coupled receptor 84 18 17.9 NM_030720 Gprk6 Gprk6 Gprotein-coupled receptor kinase 6 556 2.5 BB461269 Gprk6 Gprk6 Gprotein-coupled receptor kinase 6 299 2.1 AF040748 1810036L03Rik Gsdmdc1RIKEN cDNA 1810036L03 gene 133 6.5 AK007710 Gsg2 Gsg2 germ cell-specificgene 2 34 3.1 BE457839 Gzma Gzma granzyme A 68 14.1 NM_010370 Gzmk Gzmkgranzyme K 24 14.1 AB032200 H28 H28 histocompatibility 28 343 8.9NM_031367 H28 H28 histocompatibility 28 370 6.8 BC024930 H2-Aa H2-Aahistocompatibility 2, class II antigen A, 1265 12.3 AV018723 alpha H2-AaH2-Aa histocompatibility 2, class II antigen A, 3501 7.1 BE688749 alpha— H2-Aa — 18 46.1 AV086906 H2-Aa H2-Aa histocompatibility 2, class IIantigen A, 2137 10.8 AF119253 alpha H2-Ab1 H2-Ab1 histocompatibility 2,class II antigen A, 421 19.9 M15848 beta 1 H2-Ab1 H2-Ab1histocompatibility 2, class II antigen A, 950 13.2 NM_010379 beta 1H2-Ab1 H2-Ab1 histocompatibility 2, class II antigen A, 659 18.5 M15848beta 1 H2afx H2afx H2A histone family, member X 654 2.0 NM_010436 H2-D1H2-D1 histocompatibility 2, D region locus 1 87 3.5 X00246 H2-D1 H2-D1histocompatibility 2, D region locus 1 76 34.3 M34962 H2-D1 H2-D1histocompatibility 2, D region locus 1 43 15.6 M33151 H2-D1 H2-D1histocompatibility 2, D region locus 1 437 26.3 M86502 H2-D1 H2-D1histocompatibility 2, D region locus 1 43 11.3 M83244 H2-D1 H2-D1histocompatibility 2, D region locus 1 2224 6.2 NM_010380 H2-D1 H2-D1histocompatibility 2, D region locus 1 228 52.6 L36068 H2-D1 H2-D1histocompatibility 2, D region locus 1 152 50.7 M69068 — H2-DMa — 6 16.9BB425495 H2-DMa H2-DMa histocompatibility 2, class II, locus DMa 26120.9 NM_010386 H2-DMb1 H2-DMb1 histocompatibility 2, class II, locus Mb1121 38.0 NM_010388 H2-DMb1 H2-DMb1 histocompatibility 2, class II, locusMb1 159 45.2 BB734586 H2-DMb1 H2-DMb1 histocompatibility 2, class II,locus Mb1 347 16.8 NM_010388 H2-DMb1 H2-DMb1 histocompatibility 2, classII, locus Mb1 116 19.8 NM_010387 H2-DMb1 H2-DMb1 histocompatibility 2,class II, locus Mb1 87 53.8 BB734586 H2-Ea H2-Ea histocompatibility 2,class II antigen E 103 3.7 U13648 alpha H2-Ea H2-Ea histocompatibility2, class II antigen E 63 6.4 U13648 alpha H2-Eb1 H2-Eb1histocompatibility 2, class II antigen E 1760 8.6 NM_010382 beta H2-KH2-K histocompatibility 2, K region 136 5.9 J00406 H2-K H2-K1histocompatibility 2, K region 626 22.5 L23495 — H2-K1 MHC l = H-2Kdhomolog {alternatively 435 45.5 S70184 spliced, deletion of exon 3}[mice, DBA/2, L1210 lymphoma, mRNA Mutant, 855 nt] H2-K H2-K1histocompatibility 2, K region 606 23.9 BC011306 H2-M3 H2-M3histocompatibility 2, M region locus 3 261 4.8 NM_013819 H2-Oa H2-Oahistocompatibility 2, O region alpha locus 56 6.1 NM_008206 H2-Ob H2-Obhistocompatibility 2, O region beta locus 38 4.4 BG144448 H2-Q1 H2-Q1histocompatibility 2, Q region locus 1 125 3.7 M58156 H2-Q1 H2-Q1histocompatibility 2, Q region locus 1 35 22.6 BC010602 H2-K H2-Q5histocompatibility 2, K region 20 18.3 NM_010393 H2-Q7 H2-Q7histocompatibility 2, Q region locus 7 20 14.9 AK013097 H2-Q7 H2-Q7histocompatibility 2, Q region locus 7 37 78.5 M29881 H2-T10 H2-T10histocompatibility 2, T region locus 10 2355 4.3 NM_010395 H2-T23 H2-T23histocompatibility 2, T region locus 23 2198 8.0 NM_010398 — H2-T23 Musmusculus 2 days neonate thymus 71 6.6 NM_010398 thymic cells cDNA, RIKENfull-length enriched library, clone: C920026N01 product: weakly similarto H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-37 ALPHA CHAIN PRECURSOR[Mus musculus], full insert sequence H2-T24 H2-T24 histocompatibility 2,T region locus 24 109 3.1 L22338 Has2 Has2 hyaluronan synthase 2 37 2.5NM_008216 Havcr1 Havcr1 hepatitis A virus cellular receptor 1 700 7.0NM_134248 Havcr1 Havcr1 hepatitis A virus cellular receptor 1 1015 7.8BM211416 Havcr2 Havcr2 hepatitis A virus cellular receptor 2 39 4.7AF450241 — Hck Mus musculus transcribed sequences 28 2.2 BM246401 HckHck hemopoietic cell kinase 117 17.9 NM_010407 Hcph Hcph hemopoieticcell phosphatase 617 4.1 NM_013545 Hells Hells helicase, lymphoidspecific 65 10.4 NM_008234 4930568P13Rik Hemp1 RIKEN cDNA 4930568P13gene 36 25.3 BM238906 4930568P13Rik Hemp1 RIKEN cDNA 4930568P13 gene 1474.8 BM238906 2510038N07Rik Herc5 RIKEN cDNA 2510038N07 gene 217 12.8AI639807 2510038N07Rik Herc5 RIKEN cDNA 2510038N07 gene 64 18.0 AK0152142510038N07Rik Herc5 RIKEN cDNA 2510038N07 gene 161 25.4 AW2086682510038N07Rik Herc5 RIKEN cDNA 2510038N07 gene 72 20.4 AI639807 Hesx1Hesx1 homeo box gene expressed in ES cells 76 4.2 NM_010420 Hgf Hgfhepatocyte growth factor 74 2.7 D10212 Hgf Hgf hepatocyte growth factor49 3.0 AF042856 Hgf Hgf hepatocyte growth factor 37 2.8 BB476818 — Hif1aMus musculus transcribed sequences 10 3.9 BB409314 Hist1h2ae Hist1h2aehistone 1, H2ae 525 24.6 W91024 Hivep2 Hivep2 human immunodeficiencyvirus type I 138 2.0 AW321867 enhancer binding protein 2 Hk2 Hk2hexokinase 2 79 7.1 NM_013820 Hk3 Hk3 hexokinase 3 106 6.7 BB334625 —Hk3 — 97 14.9 BB324660 Hmgb2 Hmgb2 high mobility group box 2 544 7.3X67668 Hmgb2 Hmgb2 high mobility group box 2 337 9.1 C85885 Hn1 Hn1hematological and neurological 327 4.3 NM_008258 expressed sequence 1Hn1 Hn1 hematological and neurological 236 5.6 NM_008258 expressedsequence 1 — Hnrpa1 Mus musculus transcribed sequence with 705 3.1BI663320 strong similarity to protein ref: NP_002127.1 (H. sapiens)heterogeneous nuclear ribonucleoprotein A1, isoform a; nuclearribonucleoprotein particle A1 protein; helix-destabilizing protein;single-strand DNA-binding protein UP1; heterogeneous nuclearribonucleoprotein core protein A1; heterogeneous nuclearribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoproteinB2 protein [Homo sapiens] Hnrpa1 Hnrpa1; Hdp; heterogeneous nuclearribonucleoprotein 1077 2.1 AK007802 hnrnp-A1; A1 D15Ertd119e2610510D13Rik Hnrpa3 RIKEN cDNA 2610510D13 gene 2441 2.0 BC024454 HnrpdlHnrpdl heterogeneous nuclear ribonucleoprotein 787 2.3 NM_016690 D-likeHp Hp haptoglobin 53 9.9 NM_017370 Hpse Hpse heparanase 32 22.8 BG094050Hrasls3 Hrasls3 HRAS like suppressor 3 504 16.5 BC024581 Hrb Hrb HIV-1Rev binding protein 4 2.5 BG068396 4930534K13Rik Ibrdc3 RIKEN cDNA4930534K13 gene 280 7.3 AK015966 4930534K13Rik Ibrdc3 RIKEN cDNA4930534K13 gene 430 6.2 BG064140 Icam1 Icam1 intercellular adhesionmolecule 440 10.2 BC008626 Icos Icos inducible T-cell co-stimulator 689.8 AV313923 Icsbp1 Icsbp1 interferon consensus sequence binding 228 9.9BG069095 protein 1 Icsbp1 Icsbp1 interferon consensus sequence binding432 10.0 BG069095 protein 1 Ier5 Ier5 immediate early response 5 347 3.1BF147705 Ifi1 Ifi1 interferon inducible protein 1 1151 15.4 NM_008326Ifi202b Ifi202b interferon activated gene 202B 118 46.5 NM_011940Ifi202b Ifi202b interferon activated gene 202B 93 42.5 AV229143 Ifi203Ifi203 interferon activated gene 203 63 17.8 NM_008328 Ifi203 Ifi203interferon activated gene 203 177 9.1 BC008167 Ifi16 Ifi204 interferon,gamma-inducible protein 16 22 24.8 NM_008329 Ifi205 Ifi205 interferonactivated gene 205 12 140.4 M74124 Ifi205 Ifi205 interferon activatedgene 205 30 151.7 M74124 Ifi205 Ifi205 interferon activated gene 205 3879.7 AI481797 Ifi205 Ifi205 interferon activated gene 205 76 102.7AI481797 2310061N23Rik Ifi27 RIKEN cDNA 2310061N23 gene 219 8.2 AY090098Ifi30 Ifi30 interferon gamma inducible protein 30 3381 2.4 NM_0230652010008K16Rik Ifi35 RIKEN cDNA 2010008K16 gene 1277 6.0 AW9860542010008K16Rik Ifi35 RIKEN cDNA 2010008K16 gene 377 4.5 BC0081582010008K16Rik Ifi35 RIKEN cDNA 2010008K16 gene 371 2.5 AW986054A430056A10Rik Ifi44 RIKEN cDNA A430056A10 gene 439 5.0 BB3298089130009C22Rik Ifih1 RIKEN cDNA 9130009C22 gene 506 5.4 AY075132 Ifit1Ifit1 interferon-induced protein with 93 18.5 NM_008331tetratricopeptide repeats 1 Ifit2 Ifit2 interferon-induced protein with271 33.8 NM_008332 tetratricopeptide repeats 2 Ifit3 Ifit3interferon-induced protein with 761 6.3 NM_010501 tetratricopeptiderepeats 3 1110036C17Rik Ifitm1 RIKEN cDNA 1110036C17 gene 622 4.0BC027285 1110004C05Rik Ifitm3 RIKEN cDNA 1110004C05 gene 3701 4.2BC010291 A330075D07 Ifitm6 hypothetical protein A330075D07 34 10.6BB193024 Ifnar2 Ifnar2 interferon (alpha and beta) receptor 2 107 3.0Y09864 Ifnar2 Ifnar2 interferon (alpha and beta) receptor 2 155 2.7BB522265 Ifnar2 Ifnar2 interferon (alpha and beta) receptor 2 977 2.4AF013486 Ifng Ifng interferon gamma 32 30.3 K00083 Ifngr Ifngr1interferon gamma receptor 572 2.0 NM_010511 Ifrd1 Ifrd1interferon-related developmental 463 3.0 NM_013562 regulator 1 Igf1 Igf1insulin-like growth factor 1 606 2.0 BG075165 Igf1 Igf1 insulin-likegrowth factor 1 184 2.7 NM_010512 Igf1 Igf1 insulin-like growth factor 1236 2.2 AF440694 Igf1 Igf1 insulin-like growth factor 1 398 3.1 BG092677Igh-6 Igh-6 immunoglobulin heavy chain 6 (heavy 140 12.8 BB226392 chainof IgM) Igh-6 Igh-6 immunoglobulin heavy chain 6 (heavy 269 6.0 AI326478chain of IgM) Igsf6 Igsf6 immunoglobulin superfamily, member 6 8 25.4NM_030691 Igsf7 Igsf7 immunoglobulin superfamily, member 7 101 7.0AF251705 — Igtp Mus musculus 13 days embryo lung 35 14.3 BB485297 cDNA,RIKEN full-length enriched library, clone: D430030N05 product: unknownEST, full insert sequence Igtp Igtp interferon gamma induced GTPase 90525.9 NM_018738 AI481100 Igtp expressed sequence AI481100 365 30.9NM_019440 Ii Ii Ia-associated invariant chain 3790 6.2 BC003476 AW111922Iigp1 expressed sequence AW111922 885 36.6 BM239828 AW111922 Iigp1expressed sequence AW111922 361 53.7 BM239828 Il11 Il11 interleukin 1143 4.4 NM_008350 Il12b Il12b interleukin 12b 29 4.2 AF128214 Il12rb1Il12rb1 interleukin 12 receptor, beta 1 35 5.5 NM_008353 Il18 Il18interleukin 18 330 2.1 NM_008360 Il18bp Il18bp interleukin 18 bindingprotein 122 33.6 AF110803 Il18rap Il18rap interleukin 18 receptoraccessory protein 12 8.4 NM_010553 Il1b Il1b interleukin 1 beta 118 4.7BC011437 Il1rn Il1rn interleukin 1 receptor antagonist 40 14.3 M57525Il1rn Il1rn interleukin 1 receptor antagonist 99 6.6 NM_031167 TccrIl27ra T cell cytokine receptor 28 8.2 NM_016671 Il2rb Il2rb interleukin2 receptor, beta chain 39 12.3 BE634648 Il4i1 Il4i1 interleukin 4induced 1 46 3.9 NM_010215 Il4ra Il4ra interleukin 4 receptor, alpha 2032.8 NM_010557 Il6 Il6 interleukin 6 15 20.8 NM_031168 Il7r Il7rinterleukin 7 receptor 72 4.6 AI573431 Incenp Incenp inner centromereprotein 80 4.4 BI410774 Incenp Incenp inner centromere protein 192 9.0BB418702 Indo Indo indoleamine-pyrrole 2,3 dioxygenase 15 6.7 NM_008324Inhbb Inhbb inhibin beta-B 98 4.2 BB253137 Inpp5d Inpp5d inositolpolyphosphate-5-phosphatase D 170 4.7 U39203 Irak3 Irak3 interleukin-1receptor-associated kinase 3 43 2.8 AV228493 Irak4 Irak4 interleukin-1receptor-associated kinase 4 63 3.2 BM220651 B430217B02Rik Irf1 RIKENcDNA B430217B02 gene 665 15.7 NM_008390 — Irf2 — 53 4.9 AI606908 Irf5Irf5 interferon regulatory factor 5 205 2.7 NM_012057 Irf7 Irf7interferon regulatory factor 7 198 9.8 NM_016850 Irg1 Irg1immunoresponsive gene 1 9 80.3 L38281 Isg20 Isg20 interferon-stimulatedprotein 119 4.7 BC022751 Isgf3g Isgf3g interferon dependent positiveacting 327 3.6 NM_008394 transcription factor 3 gamma Itga4 Itga4integrin alpha 4 45 4.4 BB284583 Itga4 Itga4 integrin alpha 4 19 8.5NM_010576 — Itga4 Mus musculus adult retina cDNA, RIKEN 138 7.9 BB205589full-length enriched library, clone: A930029I05 product: unknown EST,full insert sequence Itgal Itgal integrin alpha L 118 9.3 BI554446 ItgamItgam integrin alpha M 16 12.4 NM_008401 Itgax Itgax integrin alpha X 8011.9 NM_021334 Itgb2 Itgb2 integrin beta 2 178 28.7 NM_008404 Jak2 Jak2Janus kinase 2 882 2.4 NM_008413 Jak2 Jak2 Janus kinase 2 353 3.1NM_008413 Smcx Jarid1c selected mouse cDNA on the X 35 2.1 BB165753 JunJun Jun oncogene 559 2.7 NM_010591 Kcnab2 Kcnab2 potassium voltage-gatedchannel, 35 9.0 U31908 shaker-related subfamily, beta member 2D7Ertd764e Kcnk6 DNA segment, Chr 7, ERATO Doi 764, 139 3.5 BG069589expressed Kcnn4 Kcnn4 potassium intermediate/small 45 28.2 BG865910conductance calcium-activated channel, subfamily N, member 4 — Kcnq5 Musmusculus transcribed sequences 17 2.9 BB162318 Khdrbs1 Khdrbs1 KH domaincontaining, RNA binding, 290 7.1 BB752997 signal transduction associated1 Kif11 Kif11 kinesin family member 11 41 6.6 BB827235 — Kif11 Musmusculus transcribed sequences 68 5.0 BM234447 Kif11 Kif11 kinesinfamily member 11 89 4.5 BB827235 Kif18a Kif18a kinesin family member 18A63 2.8 BC016095 Kif20a Kif20a kinesin family member 20A 65 4.3 NM_009004Kif21b Kif21b kinesin family member 21B 113 3.2 AV122249 Kif22 Kif22kinesin family member 22 248 8.4 BB251322 Kif2c Kif2c kinesin familymember 2C 43 8.7 BB104669 Kif2c Kif2c kinesin family member 2C 74 4.4NM_134471 Kif4 Kif4 kinesin family member 4 71 3.2 NM_008446 Klf5 Klf5Kruppel-like factor 5 164 2.4 BG069607 KLHL6 Klhl6 kelch-like 6 297 3.1BM247104 Klra2 Klra2 killer cell lectin-like receptor, subfamily A, 3014.3 NM_008462 member 2 Klra7 Klra7 killer cell lectin-like receptor,subfamily A, 7 7.9 U10095 member 7 Klra8 Klra8 killer cell lectin-likereceptor, subfamily A, 17 5.5 U12889 member 8 Klra3 Klra9 killer celllectin-like receptor, subfamily A, 68 6.5 U49865 member 3 Klrb1d Klrb1dkiller cell lectin-like receptor subfamily B 11 4.2 AF342896 member 1DKlrb1d Klrb1d killer cell lectin-like receptor subfamily B 25 4.6AF342896 member 1D Klrb1d Klrb1d killer cell lectin-like receptorsubfamily B 20 9.8 NM_008526 member 1D Klrb1d Klrb1d killer celllectin-like receptor subfamily B 17 10.2 AV294178 member 1D Klrc1 Klrc1killer cell lectin-like receptor subfamily C, 6 19.3 AF106009 member 1Klre1 Klre1 killer cell lectin-like receptor family E 33 3.2 BG230222member 1 Klrk1 Klrk1 killer cell lectin-like receptor subfamily K, 6621.5 AF039026 member 1 Kntc1 Kntc1 kinetochore associated 1 71 4.4AW536884 Kpna2 Kpna2 karyopherin (importin) alpha 2 1340 2.6 NM_010655Kpna3 Kpna3 karyopherin (importin) alpha 3 449 2.0 BM213828 Kpnb1 Kpnb1karyopherin (importin) beta 1 1298 3.3 BC004096 9030623C06Rik Krt20RIKEN cDNA 9030623C06 gene 37 4.4 AF473907 Laf4 Laf4 lymphoid nuclearprotein related to AF4 37 4.3 BQ177036 D7Bwg0421e Lair1 DNA segment, Chr7, Brigham & 64 11.9 AK017222 Women's Genetics 0421 expressed Laptm5Laptm5 lysosomal-associated protein 31 4.5 BB264849 transmembrane 5Laptm5 Laptm5 lysosomal-associated protein 173 30.9 BB218107transmembrane 5 — Lass6 Mus musculus adult male small intestine 57 2.3BG072448 cDNA, RIKEN full-length enriched library, clone: 2010109K09product: unclassifiable, full insert sequence Lbp Lbp lipopolysaccharidebinding protein 175 3.3 NM_008489 Lck Lck lymphocyte protein tyrosinekinase 6 3.5 AA867167 Lck Lck lymphocyte protein tyrosine kinase 23 2.2BB200032 Lck Lck lymphocyte protein tyrosine kinase 93 9.2 AA867167 LckLck lymphocyte protein tyrosine kinase 128 19.5 BC011474 Lcn2 Lcn2lipocalin 2 176 29.2 X14607 Lcp1 Lcp1 lymphocyte cytosolic protein 1 23120.8 NM_008879 Lcp1 Lcp1 lymphocyte cytosolic protein 1 515 15.0NM_008879 Lcp2 Lcp2 lymphocyte cytosolic protein 2 48 31.8 BC006948 LfngLfng lunatic fringe gene homolog (Drosophila) 146 3.0 NM_008494 Lgals1Lgals1 lectin, galactose binding, soluble 1 5227 2.9 AI642438 Lgals1Lgals1 lectin, galactose binding, soluble 1 3962 2.8 NM_008495 — Lgals3Mus musculus transcribed sequences 44 2.8 AI426376 Lgals3 Lgals3 lectin,galactose binding, soluble 3 2066 3.2 X16834 Ppicap Lgals3bppeptidylprolyl isomerase C-associated 1079 4.7 NM_011150 protein Lig1Lig1 ligase I, DNA, ATP-dependent 193 3.6 NM_010715 Gp49b Lilrb4glycoprotein 49 B 133 22.1 U05264 Litaf Litaf LPS-induced TN factor 8143.7 AV360881 Litaf Litaf LPS-induced TN factor 1740 4.3 AV360881LOC207685 LOC207685 hypothetical protein LOC207685 66 5.0 AK008551LOC207685 LOC207685 hypothetical protein LOC207685 109 2.7 AK008551LOC209387 LOC209387 tripartite motif protein 30-like 81 9.7 BG068242LOC209387 LOC209387 tripartite motif protein 30-like 15 20.2 BM241342LOC223672 LOC223672 hypothetical protein LOC223672 18 25.0 BC0204895830475I06Rik Loh11cr2a RIKEN cDNA 5830475I06 gene 588 4.9 BC004727 LoxLox lysyl oxidase 87 7.5 M65143 Lox Lox lysyl oxidase 154 7.4 M65143Loxl3 Loxl3 lysyl oxidase-like 3 121 3.5 NM_013586 4832412D13Rik Lrch1RIKEN cDNA 4832412D13 gene 241 2.2 BB755336 — Lrch1 Mus musculustranscribed sequences 22 5.8 AW909485 1300008B03Rik Lrg1 RIKEN cDNA1300008B03 gene 81 3.7 NM_029796 Lrmp Lrmp lymphoid-restricted membraneprotein 72 6.9 NM_008511 Lrp1 Lrp1 low density lipoproteinreceptor-related 38 2.1 AV345706 protein 1 Lrrfip1 Lrrfip1 leucine richrepeat (in FLII) interacting 837 3.0 BG069059 protein 1 AW319595 Lrrk1expressed sequence AW319595 233 2.3 BC027199 Lsm5 Lsm5 LSM5 homolog, U6small nuclear RNA 457 2.3 NM_025520 associated (S. cerevisiae) Lsp1 Lsp1lymphocyte specific 1 199 8.8 NM_019391 Lst1 Lst1 leukocyte specifictranscript 1 98 18.7 U72644 Lta Lta lymphotoxin A 7 5.8 NM_010735 Ltbp2Ltbp2 latent transforming growth factor beta 35 14.9 NM_013589 bindingprotein 2 Ly6c Ly6c lymphocyte antigen 6 complex, locus C 3983 2.8NM_010741 Ly6e Ly6e lymphocyte antigen 6 complex, locus E 1793 6.8BM245572 Ly6f Ly6f lymphocyte antigen 6 complex, locus F 24 4.3NM_008530 Ly6i Ly6i lymphocyte antigen 6 complex, locus I 189 15.4AF232024 Ly78 Ly78 lymphocyte antigen 78 77 3.2 NM_008533 Ly86 Ly86lymphocyte antigen 86 165 24.1 NM_010745 Lyn Lyn Yamaguchi sarcoma viral(v-yes-1) 275 3.6 M64608 oncogene homolog Lyn Lyn Yamaguchi sarcomaviral (v-yes-1) 585 2.9 M57697 oncogene homolog Lyst Lyst lysosomaltrafficking regulator 347 2.0 BB463428 Lyzs Lyzs lysozyme 483 27.0AW208566 Lyzs Lyzs lysozyme 327 56.6 AV058500 — Lztfl1 Mus musculustranscribed sequence with 1043 2.1 BF320908 strong similarity to proteinref: NP_002127.1 (H. sapiens) heterogeneous nuclear ribonucleoproteinA1, isoform a; nuclear ribonucleoprotein particle A1 protein;helix-destabilizing protein; single-strand DNA-binding protein UP1;heterogeneous nuclear ribonucleoprotein core protein A1; heterogeneousnuclear ribonucleoprotein A1B protein; heterogeneous nuclearribonucleoprotein B2 protein [Homo sapiens] Mad Mad Max dimerizationprotein 110 2.8 AV228517 Mad Mad Max dimerization protein 204 2.1AV228517 Mad2l1 Mad2l1 MAD2 (mitotic arrest deficient, homolog)- 349 3.8NM_019499 like 1 (yeast) Mafb Mafb v-maf musculoaponeurotic fibrosarcoma24 2.5 AW412521 oncogene family, protein B (avian) Maff Maff v-mafmusculoaponeurotic fibrosarcoma 91 2.7 BC022952 oncogene family, proteinF (avian) Map3k1 Map3k1 mitogen activated protein kinase kinase 319 2.4L13103 kinase 1 Map4k1 Map4k1 mitogen activated protein kinase kinase 1713.9 BB546619 kinase kinase 1 Marcks Marcks myristoylated alanine richprotein kinase 1601 2.1 AW546141 C substrate Marcks Marcks myristoylatedalanine rich protein kinase 847 2.4 AW546141 C substrate Marcks Marcksmyristoylated alanine rich protein kinase 1166 2.5 BB100920 C substrateMbc2 Mbc2 membrane bound C2 domain containing 279 4.2 BC011482 protein —Mbnl1 Mus musculus transcribed sequences 96 3.8 BM201095 — Mbnl3 Musmusculus 0 day neonate lung cDNA, 104 4.0 AV306759 RIKEN full-lengthenriched library, clone: E030002K20 product: similar to MUSCLEBLIND-LIKEPROTEIN FLJ11316/DKFZP434G2222/DJ842K24.1 [Homo sapiens], full insertsequence Mbtps2 Mbtps2 RIKEmembrane-bound transcription 46 4.0 AV272026factor protease, site 2 Mcl1 Mcl1 myeloid cell leukemia sequence 1 31112.4 BB374534 Mcl1 Mcl1 myeloid cell leukemia sequence 1 1844 2.4BC003839 Mcm2 Mcm2 minichromosome maintenance deficient 2 257 3.3NM_008564 mitotin (S. cerevisiae) Mcm3 Mcm3 minichromosome maintenancedeficient 3 115 5.2 C80350 (S. cerevisiae) Mcm3 Mcm3 minichromosomemaintenance deficient 3 23 15.8 BI658327 (S. cerevisiae) Mcm3 Mcm3minichromosome maintenance deficient 3 199 5.7 C80350 (S. cerevisiae)Mcm3 Mcm3 minichromosome maintenance deficient 3 39 3.2 C80350 (S.cerevisiae) Mcm3 Mcm3 minichromosome maintenance deficient 3 60 9.2BI658327 (S. cerevisiae) Mcm4 Mcm4 minichromosome maintenance deficient4 211 4.5 BB447978 homolog (S. cerevisiae) Mcm4 Mcm4 minichromosomemaintenance deficient 4 356 4.1 BC013094 homolog (S. cerevisiae) Mcm5Mcm5 minichromosome maintenance deficient 260 9.4 AI324988 5, celldivision cycle 46 (S. cerevisiae) Mcm5 Mcm5 minichromosome maintenancedeficient 160 6.2 NM_008566 5, cell division cycle 46 (S. cerevisiae)Mcm6 Mcm6 minichromosome maintenance deficient 6 304 3.7 BB099487 (MIS5homolog, S. pombe) (S. cerevisiae) — Mcm7 Mus musculus adult male thymuscDNA, 766 2.0 NM_008568 RIKEN full-length enriched library, clone:5830410A10 product: minichromosome maintenance deficient 7 (S.cerevisiae), full insert sequence — Mcm7 Mus musculus adult male thymuscDNA, 267 2.7 BB407228 RIKEN full-length enriched library, clone:5830410A10 product: minichromosome maintenance deficient 7 (S.cerevisiae), full insert sequence — Mcm7 Mus musculus adult male thymuscDNA, 1385 2.3 BB464359 RIKEN full-length enriched library, clone:5830410A10 product: minichromosome maintenance deficient 7 (S.cerevisiae), full insert sequence Kdt1 Mdfid kidney cell line derivedtranscript 1 889 2.2 U13371 Me2 Me2 malic enzyme 2, NAD(+)-dependent, 513.4 BM235734 mitochondrial Me2 Me2 malic enzyme 2, NAD(+)-dependent, 1294.1 BM235734 mitochondrial Mefv Mefv Mediterranean fever 140 3.7NM_019453 — Metap2 Mus musculus transcribed sequences 44 2.1 BM730703Mfap5 Mfap5 microfibrillar associated protein 5 43 3.7 NM_015776 Mfap5Mfap5 microfibrillar associated protein 5 67 7.2 NM_015776 — MGC58382Mus musculus cDNA clone MGC: 58382 58 14.2 BG961961 IMAGE: 6774154,complete cds 1200016D23Rik MGC65590 RIKEN cDNA 1200016D23 gene 5 2.8BB093351 Mgl1 Mgl1 macrophage galactose N-acetyl- 35 4.5 NM_010796galactosamine specific lectin 1 Mglap Mglap matrixgamma-carboxyglutamate (gla) 4867 2.3 NM_008597 protein Mki67 Mki67antigen identified by monoclonal antibody 129 11.7 X82786 Ki 67 — Mllt3Mus musculus transcribed sequences 24 3.0 AV381294 Mllt3 Mllt3myeloid/lymphoid or mixed lineage- 114 2.2 AK019458 leukemiatranslocation to 3 homolog (Drosophila) Mlp Mlp MARCKS-like protein 922.2 BB491008 Mlp Mlp MARCKS-like protein 538 3.2 AV110584 Mmp14 Mmp14matrix metalloproteinase 14 (membrane- 97 5.1 NM_008608 inserted) Mmp14Mmp14 matrix metalloproteinase 14 (membrane- 216 5.1 NM_008608 inserted)Mmp19 Mmp19 matrix metalloproteinase 19 7 4.4 AF153199 Mmp7 Mmp7 matrixmetalloproteinase 7 50 6.4 NM_010810 D930043C02Rik Mnab RIKEN cDNAD930043C02 gene 23 2.3 BM210927 D930043C02Rik Mnab RIKEN cDNA D930043C02gene 28 2.3 AA709668 Mns1 Mns1 meiosis-specific nuclear structuralprotein 1 27 3.7 NM_008613 4022402H07Rik Mobk1b RIKEN cDNA 4022402H07gene 1399 2.2 BC011285 — Mpa2l Mus musculus transcribed sequence with191 118.4 BM241485 weak similarity to protein sp: P32456 (H. sapiens)GBP2_HUMAN Interferon- induced guanylate-binding protein 2 (Guaninenucleotide-binding protein 2) — Mpa2l Mus musculus transcribed sequences339 72.1 BG092512 Mpeg1 Mpeg1 macrophage expressed gene 1 402 22.7L20315 Mre11a Mre11a meiotic recombination 11 homolog A (S. cerevisiae)190 2.3 NM_018736 Ms4a1 Ms4a1 membrane-spanning 4-domains, 28 4.0BB236617 subfamily A, member 1 Ms4a1 Ms4a1 membrane-spanning 4-domains,17 3.7 BB236617 subfamily A, member 1 Ms4a4b Ms4a4b membrane-spanning4-domains, 88 56.0 BB199001 subfamily A, member 4B Ms4a4d Ms4a4dmembrane-spanning 4-domains, 96 12.6 NM_025658 subfamily A, member 4D —Ms4a6b Mus musculus adult male aorta and vein 92 3.1 BB221406 cDNA,RIKEN full-length enriched library, clone: A530066O14 product: unknownEST, full insert sequence — Ms4a6b Mus musculus adult male aorta andvein 37 4.2 BB218965 cDNA, RIKEN full-length enriched library, clone:A530066O14 product: unknown EST, full insert sequence Ms4a6b Ms4a6bmembrane-spanning 4-domains, 126 45.7 NM_027209 subfamily A, member 6BMs4a6c Ms4a6c membrane-spanning 4-domains, 132 14.8 AF237910 subfamilyA, member 6C Ms4a11 Ms4a6d membrane-spanning 4-domains, 50 38.3NM_026835 subfamily A, member 11 Ms4a11 Ms4a6d membrane-spanning4-domains, 57 39.2 NM_026835 subfamily A, member 11 A430103C15Rik Ms4a7RIKEN cDNA A430103C15 gene 105 5.4 BC024402 Msn Msn moesin 1945 2.3NM_010833 Msn Msn moesin 4591 2.1 NM_010833 Msr1 Msr1 macrophagescavenger receptor 1 25 12.3 L04274 Msr1 Msr1 macrophage scavengerreceptor 1 44 9.9 AA183642 Msr1 Msr1 macrophage scavenger receptor 1 589.8 BC003814 Mt2 Mt2 metallothionein 2 3122 2.9 AA796766 Mthfd2 Mthfd2methylenetetrahydrofolate 134 3.6 BG076333 dehydrogenase (NAD+dependent), methenyltetrahydrofolate cyclohydrolase Mthfd2 Mthfd2methylenetetrahydrofolate 111 6.4 BG076333 dehydrogenase (NAD+dependent), methenyltetrahydrofolate cyclohydrolase Mvp Mvp major vaultprotein 281 3.9 NM_080638 — Mvp — 396 4.1 BB139464 Mx1 Mx1 myxovirus(influenza virus) resistance 1 54 6.9 M21039 Myadm Myadmmyeloid-associated differentiation marker 716 2.1 BI078799 Myb Mybmyeloblastosis oncogene 10 26.7 NM_033597 Myb Myb myeloblastosisoncogene 29 7.7 NM_033597 Myb Myb myeloblastosis oncogene 5 7.0 BC011513Myc Myc myelocytomatosis oncogene 198 3.5 BC006728 Myd88 Myd88 myeloiddifferentiation primary response 590 3.9 BC005591 gene 88 — Myh9 — 2112.5 C80049 Myo1f Myo1f myosin IF 57 10.4 AK021181 Myo1f Myo1f myosin IF16 30.8 AK021181 Myo1g Myo1g myosin IG 76 15.2 BB235320 Myo9b Myo9bmyosin IXb 239 2.5 NM_015742 Nasp Nasp nuclear autoantigenic spermprotein 470 2.3 BB493242 (histone-binding) Ncf1 Ncf1 neutrophilcytosolic factor 1 155 8.1 AI844633 Ncf2 Ncf2 neutrophil cytosolicfactor 2 121 5.7 NM_010877 Ncor1 Ncor1 nuclear receptor co-repressor 124 2.5 AI481996 — Nefh Mus musculus mRNA for mKIAA0845 18 10.0 M35131protein BC034753 Neil3 cDNA sequence BC034753 29 2.1 AV316939 Nek2 Nek2NIMA (never in mitosis gene a)-related 112 4.2 C77054 expressed kinase 2Nek6 Nek6 NIMA (never in mitosis gene a)-related 237 2.3 BC019524expressed kinase 6 — Net1 Mus musculus transcribed sequences 40 4.1AV247312 Nfatc1 Nfatc1 nuclear factor of activated T-cells, 71 4.5AF239169 cytoplasmic 1 Nfatc1 Nfatc1 nuclear factor of activatedT-cells, 187 3.6 NM_016791 cytoplasmic 1 Nfatc1 Nfatc1 nuclear factor ofactivated T-cells, 204 2.6 BB356861 cytoplasmic 1 Nfatc2 Nfatc2 nuclearfactor of activated T-cells, 112 3.7 BM122872 cytoplasmic 2 Nfkb1 Nfkb1nuclear factor of kappa light chain gene 654 2.6 L28118 enhancer inB-cells 1, p105 Nfkb2 Nfkb2 nuclear factor of kappa light polypeptide141 3.9 AF155372 gene enhancer in B-cells 2, p49/p100 Nfkbia Nfkbianuclear factor of kappa light chain gene 4502 3.1 AI462015 enhancer inB-cells inhibitor, alpha Nfkbia Nfkbia nuclear factor of kappa lightchain gene 666 3.2 AI462015 enhancer in B-cells inhibitor, alpha NfkbieNfkbie nuclear factor of kappa light polypeptide 122 4.5 AK011965 geneenhancer in B-cells inhibitor, epsilon — Nfkbie — 194 9.7 BB820441AA408868 Nfkbiz expreexpressed sequence AA408868 82 10.1 BM240058AA408868 Nfkbiz expreexpressed sequence AA408868 117 5.3 AB026551AA408868 Nfkbiz expreexpressed sequence AA408868 169 10.8 AB026551 NgfrNgfr nerve growth factor receptor (TNFR 32 8.3 BB151515 superfamily,member 16) Niban Niban niban protein 87 3.4 NM_022018 Nical Nical NEDD9interacting protein with calponin 22 6.0 BB209438 homology and LIMdomains Nin Nin ninein 190 2.3 AK014241 Nkg7 Nkg7 natural killer cellgroup 7 sequence 55 36.5 NM_024253 Nktr Nktr natural killer tumorrecognition sequence 133 2.2 AW987751 Nmi Nmi N-myc (and STAT)interactor 687 6.7 BC002019 Nnmt Nnmt nicotinamide N-methyltransferase53 6.6 AK006371 Nol5a Nol5a nucleolar protein 5A 326 2.4 BF660256 Nol5aNol5a nucleolar protein 5A 436 2.2 BM249243 Npc2 Npc2 Niemann Pick typeC2 100 3.9 BG071996 — Nr4a3 Mus musculus transcribed sequences 20 7.2BE692107 Nr6a1 Nr6a1 nuclear receptor subfamily 6, group A, 46 2.0U09563 member 1 Nras Nras; N-ras neuroblastoma ras oncogene 462 2.4AK010412 Nrf1 Nrf1 nuclear respiratory factor 1 97 2.1 BM2213782310014H01Rik Nrm RIKEN cDNA 2310014H01 gene 58 3.1 NM_134122 Nrn1 Nrn1neuritin 1 81 2.8 AK003046 — Nrp1 Mus musculus transcribed sequences 1932.0 AV291009 — Nt5c2 Mus musculus transcribed sequences 41 2.8 AU017183AW541137 Nup107 expressed sequence AW541137 242 2.1 BC004655 Nup153Nup153 nucleoporin 153 150 2.3 C88147 Nup210 Nup210 nucleoporin 210 3563.1 NM_018815 Nupr1 Nupr1 nuclear protein 1 743 2.1 NM_019738 Oact1Oact1 O-acyltransferase (membrane bound) 84 3.8 AV366860 domaincontaining 1 Oas1g Oas1a 2′-5′ oligoadenylate synthetase 1G 345 6.9BC018470 Oasl1 Oasl1 2′-5′ oligoadenylate synthetase-like 1 174 4.0AB067533 Oasl2 Oasl2 2′-5′ oligoadenylate synthetase-like 2 209 17.4BQ033138 Olfr56 Olfr56 olfactory receptor 56 336 39.5 NM_008330 Olr1Olr1 oxidized low density lipoprotein (lectin- 8 7.9 NM_138648 like)receptor 1 A130090K04Rik Oprm1 RIKEN cDNA A130090K04 gene 347 3.1BQ176089 Osmr Osmr oncostatin M receptor 96 5.0 AB015978 Osmr Osmroncostatin M receptor 286 4.7 AB015978 — P2rx7 Mus musculus transcribedsequences 46 2.7 AI552982 P2ry10 P2ry10 purinergic receptor P2Y,G-protein 19 18.0 AK020001 coupled 10 P2ry12 P2ry12 purinergic receptorP2Y, G-protein 32 3.2 AK013804 coupled 12 Gpr86 P2ry13 G protein-coupledreceptor 86 68 4.5 AK008013 Gpr105 P2ry14 G protein-coupled receptor 105220 2.2 AF177211 P2ry6 P2ry6 pyrimidinergic receptor P2Y, G-protein 1105.1 BC027331 coupled, 6 — Pabpc1 Mus musculus 0 day neonate thymus 632.0 AW552076 cDNA, RIKEN full-length enriched library, clone: A430039M01product: unknown EST, full insert sequence Padi2 Padi2 peptidyl argininedeiminase, type II 110 2.1 NM_008812 Panx1 Panx1 pannexin 1 88 3.2NM_019482 5330431N24Rik Parp11 RIKEN cDNA 5330431N24 gene 264 3.1BB026163 BC021340 Parp14 cDNA sequence BC021340 256 16.1 BC021340Adprtl3 Parp3 ADP-ribosyltransferase (NAD+; poly 527 2.1 AW990611(ADP-ribose polymerase)-like 3 Adprtl3 Parp3 ADP-ribosyltransferase(NAD+; poly 1373 2.6 BC014870 (ADP-ribose polymerase)-like 3 — Parp8 Musmusculus 13 days embryo forelimb 123 2.3 C85455 cDNA, RIKEN full-lengthenriched library, clone: 5930433N17 product: unknown EST, full insertsequence BC003281 Parp9 cDNA sequence BC003281 460 12.0 NM_0302531110035O14Rik Pbef1 RIKEN cDNA 1110035O14 gene 2754 2.4 AW989410D14Ertd732e Pbk DNA segment, Chr 14, ERATO Doi 732, 200 3.2 NM_023209expressed Pcna Pcna proliferating cell nuclear antigen 3700 2.3 BC010343Arpc1b Pdap1 actin related protein 2/3 complex, subunit 690 6.1 BE9799851B Pdcd1lg1 Pdcd1lg1 programmed cell death 1 ligand 1 73 45.1 NM_021893Pdcd1lg2 Pdcd1lg2 programmed cell death 1 ligand 2 57 5.6 NM_021396Pde4b Pde4b phosphodiesterase 4B, cAMP specific 76 2.9 BG793493 Pdk4Pdk4 pyruvate dehydrogenase kinase, 283 3.1 NM_013743 isoenzyme 4 Pdlim1Pdlim1 PDZ and LIM domain 1 (elfin) 272 2.6 NM_016861 Ril Pdlim4reversion induced LIM gene 63 3.6 NM_019417 Peli1 Peli1 pellino 1 4762.8 BC016515 Per1 Per1 period homolog 1 (Drosophila) 62 3.9 AF022992 PfcPfc properdin factor, complement 24 16.5 BB800282 Pfkfb3 Pfkfb36-phosphofructo-2-kinase/fructose-2,6- 164 3.4 NM_133232 biphosphatase 3Pfkp Pfkp phosphofructokinase, platelet 1402 2.7 NM_019703 Phemx Phemxpan hematopoietic expression 41 3.8 AF175771 4933417L10Rik Phf11 RIKENcDNA 4933417L10 gene 301 4.8 AV280841 E130113K22Rik Phf20l1 RIKEN cDNAE130113K22 gene 114 2.1 AV349060 B2m Phf20l1 beta-2 microglobulin 134692.0 BF715219 4931428F02Rik Phf6 RIKEN cDNA 4931428F02 gene 187 2.5AA275278 4931428F02Rik Phf6 RIKEN cDNA 4931428F02 gene 151 2.4 BG073473Pigr Pigr polymeric immunoglobulin receptor 3030 4.4 AV027632 Pigr Pigrpolymeric immunoglobulin receptor 2667 3.0 NM_011082 Pik3ap1 Pik3ap1phosphoinositide-3-kinase adaptor 64 7.8 BI684288 protein 1 Pik3cdPik3cd phosphatidylinositol 3-kinase catalytic 111 4.7 BB700084 deltapolypeptide Pik3cg Pik3cg phosphoinositide-3-kinase, catalytic, 146 2.6BB205102 gamma polypeptide Pik3r1 Pik3r1 phosphatidylinositol 3-kinase,regulatory 564 2.8 M60651 subunit, polypeptide 1 (p85 alpha) — Pik3r5Mus musculus transcribed sequences 41 5.0 AV230647 Pilra Pilra pairedimmunoglobin-like type 2 receptor 108 4.3 BB775785 alpha Pim1 Pim1proviral integration site 1 546 4.2 BE631223 Pip5k2a Pip5k2aphosphatidylinositol-4-phosphate 5- 104 2.6 AK012196 kinase, type II,alpha Pip5k2a Pip5k2a phosphatidylinositol-4-phosphate 5- 420 3.0AK012196 kinase, type II, alpha Pira10 Pira6 paired-Ig-like receptor A1069 15.0 NM_011093 — Pira6 — 10 15.5 NM_011087 Pirb Pirb paired-Ig-likereceptor B 13 47.9 U96693 Pitpnm Pitpnm1 phosphatidylinositol membrane-461 2.1 BB206460 associated Pkib Pkib protein kinase inhibitor beta,cAMP 44 3.8 AV047342 dependent, testis specific Pla2g4a Pla2g4aphospholipase A2, group IVA (cytosolic, 270 4.4 NM_008869calcium-dependent) Pla2g7 Pla2g7 phospholipase A2, group VII (platelet-338 5.8 AK005158 activating factor acetylhydrolase, plasma) Plac8 Plac8placenta-specific 8 756 14.2 AF263458 — Plagl2 Mus musculus transcribedsequence with 33 2.6 BF584971 weak similarity to protein ref:NP_081764.1 (M. musculus) RIKEN cDNA 5730493B19 [Mus musculus] Plagl2Plagl2 pleiomorphic adenoma gene-like 2 49 3.4 NM_018807 Plcg2 Plcg2phospholipase C, gamma 2 521 2.1 AW546508 Plcl2 Plcl2 phospholipaseC-like 2 144 5.4 BM207017 Plekha2 Plekha2 pleckstrin homologydomain-containing, 346 2.3 NM_031257 family A (phosphoinositide bindingspecific) member 2 Plekha2 Plekha2 pleckstrin homologydomain-containing, 139 2.0 BE852755 family A (phosphoinositide bindingspecific) member 2 Plekha2 Plekha2 pleckstrin homologydomain-containing, 611 3.1 NM_031257 family A (phosphoinositide bindingspecific) member 2 2410005C22Rik Plekha4 RIKEN cDNA 2410005C22 gene 463.2 BC024961 Cnk Plk3 cytokine inducible kinase 117 2.2 BM947855 Stk18Plk4 serine/threonine kinase 18 128 2.7 BB706079 Stk18 Plk4serine/threonine kinase 18 116 4.9 AI385771 Plp2 Plp2 proteolipidprotein 2 1503 2.0 AK012816 Plxnc1 Plxnc1 plexin C1 30 3.2 BB476707Plxnc1 Plxnc1 plexin C1 126 2.9 BB476707 Plxnc1 Plxnc1 plexin C1 48 5.5BB476707 Pnp Pnp purine-nucleoside phosphorylase 4116 2.2 AK008143 Pola1Pola1 polymerase (DNA directed), alpha 1 155 2.6 NM_008892 Pold1 Pold1polymerase (DNA directed), delta 1, 164 2.1 BC009128 catalytic subunitPold3 Pold3 polymerase (DNA-directed), delta 3, 223 1.9 AK010805accessory subunit Pole2 Pole2 polymerase (DNA directed), epsilon 2 1813.2 AF036898 (p59 subunit) Polh Polh polymerase (DNA directed), eta (RAD30 150 3.5 BB066090 related) Pou2af1 Pou2af1 POU domain, class 2,associating factor 1 15 9.4 NM_011136 Ppfia4 Ppfia4; protein tyrosinephosphatase, receptor 24 4.5 AK003571 1110008G13Rik type, f polypeptide(PTPRF), interacting protein (liprin), alpha 4 2410005L11Rik Ppil5 RIKENcDNA 2410005L11 gene 9 3.0 BG067404 Ppp1r12a Ppp1r12a proteinphosphatase 1, regulatory 1000 2.3 AV309184 (inhibitor) subunit 12A —Ppp1r12a Mus musculus 7 days embryo whole 86 2.7 BB410003 body cDNA,RIKEN full-length enriched library, clone: C430016H01 product: unknownEST, full insert sequence Ppp1r12a Ppp1r12a protein phosphatase 1,regulatory 550 2.0 BI653999 (inhibitor) subunit 12A Ppp1r12a Ppp1r12aprotein phosphatase 1, regulatory 641 2.2 AV309184 (inhibitor) subunit12A — Ppt1 Mus musculus 12 days embryo spinal 60 3.0 BB461203 ganglioncDNA, RIKEN full-length enriched library, clone: D130070K05 product:unknown EST, full insert sequence Prdm1 Prdm1 PR domain containing 1,with ZNF 157 2.1 NM_007548 domain Prg Prg1 proteoglycan, secretorygranule 2020 4.9 NM_011157 Prim2 Prim2 DNA primase, p58 subunit 137 2.2NM_008922 Prkcb Prkcb1 protein kinase C, beta 27 5.8 BF660388 PrkchPrkch protein kinase C, eta 412 2.7 BM243756 Prkch Prkch protein kinaseC, eta 259 3.4 NM_008856 Prkcq Prkcq protein kinase C, theta 159 3.0AB062122 AI325941 Prkd2 expressed sequence AI325941 151 2.2 BB204677AI325941 Prkd2 expressed sequence AI325941 103 2.7 AW557946 Prkr Prkrprotein kinase, interferon-inducible 165 5.0 BE911144 double strandedRNA dependent Procr Procr protein C receptor, endothelial 163 4.7NM_011171 Pros1 Pros1 protein S (alpha) 445 2.0 Z25469 Prrx1 Prrx1paired related homeobox 1 24 2.0 BB051738 Pscd4 Pscd4 pleckstrinhomology, Sec7 and coiled/coil 22 18.8 AK010908 domains 4 Pscdbp Pscdbppleckstrin homology, Sec7 and coiled-coil 682 3.6 BC007144 domains,binding protein BC046518 Psd4 cDNA sequence BC046518 122 2.2 BM221809Psma6 Psma6 proteasome (prosome, macropain) 12 2.8 AA189256 subunit,alpha type 6 Psmb10 Psmb10 proteasome (prosome, macropain) 525 14.7NM_013640 subunit, beta type 10 — Psmb2 Mus musculus 10 days neonate 382.4 BM201103 cerebellum cDNA, RIKEN full-length enriched library, clone:B930059K21 product: unknown EST, full insert sequence Psmb8 Psmb8proteosome (prosome, macropain) 461 27.5 NM_010724 subunit, beta type 8(large multifunctional protease 7) Psmb8 Psmb8 proteosome (prosome,macropain) 17 24.0 AV068122 subunit, beta type 8 (large multifunctionalprotease 7) Tap1 Psmb9 transporter 1, ATP-binding cassette, sub- 12729.5 AW048052 family B (MDR/TAP) Psmb9 Psmb9 proteosome (prosome,macropain) 298 30.2 NM_013585 subunit, beta type 9 (largemultifunctional protease 2) Psme1 Psme1 proteasome (prosome, macropain)28 2901 3.1 NM_011189 subunit, alpha Psme2 Psme2 proteasome (prosome,macropain) 28 1669 5.3 NM_011190 subunit, beta Ptger2 Ptger2prostaglandin E receptor 2 (subtype EP2) 19 13.1 BC005440 Ptger4 Ptger4prostaglandin E receptor 4 (subtype EP4) 51 2.8 NM_008965 Ptger4 Ptger4prostaglandin E receptor 4 (subtype EP4) 259 5.0 BC011193 Ptgs2 Ptgs2prostaglandin-endoperoxide synthase 2 32 4.4 M94967 Ptgs2 Ptgs2prostaglandin-endoperoxide synthase 2 31 9.3 M94967 Ptk9l Ptk9l proteintyrosine kinase 9-like (A6-related 125 3.4 AK002699 protein) Ptk9l Ptk9lprotein tyrosine kinase 9-like (A6-related 328 3.8 BB397672 protein)Ptpn12 Ptpn12 protein tyrosine phosphatase, non- 1107 2.2 X63440receptor type 12 Ptpn18 Ptpn18 protein tyrosine phosphatase, non- 3382.9 NM_011206 receptor type 18 Ptprc Ptprc protein tyrosine phosphatase,receptor 516 18.2 NM_011210 type, C — Ptprc Mus musculus 16 days neonatethymus 28 10.1 BM239436 cDNA, RIKEN full-length enriched library, clone:A130082N01 product: unclassifiable, full insert sequence Ptprcap Ptprcapprotein tyrosine phosphatase, receptor 140 7.5 NM_016933 type, Cpolypeptide-associated protein Ptpre Ptpre protein tyrosine phosphatase,receptor 102 4.5 U35368 type, E Ptpre Ptpre protein tyrosinephosphatase, receptor 73 3.6 U35368 type, E Pttg1 Pttg1 pituitarytumor-transforming 1 408 2.3 AF069051 9130417A21Rik Pycard RIKEN cDNA9130417A21 gene 396 6.5 BG084230 Pycs Pycs pyrroline-5-carboxylatesynthetase 136 2.9 BF148128 (glutamate gamma-semialdehyde synthetase)Pycs Pycs pyrroline-5-carboxylate synthetase 99 6.6 BB251523 (glutamategamma-semialdehyde synthetase) 2010317E03Rik Pyp RIKEN cDNA 2010317E03gene 1519 2.9 NM_026438 Qpct Qpct glutaminyl-peptide cyclotransferase 273.8 BB150720 (glutaminyl cyclase) Rab19 Rab19 RAB19, member RAS oncogenefamily 108 2.8 BM241400 Rab32 Rab32 RAB32, member RAS oncogene family564 2.6 NM_026405 Rab37 Rab37 RAB37, member of RAS oncogene family 432.1 BB433704 D330025I23Rik Rab8b RIKEN cDNA D330025I23 gene 840 4.1BM214169 Rac2 Rac2 RAS-related C3 botulinum substrate 2 169 10.9NM_009008 Rad18 Rad18 RAD18 homolog (S. cerevisiae) 73 2.3 BC011120Rad18 Rad18 RAD18 homolog (S. cerevisiae) 18 4.2 BB530954 Rad23b Rad23bRAD23b homolog (S. cerevisiae) 21 2.4 BB482313 Rad54l Rad54l RAD54 like(S. cerevisiae) 17 8.1 AV310220 Ramp1 Ramp1 receptor (calcitonin)activity modifying 66 2.3 NM_016894 protein 1 Ranbp2 Ranbp2 RAN bindingprotein 2 61 2.6 BB208180 Rap2b Rap2b RAP2B, member of RAS oncogene 603.4 BB390705 family Rap2b Rap2b RAP2B, member of RAS oncogene 196 2.7BB645629 family Rap2c Rap2c RAP2C, member of RAS oncogene 464 2.0AK008416 family Rap2c Rap2c RAP2C, member of RAS oncogene 415 2.2AK008416 family Rasa3 Rasa3 RAS p21 protein activator 3 142 4.6NM_009025 Rasd1 Rasd1 RAS, dexamethasone-induced 1 136 4.7 BB217136Rasgrp1 Rasgrp1 RAS guanyl releasing protein 1 181 3.2 BE691356 Rassf4Rassf4 Ras association (RaIGDS/AF-6) domain 28 10.0 AV291679 family 4Rbl1 Rbl1 retinoblastoma-like 1 (p107) 314 5.8 U27177 Rbl1 Rbl1retinoblastoma-like 1 (p107) 59 3.2 U27178 Rbm3 Rbm3 RNA binding motifprotein 3 193 2.5 AK011224 Rbmxrt Rbmxrt RNA binding motif protein, X887 2.1 NM_009033 chromosome retrogene Rcn Rcn1 reticulocalbin 286 4.2NM_009037 Refbp2 Refbp2 RNA and export factor binding protein 2 611 2.1NM_019484 Rel Rel reticuloendotheliosis oncogene 24 3.8 NM_009044 RelbRelb avian reticuloendotheliosis viral (v-rel) 109 3.0 NM_009046oncogene related B Rfc3 Rfc3 replication factor C (activator 1) 3 1322.3 BC026795 Rfc3 Rfc3 replication factor C (activator 1) 3 128 2.9AK013095 Eif4a2 Rfc4 eukaryotic translation initiation factor 4A2 1052.9 BB251459 Rfc4 Rfc4 replication factor C (activator 1) 4 188 3.0BC003335 — Rfwd2 Mus musculus 9.5 days embryo 40 2.0 BB294853parthenogenote cDNA, RIKEN full-length enriched library, clone:B130031H03 product: unclassifiable, full insert sequence Rgs19 Rgs19regulator of G-protein signaling 19 73 6.2 BB233670 Rgs2 Rgs2 regulatorof G-protein signaling 2 425 2.0 AF215668 Rgs2 Rgs2 regulator ofG-protein signaling 2 303 2.6 BB034265 Rgs2 Rgs2 regulator of G-proteinsignaling 2 454 2.6 AF215668 Arhb Rhob ras homolog gene family, member B2877 2.9 BC018275 Arhg Rhog ras homolog gene family, member G 467 2.0NM_019566 Arhh Rhoh ras homolog gene family, member H 67 5.0 BM243660 —Rims2 Mus musculus transcribed sequences 285 2.1 C79043 Ripk2 Ripk2receptor (TNFRSF)-interacting serine- 225 2.0 NM_138952 threonine kinase2 Ris2 Ris2 retroviral integration site 2 631 2.6 AF477481 Ris2 Ris2retroviral integration site 2 228 2.0 AF477481 9530043P15Rik Rnase6RIKEN cDNA 9530043P15 gene 66 6.5 AW825994 Rnaset2 Rnaset2; ribonucleaseT2 154 2.2 AK015947 RNASE6PL; 0610007O07Rik; 4833423A10Rik;4930532K22Rik Trpc2 Rnf121 transient receptor potential cation 35 2.5AW324327 channel, subfamily C, member 2 Rnpc2 Rnpc2 RNA-binding region(RNP1, RRM) 162 2.2 BB203348 containing 2 Rnpc2 Rnpc2 RNA-binding region(RNP1, RRM) 305 2.5 C79248 containing 2 Rnpc2 Rnpc2 RNA-binding region(RNP1, RRM) 233 2.3 C79248 containing 2 — Rnu22 Mus musculus 9 daysembryo whole 352 2.3 BQ177137 body cDNA, RIKEN full-length enrichedlibrary, clone: D030060F23 product: Mus musculus U22 snoRNA host gene(UHG) gene, complete sequence, full insert sequence — Rnu22 Mus musculus9 days embryo whole 155 7.0 BB493265 body cDNA, RIKEN full-lengthenriched library, clone: D030060F23 product: Mus musculus U22 snoRNAhost gene (UHG) gene, complete sequence, full insert sequence Rp2h Rp2hretinitis pigmentosa 2 homolog (human) 185 2.3 BB431808 Rp2h Rp2hretinitis pigmentosa 2 homolog (human) 672 2.4 BB431808 Rpa2 Rpa2replication protein A2 238 2.5 BC004578 Rpa2 Rpa2; Rf-A2 replicationprotein A2 208 2.2 AK011530 Rpgrip1 Rpgrip1 retinitis pigmentosa GTPaseregulator 45 35.9 NM_023879 interacting protein 1 Rpl12 Rpl12 ribosomalprotein L12 82 3.2 BG807990 Rps25 Rps25 ribosomal protein S25 250 2.1BM729504 3010033P07Rik Rps9 RIKEN cDNA 3010033P07 gene 188 16.9 AA762498Rrad Rrad Ras-related associated with diabetes 33 6.6 NM_019662 Rrm1Rrm1 ribonucleotide reductase M1 383 3.3 BB758819 Rrm1 Rrm1ribonucleotide reductase M1 380 3.3 BB758819 2510004L01Rik Rsad2 RIKENcDNA 2510004L01 gene 1215 2.5 BB132493 — Rtn4 Mus musculus 16 daysembryo head 158 3.4 BB648600 cDNA, RIKEN full-length enriched library,clone: C130026I10 product: unknown EST, full insert sequence — Rtn4 Musmusculus 16 days embryo head 109 2.9 BG072267 cDNA, RIKEN full-lengthenriched library, clone: C130026I10 product: unknown EST, full insertsequence Runx3 Runx3 runt related transcription factor 3 19 9.3 AV233043S100a10 S100a10 S100 calcium binding protein A10 103 1.9 BB450829(calpactin) S100a4 S100a4 S100 calcium binding protein A4 120 13.7D00208 S100a6 S100a6 S100 calcium binding protein A6 1217 2.8 NM_011313(calcyclin) S100a8 S100a8 S100 calcium binding protein A8 24 9.4NM_013650 (calgranulin A) S100a9 S100a9 S100 calcium binding protein A929 8.9 NM_009114 (calgranulin B) Saa1 Saa1 serum amyloid A 1 18 20.0NM_009117 Saa2 Saa2 serum amyloid A 2 33 3.0 NM_011314 Saa2 Saa2 serumamyloid A 2 62 7.0 NM_011314 Saa3 Saa3 serum amyloid A 3 110 8.6NM_011315 Samhd1 Samhd1 SAM domain and HD domain, 1 418 11.3 NM_018851Samhd1 Samhd1 SAM domain and HD domain, 1 185 11.4 BF148012 Samhd1Samhd1 SAM domain and HD domain, 1 8 16.3 AV376100 Samsn1 Samsn1 SAMdomain, SH3 domain and nuclear 49 9.1 NM_023380 localisation signals, 1B130024B19Rik Sart2 RIKEN cDNA B130024B19 gene 62 5.7 BM207218 Satb1Satb1 special AT-rich sequence binding protein 1 52 5.0 AV172776 Satb1Satb1 special AT-rich sequence binding protein 1 68 2.9 AV172776 Scarb2Scarb2 scavenger receptor class B, member 2 783 2.0 NM_007644 Sdc1 Sdc1syndecan 1 337 2.9 BB533095 Sdccag8 Sdccag8 serologically defined coloncancer 114 3.5 BG695418 antigen 8 — Sec8l1 Mus musculus transcribedsequence with 59 2.3 BM941583 strong similarity to protein sp: P00722(E. coli) BGAL_ECOLI Beta-galactosidase (Lactase) Sectm1 Sectm1 secretedand transmembrane 1 516 2.9 AI481997 Sectm1 Sectm1 secreted andtransmembrane 1 3261 3.0 AI481997 Sell Sell selectin, lymphocyte 69 14.0M36005 Sell Sell selectin, lymphocyte 86 9.7 M36005 E330036L07Rik Senp1RIKEN cDNA E330036L07 gene 75 2.2 BC023129 Sepw1 Sepw1 selenoprotein W,muscle 1 1468 2.0 BB464434 Serpina10 Serpina10 serine (or cysteine)proteinase inhibitor, 211 44.0 BC018416 clade A (alpha-1 antiproteinase,antitrypsin), member 10 Serpina1a Serpina1a serine (or cysteine)proteinase inhibitor, 156 6.4 NM_009243 clade A, member 1a Serpina1bSerpina1b serine (or cysteine) proteinase inhibitor, 2182 2.0 NM_009244clade A, member 1b Serpina3g Serpina3g serine (or cysteine) proteinaseinhibitor, 92 107.8 BC002065 clade A, member 3G Serpina3n Serpina3nserine (or cysteine) proteinase inhibitor, 18 10.9 NM_009252 clade A,member 3N Serpinb1a Serpinb1a serine (or cysteine) proteinase inhibitor,78 2.7 AF426024 clade B, member 1a Serpinb1a Serpinb1a serine (orcysteine) proteinase inhibitor, 256 3.2 AF426024 clade B, member 1aSerpinb6a Serpinb6a serine (or cysteine) proteinase inhibitor, 679 2.3NM_009254 clade B, member 6a Serpinb6b Serpinb6b serine (or cysteine)proteinase inhibitor, 375 4.2 NM_011454 clade B, member 6b Serpinb9Serpinb9 serine (or cysteine) proteinase inhibitor, 972 6.3 NM_009256clade B, member 9 Serpinb9 Serpinb9 serine (or cysteine) proteinaseinhibitor, 323 5.3 BE686716 clade B, member 9 Serpine1 Serpine1 serine(or cysteine) proteinase inhibitor, 80 4.3 NM_008871 clade E, member 1Serping1 Serping1 serine (or cysteine) proteinase inhibitor, 2372 5.4NM_009776 clade G, member 1 — Sertad4 Mus musculus 16 days embryo head96 5.2 BQ174721 cDNA, RIKEN full-length enriched library, clone:C130018M11 product: unclassifiable, full insert sequence Sfpi1 Sfpi1SFFV proviral integration 1 116 5.5 NM_011355 Sfrs3 Sfrs3 splicingfactor, arginine/serine-rich 3 1401 2.2 BB492363 (SRp20) Sfrs7 Sfrs7splicing factor, arginine/serine-rich 7 1701 2.1 BC027391 3300001M08RikSgol1 RIKEN cDNA 3300001M08 gene 16 3.9 BB410537 Sh3bgrl Sh3bgrlSH3-binding domain glutamic acid-rich 1195 2.0 AK004519 protein likeSh3bgr1 Sh3bgrl SH3-binding domain glutamic acid-rich 14 4.7 BB548587protein like Sh3bgrl3 Sh3bgrl3 SH3 domain binding glutamic acid-rich1255 4.7 NM_080559 protein-like 3 Sh3bp2 Sh3bp2 SH3-domain bindingprotein 2 296 2.3 BC010198 Sh3kbp1 Sh3kbp1 SH3-domain kinase bindingprotein 1 18 3.8 BB766215 Sh3kbp1 Sh3kbp1 SH3-domain kinase bindingprotein 1 161 6.3 BB326929 Shcbp1 Shcbp1 Shc SH2-domain binding protein1 35 12.4 NM_011369 — Siat4c — 32 3.4 BE954474 Siat8d Siat8dsialyltransferase 8 (alpha-2,8- 166 4.6 NM_009183 sialyltransferase) DSil Sil Tal1 interrupting locus 30 3.0 BC004585 Sit Sit SHP2 interactingtransmembrane adaptor 57 2.2 NM_019436 Slamf1 Slamf1 signalinglymphocytic activation molecule 72 3.0 BB132695 family member 1 Slamf1Slamf1 signaling lymphocytic activation molecule 12 7.9 BB132695 familymember 1 Slamf7 Slamf7 SLAM family member 7 58 5.4 AK016183 Slamf8Slamf8 SLAM family member 8 27 65.9 BC024587 Slamf9 Slamf9 SLAM familymember 9 135 5.9 NM_029612 Slbp Slbp stem-loop binding protein 1160 2.3NM_009193 Slc11a1 Slc11a1 solute carrier family 11 (proton-coupled 1776.5 NM_013612 divalent metal ion transporters), member 1 Slc15a3 Slc15a3solute carrier family 15, member 3 38 24.8 NM_023044 Slc20a1 Slc20a1solute carrier family 20, member 1 890 2.6 NM_015747 2610016M12RikSlc25a24 RIKEN cDNA 2610016M12 gene 93 3.1 BF578055 2610016M12RikSlc25a24 RIKEN cDNA 2610016M12 gene 261 4.6 BM230959 Slc28a2 Slc28a2solute carrier family 28 (sodium-coupled 9 21.0 NM_021520 nucleosidetransporter), member 2 Slc2a3 Slc2a3 solute carrier family 2(facilitated glucose 68 4.2 BB414515 transporter), member 3 Slc2a6Slc2a6 solute carrier family 2 (facilitated glucose 14 15.4 BB196807transporter), member 6 Slc31a2 Slc31a2 solute carrier family 31, member2 350 2.5 NM_025286 Tramd1 Slc36a2 tramdorin 1 (transmembrane domainrich 26 3.3 AI596194 protein) Slc38a1 Slc38a1 solute carrier family 38,member 1 193 2.4 NM_134086 Slc38a1 Slc38a1 solute carrier family 38,member 1 35 18.6 BF165681 F730005G13 Slc39a2 hypothetical proteinF730005G13 23 5.0 BB049001 Slc39a6 Slc39a6 solute carrier family 39(metal ion 375 2.4 BB825002 transporter), member 6 A230035L05Rik Slc41a2RIKEN cDNA A230035L05 gene 765 2.3 BC026874 Eeg1 Slc43a3 embryonicepithelial gene 1 452 2.2 NM_021398 Slc4a7 Slc4a7 solute carrier family4, sodium 81 2.2 BB454531 bicarbonate cotransporter, member 7 — Slc7a1Mus musculus 7 days neonate 215 2.7 BB264620 cerebellum cDNA, RIKENfull-length enriched library, clone: A730046J11 product: unclassifiable,full insert sequence — Slc7a1 Mus musculus 7 days neonate 331 2.7BB264620 cerebellum cDNA, RIKEN full-length enriched library, clone:A730046J11 product: unclassifiable, full insert sequence Slfn2 Slfn2schlafen 2 190 12.0 NM_011408 Slfn8 Slfn8 schlafen 8 72 8.6 BC024709Smc2l1 Smc2l1 SMC2 structural maintenance of 16 2.1 BI684556 chromosomes2-like 1 (yeast) Smc2l1 Smc2l1 SMC2 structural maintenance of 25 3.4BI684556 chromosomes 2-like 1 (yeast) Smc2l1 Smc2l1 SMC2 structuralmaintenance of 243 5.2 NM_008017 chromosomes 2-like 1 (yeast) Smc4l1Smc4l1 SMC4 structural maintenance of 699 3.3 AV172948 chromosomes4-like 1 (yeast) — Smc4l1 Mus musculus transcribed sequence with 56 6.7BM244144 weak similarity to protein ref: NP_081764.1 (M. musculus) RIKENcDNA 5730493B19 [Mus musculus] Smc4l1 Smc4l1 SMC4 structural maintenanceof 196 4.0 BI665568 chromosomes 4-like 1 (yeast) Smc4l1 Smc4l1 SMC4structural maintenance of 243 5.3 BI665568 chromosomes 4-like 1 (yeast)1110054A24Rik Smpdl3b RIKEN cDNA 1110054A24 gene 108 10.0 NM_133888Snrpa1 Snrpa1 small nuclear ribonucleoprotein 790 2.1 BC013777polypeptide A′ Snrpb2 Snrpb2 U2 small nuclear ribonucleoprotein B 9062.2 AW537796 Snrpb2 Snrpb2 U2 small nuclear ribonucleoprotein B 1003 2.4AV066554 Snx10 Snx10 sorting nexin 10 203 20.8 AK010399 2410003C09RikSoat1 RIKEN cDNA 2410003C09 gene 197 3.1 BC025091 — Socs2 — 75 3.3BB022048 Socs2 Socs2 suppressor of cytokine signaling 2 478 5.8NM_007706 Socs2 Socs2 suppressor of cytokine signaling 2 354 5.5NM_007706 Socs3 Socs3 suppressor of cytokine signaling 3 60 17.5NM_007707 Socs3 Socs3 suppressor of cytokine signaling 3 153 22.3BB241535 Socs3 Socs3 suppressor of cytokine signaling 3 98 17.8 BB831725Solt Solt SoxLZ/Sox6 leucine zipper binding 95 3.8 NM_021790 protein intestis — Spata5 Mus musculus transcribed sequences 30 2.9 BG069359Spata5 Spata5 spermatogenesis associated 5 180 2.4 NM_021343 — Spata5Mus musculus transcribed sequences 74 2.0 BG074352 Spata5 Spata5spermatogenesis associated 5 32 5.6 BB819052 Sphk1 Sphk1 sphingosinekinase 1 171 2.1 AF068749 Spib Spib Spi-B transcription factor(Spi-1/PU.1 78 2.4 BM244106 related) Spn Spn sialophorin 130 2.3NM_009259 Spop Spop speckle-type POZ protein 45 2.6 AA688828 Spred1Spred1 sprouty protein with EVH-1 domain 1, 890 2.0 BQ044290 relatedsequence Ssb Ssb Sjogren syndrome antigen B 427 2.0 BG796845 Ssbp2 Ssbp2single-stranded DNA binding protein 2 19 1.9 AK005150 BC030940 Ssh2 cDNAsequence BC030940 373 2.1 BB038915 0610038P07Rik Ssr3 RIKEN cDNA0610038P07 gene 1890 2.7 AU022074 Stat1 Stat1 signal transducer andactivator of 171 23.0 AW214029 transcription 1 — Stat1 Mus musculustranscribed sequences 85 19.6 BB229853 Stat1 Stat1 signal transducer andactivator of 915 14.1 AW214029 transcription 1 Stat1 Stat1 signaltransducer and activator of 808 22.7 AW214029 transcription 1 Stat2Stat2 signal transducer and activator of 145 3.2 AF088862 transcription2 Stat2 Stat2 signal transducer and activator of 138 6.1 AF088862transcription 2 Stat3 Stat3 signal transducer and activator of 746 3.3AK004083 transcription 3 Steap Steap six transmembrane epithelialantigen of 391 2.8 AF297098 the prostate Steap Steap six transmembraneepithelial antigen of 176 3.9 AF297098 the prostate Stk17b Stk17bserine/threonine kinase 17b (apoptosis- 240 9.3 AV173139 inducing)Stk17b Stk17b serine/threonine kinase 17b (apoptosis- 364 9.3 AV173139inducing) Stk17b Stk17b serine/threonine kinase 17b (apoptosis- 70 4.9AI661948 inducing) Epb7.2 Stom erythrocyte protein band 7.2 83 2.4AF093620 Strm Strm striamin 713 3.2 BE853286 Stx11 Stx11 syntaxin 11 5910.1 AK017897 Sulf1 Sulf1 sulfatase 1 24 3.3 BB751459 Sulf1 Sulf1sulfatase 1 42 5.3 BB065799 Suv39h1 Suv39h1 suppressor of variegation3-9 homolog 1 184 3.3 AF193862 (Drosophila) Suv39h2 Suv39h2 suppressorof variegation 3-9 homolog 2 29 3.1 NM_022724 (Drosophila) Syk Sykspleen tyrosine kinase 39 2.7 U36776 Syk Syk spleen tyrosine kinase 983.4 AW907526 Syk Syk spleen tyrosine kinase 20 11.5 AW907526 SyncripSyncrip synaptotagmin binding, cytoplasmic RNA 303 2.1 BG920261interacting protein Syt1 Syt1 synaptotagmin 1 64 2.1 BM118245 Syt13Syt13 synaptotagmin 13 37 3.3 BB244585 T2bp T2bp Traf2 binding protein317 3.7 BB277065 Tacc3 Tacc3 transforming, acidic coiled-coil containing47 3.8 BB787809 protein 3 Tank Tank TRAF family member-associated Nf- 235.5 BB040938 kappa B activator Tap2 Tap2 transporter 2, ATP-bindingcassette, sub- 389 11.2 BE691515 family B (MDR/TAP) Tapbp Tapbp TAPbinding protein 917 4.6 AF043943 Tapbp Tapbp TAP binding protein 23045.5 AF043943 LOC213233 Tapbpl similar to hypothetical protein FLJ10143255 7.4 BC017613 LOC213233 Tapbpl similar to hypothetical proteinFLJ10143 36 5.3 BC017613 Tbc1d8 Tbc1d8 TBC1 domain family, member 8 1352.2 BC005421 Tbk1 Tbk1 TANK-binding kinase 1 546 2.1 NM_019786 Tbx21Tbx21 T-box 21 19 12.6 NM_019507 Tcerg1 Tcerg1 transcription elongationregulator 1 29 3.7 AW046403 (CA150) Tcf7 Tcf7 transcription factor 7,T-cell specific 58 13.5 AI323642 — TCR beta-chain M. musculus mRNA forTcell receptor, V-J 22 8.2 M87849 beta junctional region (clone T1CRP8)— Tcra Mus musculus adult male thymus cDNA, 54 2.9 AV312643 RIKENfull-length enriched library, clone: 5830404G23 product: T-cell receptoralpha chain precursor V-J region (TA72) (fragment) homolog [Musmusculus], full insert sequence — Tcra Mus musculus adult male thymuscDNA, 567 8.8 U95921 RIKEN full-length enriched library, clone:5830404G23 product: T-cell receptor alpha chain precursor V-J region(TA72) (fragment) homolog [Mus musculus], full insert sequence — TcraMus musculus adult male thymus cDNA, 697 7.7 U07662 RIKEN full-lengthenriched library, clone: 5830404G23 product: T-cell receptor alpha chainprecursor V-J region (TA72) (fragment) homolog [Mus musculus], fullinsert sequence — Tcra Mus musculus T cell receptor alpha chain 612 9.2X01134 variable region (TCRAV3S9) mRNA, partial cds — Tcra Mus musculusadult male thymus cDNA, 27 7.5 BM243643 RIKEN full-length enrichedlibrary, clone: 5830404G23 product: T-cell receptor alpha chainprecursor V-J region (TA72) (fragment) homolog [Mus musculus], fullinsert sequence — Tcrb-J; — 31 3.1 AK018014 5830405F06Rik Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 21 4.0 U63547 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 68 55.0 U07661 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 22 7.0 AI021643 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 41 75.1 X67128 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 16 4.2 BF318536 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 28 7.5 M31648 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 217 28.7 U46841 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 12 6.8 U46841 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 17 24.4 X14388 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 65 55.9 M11456 Tcrb-V13Tcrb-V13 T-cell receptor beta, variable 13 170 29.2 M16120 Tes Testestis derived transcript 400 2.8 BC010465 Tfdp1 Tfdp1 transcriptionfactor Dp 1 709 2.1 BG075396 Tgfb1i1 Tgfb1i1 transforming growth factorbeta 1 induced 268 2.0 NM_009365 transcript 1 Tgfbi Tgfbi transforminggrowth factor, beta induced 294 24.1 NM_009369 — Tgfbi — 219 27.0BB533460 Tgfbi Tgfbi transforming growth factor, beta induced 229 19.6NM_009369 Tgfbi Tgfbi transforming growth factor, beta induced 556 6.1BB532080 — Tgfbr2 Mus musculus transcribed sequences 105 2.4 BB4659685730599O09Rik Tgif2 RIKEN cDNA 5730599O09 gene 93 2.4 AW556273 Tgm2 Tgm2transglutaminase 2, C polypeptide 4344 2.1 BB550124 Tgm2 Tgm2transglutaminase 2, C polypeptide 3210 2.7 BB041811 — Tgn Mus musculustranscribed sequences 16 5.8 AI451480 Tgtp Tgtp T-cell specific GTPase1220 24.4 NM_011579 Thbs1 Thbs1 thrombospondin 1 337 2.8 AI385532 Thbs1Thbs1 thrombospondin 1 727 2.7 AI385532 Thbs2 Thbs2 thrombospondin 2 742.2 NM_011581 — Thrap2 Mus musculus transcribed sequences 18 4.5 C79489Thy1 Thy1 thymus cell antigen 1, theta 53 28.3 AV028402 TimelessTimeless timeless homolog (Drosophila) 43 3.1 BM230269 Timeless Timelesstimeless homolog (Drosophila) 117 3.4 BM230269 Timp1 Timp1 tissueinhibitor of metalloproteinase 1 69 61.5 BC008107 1110005A05Rik TipinRIKEN cDNA 1110005A05 gene 507 2.3 AK011357 Tle4 Tle4 transducin-likeenhancer of split 4, E(spl) 208 2.1 AU045006 homolog (Drosophila) Tlr1Tlr1 toll-like receptor 1 40 12.4 AF316985 Tlr2 Tlr2 toll-like receptor2 145 11.9 NM_011905 Tlr3 Tlr3 toll-like receptor 3 252 2.3 NM_126166Tlr3 Tlr3 toll-like receptor 3 129 3.9 NM_126166 Tlr4 Tlr4 toll-likereceptor 4 19 3.1 BB148728 Tlr4 Tlr4 toll-like receptor 4 152 2.3AF185285 Tlr4 Tlr4 toll-like receptor 4 91 2.2 AF185285 Tlr6 Tlr6toll-like receptor 6 48 5.4 NM_011604 Tlr7 Tlr7 toll-like receptor 7 169.1 AY035889 Tm4sf7 Tm4sf7 transmembrane 4 superfamily member 7 1349 2.0NM_053082 Tm6sf1 Tm6sf1 transmembrane 6 superfamily member 1 116 5.3AV378394 Tm6sf1 Tm6sf1 transmembrane 6 superfamily member 1 280 2.8AV378394 Mtf2 Tmed5 metal response element binding 283 2.0 BG066919transcription factor 2 Tmod3 Tmod3 tropomodulin 3 447 2.1 BB224629 Tmod3Tmod3 tropomodulin 3 452 2.1 AK017725 Tmpo Tmpo thymopoietin 1030 2.5AA153892 Tmprss4 Tmprss4 transmembrane protease, serine 4 36 11.7BC021368 — Tmsb10 M. musculus mRNA for testis-specific 4515 5.7 AV148480thymosin beta-10 Tmsb10 Tmsb10 thymosin, beta 10 941 10.4 NM_025284 —Tmsb10 M. musculus mRNA for testis-specific 1945 7.8 BB096368 thymosinbeta-10 Tmsb4x Tmsb4x thymosin, beta 4, X chromosome 9065 2.7 NM_021278Tnfaip2 Tnfaip2 tumor necrosis factor, alpha-induced 749 1.9 NM_009396protein 2 Tnfaip3 Tnfaip3 tumor necrosis factor, alpha-induced 77 4.8NM_009397 protein 3 Tnfaip3 Tnfaip3 tumor necrosis factor, alpha-induced236 4.3 BM241351 protein 3 Abcb1a Tnfaip9 ATP-binding cassette,sub-family B 95 5.7 NM_054098 (MDR/TAP), member 1A Tnfrsf11b Tnfrsf11btumor necrosis factor receptor 3 4.0 AB013898 superfamily, member 11b(osteoprotegerin) Tnfrsf12a Tnfrsf12a tumor necrosis factor receptor 8102.5 NM_013749 superfamily, member 12a Tnfrsf12a Tnfrsf12a tumor necrosisfactor receptor 693 3.0 NM_013749 superfamily, member 12a Tnfrsf14Tnfrsf14 tumor necrosis factor receptor 14 10.0 BC022125 superfamily,member 14 (herpesvirus entry mediator) Tnfrsf18 Tnfrsf18 tumor necrosisfactor receptor 81 5.5 AF229434 superfamily, member 18 Tnfrsf1b Tnfrsf1btumor necrosis factor receptor 182 3.2 M60469 superfamily, member 1bTnfrsf4 Tnfrsf4 tumor necrosis factor receptor 163 4.7 NM_011659superfamily, member 4 Tnfrsf5 Tnfrsf5 tumor necrosis factor receptor 4618.8 NM_011611 superfamily, member 5 Tnfrsf5 Tnfrsf5 tumor necrosisfactor receptor 48 20.4 BB220422 superfamily, member 5 Tnfrsf5 Tnfrsf5tumor necrosis factor receptor 95 15.7 AI385482 superfamily, member 5Tnfrsf7 Tnfrsf7 tumor necrosis factor receptor 20 9.6 L24495superfamily, member 7 Tnfsf10 Tnfsf10 tumor necrosis factor (ligand) 2935.1 NM_009425 superfamily, member 10 Tnfsf13b Tnfsf13b tumor necrosisfactor (ligand) 48 3.0 BB079466 superfamily, member 13b Tnfsf13bTnfsf13b tumor necrosis factor (ligand) 101 7.4 NM_033622 superfamily,member 13b Tnfsf9 Tnfsf9 tumor necrosis factor (ligand) 29 5.3 NM_009404superfamily, member 9 Tnip1 Tnip1 TNFAIP3 interacting protein 1 724 2.4AJ242777 Top2a Top2a topoisomerase (DNA) II alpha 39 3.9 BB749838 Top2aTop2a topoisomerase (DNA) II alpha 142 14.7 BM211413 2810429C13RikTopbp1 RIKEN cDNA 2810429C13 gene 334 2.5 BC007170 Tor3a Tor3a torsinfamily 3, member A 226 2.4 NM_023141 Tor3a Tor3a torsin family 3, memberA 180 4.1 AK009693 Tor3a Tor3a torsin family 3, member A 287 3.3NM_023141 — Tox Mus musculus transcribed sequences 24 4.1 BM124834 ToxTox thymocyte selection-associated HMG box 6 10.5 BB547854 gene Tox Toxthymocyte selection-associated HMG box 89 4.7 BB547854 gene5430425C04Rik Tp53i5 RIKEN cDNA 5430425C04 gene 44 3.5 AK017334 Tpm2Tpm2 tropomyosin 2, beta 307 2.5 BC024358 Tpm2 Tpm2 tropomyosin 2, beta977 2.2 AK003186 — Tpm4 Mus musculus 7 days embryo whole 1905 2.9AV122663 body cDNA, RIKEN full-length enriched library, clone:C430002D13 product: TROPOMYOSIN 4 homolog [Homo sapiens], full insertsequence Tpst1 Tpst1 protein-tyrosine sulfotransferase 1 130 4.8NM_013837 Tpt1h Tpt1h tRNA splicing 2′ phosphotransferase 1 181 16.0BB113173 homolog (S. cerevisiae) 2610005B21Rik Tpx2 RIKEN cDNA2610005B21 gene 132 3.4 AK011311 2610005B21Rik Tpx2 RIKEN cDNA2610005B21 gene 9 6.5 AK011311 Traf1 Traf1 Tnf receptor-associatedfactor 1 40 6.1 BB218245 Traf1 Traf1 Tnf receptor-associated factor 1 3410.8 BG064103 Trem3 Trem3 triggering receptor expressed on myeloid 962.4 NM_021407 cells 3 5031403H21Rik Treml4 RIKEN cDNA 5031403H21 gene 514.6 BB740529 — Trex1 Mus musculus adult female vagina 26 6.3 AF140709cDNA, RIKEN full-length enriched library, clone: 9930022F21 product:similar to G PROTEIN COUPLED RECEPTOR [Mus musculus], full insertsequence Ifld2 Trib3 induced in fatty liver dystrophy 2 34 6.6 BB508622Trim12 Trim12 tripartite motif protein 12 13 8.3 BM244351 Trim21 Trim21tripartite motif protein 21 341 2.3 BC010580 Trim21 Trim21 tripartitemotif protein 21 325 3.9 BC010580 Trim27 Trim27 tripartite motif protein27 783 2.2 BB290427 Trim30 Trim30 tripartite motif protein 30 215 7.9AF220015 Trim30 Trim30 tripartite motif protein 30 252 9.4 BM2407199230105E10Rik Trim34 RIKEN cDNA 9230105E10 gene 427 4.5 BI653857 Trip13Trip13 thyroid hormone receptor interactor 13 31 4.5 AK010336 Trip13Trip13 thyroid hormone receptor interactor 13 56 9.0 AK010336 TslprTslpr thymic stromal-derived lymphopoietin, 313 3.7 NM_016715 receptorTtk Ttk Ttk protein kinase 30 7.1 NM_009445 Tuba1 Tuba1 tubulin, alpha 11848 3.7 NM_011653 Tuba2 Tuba2 tubulin, alpha 2 9060 2.2 BC008117 Tuba8Tuba8 tubulin, alpha 8 67 2.9 BB047533 Tubb2 Tubb2 tubulin, beta 2 9692.9 BC003475 Tubb5 Tubb5 tubulin, beta 5 568 3.6 BG064086 Tubb5 Tubb5tubulin, beta 5 2009 3.3 NM_011655 2310057H16Rik Tubb6 RIKEN cDNA2310057H16 gene 204 4.2 NM_026473 Tube1 Tube1 epsilon-tubulin 1 27 2.7AK010005 Txk Txk TXK tyrosine kinase 31 4.2 U19607 Tyki Tyki thymidylatekinase family LPS-inducible 406 3.0 AK004595 member Tyrobp Tyrobp TYROprotein tyrosine kinase binding 261 17.8 NM_011662 protein C330001M22Ubash3a hypothetical protein C330001M22 89 3.1 BB397001 Ubd Ubdubiquitin D 121 223.5 NM_023137 Ube2c Ube2c ubiquitin-conjugating enzymeE2C 133 10.5 AV162459 Ubce8 Ube2l6 ubiquitin-conjugating enzyme 8 85 8.7BC008238 Ugcg Ugcg UDP-glucose ceramide 203 2.2 BF682223glucosyltransferase Ugcg Ugcg UDP-glucose ceramide 229 2.5 AA591863glucosyltransferase Np95 Uhrf1 nuclear protein 95 60 12.5 BB702754 Np95Uhrf1 nuclear protein 95 43 6.5 BB702754 2510009H09Rik Unc5cl RIKEN cDNA2510009H09 gene 71 2.5 AK010945 Unc93b Unc93b1 unc-93 homolog B (C.elegans) 424 3.3 BC018388 Upp1 Upp1 uridine phosphorylase 1 391 8.2NM_009477 Usp18 Usp18 ubiquitin specific protease 18 165 20.6 NM_011909— Usp32 Mus musculus transcribed sequence with 34 2.1 BB740339 weaksimilarity to protein ref: NP_081764.1 (M. musculus) RIKEN cDNA5730493B19 [Mus musculus] Vasp Vasp vasodilator-stimulatedphosphoprotein 705 3.1 BC015289 — Vcam1 Mus musculus transcribedsequences 49 20.6 AV280637 Vcam1 Vcam1 vascular cell adhesion molecule 1152 25.4 L08431 1300011C24Rik Vdp RIKEN cDNA 1300011C24 gene 3412 2.0AV139821 Vim Vim vimentin 1185 8.9 AV147875 Vim Vim vimentin 1376 8.7M24849 Vim Vim vimentin 570 10.5 AV147875 Vps54 Vps54 vacuolar proteinsorting 54 (yeast) 8 2.9 BB201271 Vrk1 Vrk1 vaccinia related kinase 1243 2.0 BC016676 Vrk2 Vrk2 vaccinia related kinase 2 87 3.3 BC013520Vrk2 Vrk2 vaccinia related kinase 2 154 3.0 AK012664 Wars Warstryptophanyl-tRNA synthetase 387 2.4 BC003450 Wars Warstryptophanyl-tRNA synthetase 791 2.7 BB785450 Wars Warstryptophanyl-tRNA synthetase 193 4.6 AK004541 Wars Warstryptophanyl-tRNA synthetase 768 2.9 AI528863 Was Was Wiskott-Aldrichsyndrome homolog 25 17.0 NM_009515 (human) Waspip Waspip Wiskott-Aldrichsyndrome protein 249 4.9 C76969 interacting protein Waspip WaspipWiskott-Aldrich syndrome protein 195 4.6 C76969 interacting protein Wbp5Wbp5 WW domain binding protein 5 3473 2.1 BC007478 — Wbscr1 Mus musculustranscribed sequences 43 2.5 BI499987 Wbscr5 Wbscr5 Williams-Beurensyndrome chromosome 67 5.7 AF257136 region 5 homolog (human)D630024B06Rik Wdhd1 RIKEN cDNA D630024B06 gene 71 5.0 C77437 Whsc1 Whsc1Wolf-Hirschhorn syndrome candidate 1 104 2.8 AK017992 (human) Wisp1Wisp1 WNT1 inducible signaling pathway 145 2.4 NM_018865 protein 12700038M07Rik Wsb1 RIKEN cDNA 2700038M07 gene 786 2.1 BC019601 Xcl1 Xcl1chemokine (C motif) ligand 1 32 18.1 NM_008510 Xdh Xdh xanthinedehydrogenase 167 16.7 AV286265 Ywhah Ywhah tyrosine3-monooxygenase/tryptophan 5- 2590 2.2 NM_011738 monooxygenaseactivation protein, eta polypeptide Zap70 Zap70 zeta-chain (TCR)associated protein 45 6.2 BB204558 kinase Zbp1 Zbp1 Z-DNA bindingprotein 1 49 78.0 AK008179 Zbp1 Zbp1 Z-DNA binding protein 1 14 118.4NM_021394 Zc3hav1 Zc3hav1 zinc finger CCCH type, antiviral 1 174 2.0AK004770 Zc3hav1 Zc3hav1 zinc finger CCCH type, antiviral 1 465 4.0BB757349 Zc3hdc1 Zc3hdc1 zinc finger CCCH type domain containing 1 4626.7 BM227980 A430104C18Rik Zc3hdc7 RIKEN cDNA A430104C18 gene 193 2.4AW556219 2410141K03Rik Zcchc10 RIKEN cDNA 2410141K03 gene 159 2.1BC025078 — Zcchc6 Mus musculus transcribed sequences 113 2.1 BI6953611110051N18Rik Zcwcc3 RIKEN cDNA 1110051N18 gene 343 3.5 AI4521461110051N18Rik Zcwcc3 RIKEN cDNA 1110051N18 gene 224 3.2 BC026506 —Zfhx1b Mus musculus transcribed sequence with 65 2.3 BG061923 moderatesimilarity to protein sp: P00722 (E. coli) BGAL_ECOLI Beta-galactosidase (Lactase) — Zfhx1b Mus musculus Corpos mRNA, 3′ 59 3.1BM220939 untranslated region — Zfhx1b Mus musculus transcribed sequences65 2.3 BB488200 Zfhx1b Zfhx1b zinc finger homeobox 1b 226 2.4 NM_015753Zfp118 Zfp118 Zinc finger protein 118 59 2.2 BB176857 Zfp313 Zfp313 zincfinger protein 313 1410 2.0 BB251247 3732412P20 Zfp455 hypotheticalprotein 3732412P20 37 3.6 AV172851 Zfp472 Zfp472 zinc finger protein 472149 2.1 BC023090 Zfp52 Zfp52 zinc finger protein 52 68 2.7 BM225280Zfp52 Zfp52 zinc finger protein 52 263 2.4 BM225280 Zfp118 Zfp53 Zincfinger protein 118 132 2.3 NM_013843 Znfn1a1 Zfpn1a1 zinc fingerprotein, subfamily 1A, 1 85 19.8 AV317621 (Ikaros) — Zfpn1a1 Musmusculus, clone IMAGE: 1263252, 40 2.6 BM237812 mRNA Znfn1a3 Zfpn1a3zinc finger protein, subfamily 1A, 3 42 4.4 BB202216 (Aiolos) Znfn1a3Zfpn1a3 zinc finger protein, subfamily 1A, 3 34 21.1 BB151746 (Aiolos)Zfr Zfr zinc finger RNA binding protein 54 2.5 BB214490 Zfr Zfr zincfinger RNA binding protein 71 2.6 BM119505 Zipro1 Zipro1 zinc fingerproliferation 1 185 3.0 AI326272 B830022L21Rik Znrf1 RIKEN cDNAB830022L21 gene 190 2.4 BC006765 — Zswim6 Mus musculus transcribedsequences 116 2.0 AI427602 D10Ertd749e Zwint DNA segment, Chr 10, ERATODoi 749, 143 2.6 BC013559 expressed Brd7 bromodomain containing 7 14 2.4BB022341 — Mus musculus transcribed sequence with 229 2.5 BG143461strong similarity to protein sp: P00722 (E. coli) BGAL_ECOLIBeta-galactosidase (Lactase) — Mus musculus transcribed sequences 24 2.9BB066105 Crsp9 cofactor required for Sp1 transcriptional 59 2.2 AK009549activation, subunit 9, 33 kDa — — 104 2.6 BQ033755 — Mus musculustranscribed sequences 8 3.1 BE686253 — Mus musculus 0 day neonateeyeball 40 2.6 BB710625 cDNA, RIKEN full-length enriched library, clone:E130307M10 product: unclassifiable, full insert sequence — Mus musculustranscribed sequence with 223 3.8 AW556821 weak similarity to proteinpir: I58401 (M. musculus) I58401 protein-tyrosine kinase (EC 2.7.1.112)JAK3 - mouse — — 1919 3.2 AY052560 Srrm1 serine/arginine repetitivematrix 1 43 2.5 BB254130 — Mus musculus adult male aorta and vein 54 2.3BB224338 cDNA, RIKEN full-length enriched library, clone: A530086D01product: unknown EST, full insert sequence — — 78 4.4 BB116018 — Musmusculus transcribed sequences 37 2.5 BE691393 — Mus musculustranscribed sequences 57 3.1 BE943672 — Mus musculus transcribedsequences 12 5.8 BE447255 Loxl2 lysyl oxidase-like 2 231 2.2 AI415741 —Mus musculus 16 days neonate heart 24 3.1 BB042982 cDNA, RIKENfull-length enriched library, clone: D830032E20 product: similar toENVELOPE PROTEIN (FRAGMENT) [Friend spleen focus-forming virus], fullinsert sequence Pfkp phosphofructokinase, platelet 438 2.3 BB076574Itgb4bp integrin beta 4 binding protein 174 2.0 AK018313 — Mus musculus2 days neonate thymus 102 3.3 BI076809 thymic cells cDNA, RIKENfull-length enriched library, clone: E430008K23 product: unknown EST,full insert sequence — Mus musculus 12 days embryo 54 2.2 BM239026embryonic body between diaphragm region and neck cDNA, RIKEN full-lengthenriched library, clone: 9430088I02 product: unknown EST, full insertsequence — Mus musculus adult male thymus cDNA, 5 8.8 BB241847 RIKENfull-length enriched library, clone: 5830404C02 product: unknown EST,full insert sequence — — 12 2.2 BB800744 Cp ceruloplasmin 232 2.0BB332449 — Mus musculus transcribed sequence with 55 3.5 BG075163 strongsimilarity to protein sp: Q9NZJ4 (H. sapiens) SACS_HUMAN Sacsin Etv3 etsvariant gene 3 284 2.5 BI456953 Strn3 striatin, calmodulin bindingprotein 3 114 2.0 BB228907 — Mus musculus 2 days pregnant adult 61 5.5BE989616 female ovary cDNA, RIKEN full-length enriched library, clone:E330027C07 product: weakly similar to ZINC FINGER PROTEIN 43 (HTF6)[Homo sapiens], full insert sequence — Mus musculus 9 days embryo whole69 4.3 BF163381 body cDNA, RIKEN full-length enriched library, clone:D030060F23 product: Mus musculus U22 snoRNA host gene (UHG) gene,complete sequence, full insert sequence — Mus musculus transcribedsequences 32 2.6 AV300631 — — 104 2.7 AV084904 Zfp295 zinc fingerprotein 295 102 2.2 BB091040 — Mus musculus transcribed sequences 62 2.3BB230267 H2afz H2A histone family, member Z 765 1.9 AV215230 — Musmusculus similar to FLJ14075 80 2.1 BG071110 protein (LOC217431), mRNA —Mus musculus 0 day neonate skin cDNA, 47 2.3 AV233462 RIKEN full-lengthenriched library, clone: 4632424N07 product: unknown EST, full insertsequence — Mus musculus adult male thymus cDNA, 55 2.8 AV312603 RIKENfull-length enriched library, clone: 5830404C02 product: unknown EST,full insert sequence — Mus musculus transcribed sequences 134 2.8BI466416 — Mus musculus transcribed sequence with 20 2.8 AI452166 weaksimilarity to protein ref: NP_061226.1 (M. musculus) 2-cell- stage,variable group, member 1; variable group of 2-cell-stage gene family[Mus musculus] 1700029I01Rik RIKEN cDNA 1700029I01 gene 81 3.5 AV047635— Mus musculus transcribed sequences 62 5.9 AV247387 — Mus musculus cDNAclone MGC: 6071 130 3.3 BC022776 IMAGE: 3492410, complete cds — — 68 4.0BB256262 Smc6l1 SMC6 structural maintenance of 43 3.0 BB056038chromosomes 6-like 1 (yeast) — Mus musculus transcribed sequences 63 2.1BB473548 — Mus musculus transcribed sequences 36 2.7 AU040162 — Musmusculus 0 day neonate eyeball 48 2.1 BB541236 cDNA, RIKEN full-lengthenriched library, clone: E130112O04 product: unknown EST, full insertsequence — — 6 9.3 BB030365 — Mus musculus transcribed sequences 79 2.5BG069527 — — 8 3.4 AI661342 — Mus musculus transcribed sequences 229 2.2BM218086 2210023K21Rik RIKEN cDNA 2210023K21 gene 125 4.7 BI106821 — —94 2.1 BG074662 Igsf6 immunoglobulin superfamily, member 6 23 2.8AV078837 — Mus musculus transcribed sequence with 29 2.4 BB449580 weaksimilarity to protein pir: S12207 (M. musculus) S12207 hypotheticalprotein (B2 element) - mouse Rp2h retinitis pigmentosa 2 homolog (human)209 2.2 BF168611 — Mus musculus transcribed sequences 37 3.9 BE634580Stk4 serine/threonine kinase 4 1036 2.0 BB141897 Ccr7 chemokine (C-Cmotif) receptor 7 4 9.9 BB204380 — Mus musculus adult male thymus cDNA,28 3.1 BB165850 RIKEN full-length enriched library, clone: 5830443J22product: unknown EST, full insert sequence — Mus musculus 0 day neonateeyeball 67 2.1 BB538708 cDNA, RIKEN full-length enriched library, clone:E130013E11 product: unknown EST, full insert sequence — Mus musculussimilar to Elongation factor 154 4.1 AV328340 1-alpha 1 (EF-1-alpha-1)(Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu)(LOC381109), mRNA 2610018G03Rik RIKEN cDNA 2610018G03 gene 123 2.0AW556821 — Mus musculus transcribed sequences 36 3.5 BB208080 — Musmusculus transcribed sequences 21 3.0 BB271581 Atf4 activatingtranscription factor 4 398 2.4 AV314773 — Mus musculus transcribedsequences 52 2.3 BB458874 2610039C10Rik RIKEN cDNA 2610039C10 gene 1133.5 AK012762 — Mus musculus transcribed sequence with 42 2.1 AV372127moderate similarity to protein ref: NP_038602.1 (M. musculus) L1 repeat,Tf subfamily, member 18 [Mus musculus] — Mus musculus transcribedsequences 224 3.0 AA266723 — — 388 2.0 AV368189 E430036I04Rik RIKEN cDNAE430036I04 gene 85 6.8 BB329408 — — 98 2.4 BQ266693 Rp2h retinitispigmentosa 2 homolog (human) 188 2.2 BF168611 — Mus musculus similar toDYSKERIN 190 4.4 BB779105 (LOC245474), mRNA 0610025L06Rik RIKEN cDNA0610025L06 gene 1362 6.2 AV010467 — Mus musculus, clone IMAGE: 5066616,72 3.7 BE373131 mRNA — Mus musculus transcribed sequences 21 2.4BM196689 — — 157 2.2 BG976607 — Mus musculus transcribed sequences 9 5.0BB534560 C330006D17Rik RIKEN cDNA C330006D17 gene 191 2.4 BB397948 — —169 4.7 BG976607 — Mus musculus transcribed sequence with 96 2.2BB667685 weak similarity to protein pir: S12207 (M. musculus) S12207hypothetical protein (B2 element) - mouse — Mus musculus transcribedsequences 53 12.1 BM246630 — Mus musculus transcribed sequence with 293.8 AI451538 weak similarity to protein pir: S12207 (M. musculus) S12207hypothetical protein (B2 element) - mouse — — 299 2.3 BG976607 — Musmusculus mRNA similar to 33 5.1 BC020118 interferon-inducible GTPase(cDNA clone MGC: 49532 IMAGE: 3495064), complete cds Mllmyeloid/lymphoid or mixed-lineage 128 2.0 AK017541 leukemia — Musmusculus transcribed sequences 46 2.5 BG073023 Cp ceruloplasmin 1596 3.9BB332449 — Mus musculus similar to 2-cell-stage, 96 2.1 BG070246variable group, member 3; 2-cell-stage, variable group, member 1(LOC236374), mRNA — — 28 5.3 BC003855 — Mus musculus similar to Ig deltachain C 29 3.5 BE686052 region, membrane-bound form - mouse (LOC382646),mRNA 3010033P07Rik RIKEN cDNA 3010033P07 gene 114 2.5 AK013903 — Musmusculus transcribed sequences 94 3.6 BB376947 — Mus musculustranscribed sequences 182 2.8 BB829165 Pscdbp pleckstrin homology, Sec7and coiled-coil 1081 3.1 BB503614 domains, binding protein — — 1108 2.5BB145101 Hmmr hyaluronan mediated motility receptor 82 3.0 X64550(RHAMM) — Mus musculus 0 day neonate thymus 25 3.8 AI840829 cDNA, RIKENfull-length enriched library, clone: A430110E23 product: unknown EST,full insert sequence Nr4a2 nuclear receptor subfamily 4, group A, 23 2.8BB703394 member 2 Rod1 ROD1 regulator of differentiation 1 (S. pombe)130 3.4 BB519382 Eif4ebp1 eukaryotic translation initiation factor 4E393 2.6 AV216412 binding protein 1 — Mus musculus transcribed sequences94 2.5 BE634878 — Mus musculus adult male tongue cDNA, 19 3.3 BG061080RIKEN full-length enriched library, clone: 2310050P20 product: unknownEST, full insert sequence Col1a1 procollagen, type I, alpha 1 138 5.9BI794771 — Mus musculus 18 days pregnant adult 136 2.4 BI082172 femaleplacenta and extra embryonic tissue cDNA, RIKEN full-length enrichedlibrary, clone: 3830421G02 product: unknown EST, full insert sequence —— 512 2.9 BG976607 — — 244 3.7 BM941868 — — 1603 3.3 BF719154 Ncf1neutrophil cytosolic factor 1 35 15.5 BE370703 — Mus musculus diabeticnephropathy- 118 58.3 BM241271 related gene 1 mRNA, partial sequence —Mus musculus transcribed sequence with 148 6.7 BB160586 moderatesimilarity to protein pir: A39822 (H. sapiens) A39822 leukosialinprecursor - human — Mus musculus transcribed sequences 125 3.9 BB667149Rrm2 ribonucleotide reductase M2 412 8.2 AV301324 — Mus musculustranscribed sequences 96 2.4 BM243375 — — 138 2.1 BI155210 Ddx39 DEAD(Asp-Glu-Ala-Asp) box polypeptide 1234 2.5 AV111502 39 — — 17 4.6AV340322 Cp ceruloplasmin 915 4.3 BB332449 — Mus musculus transcribedsequence with 91 3.0 BB281100 moderate similarity to protein sp: P00722(E. coli) BGAL_ECOLI Beta- galactosidase (Lactase) — — 230 5.3 U29539Gna13 guanine nucleotide binding protein, alpha 1362 2.3 BI662324 13 —Mus musculus transcribed sequences 66 2.5 AA267568 — Mus musculus 16days neonate heart 19 4.3 BB518323 cDNA, RIKEN full-length enrichedlibrary, clone: D830028N22 product: unclassifiable, full insert sequenceRp2h retinitis pigmentosa 2 homolog (human) 202 2.2 BF168611 — Musmusculus adult male cecum cDNA, 28 4.8 AI506672 RIKEN full-lengthenriched library, clone: 9130208D14 product: unknown EST, full insertsequence — Mus musculus transcribed sequences 96 3.3 BB7672439930027N05Rik RIKEN cDNA 9930027N05 gene 41 39.3 AI662854 — Mus musculustranscribed sequence with 35 9.3 BB740904 weak similarity to proteinref: NP_081764.1 (M. musculus) RIKEN cDNA 5730493B19 [Mus musculus] —Mus musculus transcribed sequences 35 2.6 BM239760 — Mus musculustranscribed sequence with 68 2.9 BF714880 moderate similarity to proteinref: NP_081764.1 (M. musculus) RIKEN cDNA 5730493B19 [Mus musculus] —Mus musculus transcribed sequences 110 3.5 BM222853 Cp ceruloplasmin 8384.2 BB332449 Ncf1 neutrophil cytosolic factor 1 60 7.0 BE370703 — — 5937.3 BE688410 Hn1 hematological and neurological 194 7.9 AV067695expressed sequence 1 — — 986 20.1 AV066625 Myadm myeloid-associateddifferentiation marker 1120 2.1 BB500055 Vcam1 vascular cell adhesionmolecule 1 296 19.2 BB250384 Cugbp2 CUG triplet repeat, RNA bindingprotein 2 148 6.0 BB667096 — Mus musculus 3 days neonate thymus 41 40.5BB207611 cDNA, RIKEN full-length enriched library, clone: A630020E03product: unknown EST, full insert sequence — Mus musculus transcribedsequence with 510 2.3 AV216768 strong similarity to protein sp: Q61753(M. musculus) SERA_MOUSE D-3- phosphoglycerate dehydrogenase (3- PGDH)(A10) Cxcl9 chemokine (C—X—C motif) ligand 9 33 69.4 BI104444 Rod1 ROD1regulator of differentiation 1 (S. pombe) 138 4.6 BB519382 — — 19 17.8BC003855 — Mus musculus transcribed sequence with 536 3.9 C76675 strongsimilarity to protein sp: P10660 (H. sapiens) RS6_HUMAN 40S ribosomalprotein S6 (Phosphoprotein NP33) — Mus musculus transcribed sequences 2833.7 BB224524 — Mus musculus adult male aorta and vein 18 23.4 BE692425cDNA, RIKEN full-length enriched library, clone: A530049N04 product:unknown EST, full insert sequence — Mus musculus similar to toll-likereceptor 32 15.8 BI655907 (LOC279572), mRNA — Mus musculus transcribedsequences 196 3.2 AW543723 — — 31 17.1 BG072508 Etv3 ets variant gene 3198 2.1 BI456953 — Mus musculus transcribed sequences 12 2.3 BF321297 —— 19 67.1 NM_022429 — Mus musculus similar to AIM2 protein 15 4.0BE685969 (LOC383619), mRNA Cnp1 cyclic nucleotide phosphodiesterase 1354 6.3 BB251922 — — 286 2.9 BC004065 Tpm3 tropomyosin 3, gamma 621 3.8AV311925 2210023K21Rik RIKEN cDNA 2210023K21 gene 381 5.8 BI106821 — Musmusculus transcribed sequences 115 61.7 AW111920 — — 172 12.6 BB668084 —— 24 7.8 AV247013 — — 38 29.1 BE688410 — Mus musculus transcribedsequence with 21 6.6 BB535821 weak similarity to protein ref:NP_081764.1 (M. musculus) RIKEN cDNA 5730493B19 [Mus musculus] Rps3ribosomal protein S3 138 2.0 BG069767 — Mus musculus adult male aortaand vein 6 5.5 BB214834 cDNA, RIKEN full-length enriched library, clone:A530023D22 product: unclassifiable, full insert sequence — — 55 6.8BB135602 — Mus musculus, clone IMAGE: 1348774, 11 28.8 AA666504 mRNACnn3 calponin 3, acidic 943 4.2 BB490338 Hrasls3 HRAS like suppressor 3372 21.7 BB404920 — Mus musculus similar to surface protein 17 7.5BE629676 MCA-32 (LOC380732), mRNA — Mouse non-productive mRNA for T-cell6 23.2 NM_011558 receptor gamma V5-J1-C1 G1p2 interferon,alpha-inducible protein 112 16.7 AK019325 Pim1 proviral integration site1 261 4.9 AI323550 Vcam1 vascular cell adhesion molecule 1 268 39.1BB250384 1200008O12Rik RIKEN cDNA 1200008O12 gene 7 6.5 AV126179 — Musmusculus adult male cortex cDNA, 336 10.9 BB645745 RIKEN full-lengthenriched library, clone: B530033B21 product: unknown EST, full insertsequence — Mus musculus transcribed sequences 12 7.8 BB552085 G1p2interferon, alpha-inducible protein 17 10.3 AK019325 Nfkbia nuclearfactor of kappa light chain gene 1311 4.1 BB096843 enhancer in B-cellsinhibitor, alpha

TABLE 3 Transcripts decreased in GKO D5 WT D5 GKO Gene Symbol vs D5 vsAffymetrix Common Gene Title Affymetrix NCBA NCBA Genbank BC0272310610037H22Rik cDNA sequence BC027231 1.0 0.4 AU051504 0610037M15Rik0610037M15Rik RIKEN cDNA 0610037M15 15.6 3.2 BG916808 gene 1110007F12Rik1110007F12Rik RIKEN cDNA 1110007F12 3.0 0.6 BC020080 gene 1110013L07Rik1110013L07Rik RIKEN cDNA 1110013L07 3.0 1.5 BB765852 gene 1110032F04Rik1110032F04Rik RIKEN cDNA 1110032F04 1.3 0.4 BE985708 gene 1200015F23Rik1200015F23Rik RIKEN cDNA 1200015F23 1.1 0.5 AK004786 gene 1200015F23Rik1200015F23Rik RIKEN cDNA 1200015F23 1.8 0.6 AK004786 gene 1500004A08Rik1500004A08Rik RIKEN cDNA 1500004A08 2.3 1.1 BB030508 gene 1700008D07Rik1700008D07Rik RIKEN cDNA 1700008D07 0.9 0.4 AK005758 gene 1700012B18Rik1700012B18Rik RIKEN cDNA 1700012B18 0.7 0.4 BC022135 gene —1700091G21Rik Mus musculus 16 days 4.3 2.1 BG075562 neonate thymus cDNA,RIKEN full-length enriched library, clone: A130042K22 product: unknownEST, full insert sequence 1810054D07Rik 1810054D07Rik RIKEN cDNA1810054D07 5.4 1.9 BB397062 gene 1810054D07Rik 1810054D07Rik RIKEN cDNA1810054D07 4.5 2.1 BB259628 gene 1810054D07Rik 1810054D07Rik RIKEN cDNA1810054D07 5.0 2.2 AK007856 gene 1810062O14Rik 1810062O14Rik RIKEN cDNA1810062O14 7.4 3.5 AV060417 gene — 2010001M06Rik Mus musculus adult male0.9 0.3 BE200030 small intestine cDNA, RIKEN full-length enrichedlibrary, clone: 2010001M06 product: unknown EST, full insert sequence2210019E14Rik 2210019E14Rik RIKEN cDNA 2210019E14 1.5 0.8 BB771921 gene2210421G13Rik 2210421G13Rik RIKEN cDNA 2210421G13 9.3 0.8 AV081797 geneElk4 2310011G17Rik ELK4, member of ETS 0.4 0.2 AW046689 oncogene family2310047C04Rik 2310047C04Rik RIKEN cDNA 2310047C04 1.2 0.3 BM231657 gene2600014C01Rik 2600014C01Rik RIKEN cDNA 2600014C01 0.6 0.2 BC027339 gene2610042L04Rik 2610042L04Rik RIKEN cDNA 2610042L04 5.0 0.9 BM195235 gene2610042L04Rik 2610042L04Rik RIKEN cDNA 2610042L04 4.9 0.9 BM195235 gene2610305D13Rik 2610305D13Rik RIKEN cDNA 2610305D13 0.7 0.1 AK011986 gene2610528J11Rik 2610528J11Rik RIKEN cDNA 2610528J11 0.3 0.1 AK012175 gene2700007P21Rik 2700007P21Rik RIKEN cDNA 2700007P21 1.1 0.4 BB552785 geneLOC217820 2700069A02Rik hypothetical protein 0.8 0.4 BM198642 LOC2178202810022L02Rik 2810022L02Rik RIKEN cDNA 2810022L02 0.9 0.3 BC014764 gene2810429K17Rik 2810429K17Rik RIKEN cDNA 2810429K17 0.7 0.2 AK013194 gene2900024C23Rik 2900024C23Rik RIKEN cDNA 2900024C23 1.3 0.5 AK013580 gene4631426E05Rik 4631426E05Rik RIKEN cDNA 4631426E05 0.2 0.1 BB739558 gene— 4921504P05Rik — 0.8 0.4 AK014814 4930402H24Rik 4930402H24Rik RIKENcDNA 4930402H24 1.1 0.4 AK015050 gene 4930413O22Rik 4930413O22Rik RIKENcDNA 4930413O22 1.1 0.5 NM_026493 gene — 4930420O11Rik Mus musculus 4days 1.8 0.7 BB328498 neonate male adipose cDNA, RIKEN full-lengthenriched library, clone: B430318O09 product: CDNA FLJ33039 FIS, CLONETHYMU2000369, MODERATELY SIMILAR TO MUS MUSCULUS SYNTROPHIN-ASSOCIATEDSERINE-THREONINE PROTEIN KINASE MRNA homolog [ . . . 4930422I07Rik4930422I07Rik RIKEN cDNA 4930422I07 0.9 0.3 BG068263 gene —4930488P18Rik — 1.4 0.2 AV057155 4930562F07Rik 4930523C07Rik RIKEN cDNA4930562F07 1.3 0.6 AV032877 gene 4930550C14Rik 4930550C14Rik RIKEN cDNA4930550C14 1.9 0.6 AK016083 gene — 4930556N09Rik Mus musculus adult male1.3 0.5 AK016152 testis cDNA, RIKEN full- length enriched library,clone: 4930556N09 product: unclassifiable, full insert sequence1810010E01Rik 4930579G22Rik RIKEN cDNA 1810010E01 1.0 0.4 BI202437 gene4933409L06Rik 4933409L06Rik RIKEN cDNA 4933409L06 1.3 0.6 BB645791 gene— 4933412E12Rik Mus musculus 13 days 2.2 0.5 AK016788 embryo heart cDNA,RIKEN full-length enriched library, clone: D330011B05 product: unknownEST, full insert sequence — 4933412E12Rik — 1.5 0.4 BB2651474933415L06Rik 4933415L06Rik RIKEN cDNA 4933415L06 1.0 0.4 AW554226 gene— 4933417N07Rik Mus musculus adult male 1.1 0.6 AK016849 testis cDNA,RIKEN full- length enriched library, clone: 4933417N07 product: unknownEST, full insert sequence — 4933422E07Rik Mus musculus adult male 1.20.6 BE630630 bone cDNA, RIKEN full-length enriched library, clone:9830114D01 product: hypothetical protein, full insert sequence5133401N09Rik 5133401N09Rik RIKEN cDNA 5133401N09 1.9 0.7 BC026742 gene5830405N20Rik 5830405N20Rik RIKEN cDNA 5830405N20 2.5 0.8 BB202848 gene9630005B12Rik 5830411O09Rik RIKEN cDNA 9630005B12 2.4 0.8 BB431654 geneAI595338 5830443L24Rik expressed sequence 75.0 0.4 NM_029509 AI5953385830458K16Rik 5830458K16Rik RIKEN cDNA 5830458K16 9.1 1.6 BC024872 gene5830484A20Rik 5830484A20Rik RIKEN cDNA 5830484A20 1.2 0.5 BG072319 gene5830484A20Rik 5830484A20Rik RIKEN cDNA 5830484A20 4.8 2.0 AW909306 gene9130002C22Rik 9130002C22Rik RIKEN cDNA 9130002C22 24.4 6.4 BM243571 gene9130019I15Rik 9130019I15Rik RIKEN cDNA 9130019I15 46.3 13.7 AK018636gene 9130022K13Rik 9130022K13Rik RIKEN cDNA 9130022K13 5.6 1.3 AK018646gene — 9130430L19Rik Mus musculus adult male 1.5 0.7 AK020296 cecumcDNA, RIKEN full- length enriched library, clone: 9130430L19 product:unknown EST, full insert sequence 9230105E10Rik 9230105E10Rik RIKEN cDNA9230105E10 3.6 0.6 BB433710 gene 9330177P20Rik 9330177P20Rik RIKEN cDNA9330177P20 1.3 0.6 BB375580 gene — 9530028C05 Mus musculus adult male3.9 1.7 BQ175154 testis cDNA, RIKEN full- length enriched library,clone: 4921508F21 product: similar to HISTOCOMPATIBILITY 2, CLASS IIANTIGEN E BETA [Mus musculus], full insert sequence — 9530028C05 Musmusculus adult male 4.6 2.0 BQ175154 testis cDNA, RIKEN full- lengthenriched library, clone: 4921508F21 product: similar toHISTOCOMPATIBILITY 2, CLASS II ANTIGEN E BETA [Mus musculus], fullinsert sequence A030012M09Rik A030012M09Rik RIKEN cDNA A030012M09 0.90.4 BB549335 gene A130015N09Rik A130015N09Rik RIKEN cDNA A130015N09 0.50.2 AI647939 gene — A330042I21Rik Mus musculus adult male 3.6 0.4BB187486 spinal cord cDNA, RIKEN full- length enriched library, clone:A330042I21 product: unknown EST, full insert sequence — A330042I21RikMus musculus adult male 3.6 0.4 AI645293 spinal cord cDNA, RIKEN full-length enriched library, clone: A330042I21 product: unknown EST, fullinsert sequence A530088I07Rik A530088I07Rik RIKEN cDNA A530088I07 1.80.3 BB637972 gene A630024B12Rik A630024B12Rik RIKEN cDNA A630024B12 1.20.3 BB240995 gene A630077B13Rik A630077B13Rik RIKEN cDNA A630077B13183.1 1.5 BB239429 gene AA960558 AA960558 expressed sequence 1.4 0.7BB277078 AA960558 Abca13 Abca13 ATP-binding cassette, sub- 0.9 0.2BB503961 family A (ABC1), member 13 Abcc2 Abcc2 ATP-binding cassette,sub- 0.4 0.1 NM_013806 family C (CFTR/MRP), member 2 Acas2 Acas2acetyl-Coenzyme A 0.3 0.1 NM_019811 synthetase 2 (ADP forming) Adamts15Adamts15 a disintegrin-like and 0.3 0.1 AV228731 metalloprotease(reprolysin type) with thrombospondin type 1 motif, 15 Agtrap Agtrapangiotensin II, type I receptor- 0.8 0.2 NM_009642 associated proteinAI447904 AI447904 expressed sequence 70.3 9.7 BM241008 AI447904 AI447904AI447904 expressed sequence 26.2 7.6 BM241008 AI447904 — AI451557 Musmusculus transcribed 24.1 3.1 AV277444 sequences LOC226691 AI607873interferon-activatable protein 28.9 9.7 AI607873 AI649392 AI649392expressed sequence 0.9 0.4 BB496366 AI649392 AI788959 AI788959 expressedsequence 0.7 0.1 BC028826 AI788959 AI848100 AI848100 expressed sequence0.9 0.4 BB148987 AI848100 Aif1 Aif1 allograft inflammatory factor 1 36.59.1 NM_019467 4930502N02Rik Ak7 RIKEN cDNA 4930502N02 2.5 0.4 AV256298gene Akr1c20 Akr1c20 aldo-keto reductase family 1, 8.0 2.0 BC021607member C20 Akr1c21 Akr1c21 aldo-keto reductase family 1, 0.5 0.1AW146041 member C21 Aldh1a1 Aldh1a1 aldehyde dehydrogenase 0.5 0.1NM_013467 family 1, subfamily A1 Aldh1b1 Aldh1b1 aldehyde dehydrogenase1 2.7 1.2 BC020001 family, member B1 Aldh8a1 Aldh8a1 aldehydedehydrogenase 8 0.3 0.1 BC013511 family, member A1 2810455B10RikAls2cr19 RIKEN cDNA 2810455B10 1.0 0.4 AK008055 gene Amacr Amacralpha-methylacyl-CoA 0.2 0.0 NM_008537 racemase — Ankib1 Mus musculus 16days 0.9 0.3 BB373816 embryo head cDNA, RIKEN full-length enrichedlibrary, clone: C130072C03 product: hypothetical protein, full insertsequence Apg12l Apg12l autophagy 12-like (S. cerevisiae) 0.9 0.4AK016474 App App amyloid beta (A4) precursor 2.3 0.7 AV348729 proteinArhgap15 Arhgap15 Rho GTPase activating 1.9 0.8 AK018058 protein 15Arhgap18 Arhgap18 Rho GTPase activating 0.4 0.2 BE307291 protein 18Arl2bp Arl2bp ADP-ribosylation factor-like 2 0.9 0.4 NM_024191 bindingprotein 1200015K23Rik Armc8 RIKEN cDNA 1200015K23 1.2 0.5 BE995635 geneArts1 Arts1 type 1 tumor necrosis factor 4.8 1.9 NM_030711 receptorshedding aminopeptidase regulator Arts1 Arts1 type 1 tumor necrosisfactor 4.1 1.2 AV287655 receptor shedding aminopeptidase regulator Asb13Asb13 ankyrin repeat and SOCS 0.8 0.4 AF403041 box-containing protein 13Asb13 Asb13 ankyrin repeat and SOCS 0.9 0.4 AF403041 box-containingprotein 13 A330005H02Rik Atp11c RIKEN cDNA A330005H02 0.7 0.2 BB184010gene Atp1a3 Atp1a3 ATPase, Na+/K+ transporting, 1.2 0.5 BC020177 alpha 3polypeptide Atp6v1e1 Atp6v1e1 ATPase, H+ transporting, V1 0.7 0.4 C85064subunit E isoform 1 — AW112010 Mus musculus transcribed 32.5 4.1BE688358 sequences B230106I24Rik B230106I24Rik RIKEN cDNA B230106I24 0.80.3 AV369935 gene B230106I24Rik B230106I24Rik RIKEN cDNA B230106I24 1.00.5 AV369935 gene B2m B2m beta-2 microglobulin 11.6 2.0 AA170322 B3galt5B3galt5 UDP-Gal: betaGlcNAc beta 0.4 0.2 NM_0331491,3-galactosyltransferase, polypeptide 5 Bak1 Bak1BCL2-antagonist/killer 1 2.1 0.5 AF402617 BC005471 BC005471 cDNAsequence BC005471 1.5 0.7 BC005471 BC010462 BC010462 cDNA sequenceBC010462 3.5 0.3 BC010462 BC013712 BC013712 cDNA sequence BC013712 12.34.1 BB262491 BC014805 BC014805 cDNA sequence BC014805 0.7 0.2 AJ132857BC022687 BC022687 cDNA sequence BC022687 0.3 0.2 BC022687 BC023105BC023105 cDNA sequence BC023105 70.3 0.7 BC023105 BC026585 BC026585 cDNAsequence BC026585 0.2 0.1 BC026585 L259 BC028528 L259 4.1 1.8 BC0285282310015I10Rik Brd4 RIKEN cDNA 2310015I10 13.8 2.8 BC008532 gene C1r C1rcomplement component 1, r 9.4 3.8 NM_023143 subcomponent C1s C1scomplement component 1, s 12.7 2.8 BC022123 subcomponent C2 C2complement component 2 3.5 0.9 NM_013484 (within H—2S) — C2 — 4.6 0.9AV290571 — C2 — 4.4 1.1 AV227574 C230080I20Rik C230080I20Rik RIKEN cDNAC230080I20 0.6 0.2 BB795533 gene C2ta C2ta class II transactivator 13.21.6 AF042158 C2ta C2ta class II transactivator 10.8 1.5 AF042158C330005L02Rik C330005L02Rik RIKEN cDNA C330005L02 0.9 0.4 BE134115 geneC6.1A C6.1A c6.1a protein 0.9 0.5 AI462244 — C730040L01Rik Mus musculus10 days 1.3 0.2 BB391874 neonate cortex cDNA, RIKEN full-length enrichedlibrary, clone: A830089I03 product: hypothetical KRAB box containingprotein, full insert sequence Car5b Car5b carbonic anhydrase 5b, 1.1 0.4NM_019513 mitochondrial Card11 Card11 caspase recruitment domain 4.6 2.0AV095659 family, member 11 Casp1 Casp1 caspase 1 9.4 2.2 BC008152 Casp12Casp12 caspase 12 3.6 1.7 NM_009808 Casp4 Casp4 caspase 4,apoptosis-related 13.6 6.8 NM_007609 cysteine protease Cbs Cbscystathionine beta-synthase 0.6 0.1 BC026595 Cbx5 Cbx5 chromobox homolog5 0.9 0.4 NM_007626 (Drosophila HP1a) Ccl19 Ccl19 chemokine (C-C motif)ligand 1.8 0.1 NM_011888 19 Ccl21a Ccl21a chemokine (C-C motif) ligand0.9 0.1 NM_011335 21a (serine) — Ccl27 — 0.7 0.1 BQ174669 Ccl27 Ccl27chemokine (C-C motif) ligand 0.6 0.2 NM_011336 27 Ccl28 Ccl28 chemokine(C-C motif) ligand 0.9 0.0 BG867337 28 Ccl28 Ccl28 chemokine (C-C motif)ligand 1.1 0.3 BE196980 28 Ccl28 Ccl28 chemokine (C-C motif) ligand 0.90.1 BG867337 28 Ccl5 Ccl5 chemokine (C-C motif) ligand 5 140.5 9.6NM_013653 Ccl8 Ccl8 chemokine (C-C motif) ligand 8 16.0 6.2 NM_021443Ccr9 Ccr9 chemokine (C-C motif) 2.1 0.6 NM_009913 receptor 9 Mox2 Cd200antigen identified by 2.2 1.0 AF004023 monoclonal antibody MRC OX-2 Cd86Cd86 CD86 antigen 10.4 4.5 NM_019388 — Cdca3 — 1.7 0.7 AV352659 Cds1Cds1 CDP-diacylglycerol synthase 1 2.0 0.9 BI152841 4932437H03 Cenpjhypothetical protein 1.2 0.6 BG068259 4932437H03 Chpt1 Chpt1 cholinephosphotransferase 1 0.5 0.2 BC016251 Clrf Clec2h; Clrf C-type lectinrelated f 0.1 0.0 AK017207 Clic5 Clic5 chloride intracellular channel 50.7 0.1 BB610000 Clic5 Clic5 chloride intracellular channel 5 0.8 0.2AA210377 Clic5 Clic5 chloride intracellular channel 5 1.1 0.2 BB028501Clrf Clrf C-type lectin related f 0.2 0.0 AF350410 Cml5 Cml5camello-like 5 0.6 0.2 BC024605 Arvcf Comt armadillo repeat gene deleted0.8 0.2 NM_007744 in velo-cardio-facial syndrome Cpeb4 Cpeb4 cytoplasmicpolyadenylation 0.9 0.4 NM_026252 element binding protein 4 — Cpt2 — 1.10.5 AV236319 Csprs Csprs component of Sp100-rs 1.4 0.1 NM_033616 CsprsCsprs component of Sp100-rs 1.8 0.1 BB148221 2210401K11Rik Ctbs RIKENcDNA 2210401K11 0.6 0.3 BC022594 gene 2210401K11Rik Ctbs RIKEN cDNA2210401K11 0.8 0.4 BC022594 gene Cxcl10 Cxcl10 chemokine (C—X—C motif)81.6 3.1 NM_021274 ligand 10 Cxcl11 Cxcl11 chemokine (C—X—C motif) 99.23.6 NM_019494 ligand 11 Cxcl9 Cxcl9 chemokine (C—X—C motif) 176.4 0.2NM_008599 ligand 9 Cxcr3 Cxcr3 chemokine (C—X—C motif) 10.2 2.6NM_009910 receptor 3 Cybb Cybb cytochrome b-245, beta 14.2 5.9 NM_007807polypeptide Cyp4v3 Cyp4v3 cytochrome P450, family 4, 3.9 1.8 NM_133969subfamily v, polypeptide 3 — D030011O10Rik Mus musculus transcribed 0.60.3 BE994639 sequence with weak similarity to protein pir: T17242 (H.sapiens) T17242 hypothetical protein DKFZp586B1417.1 - human (fragment)D11Ertd759e D11Ertd759e DNA segment, Chr 11, 4.9 1.8 AW556558 ERATO Doi759, expressed D11Lgp2e D11Lgp2e DNA segment, Chr 11, Lothar 6.1 0.6NM_030150 Hennighausen 2, expressed D11Lgp2e D11Lgp2e DNA segment, Chr11, Lothar 10.0 2.3 AF316999 Hennighausen 2, expressed — D12Ertd551e Musmusculus adult male 5.5 2.3 BQ175646 tongue cDNA, RIKEN full- lengthenriched library, clone: 2310058N22 product: unknown EST, full insertsequence D12Ertd647e D12Ertd647e DNA segment, Chr 12, 5.8 1.8 AW554405ERATO Doi 647, expressed D12Ertd647e D12Ertd647e DNA segment, Chr 12,4.1 1.4 BI655075 ERATO Doi 647, expressed — D12Ertd771e Mus musculus 13days 1.3 0.6 BB392503 embryo male testis cDNA, RIKEN full-lengthenriched library, clone: 6030490B17 product: unknown EST, full insertsequence D5Ertd135e D5Ertd135e DNA segment, Chr 5, ERATO 0.5 0.3BB401993 Doi 135, expressed D7Bwg0421e D7Bwg0421e DNA segment, Chr 7,8.1 2.7 BB667693 Brigham & Women's Genetics 0421 expressed 2210404A22RikD8Ertd594e RIKEN cDNA 2210404A22 0.9 0.3 AK008821 gene Ddx47 Ddx47 DEAD(Asp-Glu-Ala-Asp) box 0.4 0.1 BB305306 polypeptide 47 Defcr9 Defcr9defensin related cryptdin 9 1.4 0.5 U03065 Dnase1l3 Dnase1l3deoxyribonuclease 1-like 3 6.4 0.4 BC012671 Dnase1l3 Dnase1l3deoxyribonuclease 1-like 3 8.8 0.9 BC012671 D14Wsu89e Dock9 DNA segment,Chr 14, 0.6 0.2 BB795072 Wayne State University 89, expressed Dsg2 Dsg2desmoglein 2 1.9 0.9 C79957 Dsg2 Dsg2 desmoglein 2 1.3 0.6 AB072269 —Dtx3l Mus musculus transcribed 9.1 2.1 AV327407 sequence with weaksimilarity to protein ref: NP_081764.1 (M. musculus) RIKEN cDNA5730493B19 [Mus musculus] E130309F12Rik E130309F12Rik RIKEN cDNAE130309F12 0.7 0.0 BB523550 gene E430019B13Rik E430019B13Rik RIKEN cDNAE430019B13 2.2 0.9 BE630983 gene 1300018P11Rik Eif4e3 RIKEN cDNA1300018P11 5.1 2.4 BC027014 gene 2810013J18Rik Eme2 RIKEN cDNA2810013J18 1.0 0.4 AK012738 gene Entpd5 Entpd5 ectonucleosidetriphosphate 0.4 0.2 NM_007647 diphosphohydrolase 5 Entpd5 Entpd5ectonucleoside triphosphate 0.4 0.2 NM_007647 diphosphohydrolase 5Entpd5 Entpd5 ectonucleoside triphosphate 0.4 0.2 AF136571diphosphohydrolase 5 Entpd5 Entpd5 ectonucleoside triphosphate 0.5 0.2NM_007647 diphosphohydrolase 5 2310046K10Rik Epsti1 RIKEN cDNA2310046K10 13.4 3.8 AK017174 gene Etv1 Etv1 ets variant gene 1 0.4 0.1NM_007960 2610104C07Rik Exosc1 RIKEN cDNA 2610104C07 1.2 0.6 BC024423gene Fabp7 Fabp7 fatty acid binding protein 7, 5.2 0.3 NM_021272 brain1110064L07Rik Fbxw17 RIKEN cDNA 1110064L07 4.8 2.3 AV016303 gene Fcrl3Fcrl3 Fc receptor-like 3 20.5 5.4 BC027310 Fgl2 Fgl2 fibrinogen-likeprotein 2 28.1 3.9 BF136544 Fgl2 Fgl2 fibrinogen-like protein 2 46.7 5.6BF136544 1110008K06Rik Fln29 RIKEN cDNA 1110008K06 4.0 1.6 AK003586 geneFmo4 Fmo4 flavin containing 0.4 0.0 AF461145 monooxygenase 4 Fmo5 Fmo5flavin containing 0.3 0.1 NM_010232 monooxygenase 5 Fmr1 Fmr1 fragile Xmental retardation 1.2 0.6 AF461114 syndrome 1 homolog 6030440G05RikFrmd4b RIKEN cDNA 6030440G05 0.7 0.3 BM119551 gene — Gabra2 Mus musculustranscribed 0.9 0.4 BB433285 sequences A530057M15Rik Galm RIKEN cDNAA530057M15 0.6 0.3 AV307219 gene Gbp2 Gbp2 guanylate nucleotide binding53.4 2.3 BE197524 protein 2 Gbp2 Gbp2 guanylate nucleotide binding 100.22.9 NM_010260 protein 2 Gbp3 Gbp4 guanylate nucleotide binding 42.9 7.5NM_018734 protein 3 Gca Gca grancalcin 1.2 0.5 BC021450 Gca Gcagrancalcin 1.5 0.4 BC021450 Ghr Ghr growth hormone receptor 0.5 0.2M33324 Ian1 Gimap4 immune associated 3.0 1.1 BC005577 nucleotide 1 Ian1Gimap4 immune associated 2.4 0.9 BC005577 nucleotide 1 Ian3 Gimap7immune associated 14.1 5.4 BC026200 nucleotide 3 Glipr1 Glipr1 GLIpathogenesis-related 1 14.8 7.4 BC025083 (glioma) Gnb4 Gnb4 guaninenucleotide binding 2.1 1.0 BI713933 protein, beta 4 Gpr1 Gpr1 Gprotein-coupled receptor 1 1.2 0.5 AW541072 Gpr18 Gpr18 Gprotein-coupled receptor 18 9.9 3.4 BG145550 1810036L03Rik Gsdmdc1 RIKENcDNA 1810036L03 6.5 2.5 AK007710 gene Gstt2 Gstt2 glutathioneS-transferase, 0.7 0.3 BC012707 theta 2 Gzmk Gzmk granzyme K 14.1 3.9AB032200 H28 H28 histocompatibility 28 1.6 0.5 NM_031367 H28 H28histocompatibility 28 6.8 1.1 BC024930 H28 H28 histocompatibility 28 8.91.1 NM_031367 — H2-Aa — 46.1 10.5 AV086906 H2-Ab1 H2-Ab1histocompatibility 2, class II 13.2 4.0 NM_010379 antigen A, beta 1H2-Bl H2-Bl histocompatibility 2, 1.6 0.5 NM_008199 blastocyst H2-D1H2-D1 histocompatibility 2, D region 6.2 0.0 NM_010380 locus 1 H2-DMb1H2-DMb1 histocompatibility 2, class II, 19.8 3.8 NM_010387 locus Mb1H2-DMb1 H2-DMb1 histocompatibility 2, class II, 38.0 4.3 NM_010388 locusMb1 H2-DMb1 H2-DMb1 histocompatibility 2, class II, 45.2 4.8 BB734586locus Mb1 H2-K H2-K1 histocompatibility 2, K region 22.5 7.1 L23495 —H2-K1 MHC I = H-2Kd homolog 45.5 10.8 S70184 {alternatively spliced,deletion of exon 3} [mice, DBA/2, L1210 lymphoma, mRNA Mutant, 855 nt]H2-M3 H2-M3 histocompatibility 2, M region 4.8 2.0 NM_013819 locus 3H2-Oa H2-Oa histocompatibility 2, O region 6.1 1.4 NM_008206 alpha locusH2-Ob H2-Ob histocompatibility 2, O region 4.4 1.1 BG144448 beta locusH2-Q1 H2-Q1 histocompatibility 2, Q region 22.6 3.1 BC010602 locus 1H2-Q7 H2-Q7 histocompatibility 2, Q region 78.5 24.8 M29881 locus 7H2-T10 H2-T10 histocompatibility 2, T region 4.3 0.7 NM_010395 locus 10H2-T23 H2-T23 histocompatibility 2, T region 8.0 0.9 NM_010398 locus 23— H2-T23 Mus musculus 2 days 6.6 1.3 NM_010398 neonate thymus thymiccells cDNA, RIKEN full-length enriched library, clone: C920026N01product: weakly similar to H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-37ALPHA CHAIN PRECURSOR [Mus musculus], full insert sequence H2-T24 H2-T24histocompatibility 2, T region 3.1 0.6 L22338 locus 24 Hadhsc HadhscL-3-hydroxyacyl-Coenzyme A 0.4 0.1 BB114220 dehydrogenase, short chainHdc Hdc histidine decarboxylase 0.9 0.1 BG072171 Hdc Hdc histidinedecarboxylase 0.9 0.1 AF109137 Helic1 Helic1 helicase, ATP binding 1 1.40.6 BB501662 2510038N07Rik Herc5 RIKEN cDNA 2510038N07 20.4 1.2 AI639807gene 2510038N07Rik Herc5 RIKEN cDNA 2510038N07 18.0 2.0 AK015214 gene2510038N07Rik Herc5 RIKEN cDNA 2510038N07 12.8 1.0 AI639807 gene2510038N07Rik Herc5 RIKEN cDNA 2510038N07 25.4 1.9 AW208668 gene — Hk3 —14.9 4.0 BB324660 — Hnrpm Mus musculus transcribed 0.9 0.4 AW493461sequences Hpse Hpse heparanase 22.8 11.4 BG094050 Hrasls3 Hrasls3 HRASlike suppressor 3 16.5 0.8 BC024581 Hsd11b1 Hsd11b1 hydroxysteroid11-beta 0.3 0.2 NM_008288 dehydrogenase 1 Hsf2bp Hsf2bp heat shocktranscription factor 0.6 0.2 AK016553 2 binding protein Icsbp1 Icsbp1interferon consensus 9.9 2.8 BG069095 sequence binding protein 1 Icsbp1Icsbp1 interferon consensus 10.0 3.7 BG069095 sequence binding protein 1Idh1 Idh1 isocitrate dehydrogenase 1 0.8 0.3 AI788952 (NADP+), solubleIfi1 Ifi1 interferon inducible protein 1 15.4 1.1 NM_008326 Ifi202bIfi202b interferon activated gene 42.5 5.8 AV229143 202B Ifi202b Ifi202binterferon activated gene 46.5 3.2 NM_011940 202B Ifi203 Ifi203interferon activated gene 203 17.8 8.8 NM_008328 Ifi203 Ifi203interferon activated gene 203 9.1 2.7 BC008167 Ifi16 Ifi204 interferon,gamma-inducible 24.8 5.5 NM_008329 protein 16 Ifi205 Ifi205 interferonactivated gene 205 151.7 40.3 M74124 Ifi205 Ifi205 interferon activatedgene 205 102.7 10.1 AI481797 Ifi205 Ifi205 interferon activated gene 20579.7 13.6 AI481797 2010008K16Rik Ifi35 RIKEN cDNA 2010008K16 4.5 1.7BC008158 gene 2010008K16Rik Ifi35 RIKEN cDNA 2010008K16 6.0 2.3 AW986054gene A430056A10Rik Ifi44 RIKEN cDNA A430056A10 5.0 0.7 BB329808 gene9130009C22Rik Ifih1 RIKEN cDNA 9130009C22 5.4 1.7 AY075132 gene Ifit1Ifit1 interferon-induced protein 18.5 3.5 NM_008331 withtetratricopeptide repeats 1 Ifit2 Ifit2 interferon-induced protein 33.82.0 NM_008332 with tetratricopeptide repeats 2 Ifit3 Ifit3interferon-induced protein 6.3 0.6 NM_010501 with tetratricopeptiderepeats 3 Ifng Ifng interferon gamma 30.3 2.5 K00083 Igf1 Igf1insulin-like growth factor 1 2.7 1.1 NM_010512 Igf1 Igf1 insulin-likegrowth factor 1 2.0 0.9 BG075165 Igh-6 Igh-6 immunoglobulin heavy chain6.0 1.9 AI326478 6 (heavy chain of IgM) Igk-V1 Igk-V1 immunoglobulinkappa chain 1.4 0.2 U29768 variable 1 (V1) Igk-V8 Igk-V8 immunoglobulinkappa chain 1.5 0.2 BI107286 variable 8 (V8) Igsf7 Igsf7 immunoglobulinsuperfamily, 7.0 3.4 AF251705 member 7 Igtp Igtp interferon gammainduced 25.9 0.8 NM_018738 GTPase — Igtp Mus musculus 13 days 14.3 1.0BB485297 embryo lung cDNA, RIKEN full-length enriched library, clone:D430030N05 product: unknown EST, full insert sequence AI481100 Igtpexpressed sequence 30.9 1.2 NM_019440 AI481100 AW111922 Iigp1 expressedsequence 36.6 0.6 BM239828 AW111922 AW111922 Iigp1 expressed sequence53.7 0.7 BM239828 AW111922 Il12b Il12b interleukin 12b 1.7 0.3 AF128214Il12rb1 Il12rb1 interleukin 12 receptor, beta 1 5.5 2.6 NM_008353 Il15Il15 interleukin 15 1.0 0.2 NM_008357 Il18 Il18 interleukin 18 2.1 0.9NM_008360 Il18bp Il18bp interleukin 18 binding protein 33.6 1.5 AF110803Temt Inmt thioether S-methyltransferase 0.2 0.0 NM_009349 B430217B02RikIrf1 RIKEN cDNA B430217B02 15.7 2.2 NM_008390 gene Irf7 Irf7 interferonregulatory factor 7 9.8 2.9 NM_016850 Irg1 Irg1 immunoresponsive gene 180.3 31.1 L38281 Itga4 Itga4 integrin alpha 4 8.5 3.3 NM_010576 Itm2aItm2a integral membrane protein 2A 1.1 0.5 BI966443 Itm2a Itm2a integralmembrane protein 2A 1.0 0.4 BI966443 Itpka Itpka inositol1,4,5-trisphosphate 3- 1.7 0.9 BC027291 kinase A Klra2 Klra2 killer celllectin-like receptor, 14.3 2.5 NM_008462 subfamily A, member 2 Klra7Klra7 killer cell lectin-like receptor, 7.9 1.8 U10095 subfamily A,member 7 Klra8 Klra8 killer cell lectin-like receptor, 5.5 0.9 U12889subfamily A, member 8 Klra3 Klra9 killer cell lectin-like receptor, 6.51.9 U49865 subfamily A, member 3 Klrb1d Klrb1d killer cell lectin-likereceptor 4.6 1.3 AF342896 subfamily B member 1D Klrb1d Klrb1d killercell lectin-like receptor 9.8 3.3 NM_008526 subfamily B member 1D Klrc1Klrc1 killer cell lectin-like receptor 19.3 7.6 AF106009 subfamily C,member 1 Klrk1 Klrk1 killer cell lectin-like receptor 21.5 3.5 AF039026subfamily K, member 1 D7Bwg0421e Lair1 DNA segment, Chr 7, 11.9 4.0AK017222 Brigham & Women's Genetics 0421 expressed — Leprel1 Musmusculus 12 days 0.9 0.4 BB105009 embryo embryonic body betweendiaphragm region and neck cDNA, RIKEN full- length enriched library,clone: 9430093N11 product: unknown EST, full insert sequence Letm1 Letm1leucine zipper-EF-hand 0.6 0.3 BG060855 containing transmembrane protein1 Lgals8 Lgals8 lectin, galactose binding, 1.1 0.5 AI987967 soluble 8 —Lmtk2 Mus musculus transcribed 1.2 0.3 BB449235 sequence with strongsimilarity to protein sp: P00722 (E. coli) BGAL_ECOLI Beta-galactosidase (Lactase) LOC207685 LOC207685 hypothetical protein 2.7 0.5AK008551 LOC207685 LOC209387 LOC209387 tripartite motif protein 30-like20.2 7.5 BM241342 LOC223672 LOC223672 hypothetical protein 25.0 0.7BC020489 LOC223672 Ly6c Ly6c lymphocyte antigen 6 2.8 1.0 NM_010741complex, locus C Ly6i Ly6i lymphocyte antigen 6 15.4 0.4 AF232024complex, locus I Ly86 Ly86 lymphocyte antigen 86 24.1 11.6 NM_0107452410018D16Rik Mat2b RIKEN cDNA 2410018D16 1.0 0.5 NM_134017 gene —MDABG2-4 Mus musculus nucleosome- 2.0 0.6 AB007986 reactive monoclonalantibody PR1-3, Ig light chain variable region mRNA, partial cds. Mgat3Mgat3 mannoside 0.2 0.1 NM_010795 acetylglucosaminyltransferase 3MGC25972 MGC25972 similar to cytochrome P450, 0.4 0.1 BC025936 4a10 Mia2Mia2 melanoma inhibitory activity 2 0.9 0.3 AF390177 — Mpa2l Musmusculus transcribed 72.1 1.7 BG092512 sequences — Mpa2l Mus musculustranscribed 118.4 1.5 BM241485 sequence with weak similarity to proteinsp: P32456 (H. sapiens) GBP2_HUMAN Interferon-induced guanylate- bindingprotein 2 (Guanine nucleotide-binding protein 2) Mpeg1 Mpeg1 macrophageexpressed gene 1 22.7 6.9 L20315 Ms4a1 Ms4a1 membrane-spanning 4- 4.02.0 BB236617 domains, subfamily A, member 1 Ms4a4b Ms4a4bmembrane-spanning 4- 56.0 11.5 BB199001 domains, subfamily A, member 4BMs4a4d Ms4a4d membrane-spanning 4- 12.6 0.7 NM_025658 domains, subfamilyA, member 4D Ms4a6b Ms4a6b membrane-spanning 4- 45.7 15.7 NM_027209domains, subfamily A, member 6B Ms4a6c Ms4a6c membrane-spanning 4- 14.85.8 AF237910 domains, subfamily A, member 6C Mtac2d1 Mtac2d1 membranetargeting (tandem) 0.4 0.1 BB548141 C2 domain containing 1 Mtap7 Mtap7microtubule-associated 1.2 0.6 AK006385 protein 7 Mx1 Mx1 myxovirus(influenza virus) 6.9 1.8 M21039 resistance 1 — Net1 Mus musculustranscribed 4.1 1.2 AV247312 sequences Ngfr Ngfr nerve growth factorreceptor 8.3 3.1 BB151515 (TNFR superfamily, member 16) Nmi Nmi N-myc(and STAT) interactor 6.7 1.4 BC002019 Nt5c2 Nt5c2 5′-nucleotidase,cytosolic II 1.1 0.4 BI202534 Nt5c2 Nt5c2; GMP; 5′-nucleotidase,cytosolic II 1.6 0.7 BC006028 NT5B; PNT5; cN-II; 2010002I23Rik Oas1gOas1a 2′-5′ oligoadenylate 6.9 2.4 BC018470 synthetase 1G Oasl2 Oasl22′-5′ oligoadenylate 17.4 1.9 BQ033138 synthetase-like 2 Og9x Og9x OG9homeobox gene 0.7 0.4 BB705267 BC047207 Olfml1 cDNA sequence BC0472070.7 0.3 BB055163 Olfr56 Olfr56 olfactory receptor 56 39.5 2.3 NM_008330A130090K04Rik Oprm1 RIKEN cDNA A130090K04 1.3 0.4 BB703415 geneA130090K04Rik Oprm1 RIKEN cDNA A130090K04 3.1 1.1 BQ176089 gene Osbpl6Osbpl6 oxysterol binding protein-like 6 0.5 0.2 BG070848 Paip1 Paip1polyadenylate binding protein- 0.8 0.1 BB381990 interacting protein 1Paip1 Paip1 polyadenylate binding protein- 0.9 0.0 BC019726 interactingprotein 1 5330431N24Rik Parp11 RIKEN cDNA 5330431N24 3.1 1.3 BB026163gene BC021340 Parp14 cDNA sequence BC021340 16.1 3.0 BC021340 Adprtl3Parp3 ADP-ribosyltransferase 2.6 0.8 BC014870 (NAD+; poly (ADP-ribosepolymerase)-like 3 Adprtl3 Parp3 ADP-ribosyltransferase 2.1 1.0 AW990611(NAD+; poly (ADP-ribose polymerase)-like 3 BC003281 Parp9 cDNA sequenceBC003281 12.0 2.9 NM_030253 1110035O14Rik Pbef1 RIKEN cDNA 1110035O142.4 1.0 AW989410 gene Pclo Pclo piccolo (presynaptic 0.6 0.1 AW493746cytomatrix protein) Pdcd1lg1 Pdcd1lg1 programmed cell death 1 45.1 4.7NM_021893 ligand 1 Pde9a Pde9a phosphodiesterase 9A 0.6 0.3 NM_008804Pdzk1 Pdzk1; Pdzd1; PDZ domain containing 1 0.4 0.2 AK006269 mPDZK1;D3Ertd537e; 1700023D20Rik; 2610507N21Rik; 4921513F16Rik Peli1 Peli1pellino 1 2.1 1.0 BC016515 4933417L10Rik Phf11 RIKEN cDNA 4933417L10 4.81.1 AV280841 gene Phip Phip pleckstrin homology domain 1.3 0.5 BI737352interacting protein Pigr Pigr polymeric immunoglobulin 4.4 1.7 AV027632receptor Pigr Pigr polymeric immunoglobulin 3.0 1.2 NM_011082 receptor —Pink1 — 0.4 0.2 AV371921 — Plec1 Mus musculus similar to 1.4 0.5BI525140 Plec1 protein (LOC381010), mRNA Pnp Pnp purine-nucleoside 2.20.8 AK008143 phosphorylase Mt1a Polr2k metallothionein-I activator 0.90.4 AA175187 Ppargc1 Ppargc1a peroxisome proliferative 0.5 0.2 BB745167activated receptor, gamma, coactivator 1 — Ppt1 Mus musculus 12 days 3.00.6 BB461203 embryo spinal ganglion cDNA, RIKEN full-length enrichedlibrary, clone: D130070K05 product: unknown EST, full insert sequencePpt1 Ppt1 palmitoyl-protein thioesterase 1 1.0 0.5 AF326558 Prkr Prkrprotein kinase, interferon- 5.0 2.0 BE911144 inducible double strandedRNA dependent — Prok1 Mus musculus 3 days 0.6 0.3 BE651535 neonatethymus cDNA, RIKEN full-length enriched library, clone: A630076J17product: unclassifiable, full insert sequence Psmb10 Psmb10 proteasome(prosome, 14.7 3.6 NM_013640 macropain) subunit, beta type 10 Psmb8Psmb8 proteosome (prosome, 27.5 4.1 NM_010724 macropain) subunit, betatype 8 (large multifunctional protease 7) Psmb8 Psmb8 proteosome(prosome, 24.0 3.4 AV068122 macropain) subunit, beta type 8 (largemultifunctional protease 7) Psmb9 Psmb9 proteosome (prosome, 30.2 2.1NM_013585 macropain) subunit, beta type 9 (large multifunctionalprotease 2) Tap1 Psmb9 transporter 1, ATP-binding 29.5 3.9 AW048052cassette, sub-family B (MDR/TAP) Psme1 Psme1 proteasome (prosome, 3.11.5 NM_011189 macropain) 28 subunit, alpha Psme2 Psme2 proteasome(prosome, 5.3 1.9 NM_011190 macropain) 28 subunit, beta Psme4 Psme4proteasome (prosome, 0.8 0.3 BG075584 macropain) activator subunit 4 —Ptbp2 Mus musculus 16 days 1.3 0.6 BB155176 neonate thymus cDNA, RIKENfull-length enriched library, clone: A130023P20 product: unclassifiable,full insert sequence Ptprcap Ptprcap protein tyrosine phosphatase, 7.53.5 NM_016933 receptor type, C polypeptide- associated protein — PtprkMus musculus transcribed 1.0 0.4 BG802688 sequences 2410027J01Rik QprtRIKEN cDNA 2410027J01 0.6 0.1 AI195046 gene — Rab11fip3 Mus musculus 0day neonate 0.4 0.2 BQ266518 kidney cDNA, RIKEN full- length enrichedlibrary, clone: D630036H09 product: similar to EFERIN [Homo sapiens],full insert sequence Rab17 Rab17 RAB17, member RAS 0.6 0.3 NM_008998oncogene family Rab19 Rab19 RAB19, member RAS 2.8 0.9 BM241400 oncogenefamily Rbl1 Rbl1 retinoblastoma-like 1 (p107) 5.8 2.2 U27177 — Rkhd2 Musmusculus 16 days 0.8 0.2 BB369687 embryo head cDNA, RIKEN full-lengthenriched library, clone: C130049H14 product: unknown EST, full insertsequence 4930474F22Rik Rnase10 RIKEN cDNA 4930474F22 1.2 0.3 AK015573gene Rnaset2 Rnaset2; ribonuclease T2 2.2 0.6 AK015947 RNASE6PL;0610007O07Rik; 4833423A10Rik; 4930532K22Rik Samhd1 Samhd1 SAM domain andHD domain, 1 16.3 5.3 AV376100 Samhd1 Samhd1 SAM domain and HD domain, 111.4 4.1 BF148012 Samhd1 Samhd1 SAM domain and HD domain, 1 11.3 2.7NM_018851 D11Moh48 Scrn2 DNA segment, Chr 11, KL 0.3 0.1 BC021346 Mohlke48 D11Moh48 Scrn2 DNA segment, Chr 11, KL 0.3 0.1 BB735480 Mohlke 48Sec8 Sec8l1 SEC8 (S. cerevisiae) 0.9 0.4 AK010695 Sectm1 Sectm1 secretedand transmembrane 1 3.0 0.0 AI481997 Sell Sell selectin, lymphocyte 14.06.5 M36005 Sell Sell selectin, lymphocyte 9.7 4.7 M36005 Serpina10Serpina10 serine (or cysteine) 44.0 17.5 BC018416 proteinase inhibitor,clade A (alpha-1 antiproteinase, antitrypsin), member 10 Sfrp1 Sfrp1secreted frizzled-related 0.5 0.2 BI658627 sequence protein 1 Sfrp1Sfrp1 secreted frizzled-related 0.5 0.2 BI658627 sequence protein 1 SgcbSgcb sarcoglycan, beta (dystrophin- 0.9 0.3 AK014381 associatedglycoprotein) Slamf7 Slamf7 SLAM family member 7 5.4 1.1 AK016183 Slamf8Slamf8 SLAM family member 8 65.9 9.5 BC024587 1200003C15Rik Slc16a9RIKEN cDNA 1200003C15 0.3 0.1 AK004684 gene 1200003C15Rik Slc16a9 RIKENcDNA 1200003C15 0.4 0.1 AK004684 gene Slc18a1 Slc18a1 solute carrierfamily 18 0.3 0.1 BB011871 (vesicular monoamine), member 1 Slc1a1 Slc1a1solute carrier family 1, 0.5 0.2 AF087578 member 1 Slc1a4 Slc1a4 solutecarrier family 1 1.8 0.6 BB277461 (glutamate/neutral amino acidtransporter), member 4 Slc1a4 Slc1a4 solute carrier family 1 1.5 0.6BB277461 (glutamate/neutral amino acid transporter), member 4 Slc22a5Slc22a5 solute carrier family 22 0.4 0.2 NM_011396 (organic cationtransporter), member 5 Slc26a7 Slc26a7 solute carrier family 26, 0.5 0.2AV292356 member 7 Slc2a5 Slc2a5 solute carrier family 2 0.2 0.0NM_019741 (facilitated glucose transporter), member 5 A230035L05RikSlc41a2 RIKEN cDNA A230035L05 2.3 1.0 BC026874 gene AI315119 Slc5a12expressed sequence 0.3 0.1 BB503566 AI315119 Xtrp2 Slc6a18 X transporterprotein 2 0.7 0.3 AF075266 4632401C08Rik Slc6a19 RIKEN cDNA 4632401C080.4 0.1 AK014544 gene 4632401C08Rik Slc6a19 RIKEN cDNA 4632401C08 0.40.1 BM119683 gene Slco1a1 Slco1a1 solute carrier organic anion 0.2 0.0AB031813 transporter family, member 1a1 Slfn8 Slfn8 schlafen 8 8.6 2.7BC024709 Smpdl3a Smpdl3a sphingomyelin 0.6 0.2 NM_020561phosphodiesterase, acid-like 3A Snx10 Snx10 sorting nexin 10 20.8 8.4AK010399 Sod3 Sod3 superoxide dismutase 3, 0.3 0.1 NM_011435extracellular Sostdc1 Sostdc1 sclerostin domain containing 1 0.4 0.2BC021458 Srd5a2l Srd5a2l steroid 5 alpha-reductase 2- 1.1 0.4 BB825787like — Ss18 Mus musculus transcribed 1.1 0.5 BB199855 sequences — Stat1Mus musculus transcribed 19.6 1.4 BB229853 sequences Stat1 Stat1 signaltransducer and 22.7 1.1 AW214029 activator of transcription 1 Stat1Stat1 signal transducer and 14.1 1.1 AW214029 activator of transcription1 Stat1 Stat1 signal transducer and 23.0 2.0 AW214029 activator oftranscription 1 Stat2 Stat2 signal transducer and 6.1 1.7 AF088862activator of transcription 2 Stat2 Stat2 signal transducer and 3.2 1.3AF088862 activator of transcription 2 4921538B17Rik Steap2 RIKEN cDNA4921538B17 1.2 0.5 BB529332 gene Mrpl16 Stx3 mitochondrial ribosomal 0.60.1 D29800 protein L16 Sult1c1 Sult1c2 sulfotransferase family, 0.5 0.2NM_026935 cytosolic, 1C, member 1 Syn2 Syn2 synapsin II 0.3 0.1NM_013681 Syt1 Syt1 synaptotagmin 1 2.1 0.9 BM118245 Tap2 Tap2transporter 2, ATP-binding 11.2 2.5 BE691515 cassette, sub-family B(MDR/TAP) Tapbp Tapbp TAP binding protein 4.6 1.0 AF043943 Tapbp TapbpTAP binding protein 5.5 2.1 AF043943 LOC213233 Tapbpl similar tohypothetical protein 5.3 1.5 BC017613 FLJ10143 4432405K22Rik Tbc1d15RIKEN cDNA 4432405K22 1.2 0.6 BF577643 gene Tcf7 Tcf7 transcriptionfactor 7, T-cell 13.5 4.5 AI323642 specific — TCR beta-chain M. musculusmRNA for Tcell 8.2 2.4 M87849 receptor, V-J beta junctional region(clone T1CRP8) — Tcra Mus musculus T cell receptor 9.2 3.9 X01134 alphachain variable region (TCRAV3S9) mRNA, partial cds — Tcra Mus musculusadult male 7.7 3.0 U07662 thymus cDNA, RIKEN full- length enrichedlibrary, clone: 5830404G23 product: T- cell receptor alpha chainprecursor V-J region (TA72) (fragment) homolog [Mus musculus], fullinsert sequence — Tcra Mus musculus adult male 1.7 0.7 BB032962 thymuscDNA, RIKEN full- length enriched library, clone: 5830474E17 product: T-cell receptor alpha chain precursor V-J region (TA72) (fragment) homolog[Mus musculus], full insert sequence — Tcrb-J; — 3.1 0.5 AK0180145830405F06Rik Tcrb-V13 Tcrb-V13 T-cell receptor beta, variable 55.0 25.2U07661 13 Tcrb-V13 Tcrb-V13 T-cell receptor beta, variable 55.9 21.5M11456 13 Tcrb-V13 Tcrb-V13 T-cell receptor beta, variable 6.8 1.0U46841 13 Tcrb-V13 Tcrb-V13 T-cell receptor beta, variable 75.1 29.5X67128 13 Tex9 Tex9 testis expressed gene 9 1.3 0.4 AK008505 — Tgfbr2Mus musculus transcribed 2.4 0.6 BB465968 sequences Tgtp Tgtp T-cellspecific GTPase 24.4 1.7 NM_011579 Timp3 Timp3 tissue inhibitor of 0.50.2 BI111620 metalloproteinase 3 Syn2 Timp4 synapsin II 0.5 0.2 AK013810Tlr3 Tlr3 toll-like receptor 3 3.9 1.2 NM_126166 1810015P03Rik Tmed6RIKEN cDNA 1810015P03 0.5 0.2 NM_025458 gene 2810428F02Rik Tmem19 RIKENcDNA 2810428F02 0.8 0.4 AK018383 gene Tmprss4 Tmprss4 transmembraneprotease, 11.7 2.0 BC021368 serine 4 Tnfrsf14 Tnfrsf14 tumor necrosisfactor receptor 10.0 0.9 BC022125 superfamily, member 14 (herpesvirusentry mediator) Tnfrsf5 Tnfrsf5 tumor necrosis factor receptor 15.7 4.4AI385482 superfamily, member 5 Tnfrsf5 Tnfrsf5 tumor necrosis factorreceptor 18.8 7.6 NM_011611 superfamily, member 5 Tnfrsf5 Tnfrsf5 tumornecrosis factor receptor 20.4 6.6 BB220422 superfamily, member 5 Tnfsf10Tnfsf10 tumor necrosis factor (ligand) 5.1 0.4 NM_009425 superfamily,member 10 Top2b Top2b topoisomerase (DNA) II beta 1.8 0.6 BB1665925430425C04Rik Tp53i5 RIKEN cDNA 5430425C04 3.5 1.2 AK017334 gene — Trex1Mus musculus adult female 6.3 2.9 AF140709 vagina cDNA, RIKEN full-length enriched library, clone: 9930022F21 product: similar to G PROTEINCOUPLED RECEPTOR [Mus musculus], full insert sequence Trim12 Trim12tripartite motif protein 12 8.3 2.5 BM244351 Trim21 Trim21 tripartitemotif protein 21 2.3 1.0 BC010580 Trim21 Trim21 tripartite motif protein21 3.9 1.1 BC010580 Trim25 Trim25 tripartite motif protein 25 1.2 0.5AI746456 Trim30 Trim30 tripartite motif protein 30 7.9 2.8 AF2200159230105E10Rik Trim34 RIKEN cDNA 9230105E10 4.5 1.7 BI653857 gene Gtl6Trip12 gene trap locus 6 0.9 0.4 BG923744 E130308C19Rik Tspyl5 RIKENcDNA E130308C19 1.6 0.4 AV332105 gene Tuba8 Tuba8 tubulin, alpha 8 2.91.0 BB047533 Tyki Tyki thymidylate kinase family 1.9 0.5 AK004595LPS-inducible member C330001M22 Ubash3a hypothetical protein 3.1 1.3BB397001 C330001M22 Ubd Ubd ubiquitin D 223.5 3.3 NM_023137 Ubce8 Ube2l6ubiquitin-conjugating enzyme 8 8.7 1.2 BC008238 — Ubr1 Mus musculustranscribed 0.9 0.4 AV299235 sequence with weak similarity to proteinpir: RGECDW (E. coli) RGECDW transcription activator of D-serinedehydratase - Escherichia coli Ugt8 Ugt8 UDP-glucuronosyltransferase 80.5 0.2 NM_011674 Upb1 Upb1 ureidopropionase, beta 0.4 0.1 NM_133995Upp1 Upp1 uridine phosphorylase 1 8.2 2.1 NM_009477 Usp18 Usp18ubiquitin specific protease 18 20.6 1.6 NM_011909 Wars Warstryptophanyl-tRNA synthetase 2.4 0.9 BC003450 Wars Warstryptophanyl-tRNA synthetase 2.7 0.8 BB785450 — Wld — 0.8 0.3 AF260924Wrn Wrn Werner syndrome homolog 1.6 0.5 D86527 (human) Xdh Xdh xanthinedehydrogenase 16.7 6.1 AV286265 — Ywhaq Mus musculus 16 days 1.3 0.5AV024540 neonate thymus cDNA, RIKEN full-length enriched library, clone:A130046D12 product: 14-3-3 PROTEIN TAU (14-3-3 PROTEIN THETA), fullinsert sequence Zbp1 Zbp1 Z-DNA binding protein 1 78.0 3.9 AK008179 Zbp1Zbp1 Z-DNA binding protein 1 118.4 3.0 NM_021394 9430083K24Rik Zbtb5RIKEN cDNA 9430083K24 1.3 0.6 AI267092 gene Zc3hdc1 Zc3hdc1 zinc fingerCCCH type 6.7 2.2 BM227980 domain containing 1 Zfp287 Zfp287 zinc fingerprotein 287 1.4 0.6 BI714160 AI839779 Zfp365 expressed sequence 0.5 0.2AV327248 AI839779 Zfp386 Zfp386 zinc finger protein 386 1.8 0.8NM_019565 (Kruppel-like) 4633401C23Rik Zfp84 RIKEN cDNA 4633401C23 1.30.6 AI465811 gene Znfn1a3 Zfpn1a3 zinc finger protein, subfamily 4.4 1.9BB202216 1A, 3 (Aiolos) Zfr Zfr zinc finger RNA binding 2.6 1.0 BM119505protein — Mus musculus similar to 2- 2.1 0.9 BG070246 cell-stage,variable group, member 3; 2-cell-stage, variable group, member 1(LOC236374), mRNA — — 0.4 0.2 AK016021 — — 9.3 3.4 BB030365 — — 6.8 0.6BB135602 — Mus musculus transcribed 0.7 0.2 BG071026 sequences2210023K21Rik RIKEN cDNA 2210023K21 4.7 2.3 BI106821 gene — — 3.6 1.5AV340322 — Mus musculus transcribed 1.3 0.2 BB738659 sequences — Musmusculus transcribed 0.3 0.1 BM054266 sequence with moderate similarityto protein ref: NP_114409.1 (H. sapiens) hypothetical protein MGC1314similar to fucosidase, alpha-L-1, tissue [Homo sapiens] Vcam1 vascularcell adhesion 19.2 8.8 BB250384 molecule 1 — Mus musculus anti-MUC1 1.50.5 AY058911 antibody SM3 Ig heavy chain variable region mRNA, partialcds — Mus musculus LOC380741 1.6 0.5 BB323723 (LOC380741), mRNA — Musmusculus cDNA clone 0.8 0.2 BB553937 IMAGE: 5151706, partial cds — Musmusculus transcribed 1.5 0.1 BG862223 sequence with moderate similarityto protein pir: A47643 (M. musculus) A47643 hypothetical protein- mouse(fragment) — Mus musculus adult male 1.6 0.7 BB022773 pituitary glandcDNA, RIKEN full-length enriched library, clone: 5330412J20 product:unknown EST, full insert sequence — — 1.4 0.3 BG065699 — Mus musculus 0day neonate 1.5 0.7 AV251099 head cDNA, RIKEN full-length enrichedlibrary, clone: 4833429G05 product: unknown EST, full insert sequence —Mus musculus transcribed 1.1 0.5 BB378649 sequences — Mus musculussimilar to 1.9 0.7 AW123234 transmembrane protein SHREW1 (LOC230959),mRNA — Mus musculus transcribed 0.8 0.3 AV370837 sequence with strongsimilarity to protein sp: P00722 (E. coli) BGAL_ECOLI Beta-galactosidase (Lactase) — — 0.6 0.2 AW319988 — Mus musculus 0 dayneonate 0.5 0.2 BB750877 kidney cDNA, RIKEN full- length enrichedlibrary, clone: D630022F07 product: hypothetical protein, full insertsequence — Mus musculus cDNA clone 3.3 0.8 BC022776 MGC: 6071 IMAGE:3492410, complete cds — Mouse non-productive mRNA 2.1 0.6 NM_011558 forT-cell receptor gamma V5- J1-C1 — — 67.1 8.6 NM_022429 — Mus musculustranscribed 0.7 0.3 AW124641 sequence with strong similarity to proteinsp: P00722 (E. coli) BGAL_ECOLI Beta- galactosidase (Lactase) — Musmusculus transcribed 1.5 0.3 BB436326 sequence with moderate similarityto protein ref: NP_079184.1 (H. sapiens) hypothetical protein FLJ12973[Homo sapiens] — Mus musculus transcribed 1.1 0.1 C77501 sequence withweak similarity to protein ref: NP_443092.1 (H. sapiens) kruppel-likezinc finger protein [Homo sapiens] — Mus musculus transcribed 1.2 0.4BB201888 sequence with moderate similarity to protein pir: R5HU35 (H.sapiens) R5HU35 ribosomal protein L35a - human — Mus musculustranscribed 1.4 0.6 BB343967 sequences Rnaset2 ribonuclease T2 1.7 0.8AV101824 — Mus musculus diabetic 58.3 13.4 BM241271 nephropathy-relatedgene 1 mRNA, partial sequence — Mus musculus transcribed 0.7 0.3BE979870 sequences — Mus musculus transcribed 5.0 1.2 BB534560 sequences— Mus musculus transcribed 1.1 0.4 AV230978 sequences Cxcl9 chemokine(C—X—C motif) 69.4 0.7 BI104444 ligand 9 — Mus musculus adult male 5.52.6 BB214834 aorta and vein cDNA, RIKEN full-length enriched library,clone: A530023D22 product: unclassifiable, full insert sequence Nalp6NACHT, leucine rich repeat 0.6 0.2 BB071996 and PYD containing 6 — Musmusculus 9 days embryo 1.1 0.5 BB442202 whole body cDNA, RIKENfull-length enriched library, clone: D030030M01 product: unknown EST,full insert sequence — Mus musculus transcribed 61.7 0.4 AW111920sequences Clic5 chloride intracellular channel 5 0.9 0.2 BB236747 — Musmusculus adult male 10.9 1.4 BB645745 cortex cDNA, RIKEN full- lengthenriched library, clone: B530033B21 product: unknown EST, full insertsequence — — 1.5 0.1 BG297038 G1p2 interferon, alpha-inducible 16.7 3.0AK019325 protein — Mus musculus adult male 1.4 0.5 AV254764 testis cDNA,RIKEN full- length enriched library, clone: 4921513I01 product: unknownEST, full insert sequence — — 12.6 1.0 BB668084 — — 17.1 0.5 BG072508 —Mus musculus mRNA similar 5.1 0.7 BC020118 to interferon-inducibleGTPase (cDNA clone MGC: 49532 IMAGE: 3495064), complete cds — Musmusculus adult male 0.9 0.1 BB428710 hippocampus cDNA, RIKEN full-lengthenriched library, clone: C630020O05 product: unknown EST, full insertsequence — Mus musculus 0 day neonate 1.5 0.7 BB313276 eyeball cDNA,RIKEN full- length enriched library, clone: E130009O20 product: unknownEST, full insert sequence — Mus musculus adult male 2.3 0.3 BB224338aorta and vein cDNA, RIKEN full-length enriched library, clone:A530086D01 product: unknown EST, full insert sequence Hrasls3 HRAS likesuppressor 3 21.7 1.0 BB404920 — — 4.6 0.8 AV340322

TABLE 4 GRIT expression in WT and GKO grafts ISO D5 ISO D5 vs WT D5 GeneSymbol Gene Title Affymetrix vs NCBA ISO.GKO D5 vs NCBA Iigp1 interferoninducible GTPase 1 27.5 8.1 45.7 Tgtp T-cell specific GTPase 16.6 8.128.4 Mpa2l macrophage activation 2 like 14.9 12.5 92.9 Gbp2 guanylatenucleotide binding protein 2 12.8 33.2 47.7 Gbp2 guanylate nucleotidebinding protein 2 11.5 8.6 76.1 Iigp1 interferon inducible GTPase 1 11.27.4 20.4 Igtp interferon gamma induced GTPase 9.3 4.8 17.8 Cxcl10chemokine (C—X—C motif) ligand 10 7.0 100.9 H2-DMb1 histocompatibility2, class II, locus 6.5 2.6 11.3 Mb1 Gtpi-pending interferon-g inducedGTPase 5.8 5.0 24.7 Ubd ubiquitin D 5.3 4.5 91.8 Psmb8 proteosome(prosome, macropain) 4.8 2.0 25.5 subunit, beta type 8 (largemultifunctional protease 7) Stat1 signal transducer and activator of 3.93.3 11.7 transcription 1 Cxcl9 chemokine (C—X—C motif) ligand 9 3.7 14.799.8 Mpeg1 macrophage expressed gene 1 3.6 16.4 Psmb9 proteosome(prosome, macropain) 3.6 3.9 19.1 subunit, beta type 9 (largemultifunctional protease 2) H2-DMb2 histocompatibility 2, class II,locus 3.4 6.3 13.3 Mb2 Psmb10 proteasome (prosome, macropain) 3.4 3.014.5 subunit, beta type 10 Ifi1 interferon inducible protein 1 3.1 3.98.2 Ifi47 interferon gamma inducible protein 3.1 3.7 21.4 Brd4bromodomain containing 4 3.0 9.4 Ifit2 interferon-induced protein with2.8 2.1 25.1 tetratricopeptide repeats 2 Pdcd1lg1 programmed cell death1 ligand 1 2.7 4.5 29.6 Fgl2 fibrinogen-like protein 2 2.7 14.45033415K03Rik RIKEN cDNA 5033415K03 gene 2.7 17.5 Il18bp interleukin 18binding protein 2.6 6.6 17.3 Stat1 signal transducer and activator of2.6 7.1 7.7 transcription 1 H2-K histocompatibility 2, K region 2.6 4.79.0 Xdh xanthine dehydrogenase 2.6 11.7 Pigr polymeric immunoglobulinreceptor 2.4 6.5 Parp14 poly (ADP-ribose) polymerase family, 2.4 2.711.4 member 14 Ccl5 chemokine (C-C motif) ligand 5 2.4 62.5 34.8BE688358NCBI ESTs 2.2 3.5 16.0 5830458K16Rik RIKEN cDNA 5830458K16 gene2.2 2.1 9.2 H2-T23 histocompatibility 2, T region locus 23 2.2 2.7 7.3Arts1-pending type 1 tumor necrosis factor receptor 2.1 2.8 sheddingaminopeptidase regulator C2ta class II transactivator 2.1 3.8 7.7 Fabp7fatty acid binding protein 7, brain 2.1 2.8 G1p2 interferon,alpha-inducible protein 2.1 8.0 Oasl2 2′-5′ oligoadenylatesynthetase-like 2 1.9 14.7 Ms4a6b membrane-spanning 4-domains, 1.9 14.1subfamily A, member 6B Tapbp TAP binding protein 1.9 2.4 4.6 H2-Ab1histocompatibility 2, class II antigen 1.9 5.0 5.9 A, beta 1 Ms4a4dmembrane-spanning 4-domains, 1.8 3.8 subfamily A, member 4D Zbp1 Z-DNAbinding protein 1 1.8 2.9 12.2 C1s complement component 1, s 1.7 12.7subcomponent Lair1 leukocyte-associated Ig-like receptor 1 1.7 3.3 Ccl8chemokine (C-C motif) ligand 8 1.6 3.1 3.1 Slamf8 Slamf8 1.6 3.4 15.4H2-T10 histocompatibility 2, T region locus 10 1.6 3.5 Serpina10hypothetical protein MGC25863 1.5 8.8 H2-K histocompatibility 2, Kregion 1.5 2.1 14.5 Irf7 interferon regulatory factor 7 1.4 6.4 C1rcomplement component 1, r 1.3 7.4 subcomponent Ifit1 interferon-inducedprotein with 1.3 4.2 5.9 tetratricopeptide repeats 1 Ube1l Ube1l 1.2 4.2Hrasls3 HRAS like suppressor 3 1.0 7.2 C2 complement component 2 (withinH- 0.8 3.1 2S) B2m Beta-2 microglobulin 0.8 5.5

TABLE 5 GRIT-like transcript expression in WT and GKO grafts ISO D5 WTD5 vs ISO D5 vs vs Gene Symbol Gene Title Affymetrix NCBA ISO.GKO NCBAH2-Aa histocompatibility 2, class II antigen A, 5.1 3.8 10.8 alphaMs4a6d membrane-spanning 4-domains, 4.0 21.2 subfamily A, member 6DHist1h2ad histone 1, H2ad 3.4 32.4 H2-DMa histocompatibility 2, classII, locus DMa 3.4 3.6 11.3 Top2a topoisomerase (DNA) II alpha 3.4 8.5H2-Aa histocompatibility 2, class II antigen A, 3.3 3.0 6.8 alpha IiIa-associated invariant chain 3.1 3.5 5.5 Ctss cathepsin S 2.9 8.9 Tgfbitransforming growth factor, beta 2.9 17.3 induced, 68 kDa Ccr5 chemokine(C-C motif) receptor 5 2.5 12.1 H2-Eb1 histocompatibility 2, class IIantigen E 2.5 3.5 6.8 beta C1qb complement component 1, q 2.3 8.7subcomponent, beta polypeptide Ifi27 interferon, alpha-inducible protein27 2.2 3.2 Tgfbi transforming growth factor, beta 2.2 17.2 induced, 68kDa Coro1a coronin, actin binding protein 1A 2.1 35.2 C1qg complementcomponent 1, q 2.1 8.8 subcomponent, gamma polypeptide Coro1a coronin,actin binding protein 1A 2.0 55.3 Gzma granzyme A 1.9 2.7 4.6 Hckhemopoietic cell kinase 1.8 7.0 Ppicap peptidylprolyl isomeraseC-associated 1.7 4.8 protein Serping1 serine (or cysteine) proteinaseinhibitor, 1.7 4.3 clade G, member 1 Itgax integrin alpha X 1.5 2.0 5.9Was Wiskott-Aldrich syndrome homolog 1.4 5.9 (human) Tmsb10 thymosin,beta 10 1.4 6.3 Tgfbi transforming growth factor, beta 1.4 14.0 induced,68 kDa Tmsb10 thymosin, beta 10 1.4 4.1 Epsti1 epithelial stromalinteraction 1 (breast) 1.4 7.6 Ly6f lymphocyte antigen 6 complex, locusF 1.3 2.6 Ifitm3 interferon induced transmembrane 1.3 2.4 protein 3Ifitm6 interferon induced transmembrane 1.3 2.6 protein 6 AW413625expressed sequence AW413625 1.2 2.3 3.7 Tnfsf13b tumor necrosis factor(ligand) 1.2 2.8 superfamily, member 13b AU020206 Mus musculus 3 daysneonate thymus 1.2 5.1 cDNA, RIKEN full-length enriched library, clone:A630040D01 Ifitm1 interferon induced transmembrane 1.2 2.4 2.5 protein 1AI132321 Mus musculus 0 day neonate thymus 1.1 2.3 5.1 cDNA, RIKENfull-length enriched library, clone: A430098J23 Gpm6b glycoprotein m6b1.1 2.3 Cugbp2 CUG triplet repeat, RNA binding protein 2 0.9 3.5 Emr4EGF-like module containing, mucin-like, 0.9 3.0 hormone receptor-likesequence 4 Cxcl14 chemokine (C—X—C motif) ligand 14 0.8 3.0 Socs2suppressor of cytokine signaling 2 0.8 2.2 9230117N10Rik RIKEN cDNA9230117N10 gene 0.7 3.8 Cxcl14 chemokine (C—X—C motif) ligand 14 0.4 7.6

TABLE 6 Transcripts decreased in GKO D5 but not induced by rIFNγ ISO D5WT D5 vs ISO D5 vs vs Gene Symbol Title_Affy NCBA ISO.GKO NCBA5830443L24Rik RIKEN cDNA 5830443L24 gene 8.1 6.8 74.8 BC023105 cDNAsequence BC023105 7.5 20.0 10.9 Cxcl11 chemokine (C—X—C motif) ligand 115.8 2.5 70.4 Ifi202b interferon activated gene 202B 4.9 33.1 Ly86lymphocyte antigen 86 3.4 12.9 Dnr12 Diabetic nephropathy-like protein(Dnr12) 3.1 3.2 20.4 mRNA, partial sequence Ubce8 ubiquitin-conjugatingenzyme 8 3.0 5.7 H2-D1 histocompatibility 2, D region locus 1 3.0 5.17.7 Trim34 tripartite motif protein 34 3.0 9.9 Aif1 allograftinflammatory factor 1 2.8 16.5 Klra2 killer cell lectin-like receptor,subfamily A, 2.7 7.3 member 2 Ptprcap protein tyrosine phosphatase,receptor 2.4 15.9 type, C polypeptide-associated protein Ms4a4cmembrane-spanning 4-domains, 2.4 3.2 14.0 subfamily A, member 4C H28histocompatibility 28 2.3 6.5 BC013712 cDNA sequence BC013712 2.2 2.47.1 Ms4a6c membrane-spanning 4-domains, 2.2 7.3 subfamily A, member 6CH28 Histocompatibility 28 2.2 4.4 H2-Q1 histocompatibility 2, Q regionlocus 1 2.1 5.8 10.9 Tnfrsf5 tumor necrosis factor receptor 2.1 2.6 6.7superfamily, member 5 Ifi205 interferon activated gene 205 2.1 3.6 25.4Vcam1 vascular cell adhesion molecule 1 2.1 2.4 12.5 Sell selectin,lymphocyte 2.0 7.8 Tap2 transporter 2, ATP-binding cassette, sub- 1.92.9 7.4 family B (MDR/TAP) Icsbp interferon concensus sequence binding1.9 8.4 protein Nmi N-myc (and STAT) interactor 1.9 5.4 Tnfsf10 tumornecrosis factor (ligand) 1.8 6.7 superfamily, member 10 Gbp4 guanylatenucleotide binding protein 4 1.8 12.6 Parp9 poly (ADP-ribose) polymerasefamily, 1.7 2.3 8.7 member 9 Ifi205 interferon activated gene 205 1.73.3 15.9 Casp1 caspase 1 1.7 6.6 Irf1 interferon regulatory factor 1 1.72.5 8.7 Igh-6 immunoglobulin heavy chain 6 (heavy 1.7 2.2 4.2 chain ofIgM) Ifit3 interferon-induced protein with 1.7 5.4 tetratricopeptiderepeats 3 Casp11 caspase 11, apoptosis-related cysteine 1.7 8.4 protease(caspase 4 precursor) Usp18 ubiquitin specific protease 18 1.7 8.5Zc3hdc1 hypothetical protein 9930021O16 1.7 5.2 Samhd1 SAM domain and HDdomain, 1 1.7 8.5 Fcrl3 Fc receptor-like 3 1.7 6.6 Oas1g 2′-5′oligoadenylate synthetase 1G 1.6 3.3 Snx10 sorting nexin 10 1.6 14.00610037M15Rik RIKEN cDNA 0610037M15 gene 1.6 6.4 Ifi203 interferonactivated gene 203 1.6 5.7 Stat2 signal transducer and activator of 1.64.4 transcription 2 Gzmk granzyme K 1.6 2.5 Ifi44 interferon-inducedprotein 44 1.5 4.2 IFNg interferon gamma 1.5 8.2 Slamf6 SLAM familymember 6 1.5 2.2 H2-Q7 histocompatibility 2, Q region locus 7 1.5 3.311.2 Il12rb1 interleukin 12 receptor, beta 1 1.5 4.6 Ifi35interferon-induced protein 35 1.5 4.2 Trim30 tripartite motif protein 301.5 4.4 Cybb cytochrome b-245, beta polypeptide 1.5 5.1 H2-M3histocompatibility 2, M region locus 3 1.5 4.4 Glipr1 GLIpathogenesis-related 1 (glioma) 1.4 5.6 Slfn8 schlafen 8 1.4 3.0 Ifih1interferon induced with helicase C 1.4 3.5 domain 1 Trim21 tripartitemotif protein 21 1.4 3.0 Trim21 tripartite motif protein 21 1.4 2.3Stat2 signal transducer and activator of 1.4 8.5 transcription 2 Parp3poly (ADP-ribose) polymerase family, 1.3 4.4 member 3 2610042L04RikRIKEN cDNA 2610042L04 gene 1.3 4.7 H2-T24 histocompatibility 2, T regionlocus 24 1.3 2.5 Slc41a2 solute carrier family 41, member 2 1.3 3.2Sectm1 secreted and transmembrane 1 1.3 3.2 Gimap7 GTPase, IMAP familymember 7 1.3 2.7 6.0 Cyp4v3 cytochrome P450, family 4, subfamily v, 1.32.0 polypeptide 3 Psme2 proteasome (prosome, macropain) 28 1.3 4.2subunit, beta Mx1 myxovirus (influenza virus) resistance 1 1.3 4.5Dnase1l3 deoxyribonuclease 1-like 3 1.3 23.9 Ifi204 interferon activatedgene 204 1.2 2.9 9.0 Tnfrsf5 tumor necrosis factor receptor 1.2 2.8 3.9superfamily, member 5 Wars tryptophanyl-tRNA synthetase 1.2 3.5 Ly6clymphocyte antigen 6 complex, locus C 1.2 2.2 Psme1 proteasome (prosome,macropain) 28 1.2 2.8 subunit, alpha 4930422C14 hypothetical protein4930422C14 1.2 8.2 D11Lgp2e DNA segment, Chr 11, Lothar 1.2 16.8Hennighausen 2, expressed Samhd1 SAM domain and HD domain, 1 1.1 6.9Dnase1l3 deoxyribonuclease 1-like 3 1.1 2.4 Gimap4 GTPase, IMAP familymember 4 1.1 2.4 1110007F12Rik RIKEN cDNA 1110007F12 gene 1.1 3.9 H2-Oahistocompatibility 2, O region alpha locus 1.1 2.7 Pnp purine-nucleosidephosphorylase 1.1 2.4 Rbl1 retinoblastoma-like 1 (p107) 1.1 4.1C920025E04Rik RIKEN cDNA C920025E04 gene 1.1 3.0 Cxcr3 chemokine (C—X—Cmotif) receptor 3 1.1 4.1 Klrk1 killer cell lectin-like receptorsubfamily K, 1.1 3.9 member 1 Icsbp interferon concensus sequencebinding 1.0 2.0 8.1 protein Klra7 killer cell lectin-like receptor,subfamily A, 1.0 2.7 member 7 BC010462 cDNA sequence BC010462 1.0 2.9Pbef-pending pre-B-cell colony-enhancing factor 1.0 2.1 Prkr proteinkinase, interferon-inducible 1.0 3.0 double stranded RNA dependent Warstryptophanyl-tRNA synthetase 1.0 4.0 Asahl N-acylsphingosineamidohydrolase (acid 1.0 2.5 ceramidase)-like Tlr3 toll-like receptor 31.0 2.4 1810054D07Rik RIKEN cDNA 1810054D07 gene 1.0 4.6 9530028C05product: similar to 0.9 2.9 HISTOCOMPATIBILITY 2, CLASS II ANTIGEN EBETA [Mus musculus], full insert sequence. Sell selectin, lymphocyte 0.93.7 Eif4e3 eukaryotic translation initiation factor 4E 0.9 3.1 member 32310016F22Rik RIKEN cDNA 2310016F22 gene 0.9 17.4 Irg1 immunoresponsivegene 1 0.9 34.6 Klrb1b killer cell lectin-like receptor subfamily B 0.92.7 member 1B Tcf7 transcription factor 7, T-cell specific 0.9 10.1Slamf7 SLAM family member 7 0.8 4.2 Ifi203 interferon activated gene 2030.8 4.4 Cd3z CD3 antigen, zeta polypeptide 0.8 6.9 MGI: 1923551 FLN29gene product 0.7 3.0 Trim34 tripartite motif protein 34 0.7 2.2 Uppuridine phosphorylase 0.6 6.5 Ngfr nerve growth factor receptor 0.5 9.92.3 Ifi203 interferon activated gene 203 0.3 23.6

TABLE 7 Injury-induced RITs in rejection ISO ISO ISO WT WT WT WT WT GeneSymbol Gene Title D21 D7 D5 D5 D7 D14 D21 D42 Genbank 1110028E10RikRIKEN cDNA 1110028E10 gene 1.5 2.1 0.9 2.4 2.2 2.7 2.7 3.1 BB4788921200016E24Rik RIKEN cDNA 1200016E24 gene 0.9 2.6 0.9 2.8 1.9 2.0 2.8 2.5BF719154 1200016E24Rik RIKEN cDNA 1200016E24 gene 1.1 2.4 1.0 2.6 2.41.5 3.2 1.6 AU018141 2610042L04Rik RIKEN cDNA 2610042L04 gene 1.2 1.52.2 4.9 3.0 6.7 3.8 4.2 BM195235 9030408N13Rik RIKEN cDNA 9030408N13gene 1.1 2.5 1.6 6.2 9.2 11.9 11.9 11.1 NM_025779 Abp1 amiloride bindingprotein 1 (amine oxidase, 0.8 3.1 0.9 4.0 2.6 10.0 8.0 5.0 BC021880copper-containing) Adamts1 a disintegrin-like and metalloprotease(reprolysin 1.1 2.9 1.5 4.2 2.2 5.4 4.0 4.7 D67076 type) withthrombospondin type 1 motif, 1 Adamts4 a disintegrin-like andmetalloprotease (reprolysin 1.1 3.3 1.1 3.2 2.7 4.4 4.1 5.6 BB443585type) with thrombospondin type 1 motif, 4 Aldh1a2 aldehyde dehydrogenasefamily 1, subfamily A2 0.5 4.0 1.3 4.1 2.7 2.6 3.7 4.5 NM_009022 Anlnanillin, actin binding protein (scraps homolog, 1.3 2.3 1.9 2.3 3.3 4.03.3 3.6 BI690018 Drosophila) Arrb2 similar to Beta-arrestin 2 (Arrestin,beta 2) 0.9 2.1 1.0 5.2 8.6 11.4 10.8 9.8 BC016642 Asns asparaginesynthetase 0.6 2.2 1.1 3.0 1.5 3.6 3.2 5.0 AV212753 Basp1 brainabundant, membrane attached signal 1.0 2.2 1.4 4.9 6.0 14.2 13.6 18.3AK011545 protein 1 Bcl3 B-cell leukemia/lymphoma 3 1.7 3.6 1.8 7.2 8.04.8 7.0 4.7 NM_033601 Bcl6 B-cell leukemia/lymphoma 6 3.9 2.3 2.3 2.12.5 2.3 2.4 2.1 BB183854 Birc1b baculoviral IAP repeat-containing 1b 0.91.5 2.1 2.5 2.8 6.2 4.0 5.9 NM_010872 Bsf3-pending B-cell stimulatingfactor 3 0.6 2.0 2.1 2.1 2.2 3.5 5.0 3.3 BB825816 C1qa complementcomponent 1, q subcomponent, 1.4 3.9 2.8 10.3 15.7 29.2 24.1 28.8NM_007572 alpha polypeptide C1qb complement component 1, q subcomponent,2.3 2.2 2.0 3.4 5.0 10.2 6.6 7.7 AW227993 beta polypeptide C79673expressed sequence C79673 1.4 2.7 1.4 19.9 24.5 41.2 33.5 38.1 BG066664Car13 carbonic anhydrase 13 0.6 2.1 1.5 4.2 2.2 4.5 3.7 3.3 NM_024495Casp12 caspase 12 1.1 1.5 2.3 3.0 2.5 9.1 6.6 7.0 NM_009808 Ccl2chemokine (C-C motif) ligand 2 1.1 2.9 1.2 7.4 7.5 10.7 9.3 10.5AF065933 Ccl9 chemokine (C-C motif) ligand 9 0.7 2.4 1.2 3.1 5.0 6.411.4 12.1 NM_011338 Ccl9 chemokine (C-C motif) ligand 9 1.0 5.8 1.1 8.612.1 18.2 23.3 33.2 AF128196 Ccnb1 cyclin B1 1.0 2.7 2.4 9.9 6.7 8.6 5.65.5 X58708 Ccr2 chemokine (C-C) receptor 2 1.0 6.9 3.9 23.1 30.9 39.422.4 9.4 U47035 Ccr2 chemokine (C-C) receptor 2 1.9 3.2 3.6 13.4 17.717.5 14.1 7.8 NM_009915 Cd14 CD14 antigen 0.9 3.6 1.3 7.3 2.8 5.4 4.24.6 NM_009841 Cd44 CD44 antigen 1.1 3.7 2.1 9.8 14.3 29.6 28.9 25.0BC005676 Cdc2a cell division cycle 2 homolog A (S. pombe) 0.3 3.4 1.35.1 5.0 5.3 3.6 3.7 NM_007659 Ch25h cholesterol 25-hydroxylase 1.0 2.11.4 6.7 8.0 12.3 6.7 12.7 NM_009890 Clca2 chloride channel calciumactivated 2 0.7 2.2 2.2 2.2 1.4 3.7 2.1 5.3 AF108501 Clca2 chloridechannel calcium activated 2 1.1 2.8 2.6 2.1 1.3 1.1 1.8 2.0 AF108501Clecsf10 C-type (calcium dependent, carbohydrate 1.0 3.6 1.5 4.8 7.0 8.18.8 13.4 NM_020001 recognition domain) lectin, superfamily member 10Clecsf10 C-type (calcium dependent, carbohydrate 1.0 4.0 1.3 5.0 6.816.5 10.4 19.5 AF240358 recognition domain) lectin, superfamily member10 Clecsf6 C-type (calcium dependent, carbohydrate 1.1 4.3 3.8 4.7 7.012.8 14.3 14.4 NM_011999 recognition domain) lectin, superfamily member6 Clecsf6 C-type (calcium dependent, carbohydrate 1.4 3.4 1.8 3.5 6.016.3 14.1 13.4 BC006623 recognition domain) lectin, superfamily member 6Clecsf8 C-type (calcium dependent, carbohydrate 1.1 2.4 1.6 2.1 2.9 2.93.1 7.4 NM_010819 recognition domain) lectin, superfamily member 8Clecsf9 C-type (calcium dependent, carbohydrate 1.0 4.3 2.8 16.2 18.512.2 7.5 11.6 BC003218 recognition domain) lectin, superfamily member 9Col1a1 procollagen, type I, alpha 1 0.4 2.0 1.3 5.0 8.4 4.8 9.1 3.4BI794771 Col1a1 procollagen, type I, alpha 1 2.0 6.8 1.9 11.3 26.7 18.931.4 17.8 U08020 Col1a2 procollagen, type I, alpha 2 1.0 2.4 1.5 4.3 6.38.9 7.0 7.6 BF227507 Col1a2 procollagen, type I, alpha 2 1.1 3.7 2.6 6.39.4 14.7 12.0 8.9 AW545978 Col3a1 procollagen, type III, alpha 1 1.1 4.82.6 5.4 6.8 15.5 8.9 11.0 BG968894 Col3a1 procollagen, type III, alpha 11.2 3.8 2.4 4.8 6.7 16.3 9.3 9.6 AW550625 Cp ceruloplasmin 0.5 2.6 1.62.8 1.2 2.9 2.6 1.6 BB531328 Cp ceruloplasmin 0.7 2.8 1.2 4.0 1.7 3.03.8 2.4 BB009037 Cp ceruloplasmin 0.9 3.1 1.5 3.5 2.9 3.5 5.2 2.2NM_007752 Cp ceruloplasmin 0.9 3.1 1.7 4.4 1.8 3.0 4.1 2.3 NM_007752 Cpceruloplasmin 1.0 2.9 1.7 3.8 1.6 3.1 3.6 2.1 NM_007752 Cpecarboxypeptidase E 1.3 2.5 2.5 2.2 1.3 1.3 1.6 0.9 BC010197 Crap cardiacresponsive adriamycin protein 0.6 2.2 1.2 2.1 1.3 4.0 4.0 4.1 AK009959Crap cardiac responsive adriamycin protein 0.7 3.5 1.8 3.3 1.6 7.4 6.39.3 NM_013468 Crlf1 cytokine receptor-like factor 1 1.9 5.2 1.2 10.612.2 11.5 13.4 18.1 NM_018827 Cspg2 chondroitin sulfate proteoglycan 20.7 2.2 1.3 4.0 3.7 11.3 5.2 11.1 BI692925 Cx3cr1 chemokine (C—X3—C)receptor 1 1.3 2.0 1.8 2.5 3.0 4.7 7.2 4.1 BC012653 Cxcl13 chemokine(C—X—C motif) ligand 13 1.2 2.9 1.3 3.6 2.3 1.3 2.0 1.8 NM_018866 Ddx3yDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y- 3.0 2.5 3.2 2.1 2.5 3.0 3.02.9 BB667072 linked Ddx3y DEAD (aspartate-glutamate-alanine-aspartate)2.5 2.9 3.2 2.4 2.2 2.1 2.3 2.9 AJ007376 box polypeptide, Y chromosomeDdx3y DEAD (aspartate-glutamate-alanine-aspartate) 3.1 3.5 3.3 3.1 3.14.1 3.2 3.8 AA210261 box polypeptide, Y chromosome Dpysl3dihydropyrimidinase-like 3 1.5 2.2 2.0 3.6 1.9 4.7 4.1 3.0 AV161550 Egr2early growth response 2 0.6 2.0 1.3 3.7 4.6 6.2 7.7 6.6 X06746 Eif2s3yeukaryotic translation initiation factor 2, subunit 2.4 2.8 2.4 2.9 2.43.6 2.9 3.0 NM_012011 3, structural gene Y-linked Emr1 EGF-like modulecontaining, mucin-like, hormone receptor- 1.2 2.4 1.8 2.9 5.0 10.0 10.411.3 U66888 like sequence 1 Evi2 ecotropic viral integration site 2 1.12.2 2.3 5.8 7.7 12.8 9.4 8.9 NM_010161 F13a coagulation factor XIII,alpha subunit 1.2 2.5 1.7 2.8 2.9 3.7 3.2 9.3 NM_028784 Fbn1 fibrillin 11.1 2.3 2.0 2.5 2.8 5.6 4.1 5.4 NM_007993 Fcgr1 Fc receptor, IgG, highaffinity I 1.2 2.2 2.0 7.0 9.7 23.7 11.0 21.4 AF143181 Fcgr3 Fcreceptor, IgG, low affinity III 1.2 3.0 2.1 5.2 8.3 25.9 17.6 30.6NM_010188 Fga fibrinogen, alpha polypeptide 1.0 3.9 0.8 7.3 2.7 1.1 0.60.7 BC005467 Fn1 fibronectin 1 1.1 2.3 1.6 2.1 3.1 7.6 7.6 7.8 BC004724Fos FBJ osteosarcoma oncogene 0.9 2.1 1.2 5.3 5.6 9.6 5.7 7.6 AV026617G7e-pending G7e protein 1.0 2.3 1.3 4.6 3.7 6.0 5.2 4.5 NM_033075G7e-pending G7e protein 1.1 2.5 1.4 4.9 3.8 6.2 6.3 3.8 BC027314 Gm1549gene model 1549, (NCBI) 1.1 1.2 2.2 2.6 2.2 2.7 1.1 2.6 AJ319753 Gp49bglycoprotein 49 B 1.4 5.2 2.6 10.1 13.9 28.0 17.8 32.0 U05264 Havcr1hepatitis A virus cellular receptor 1 0.5 4.2 1.4 3.1 1.0 3.1 0.7 1.3NM_134248 Hmmr hyaluronan mediated motility receptor (RHAMM) 0.6 2.2 1.42.8 2.9 2.0 1.9 1.8 NM_013552 Igl-V1 immunoglobulin lambda chain,variable 1 3.7 4.6 2.1 3.3 3.3 36.1 40.9 32.9 AK008145 Igsf6immunoglobulin superfamily, member 6 1.0 2.6 0.9 13.7 18.5 30.5 22.425.3 NM_030691 Il1b interleukin 1 beta 1.2 3.7 1.1 2.1 2.2 5.1 3.5 5.2BC011437 Il1rn interleukin 1 receptor antagonist 0.9 3.1 1.7 4.7 3.911.8 5.5 12.5 M57525 Itgam integrin alpha M (CD11b) 1.2 3.8 2.1 5.5 7.911.0 8.8 10.8 NM_008401 Kif20a kinesin family member 20A 1.3 2.2 2.6 3.43.9 4.2 2.9 3.4 NM_009004 Kif22-ps kinesin family member 22, pseudogene0.9 2.8 2.2 5.8 5.3 5.7 3.8 4.0 BB251322 Krt20 keratin 20 1.1 2.4 1.52.9 1.5 8.7 7.8 11.8 AF473907 Lcn2 lipocalin 2 1.0 15.4 2.2 27.6 11.840.9 35.8 53.0 X14607 Lcp1 lymphocyte cytosolic protein 1 0.9 2.3 1.514.1 15.8 20.0 15.2 18.3 BC022943 Lgals1 lectin, galactose binding,soluble 1 0.7 2.0 1.3 2.6 2.5 4.1 2.8 4.1 AI642438 Lgals1 lectin,galactose binding, soluble 1 0.9 2.0 1.1 3.0 2.8 3.6 3.1 3.1 NM_008495Lif leukemia inhibitory factor 1.8 3.3 1.4 4.5 3.8 3.8 3.7 4.7 BB235045Lox lysyl oxidase 0.6 5.8 2.3 8.0 6.3 22.5 12.5 31.2 M65143 Lox lysyloxidase 0.8 2.5 1.3 4.1 3.1 9.8 6.8 12.9 NM_010728 Lrg1 leucine-richalpha-2-glycoprotein 1.3 6.3 0.5 8.3 2.5 5.3 5.2 4.2 NM_029796 Lyzslysozyme 1.4 7.7 2.7 22.8 26.8 39.5 43.7 22.1 AV058500 Lyzs lysozyme 1.54.9 1.8 13.6 19.0 25.2 21.3 25.9 AW208566 Lyzs lysozyme 1.6 7.9 2.7 19.020.9 38.2 19.1 32.7 AV066625 Mad2l1 MAD2 (mitotic arrest deficient,homolog)-like 1 0.9 2.2 1.6 4.6 3.8 4.5 2.8 2.8 NM_019499 (yeast) Mcmdmini chromosome maintenance deficient (S. cerevisiae) 1.3 1.8 2.2 6.15.7 5.1 5.0 3.6 C80350 Mcmd6 mini chromosome maintenance deficient 6 (S.cerevisiae) 1.0 2.0 1.8 4.5 5.2 4.4 3.7 3.0 BB099487 Mki67 antigenidentified by monoclonal antibody Ki 67 0.8 2.6 2.2 9.8 11.3 7.8 8.8 3.7X82786 Ms4a6d membrane-spanning 4-domains, subfamily A, 0.9 5.6 3.3 19.733.6 53.6 29.3 39.4 NM_026835 member 6D Ms4a7 membrane-spanning4-domains, subfamily A, 1.3 2.5 2.1 2.9 5.5 13.9 15.4 15.4 BC024402member 7 Msn moesin 1.2 2.0 1.3 2.9 2.6 3.4 2.4 2.9 NM_010833 Ncf2neutrophil cytosolic factor 2 1.3 2.1 2.0 4.6 5.7 13.6 9.3 11.5NM_010877 Osmr oncostatin receptor 1.0 2.4 1.8 3.5 2.7 4.3 5.5 4.7NM_011019 Pira6 paired-Ig-like receptor A6 1.2 2.4 2.2 6.9 9.6 16.9 9.28.4 NM_011093 Plac8 placenta-specific 8 0.8 2.0 1.3 7.5 7.1 6.5 5.9 5.0AF263458 Plek pleckstrin 0.9 2.6 2.3 8.3 11.9 18.2 12.5 15.4 AF181829Postn periostin, osteoblast specific factor 1.0 2.8 2.5 2.7 2.9 8.0 7.214.4 BI110565 Prc1 protein regulator of cytokinesis 1 0.7 2.4 3.1 5.44.3 6.0 3.7 3.6 BC005475 Ptgs2 prostaglandin-endoperoxide synthase 2 0.84.8 2.0 4.1 6.9 13.4 5.6 9.3 M88242 Rad51ap1 RAD51 associated protein 10.7 2.1 0.6 4.7 3.4 2.2 2.6 2.5 BC003738 Rarres2 retinoic acid receptorresponder (tazarotene 2.2 2.4 1.3 3.6 2.7 7.4 5.9 6.5 AV012073 induced)2 Rrm2 ribonucleotide reductase M2 0.9 2.3 1.4 5.1 3.4 3.9 2.4 3.2NM_009104 Rrm2 ribonucleotide reductase M2 1.0 2.2 1.5 4.8 3.9 4.8 3.12.5 AV301324 Runx1 runt related transcription factor 1 0.9 2.3 1.3 3.83.2 7.5 7.8 8.8 BI696226 S100a8 S100 calcium binding protein A8(calgranulin A) 0.5 8.6 0.6 4.8 2.4 2.5 3.6 3.6 NM_013650 Saa1 serumamyloid A 1 1.0 5.8 1.7 27.3 3.7 6.3 3.2 1.3 NM_009117 Saa2 serumamyloid A 2 0.8 3.6 1.0 8.9 1.6 3.9 1.6 1.3 NM_011314 Saa3 serum amyloidA 3 0.8 2.4 0.9 5.5 4.2 3.6 2.1 4.7 NM_011315 Serpine1 serine (orcysteine) proteinase inhibitor, clade E, 1.1 5.6 0.9 6.5 10.0 23.4 11.032.2 NM_008871 member 1 Slc25a24 solute carrier family 25 (mitochondrialcarrier, 0.8 2.0 1.5 2.3 2.2 5.4 3.5 4.1 BF578055 phosphate carrier),member 24 Smcy selected mouse cDNA on the Y 2.2 2.5 2.4 2.3 2.8 2.3 2.72.1 AF127244 Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B 1.02.5 1.6 4.9 3.4 8.8 5.5 5.7 NM_133888 Socs3 suppressor of cytokinesignaling 3 0.7 6.8 2.5 16.9 12.9 19.2 13.5 18.9 BB241535 Socs3suppressor of cytokine signaling 3 1.4 6.2 1.2 12.4 11.4 9.4 11.6 12.9BB831725 Sprr2f small proline-rich protein 2F 0.8 5.8 1.4 2.4 1.1 46.426.1 22.6 NM_011472 Stk17b serine/threonine kinase 17b(apoptosis-inducing) 1.4 2.0 1.5 5.7 7.7 11.4 7.7 7.1 BG064688 Syncripsynaptotagmin binding, cytoplasmic RNA 3.1 3.6 2.7 4.0 3.4 4.7 3.2 4.0BG920261 interacting protein Tapbpl TAP binding protein-like 0.8 1.2 2.38.7 7.4 7.4 6.9 5.1 BC017613 Tgfbi transforming growth factor, betainduced, 68 kDa 1.0 2.5 2.1 4.6 4.6 8.0 6.0 5.3 BB532080 Tiarp-pendingTnfa-induced adipose-related protein 1.0 3.4 1.4 4.1 1.4 1.3 2.4 2.1NM_054098 Timd2 T-cell immunoglobulin and mucin domain 1.8 2.7 2.4 2.51.6 1.6 0.5 1.0 BC025096 containing 2 Timd2 T-cell immunoglobulin andmucin domain 2.8 4.1 3.5 5.2 3.3 3.3 1.7 2.4 BC028829 containing 2 Timp1tissue inhibitor of metalloproteinase 1 1.3 8.3 1.9 15.5 15.3 29.1 16.626.4 BC008107 Tnc tenascin C 0.3 3.3 1.4 2.4 3.3 4.4 5.5 10.4 NM_011607Tnfrsf12a tumor necrosis factor receptor superfamily, 1.2 3.1 1.2 5.63.1 5.6 4.4 4.1 NM_013749 member 12a Tnfrsf12a tumor necrosis factorreceptor superfamily, 1.2 2.3 1.2 4.9 2.7 4.8 4.3 2.9 NM_013749 member12a Tpte transmembrane phosphatase with tensin 2.5 3.0 3.2 2.6 1.1 2.12.8 1.4 AJ311312 homology Tubb6 tubulin, beta 6 0.8 5.8 1.0 13.5 12.013.0 11.2 21.8 NM_026473 Ugcg UDP-glucose ceramide glucosyltransferase2.1 2.0 1.3 2.4 3.0 6.0 3.9 4.5 NM_011673 Uty ubiquitously transcribedtetratricopeptide repeat 2.2 2.7 2.5 2.2 1.5 1.6 1.2 1.7 NM_009484 gene,Y chromosome Vcam1 vascular cell adhesion molecule 1 0.9 4.3 1.4 11.33.6 29.8 8.3 8.2 L08431 Vim vimentin 0.9 2.0 1.5 5.6 8.1 12.5 7.2 9.5AV147875 Ywhag 3-monooxgenase/tryptophan 5-monooxgenase 2.4 2.1 0.3 2.02.2 2.7 1.9 2.2 NM_018871 activation protein, gamma polypeptide

TABLE 8 Functional annotation of injury-induced RIT Gene ISO D7 vs ISOD5 vs WT D5 vs IFN-γ Tgf-β1 Symbol Gene Title Affymetrix NCBA NCBA NCBAregulated regulated Timp1 tissue inhibitor of metalloproteinase 1 8.31.9 15.5 yes yes Socs3 suppressor of cytokine signaling 3 6.8 2.5 16.9yes yes Col3a1 procollagen, type III, alpha 1 4.8 2.6 5.4 yes yes Il1binterleukin 1 beta 3.7 1.1 2.1 yes Cd14 CD14 antigen 3.6 1.3 7.3 yes yesAdamts4 a disintegrin-like and metalloprotease 3.3 1.1 3.2 yes motif, 4Fcgr3 Fc receptor, IgG, low affinity III 3.0 2.1 5.2 yes Ccl2 chemokine(C-C motif) ligand 2 2.9 1.2 7.4 yes Plek pleckstrin 2.6 2.3 8.3 yes Cpceruloplasmin 2.6 1.6 2.8 yes Smpdl3b sphingomyelin phosphodiesterase,acid- 2.5 1.6 4.9 yes like 3B Lox lysyl oxidase 2.5 1.3 4.1 yes yesTgfbi transforming growth factor, beta induced, 2.5 2.1 4.6 yes yes 68kDa Col1a2 procollagen, type I, alpha 2 2.4 1.5 4.3 yes yes Fbn1fibrillin 1 2.3 2.0 2.5 yes Fn1 fibronectin 1 2.3 1.6 2.1 yes yes Fcgr1Fc receptor, IgG, high affinity I 2.2 2.0 7.0 yes Cspg2 chondroitinsulfate proteoglycan 2 2.2 1.3 4.0 yes yes (Versican) Arrb2 similar toBeta-arrestin 2 (Arrestin, beta 2) 2.1 1.0 5.2 yes Fos FBJ osteosarcomaoncogene 2.1 1.2 5.3 yes Ncf2 neutrophil cytosolic factor 2 2.1 2.0 4.6yes Col1a1 procollagen, type I, alpha 1 2.0 1.3 5.0 yes yes Vim vimentin2.0 1.5 5.6 yes yes Casp12 caspase 12 1.5 2.3 3.0 yes Postn periostin,osteoblast specific factor 2.8 2.5 2.7 yes Bold letters indicate similareffects of cytokines, whereas italics indicate opposite effects.

Example 2 RITs and GRITs Identified Using a Second Algorithm

A second, more refined algorithm was used to identify RITs and GRITs.This method involved RMA (robust multichip analysis).

Revised GRITs Algorithm

Statistical analysis: Raw microarray data was pre-processed using an RMAmethod (Bioconductor 1.7; R version 2.2). Microarrays for control andtreatment groups were preprocessed separately for each mouse straincombination. After preprocessing, data sets were subjected tovariance-based filtering, i.e., all probe sets that had aninter-quartile range of less than 0.5 (log 2 units), across all chips,were removed. Filtered data were then used for transcript selection. Tobe selected, a transcript was required to have a corrected p-value of0.01 or lower, and had to be increased at least two-fold vs. appropriatecontrols. Corrected p-values (q-values) were calculated using the“limma” package (fdr adjustment method), which was uses an empiricalBayes method for assigning significance. The mean normalized value forreplicate samples was used for further analysis. Finally, the data wereimported into the GeneSpring™ 7.2 (Agilent, Palo Alto, Calif.) forfurther analyses and creation of transcript lists.

Selection and removal of transcripts associated with cytotoxic T cells:The previously defined CTL associated transcripts (CAT) selection wasrefined, using the transcriptome of CD8+ cells isolated from allo.CBA D5into B6 allografts, and the CTL cell line transciptome. Microarray datawere normalized (GCOS/GeneSpring) to normal B6 kidneys. Transcriptsexpressed in the CTL line and in CD8 cells isolated from day 5allografts (P flags in both samples) were selected based on their≧5-fold expression vs. normal NCBA kidney. This selection yielded 1849probe sets. These CTL and CD8-associated transcripts (expanded CATs)were removed from all transcript lists prior to any analyss. Anexception was made for Psmb8, Psmb9 and Cc15 transcripts. Althoughprominently expressed in CTL, they also were expressed in rIFNg treatedkidneys and/or a macrophage cell line.

Selection and removal of transcripts related to strain differences,somatically rearranged genes, and NK receptors: All probe sets showingdifferences in the basal signal (either 5-fold increased or decreased)between normal CBA, B6 and BALB/c kidneys were selected by the RMA-basedmethod. These probe sets then were removed from the final transcriptlists to reduce the influence of strain differences. Transcriptsexpressed by somatically rearranged genes, i.e., immunoglobulin genes,also were removed. In addition, transcripts for NK receptors of the Klrfamily were removed.

Development of the unique transcript lists: The term “transcript” refersto an mRNA identified by one or more numbered Affymetrix probe sets,while a “unique transcript” refers to an mRNA identified by only oneprobe set; these show the highest fold change of expression in theallografts at day 5 post-transplant. Certain probe sets representing thesame transcript could appear in more than one list. These werearbitrarily kept only in the first list in which they appeared (e.g.,tGRITs), and were eliminated from other lists (e.g., oGRITs, see below).All transcript name abbreviations use Entrez Gene nomenclature, which isavailable on the World Wide Web at ncbi.nlm.nih.gov/entrez).

IFN-γ—Dependent Rejection Induced Transcripts (GRITs)

The algorithms for transcript selection (applied after removing CATs andstrain-differing transcripts) are shown in FIGS. 8A, 8B, and 8C.Fifty-eight transcripts were identified that were rIFN-γ-dependent innormal kidneys of CBA, B6 and BALB/c mice.

Transcripts increased at least 2-fold in day 5 allografts were termed“rejection-induced.” The inflammatory changes at day 5 did not fulfillthe histologic criteria for rejection (tubulitis), but the patternsestablished at day 5 were highly conserved as rejection lesions evolved.1319 unique rejection-induced transcripts were identified in D5 kidneyallografts of B6, CBA, and BALB/c strains (FIG. 8B).

Rejection-induced transcripts that were IFN-γ-dependent in rejectionwere identified by studying allografts in IFN-γ-deficient (GKO) hosts.Kidney allografts from wild-type BALB/c into B6 (allo.BALB/c) werecompared to BALB/c.GKO donors (H-2d) transplanted into B6.GKO (H-2b)recipients (allo.GKO D5). 443 rejection-induced transcripts wereidentified that were at least 2-fold (signal ratio) greater when IFN-γwas present than when it was absent. Of these, 55 transcripts (47 ofwhich were unique transcripts) also were increased by rIFN-γ (FIG. 8C,Table 9), and thus were labeled true interferon gamma dependentrejection-induced transcripts (tGRITs). The remaining transcripts, 270of which were unique transcripts, were not 2-fold induced by rIFN-γ innormal kidneys, but nevertheless were IFN-γ dependent in rejectingkidneys (FIG. 8C). To reflect their lower inducibility by rIFN-γ, thesetranscripts were termed “occult” GRITs (oGRITs; Table 10).

The “tGRIT” and “oGRIT” terms used in this example are equivalent to the“GRIT” term used in Example 1, i.e., the GRIT category includes tGRITsand oGRITs. On average, there was 70% overlap between the GRITsidentified by the RMA method with the (GCOS/GeneSpring) method describedin Example 1.

Injury and Repair Induced Transcripts (IRITs) Algorithm

Transcript selection: Samples preprocessing, normalization and datafiltering was done using the RMA-based method. Data also were correctedfor the tGRITs, oGRITs and new CTL associated transcripts beforetranscript selection. The following algorithm was used (FIG. 9):transcripts were required to be increased in at least one of theisografts day 1-day 21 (≧2-fold, p(fdr)=0.01, where “fdr” is the falsediscovery rate), and also in allo.CBA D5 (≧2-fold, p(fdr)=0.01).Transcripts satisfying these criteria were selected, and the overlapping372 transcripts were termed injury and repair-induced transcripts(IRITs). The final list, corrected for polymorphisms, contained 303unique (highest expression in allo.CBA D5 vs NCBA) IRITs (Table 11).

The IRITs listed in Table 11 show a substantial overlap with the RITs,the injury-induced RITs and the GRIT-like lists of transcriptsestablished as described in Example 1. In addition, the IRITsrecapitulate the Tgfb1 effect on the transcriptome of rejecting mousekidneys, similarly to GRIT-like and injury-induced RITs.

TABLE 9 Refined true gamma interferon-dependent rejection-inducedtranscripts (tGRIT) allo.CBA NCBA D5 vs Gene symbol Gene title raw NCBAGenBank — — 144 25.0 BB734586 AI451557 expressed sequence AI451557 2335.1 AV277444 AW112010 expressed sequence AW112010 144 46.8 BE688358 B2mbeta-2 microglobulin 3304 4.8 AI099111 Bst2 bone marrow stromal cellantigen 2 134 12.9 BC008532 C1r complement component 1, r 86 13.3NM_023143 subcomponent C2 Complement component 2 (within H-2S), 315 4.4AV227574 mRNA (cDNA clone MGC: 18582 IMAGE: 3992881) Cxcl9 chemokine(C—X—C motif) ligand 9 81 129.5 NM_008599 D12Ertd647e DNA segment, Chr12, ERATO Doi 647, 652 4.8 AW554405 expressed Gbp2 guanylate nucleotidebinding protein 2 95 133.2 NM_010260 Gbp4 guanylate nucleotide bindingprotein 4 68 54.4 NM_018734 H2-Aa /// H2- histocompatibility 2, class IIantigen A, 926 10.2 AF119253 Ea alpha /// histocompatibility 2, class IIantigen E alpha H2-Ab1 histocompatibility 2, class II antigen A, 35118.8 M15848 beta 1 H2-D1 /// H2- histocompatibility 2, D region locus 1/// 230 17.2 L23495 K1 /// H2-L /// histocompatibility 2, K1, K region/// LOC56628 histocompatibility 2, D region /// MHC (A.CA/J(H-2K-f)class I antigen H2-DMa histocompatibility 2, class II, locus DMa 10021.2 NM_010386 H2-DMb1 histocompatibility 2, class II, locus Mb1 58 19.2NM_010387 H2-DMb1 /// histocompatibility 2, class II, locus Mb1 /// 17917.7 NM_010388 H2-DMb2 histocompatibility 2, class II, locus Mb2 H2-DMb2histocompatibility 2, class II, locus Mb2 81 25.3 NM_010388 H2-Eb1histocompatibility 2, class II antigen E beta 679 9.7 NM_010382 H2-K1histocompatibility 2, K1, K region 373 15.8 S70184 H2-T10 /// H2-histocompatibility 2, T region locus 10 /// 784 5.4 NM_010395 T22 ///H2-T9 histocompatibility 2, T region locus 22 /// histocompatibility 2,T region locus 9 H2-T23 histocompatibility 2, T region locus 23 862 9.5NM_010398 Herc5 hect domain and RLD 5 55 32.3 AW208668 Igtp interferongamma induced GTPase 342 34.4 NM_018738 Ii la-associated invariant chain1240 8.8 BC003476 Iigp1 interferon inducible GTPase 1 99 69.1 BM239828Iigp2 interferon inducible GTPase 2 127 34.1 NM_019440 Il18bpinterleukin 18 binding protein 116 19.6 AF110803 Irgm immunity-relatedGTPase family, M 485 14.5 NM_008326 Lgals3bp lectin,galactoside-binding, soluble, 3 360 5.3 NM_011150 binding proteinLOC56628 MHC (A.CA/J(H-2K-f) class I antigen 63 3.8 M58156 Mpa2lmacrophage activation 2 like 50 174.1 BM241485 Mpeg1 macrophageexpressed gene 1 217 18.8 L20315 Oasl2 2′-5′ oligoadenylatesynthetase-like 2 56 22.8 BQ033138 Parp14 poly (ADP-ribose) polymerasefamily, 95 19.1 BC021340 member 14 Psmb10 proteasome (prosome,macropain) 251 16.2 NM_013640 subunit, beta type 10 Psmb8 proteosome(prosome, macropain) 205 29.6 NM_010724 subunit, beta type 8 (largemultifunctional peptidase 7) Psmb9 proteosome (prosome, macropain) 14225.3 NM_013585 subunit, beta type 9 (large multifunctional peptidase 2)Psme1 proteasome (prosome, macropain) 28 1008 4.5 NM_011189 subunit,alpha Serpina10 serine (or cysteine) peptidase inhibitor, 95 44.9BC018416 clade A (alpha-1 antiproteinase, antitrypsin), member 10Serping1 serine (or cysteine) peptidase inhibitor, 721 7.0 NM_009776clade G, member 1 Stat1 signal transducer and activator of 350 23.9AW214029 transcription 1 Tap1 transporter 1, ATP-binding cassette, sub-60 24.0 AW048052 family B (MDR/TAP) Tapbp TAP binding protein 962 6.1AF043943 Tgtp T-cell specific GTPase 481 32.6 NM_011579 Ubd ubiquitin D47 255.8 NM_023137 Xdh xanthine dehydrogenase 53 16.7 AV286265

TABLE 10 Refined occult gamma interferon-dependent rejection-inducedtranscripts (oGRIT) NCBA allo.CBA D5 Gene Symbol Gene Title Raw vs NCBAGenBank 1-Mar membrane-associated ring finger 21 7.4 BB134696 (C3HC4) 16-Sep septin 6 81 4.0 BC010489 — — 307 2.7 AV340322 — — 261 3.4 AV340322— — 50 2.9 BG695418 — — 51 15.6 BB668084 — Transcribed locus 28 3.2BB376947 — Transcribed locus 52 60.2 AW111920 — Transcribed locus 12 3.1BG144448 — — 15 2.9 BQ266693 — Transcribed locus, weakly similar to 175.4 BB740904 NP_795929.1 hypothetical protein LOC319587 [Mus musculus] —16 days neonate thymus cDNA, RIKEN 113 5.8 BI653857 full-length enrichedlibrary, clone: A130050C20 product: hypothetical Butyrophylin-like/SPla/RYanodine receptor SPRY/B302, (SPRY)-like containing protein,full insert sequence — — 15 4.9 BG072508 — — 32 11.8 BB5589170610025L06Rik RIKEN cDNA 0610025L06 gene 183 3.9 AK012581 0610033I05RikRIKEN cDNA 0610033I05 gene 137 3.5 BC003333 1110007F12Rik RIKEN cDNA1110007F12 gene 422 3.7 BC020080 1110038F14Rik RIKEN cDNA 1110038F14gene 187 2.0 NM_054099 1500004A08Rik RIKEN cDNA 1500004A08 gene 109 2.5BB030508 1810009K13Rik RIKEN cDNA 1810009K13 gene 136 2.1 AK0074071810054D07Rik RIKEN cDNA 1810054D07 gene 15 4.1 BB397062 2310016F22Rik/// RIKEN cDNA 2310016F22 gene /// 39 11.0 BC020489 LOC223672hypothetical protein LOC223672 2700019D07Rik RIKEN cDNA 2700019D07 gene160 2.7 BM937429 2810417H13Rik RIKEN cDNA 2810417H13 gene 14 16.9AK017673 4933430F08Rik RIKEN cDNA 4933430F08 gene 128 6.4 AK0169905133401N09Rik RIKEN cDNA 5133401N09 gene 464 2.5 BC026742 5830443L24RikRIKEN cDNA 5830443L24 gene 49 115.5 NM_029509 5830458K16Rik RIKEN cDNA5830458K16 gene 149 13.3 BC024872 9130017N09Rik RIKEN cDNA 9130017N09gene 163 2.6 BQ030875 9330175E14Rik RIKEN cDNA 9330175E14 gene 27 2.7BB082472 9530028C05 hypothetical protein 9530028C05 80 5.0 BQ1751549830147J24Rik RIKEN cDNA 9830147J24 gene 46 56.7 BM241271 A430107D22RikRIKEN cDNA A430107D22 gene 60 3.4 AV312663 A630077B13Rik RIKEN cDNAA630077B13 gene 17 92.0 BB239429 AB124611 cDNA sequence AB124611 33 10.5BM246462 Adar RNA adenosine deaminase 1 (Adar) 30 3.3 BB308291 mRNA,complete cds, alternatively spliced AI447904 expressed sequence AI44790412 44.0 BM241008 AI447904 /// expressed sequence AI447904 /// 32 29.7BM241008 BC094916 cDNA sequence BC094916 AI451617 expressed sequenceAI451617 19 11.2 BM241342 AI480535 expressed sequence AI480535 517 2.5BQ176847 AI607873 expressed sequence AI607873 10 11.6 AI607873 AI661384expressed sequence AI661384 11 5.3 BB034038 Aif1 allograft inflammatoryfactor 1 47 23.0 NM_019467 Ak7 adenylate kinase 7 231 3.0 AV256298 Akt3thymoma viral proto-oncogene 3 74 3.5 BB521695 Arid5a AT richinteractive domain 5A (Mrf1 74 3.0 BC027152 like) AsahlN-acylsphingosine amidohydrolase 140 6.8 BI106821 (acid ceramidase)-likeAtp8a1 ATPase, aminophospholipid transporter 67 6.0 AW610650 (APLT),class I, type 8A, member 1 AU020206 expressed sequence AU020206 69 12.1BI151331 B230217C12Rik RIKEN cDNA B230217C12 gene 30 3.3 BB376573BC006779 cDNA sequence BC006779 95 4.9 BE853170 BC010462 cDNA sequenceBC010462 84 4.1 BC010462 BC013672 cDNA sequence BC013672 12 3.8 BC013672BC013712 cDNA sequence BC013712 97 9.6 BB262491 BC023105 cDNA sequenceBC023105 20 42.8 BC023105 BC027057 cDNA sequence BC027057 24 3.9BB040051 Btla B and T lymphocyte associated 29 8.8 BM240873 C1scomplement component 1, s 156 13.0 BC022123 subcomponent C2ta class IItransactivator 29 9.5 AF042158 C2ta class II transactivator 40 6.7AF042158 C4 complement component 4 (within H-2S) 367 6.9 NM_009780 Card4caspase recruitment domain 4 132 3.0 BB138330 Casp1 caspase 1 44 9.6BC008152 Casp11 caspase 11, apoptosis-related cysteine 39 13.6 NM_007609peptidase Casp12 caspase 12 33 9.5 NM_009808 Casp7 caspase 7 140 4.0NM_007611 Ccl19 chemokine (C-C motif) ligand 19 305 2.1 NM_011888 Ccl5chemokine (C-C motif) ligand 5 75 36.7 NM_013653 Ccl8 chemokine (C-Cmotif) ligand 8 36 22.0 NM_021443 Ccr5 chemokine (C-C motif) receptor 524 11.5 X94151 Ccr9 chemokine (C-C motif) receptor 9 16 2.4 AJ131357Ccrl2 chemokine (C-C motif) receptor-like 2 73 2.7 AJ318863 Cd2 CD2antigen 26 8.4 NM_013486 Cd274 CD274 antigen 50 27.3 NM_021893 Cd28 CD28antigen 13 21.6 NM_007642 Cd40 CD40 antigen 70 7.1 BB220422 Cd48 CD48antigen 29 25.5 BE634960 Cd5 CD5 antigen 21 10.0 NM_007650 Cd6 CD6antigen 57 3.0 U12434 Cd69 CD69 antigen 12 6.4 AK017979 Cd72 CD72antigen 40 5.7 BC003824 Cd86 CD86 antigen 27 8.8 NM_019388 Cerklceramide kinase-like 34 13.8 BB205589 Clec2d C-type lectin domain family2, member d 211 3.1 NM_053109 Csprs component of Sp100-rs 84 2.8BB148221 Ctsc cathepsin C 13 9.7 BM237633 Ctsw cathepsin W 49 11.9NM_009985 Cxcl10 chemokine (C—X—C motif) ligand 10 69 95.2 NM_021274Cxcl11 chemokine (C—X—C motif) ligand 11 37 169.3 NM_019494 Cxcl16chemokine (C—X—C motif) ligand 16 652 3.3 BC019961 Cxcl16 /// chemokine(C—X—C motif) ligand 16 /// 99 2.9 AI662455 LOC574428 zinc finger, MYNDdomain containing 15 Cxcr3 chemokine (C—X—C motif) receptor 3 60 8.2NM_009910 Cxcr6 chemokine (C—X—C motif) receptor 6 28 15.4 AF301018 Cybbcytochrome b-245, beta polypeptide 52 21.8 NM_007807 Cyp4v3 cytochromeP450, family 4, subfamily 49 3.5 NM_133969 v, polypeptide 3 D11Ertd759eDNA segment, Chr 11, ERATO Doi 363 5.0 AW556558 759, expressed D11Lgp2eDNA segment, Chr 11, Lothar 42 6.8 AF316999 Hennighausen 2, expressedD14Ertd668e DNA segment, Chr 14, ERATO Doi 115 6.5 AV280841 668,expressed Dck deoxycytidine kinase 13 7.8 NM_007832 Dnase1l3deoxyribonuclease 1-like 3 28 6.3 BC012671 Dtx3l deltex 3-like(Drosophila) 136 12.0 AV327407 Eif2ak2 eukaryotic translation initiationfactor 2- 81 3.2 BE911144 alpha kinase 2 Eif4e3 eukaryotic translationinitiation factor 162 5.2 BC027014 4E member 3 Enc1 ectodermal-neuralcortex 1 77 4.4 BM120053 Epsti1 epithelial stromal interaction 1(breast) 37 20.0 BF020640 Evl Ena-vasodilator stimulated 45 8.3 AW553781phosphoprotein Fabp7 fatty acid binding protein 7, brain 259 6.6NM_021272 Fas Fas (TNF receptor superfamily 85 3.2 NM_007987 member)Fbxo39 F-box protein 39 168 11.3 BB645745 Fbxo6b F-box only protein 6b301 2.8 NM_015797 Fbxw17 F-box and WD-40 domain protein 17 181 3.3AV016303 Fcgr1 Fc receptor, IgG, high affinity I 35 20.5 AF143181 Fcgr1Fc receptor, IgG, high affinity I 80 2.6 BB075261 Fcgr3a Fc fragment ofIgG, low affinity IIIa, 47 22.5 BC027310 receptor Fgd2 FYVE, RhoGEF andPH domain 66 2.2 NM_013710 containing 2 Fgf13 fibroblast growth factor13 18 2.0 AF020737 Fgl2 fibrinogen-like protein 2 31 45.9 BF136544 FybFYN binding protein (Fyb), mRNA 31 4.2 BE853428 G1p2 interferon,alpha-inducible protein 40 17.2 AK019325 Gbp1 guanylate nucleotidebinding protein 1 22 23.9 NM_010259 Gdap10 ganglioside-induceddifferentiation- 99 4.8 NM_010268 associated-protein 10 Gimap3 GTPase,IMAP family member 3 91 6.2 NM_031247 Gimap4 GTPase, IMAP family member4 677 3.6 BC005577 Gimap7 GTPase, IMAP family member 7 28 12.3 BC026200Gja4 gap junction membrane channel protein 86 2.0 AF216832 alpha 4 Gm376PREDICTED: similar to putative 9 3.7 BB241847 purinergic receptor FKSG79[Mus musculus], mRNA sequence Gpr18 G protein-coupled receptor 18 3210.8 BG145550 Gsdmdc1 gasdermin domain containing 1 119 4.1 AK007710Gvin1 GTPase, very large interferon inducible 1 98 43.2 BM243571 Gzmkgranzyme K 23 6.2 AB032200 H28 histocompatibility 28 106 10.0 BC024930H2-D1 histocompatibility 2, D region locus 1 43 10.0 M33151 H2-M3histocompatibility 2, M region locus 3 106 6.5 NM_013819 H2-Oahistocompatibility 2, O region alpha 43 4.6 NM_008206 locus H2-Q5histocompatibility 2, Q region locus 5 40 5.5 NM_010393 H2-Q8histocompatibility 2, Q region locus 8 23 2.2 AK013097 H2-T24histocompatibility 2, T region locus 24 46 3.6 L22338 Hck hemopoieticcell kinase 41 18.7 NM_010407 Hk3 hexokinase 3 84 2.9 BB324660 HpseHeparanase (Hpse), mRNA 42 5.6 BG094050 Hrasls3 HRAS like suppressor 3166 20.1 BB404920 Ibrdc3 IBR domain containing 3 133 8.4 AK015966 Icosinducible T-cell co-stimulator 21 5.4 AB023132 Ifi202b interferonactivated gene 202B 27 64.8 AV229143 Ifi203 /// Ifi204 /// interferonactivated gene 203 /// 11 82.9 AI481797 Ifi205 /// Mnda /// interferonactivated gene 204 /// LOC545386 interferon activated gene 205 ///myeloid cell nuclear differentiation antigen /// similar to Interferon-activatable protein 205 (IFI-205) (D3 protein) Ifi203 /// interferonactivated gene 203 /// similar 64 10.1 BC008167 LOC547362 tointerferon-inducible protein 203 Ifi204 /// Mnda interferon activatedgene 204 /// 13 13.7 NM_008329 myeloid cell nuclear differentiationantigen Ifi205 /// Mnda interferon activated gene 205 /// 29 92.9AI481797 myeloid cell nuclear differentiation antigen Ifi27 interferon,alpha-inducible protein 27 119 7.4 AY090098 Ifi35 interferon-inducedprotein 35 406 6.6 AW986054 Ifi44 interferon-induced protein 44 121 8.0BB329808 Ifi47 interferon gamma inducible protein 47 196 40.5 NM_008330Ifih1 interferon induced with helicase C 181 5.5 AY075132 domain 1 Ifit1interferon-induced protein with 29 23.3 NM_008331 tetratricopeptiderepeats 1 Ifit2 interferon-induced protein with 125 32.5 NM_008332tetratricopeptide repeats 2 Ifit3 interferon-induced protein with 3176.6 NM_010501 tetratricopeptide repeats 3 IFNg interferon gamma 25 22.9K00083 Il10ra interleukin 10 receptor, alpha 29 4.8 NM_008348 Il12rb1interleukin 12 receptor, beta 1 32 2.4 NM_008353 Il16 interleukin 16 882.6 BC026894 Il18 interleukin 18 141 2.6 NM_008360 Il2rb interleukin 2receptor, beta chain 55 4.7 M28052 Il2rb interleukin 2 receptor, betachain 27 8.6 M28052 Il2rg interleukin 2 receptor, gamma chain 121 18.6L20048 Indo indoleamine-pyrrole 2,3 dioxygenase 21 2.6 NM_008324 Inpp1inositol polyphosphate-1-phosphatase 63 3.0 NM_008384 Irf1 interferonregulatory factor 1 312 14.9 NM_008390 Irf7 interferon regulatory factor7 118 6.4 NM_016850 Irf8 interferon regulatory factor 8 157 12.0BG069095 Irg1 immunoresponsive gene 1 31 17.9 L38281 Isg20interferon-stimulated protein 51 5.4 BC022751 Itgal integrin alpha L 412.9 AF065902 Itgal integrin alpha L 41 20.3 BI554446 Lair1leukocyte-associated Ig-like receptor 1 29 7.8 AK017222 Lck lymphocyteprotein tyrosine kinase 40 25.5 BC011474 LOC432460 similar to RIKEN cDNA6330442E10 23 2.7 BB302103 gene LOC544986 /// similar to hypotheticalprotein 47 7.3 BM195235 LOC544991 /// LOC67055 /// similar tohypothetical LOC544997 /// protein LOC67055 /// similar to B930046C15Rikhypothetical protein LOC67055 /// /// LOC545001 /// RIKEN cDNAB930046C15 gene /// LOC545005 /// hypothetical protein LOC545001 ///LOC545007 /// hypothetical protein LOC545005 /// LOC545008 ///hypothetical protein LOC545007 /// 2610042L04Rik /// similar tohypothetical protein LOC545017 LOC67055 /// RIKEN cDNA 2610042L04 gene/// similar to hypothetical protein LOC67055 LOC547214 similar to Gprotein coupled receptor 14 3.8 AF140709 Lst1 leukocyte specifictranscript 1 125 8.9 U72644 Ly6c lymphocyte antigen 6 complex, locus C1041 3.9 NM_010741 Ly6i lymphocyte antigen 6 complex, locus I 125 11.2AF232024 Ly75 lymphocyte antigen 75 12 3.7 NM_013825 MGI: 1933403 type 1tumor necrosis factor receptor 154 4.7 NM_030711 shedding aminopeptidaseregulator Mlkl mixed lineage kinase domain-like 37 14.3 AK018636 Ms4a4bmembrane-spanning 4-domains, 18 92.0 BB199001 subfamily A, member 4BMs4a4c membrane-spanning 4-domains, 11 48.3 NM_022429 subfamily A,member 4C Ms4a4d membrane-spanning 4-domains, 31 15.2 NM_025658subfamily A, member 4D Ms4a6b membrane-spanning 4-domains, 30 70.6NM_027209 subfamily A, member 6B Ms4a6c membrane-spanning 4-domains, 10614.0 AF237910 subfamily A, member 6C Mx1 myxovirus (influenza virus)resistance 1 22 3.8 M21039 Myb myeloblastosis oncogene 10 2.9 BC011513Nkg7 natural killer cell group 7 sequence 57 23.5 NM_024253 Nmi N-myc(and STAT) interactor 267 7.2 BC002019 Oas1a 2′-5′ oligoadenylatesynthetase 1A 119 8.7 BC018470 Oasl1 2′-5′ oligoadenylatesynthetase-like 1 48 8.4 AB067533 P2ry13 purinergic receptor P2Y,G-protein 35 3.4 AK008013 coupled 13 P2ry14 purinergic receptor P2Y,G-protein 57 3.1 AF177211 coupled, 14 Parp11 poly (ADP-ribose)polymerase family, 155 2.7 BB026163 member 11 Parp12 poly (ADP-ribose)polymerase family, 161 8.6 BM227980 member 12 Parp3 poly (ADP-ribose)polymerase family, 141 4.4 BC014870 member 3 Parp9 poly (ADP-ribose)polymerase family, 179 12.0 NM_030253 member 9 Parvg parvin, gamma 412.5 NM_022321 Pbef1 pre-B-cell colony-enhancing factor 1 823 3.1AW989410 Pigr polymeric immunoglobulin receptor 857 3.7 NM_011082 Plac8placenta-specific 8 208 21.7 AF263458 Pml promyelocytic leukemia 58 2.7BB667149 Pnp purine-nucleoside phosphorylase 2805 2.1 BC003788 Pnp ///purine-nucleoside phosphorylase /// 1262 2.7 AK008143 LOC545044 similarto purine-nucleoside phosphorylase Ppa1 pyrophosphatase (inorganic) 1609 3.6 NM_026438 Ppfia4 protein tyrosine phosphatase, receptor 35 2.8AK003571 type, f polypeptide (PTPRF), interacting protein (liprin),alpha 4 Prkcq protein kinase C, theta 118 3.0 AB062122 Procr protein Creceptor, endothelial 101 4.5 NM_011171 Psme2 proteasome (prosome,macropain) 28 709 6.2 NM_011190 subunit, beta Ptprcap protein tyrosinephosphatase, receptor 141 3.7 NM_016933 type, C polypeptide-associatedprotein Rasa4 RAS p21 protein activator 4 32 2.3 NM_133914 Rbl1retinoblastoma-like 1 (p107) 82 8.2 U27177 Rgs1 regulator of G-proteinsignaling 1 45 8.0 NM_015811 Rnase6 ribonuclease, RNase A family, 6 314.8 AW825994 Rsad2 radical S-adenosyl methionine domain 433 3.0 BB132493containing 2 Samhd1 SAM domain and HD domain, 1 119 18.7 NM_018851 Scap1src family associated phosphoprotein 1 39 2.9 BG075562 Sectm1 secretedand transmembrane 1 1125 4.0 AI481997 Serpina3g serine (or cysteine)peptidase inhibitor, 44 98.9 BC002065 clade A, member 3G Serpinb9 serine(or cysteine) peptidase inhibitor, 390 6.5 NM_009256 clade B, member 9Sh2d1a SH2 domain protein 1A 12 3.5 NM_011364 Slamf6 SLAM family member6 19 12.8 AF248636 Slamf7 SLAM family member 7 23 4.2 AK016183 Slamf8SLAM family member 8 18 45.2 BC024587 Slc28a2 /// solute carrier family28 (sodium- 14 8.5 NM_021520 LOC381417 coupled nucleoside transporter),member 2 /// similar to solute carrier family 28 (sodium-couplednucleoside transporter), member 2 Slc2a6 solute carrier family 2(facilitated 33 3.0 BB196807 glucose transporter), member 6 Slfn1schlafen 1 24 17.5 NM_011407 Slfn8 schlafen 8 55 4.3 BC024709 Snx10sorting nexin 10 103 17.3 AK010399 Socs1 suppressor of cytokinesignaling 1 45 5.3 AB000710 Sp100 nuclear antigen Sp100 81 2.7 U83636Stat2 signal transducer and activator of 50 5.0 AF088862 transcription 2Tap2 transporter 2, ATP-binding cassette, 171 11.3 BE691515 sub-family B(MDR/TAP) Tapbpl TAP binding protein-like 21 3.6 BC017613 Tapbpl TAPbinding protein-like 131 5.7 BC017613 Tbc1d10c TBC1 domain family,member 10c 58 6.8 AV060417 Tbx21 T-box21 18 5.5 NM_019507 Tcf7transcription factor 7, T-cell specific 32 9.3 AI323642 Tinagltubulointerstitial nephritis antigen-like 500 2.4 BC005738 Tlr3toll-like receptor 3 43 2.6 NM_126166 Tmprss4 transmembrane protease,serine 4 65 3.2 BC021368 Tnfrsf14 tumor necrosis factor receptor 43 3.2BC022125 superfamily, member 14 (herpesvirus entry mediator) Tnfrsf7tumor necrosis factor receptor 23 5.5 L24495 superfamily, member 7Tnfsf10 tumor necrosis factor (ligand) 118 5.9 NM_009425 superfamily,member 10 Tor3a torsin family 3, member A 63 4.8 AK009693 Tox thymocyteselection-associated HMG 22 5.3 BB547854 box gene Tpst1 protein-tyrosinesulfotransferase 1 132 2.9 NM_013837 Trafd1 TRAF type zinc finger domain237 4.3 AK003586 containing 1 Treml4 triggering receptor expressed on 136.2 BB740529 myeloid cells-like 4 Trex1 three prime repair exonuclease 1157 3.8 NM_011637 Trim21 tripartite motif protein 21 125 5.1 BC010580Trim30 tripartite motif protein 30 48 11.5 AF220015 Trim34 ///tripartite motif protein 34 /// similar to 29 9.7 AF220142 LOC434218tripartite motif protein TRIM34 alpha Tuba8 tubulin, alpha 8 37 3.0NM_017379 Tyki thymidylate kinase family LPS-inducible 131 3.1 AK004595member Ube1l ubiquitin-activating enzyme E1-like 61 6.2 AK004894 Ube2l6ubiquitin-conjugating enzyme E2L 6 50 7.8 BC008238 Unc93b1 unc-93homolog B1 (C. elegans) 368 1.9 BC018388 Upp1 uridine phosphorylase 1135 10.3 NM_009477 Usp18 ubiquitin specific peptidase 18 50 29.5NM_011909 Vcam1 vascular cell adhesion molecule 1 112 45.1 BB250384 Warstryptophanyl-tRNA synthetase 322 3.3 AI528863 Zap70 zeta-chain (TCR)associated protein 43 6.4 NM_009539 kinase Zbp1 Z-DNA binding protein 175 23.3 AK008179 Zc3h12d zinc finger CCCH-type containing 12D 19 6.7BB508669 Zfpn1a3 zinc finger protein, subfamily 1A, 3 16 14.6 BB151746(Aiolos)

TABLE 11 Refined injury and repair-induced transcripts (IRIT) allo.CBAD5 Gene Symbol Gene Title vs NCBA Genbank — Transcribed locus 2.8AA266723 1110006O17Rik RIKEN cDNA 1110006O17 gene 4.6 BB7366361200008O12Rik RIKEN cDNA 1200008O12 gene 12.5 AK004655 1200016E24RikRIKEN cDNA 1200016E24 gene 4.5 BF719154 1300002K09Rik RIKEN cDNA1300002K09 gene 4.7 AV222559 2200002D01Rik RIKEN cDNA 2200002D01 gene2.2 AK008617 2310014H01Rik RIKEN cDNA 2310014H01 gene 5.2 AK0093402410006H16Rik RIKEN cDNA 2410006H16 gene 2.3 AA939619 2410129E14RikRIKEN cDNA 2410129E14 gene 3.9 AA986082 2610510J17Rik RIKEN cDNA2610510J17 gene 2.3 BM230253 2810052M02Rik RIKEN cDNA 2810052M02 gene3.8 NM_023320 2810406C15Rik RIKEN cDNA 2810406C15 gene 4.8 BC0254604833427B12Rik RIKEN cDNA 4833427B12 gene 3.1 AW488914 4930579G24RikRIKEN cDNA 4930579G24 gene 2.8 BB821996 9030408N13Rik RIKEN cDNA9030408N13 gene 10.9 NM_025779 9030623C06Rik RIKEN cDNA 9030623C06 gene3.6 AF473907 9230117N10Rik RIKEN cDNA 9230117N10 gene 13.0 NM_133775Abca1 ATP-binding cassette, sub-family A (ABC1), 2.3 BB144704 member 1Abp1 amiloride binding protein 1 (amine oxidase, 6.3 BC021880copper-containing) Acta2 actin, alpha 2, smooth muscle, aorta 2.0NM_007392 Actn1 actinin, alpha 1 3.9 BE853286 Adam12 a disintegrin andmetallopeptidase domain 2.0 NM_007400 12 (meltrin alpha) Adam8 adisintegrin and metallopeptidase domain 8 4.2 NM_007403 Adamts1 adisintegrin-like and metallopeptidse 6.0 D67076 (reprolysin type) withthrombospondin type 1 motif, 1 Adamts4 a disintegrin-like andmetallopeptidase 2.2 BB443585 (reprolysin type) with thrombospondin type1 motif, 4 Adfp adipose differentiation related protein 3.6 NM_007408Adn adipsin 3.5 NM_013459 Aldh1a2 aldehyde dehydrogenase family 1, 11.2NM_009022 subfamily A2 Alox5ap arachidonate 5-lipoxygenase activating16.8 BC026209 protein Anln anillin, actin binding protein (scraps 4.6BI690018 homolog, Drosophila) Anxa1 annexin A1 3.2 NM_010730 Anxa2annexin A2 3.4 NM_007585 Anxa3 annexin A3 4.0 AW702161 Apobec1apolipoprotein B editing complex 1 3.5 BC003792 Arg2 arginase type II7.9 NM_009705 Arhgap11a Rho GTPase activating protein 11A 3.1 AV349116Arpc1b actin related protein 2/3 complex, subunit 7.8 BE979985 1B Asf1bASF1 anti-silencing function 1 homolog B 4.4 BC003428 (S. cerevisiae)Asns asparagine synthetase 6.1 AV212753 Atad2 ATPase family, AAA domaincontaining 2 6.0 BM206009 Aurka aurora kinase A 4.5 U80932 Aurkb aurorakinase B 4.6 BC003261 AW492955 expressed sequence AW492955 3.3 AW492955Bak1 BCL2-antagonist/killer 1 3.4 NM_007523 Basp1 brain abundant,membrane attached signal 8.6 AK011545 protein 1 Bcl3 B-cellleukemia/lymphoma 3 3.8 NM_033601 Bgn biglycan 2.6 BC019502 Birc3baculoviral IAP repeat-containing 3 6.6 NM_007464 Brrn1 barren homolog(Drosophila) 4.4 BB725358 Bub1 budding uninhibited by benzimidazoles 17.4 AF002823 homolog (S. cerevisiae) C1qa complement component 1, q 12.6NM_007572 subcomponent, alpha polypeptide C1qb complement component 1, q40.7 BB111335 subcomponent, beta polypeptide C1qg complement component1, q 15.2 NM_007574 subcomponent, gamma polypeptide C3 complementcomponent 3 40.6 K02782 C330027C09Rik RIKEN cDNA C330027C09 gene 4.3AU018569 C3ar1 complement component 3a receptor 1 5.9 NM_009779 C79407expressed sequence C79407 3.5 BE951628 Capg capping protein (actinfilament), gelsolin-like 7.4 NM_007599 Ccl12 chemokine (C-C motif)ligand 12 14.5 U50712 Ccl2 chemokine (C-C motif) ligand 2 11.0 AF065933Ccl6 chemokine (C-C motif) ligand 6 10.6 BC002073 Ccl9 chemokine (C-Cmotif) ligand 9 9.3 AF128196 Ccna2 cyclin A2 7.3 X75483 Ccnb1 cyclin B16.4 AU015121 Ccnb1-rs1 /// cyclin B1, related sequence 1 /// cyclin B15.3 NM_007629 Ccnb1 Ccnb2 cyclin B2 7.8 AK013312 Ccnf cyclin F 2.4NM_007634 Ccr1 chemokine (C-C motif) receptor 1 9.8 AV231648 Ccr2chemokine (C-C motif) receptor 2 21.3 BB148128 Ccr2 chemokine (C-Cmotif) receptor 2 18.1 BB148128 Cd14 CD14 antigen 20.8 NM_009841 Cd52CD52 antigen 31.9 NM_013706 Cd68 CD68 antigen 11.9 BC021637 Cdc20 celldivision cycle 20 homolog (S. cerevisiae) 5.8 BB041150 Cdca1 celldivision cycle associated 1 5.7 AK010351 Cdca3 cell division cycleassociated 3 3.7 BI081061 Cdca5 cell division cycle associated 5 3.2NM_026410 Cdca8 cell division cycle associated 8 3.7 AV307110 Cdh11cadherin 11 3.8 NM_009866 Cdkn1a cyclin-dependent kinase inhibitor 1A(P21) 3.9 AK007630 Cebpb CCAAT/enhancer binding protein (C/EBP), 3.8NM_009883 beta Cebpd CCAAT/enhancer binding protein (C/EBP), 8.0BB831146 delta Cenpf centromere autoantigen F 3.3 BE848253 Cfhcomplement component factor h 2.3 AI987976 Cfi complement componentfactor i 3.0 NM_007686 Chrnb1 cholinergic receptor, nicotinic, beta 2.3M14537 polypeptide 1 (muscle) Ckap2 cytoskeleton associated protein 22.9 BM208103 Ckap4 cytoskeleton-associated protein 4 2.1 BB818012Cklfsf3 chemokine-like factor super family 3 3.4 NM_024217 Clca1 ///Clca2 chloride channel calcium activated 1 /// 3.7 AF108501 chloridechannel calcium activated 2 Clec4a2 C-type lectin domain family 4,member a2 3.0 NM_011999 Clec4a2 /// C-type lectin domain family 4,member a2 /// 2.7 BC006623 Clec4b C-type lectin domain family 4, memberb Clec4a3 C-type lectin domain family 4, member a3 23.8 AK014135 Clec4nC-type lectin domain family 4, member n 6.6 NM_020001 Clec7a C-typelectin domain family 7, member a 13.0 NM_020008 Clu clusterin 3.6AV152288 Cnn2 calponin 2 3.9 BI663014 Col15a1 procollagen, type XV 2.1AF011450 Col1a1 procollagen, type I, alpha 1 8.5 BI794771 Col1a2procollagen, type I, alpha 2 9.6 BF227507 Col1a2 procollagen, type I,alpha 2 5.4 BF227507 Col3a1 procollagen, type III, alpha 1 13.4 AW550625Col5a1 procollagen, type V, alpha 1 3.6 AW744319 Col5a2 procollagen,type V, alpha 2 7.2 AV229424 Col6a1 procollagen, type VI, alpha 1 2.1NM_009933 Col6a2 procollagen, type VI, alpha 2 2.4 BI455189 Col6a3procollagen, type VI, alpha 3 2.7 AF064749 Col8a1 procollagen, typeVIII, alpha 1 3.1 AV292255 Colec12 collectin sub-family member 12 2.4NM_130449 Cp ceruloplasmin 6.8 BB332449 Cp ceruloplasmin 6.0 BB009037Crlf1 cytokine receptor-like factor 1 3.9 NM_018827 Cry1 cryptochrome 1(photolyase-like) 2.3 BG069864 Csrp1 cysteine and glycine-rich protein 12.4 BF124540 Cstb cystatin B 3.8 NM_007793 Ctsc cathepsin C 10.5NM_009982 Ctss cathepsin S 19.4 NM_021281 Cx3cl1 chemokine (C—X3—Cmotif) ligand 1 2.3 AF010586 Cxcl1 chemokine (C—X—C motif) ligand 1 10.9NM_008176 Cxcl14 chemokine (C—X—C motif) ligand 14 10.6 AF252873 Cybbcytochrome b-245, beta polypeptide 21.0 AV373944 D17H6S56E-5 DNAsegment, Chr 17, human D6S56E 5 9.6 NM_033075 Dcamkl1 Double cortin andcalcium/calmodulin- 9.2 BB757120 dependent protein kinase-like 1, mRNA(cDNA clone IMAGE: 5006471) Dck deoxycytidine kinase 11.8 BB030204 Dptdermatopontin 3.2 NM_019759 Dpysl3 dihydropyrimidinase-like 3 2.5AV162270 Ect2 ect2 oncogene 3.3 NM_007900 Efemp2 epidermal growthfactor-containing fibulin- 2.0 NM_021474 like extracellular matrixprotein 2 Efhd2 EF hand domain containing 2 5.6 AK007560 Emilin1 elastinmicrofibril interfacer 1 2.1 NM_133918 Emr1 EGF-like module containing,mucin-like, 4.9 U66888 hormone receptor-like sequence 1 Entpd1ectonucleoside triphosphate 4.0 BI151440 diphosphohydrolase 1 Ercc6Iexcision repair cross-complementing rodent 2.9 BC004701 repairdeficiency complementation group 6- like Esco2 establishment of cohesion1 homolog 2 (S. cerevisiae) 3.7 AK010391 F13a1 coagulation factor XIII,A1 subunit 6.2 NM_028784 F2r coagulation factor II (thrombin) receptor3.3 AV024285 Fbn1 fibrillin 1 4.0 NM_007993 Fcer1g Fc receptor, IgE,high affinity I, gamma 16.5 NM_010185 polypeptide Fcgr3 Fc receptor,IgG, low affinity III 14.4 NM_010188 Fga fibrinogen, alpha polypeptide8.6 BC005467 Fgg fibrinogen, gamma polypeptide 3.1 NM_133862 Fignl1fidgetin-like 1 6.4 NM_021891 Flna filamin, alpha 2.9 BM233746 Fn1fibronectin 1 2.8 BC004724 Fshprh1 FSH primary response 1 2.1 BB258991Fstl1 follistatin-like 1 4.5 BI452727 Fxyd5 FXYD domain-containing iontransport 8.7 NM_008761 regulator 5 Gch1 GTP cyclohydrolase 1 2.4NM_008102 Gda guanine deaminase 16.3 AW911807 Golph2 golgiphosphoprotein 2 2.4 BC011152 H2afx H2A histone family, member X 2.0NM_010436 Havcr1 hepatitis A virus cellular receptor 1 7.8 NM_134248Hells helicase, lymphoid specific 10.2 NM_008234 Hesx1 homeo box geneexpressed in ES cells 2.7 NM_010420 Hmga1 high mobility group AT-hook 12.8 NM_016660 Hmmr hyaluronan mediated motility receptor 3.3 X64550(RHAMM) Hp haptoglobin 5.9 NM_017370 Icam1 intercellular adhesionmolecule 10.5 BC008626 Ifitm1 interferon induced transmembrane protein 15.2 BC027285 Ifitm3 interferon induced transmembrane protein 3 5.0BC010291 Il1b interleukin 1 beta 3.3 BC011437 Il6 interleukin 6 10.3NM_031168 Inhbb inhibin beta-B 4.7 BB253137 Isgf3g interferon dependentpositive acting 3.6 NM_008394 transcription factor 3 gamma Itgamintegrin alpha M 6.5 NM_008401 Kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic2.4 NM_134090 reticulum protein retention receptor 3 Kif11 kinesinfamily member 11 4.7 BM234447 Kif20a kinesin family member 20A 2.4NM_009004 Kif22 kinesin family member 22 8.2 BB251322 Kif2c kinesinfamily member 2C 4.0 BB104669 Klf4 Kruppel-like factor 4 (gut) 2.7BG069413 Lbp lipopolysaccharide binding protein 4.6 NM_008489 Lcn2lipocalin 2 57.7 X14607 Lcp1 lymphocyte cytosolic protein 1 16.8NM_008879 Lepr leptin receptor 2.4 BM124366 Lgals1 lectin, galactosebinding, soluble 1 3.5 AI642438 Lgals3 lectin, galactose binding,soluble 3 3.9 X16834 Lhfp lipoma HMGIC fusion partner 2.0 AV149705 Lig1ligase I, DNA, ATP-dependent 3.4 NM_010715 Lilrb3 leukocyteimmunoglobulin-like receptor, 7.3 U96693 subfamily B (with TM and ITIMdomains), member 3 Litaf LPS-induced TN factor 4.5 AV360881 Lmna lamin A2.4 AV238225 Lox lysyl oxidase 7.5 M65143 Lrg1 leucine-richalpha-2-glycoprotein 1 4.5 NM_029796 Lum lumican 2.8 AK014312 Ly86lymphocyte antigen 86 21.0 NM_010745 Lyzs lysozyme 26.8 AW208566 Lzp-s Plysozyme structural 22.0 AV066625 Mad2l1 MAD2 (mitotic arrest deficient,homolog)- 3.6 NM_019499 like 1 (yeast) Marcks myristoylated alanine richprotein kinase C 2.8 AW546141 substrate Marcksl1 MARCKS-like 1 4.7AV110584 Mcm2 minichromosome maintenance deficient 2 3.5 NM_008564mitotin (S. cerevisiae) Mcm3 minichromosome maintenance deficient 3 4.9C80350 (S. cerevisiae) Mcm4 minichromosome maintenance deficient 4 5.1BC013094 homolog (S. cerevisiae) Mcm7 minichromosome maintenancedeficient 7 2.7 BB464359 (S. cerevisiae) Melk maternal embryonic leucinezipper kinase 4.4 NM_010790 Mfap5 microfibrillar associated protein 58.0 NM_015776 Mgp matrix Gla protein 3.0 NM_008597 Mgst1 microsomalglutathione S-transferase 1 2.1 BI150149 Mmd monocyte to macrophagedifferentiation- 2.0 BC021914 associated Mmp14 matrix metallopeptidase14 (membrane- 4.5 NM_008608 inserted) Mmp7 matrix metallopeptidase 7 4.1NM_010810 Ms4a7 membrane-spanning 4-domains, subfamily 5.5 BC024402 A,member 7 Mt2 metallothionein 2 5.3 AA796766 Mvp major vault protein 3.5NM_080638 Myadm myeloid-associated differentiation marker 2.5 BB500055Myc myelocytomatosis oncogene 3.5 BC006728 Myh9 myosin, heavypolypeptide 9, non-muscle 2.4 C80049 Ncf1 neutrophil cytosolic factor 16.8 BE370703 Nek2 NIMA (never in mitosis gene a)-related 2.2 C77054expressed kinase 2 Nek6 NIMA (never in mitosis gene a)-related 2.6BB528391 expressed kinase 6 Nfkbia nuclear factor of kappa light chaingene 4.8 AI462015 enhancer in B-cells inhibitor, alpha Nfkbiz nuclearfactor of kappa light polypeptide 18.1 AB026551 gene enhancer in B-cellsinhibitor, zeta Nrm nurim (nuclear envelope membrane protein) 2.0NM_134122 Nuak2 NUAK family, SNF1-like kinase, 2 2.1 AK004737 Nusap1nucleolar and spindle associated protein 1 7.4 BC009096 Olfml3olfactomedin-like 3 2.0 NM_133859 Osmr oncostatin M receptor 7.9AB015978 P2ry6 pyrimidinergic receptor P2Y, G-protein 5.9 BC027331coupled, 6 Pbk PDZ binding kinase 3.5 NM_023209 Pdgfrb platelet derivedgrowth factor receptor, beta 2.0 AA499047 polypeptide Pdlim7 PDZ and LIMdomain 7 2.8 AK010339 Pdxk pyridoxal (pyridoxine, vitamin B6) kinase 2.0BG063905 Pea15 phosphoprotein enriched in astrocytes 15 2.3 AI323543 Pfcproperdin factor, complement 5.0 BB800282 Pik3ap1phosphoinositide-3-kinase adaptor protein 1 5.3 BI684288 Pld4phospholipase D family, member 4 13.0 BB210623 Plk4 polo-like kinase 4(Drosophila) 6.0 AI385771 Plp2 proteolipid protein 2 2.5 AK012816 Pltpphospholipid transfer protein 2.7 NM_011125 Pola1 polymerase (DNAdirected), alpha 1 2.9 NM_008892 Pole polymerase (DNA directed), epsilon3.3 NM_011132 Prc1 protein regulator of cytokinesis 1 2.6 BC005475Ptger4 prostaglandin E receptor 4 (subtype EP4) 6.3 BC011193 Ptgfrnprostaglandin F2 receptor negative 2.2 AV253087 regulator Ptgs2prostaglandin-endoperoxide synthase 2 5.3 M94967 Ptprc protein tyrosinephosphatase, receptor type, C 27.0 NM_011210 Pycard PYD and CARD domaincontaining 7.6 BG084230 Racgap1 Rac GTPase-activating protein 1 4.7NM_012025 Rad51 RAD51 homolog (S. cerevisiae) 8.4 NM_011234 Rcn1reticulocalbin 1 5.4 NM_009037 Relb avian reticuloendotheliosis viral(v-rel) 3.7 NM_009046 oncogene related B Rhob ras homolog gene family,member B 3.8 BC018275 Ris2 retroviral integration site 2 2.4 AF477481Rprc1 arginine/proline rich coiled-coil 1 2.2 BC019977 Rras Harvey ratsarcoma oncogene, subgroup R 2.6 NM_009101 Rrm2 ribonucleotide reductaseM2 9.1 NM_009104 S100a10 S100 calcium binding protein A10 2.4 AV295650(calpactin) S100a11 S100 calcium binding protein A11 2.6 BC021916(calizzarin) S100a6 S100 calcium binding protein A6 (calcyclin) 4.6NM_011313 S100a8 S100 calcium binding protein A8 7.6 NM_013650(calgranulin A) S100a9 S100 calcium binding protein A9 7.1 NM_009114(calgranulin B) Saa1 serum amyloid A 1 9.6 NM_009117 Sart2 squamous cellcarcinoma antigen 6.8 BM207218 recognized by T cells 2 Scarb2 scavengerreceptor class B, member 2 2.2 NM_007644 Sdc1 syndecan 1 3.3 BB533095Serpina3n serine (or cysteine) peptidase inhibitor, 5.6 NM_009252 cladeA, member 3N Serpinb6b serine (or cysteine) peptidase inhibitor, 5.6NM_011454 clade B, member 6b Serpine1 serine (or cysteine) peptidaseinhibitor, 5.4 NM_008871 clade E, member 1 Sertad4 SERTA domaincontaining 4 7.2 BQ174721 Sh3bgrl3 SH3 domain binding glutamic acid-rich5.8 NM_080559 protein-like 3 Shcbp1 Shc SH2-domain binding protein 1 5.4NM_011369 Sirpb1 signal-regulatory protein beta 1 26.9 AI662854 Slamf9SLAM family member 9 4.0 NM_029612 Slc15a3 solute carrier family 15,member 3 13.3 NM_023044 Slc25a24 solute carrier family 25 (mitochondrial5.9 BM230959 carrier, phosphate carrier), member 24 Slc34a2 solutecarrier family 34 (sodium phosphate), 6.7 NM_011402 member 2 Slc7a12solute carrier family 7 (cationic amino acid 3.6 NM_080852 transporter,y+ system), member 12 Smc2l1 SMC2 structural maintenance of 6.1NM_008017 chromosomes 2-like 1 (yeast) Smpdl3b sphingomyelinphosphodiesterase, acid-like 7.6 NM_133888 3B Socs3 suppressor ofcytokine signaling 3 29.6 BB831725 Sp100 nuclear antigen Sp100 2.6AV284523 Sparc secreted acidic cysteine rich glycoprotein 2.1 NM_009242Spbc24 spindle pole body component 24 homolog 2.3 BF577722 (S.cerevisiae) Stat3 signal transducer and activator of 3.1 AK004083transcription 3 Tacc3 transforming, acidic coiled-coil containing 4.0NM_011524 protein 3 Tagln2 transgelin 2 2.2 C76322 Tcf19 transcriptionfactor 19 2.5 BC004617 Tgfb1 transforming growth factor, beta 1 3.2NM_011577 Tgfbi transforming growth factor, beta induced 31.0 BB533460Tgm2 transglutaminase 2, C polypeptide 2.2 BC016492 Timp1 tissueinhibitor of metalloproteinase 1 40.8 BC008107 Tlr2 toll-like receptor 29.8 NM_011905 Tmcc2 transmembrane and coiled-coil domains 2 2.1 AK004359Tmepai transmembrane, prostate androgen induced 2.4 AV370981 RNA Tmsb10thymosin, beta 10 12.3 NM_025284 Tnfrsf12a tumor necrosis factorreceptor superfamily, 2.7 NM_013749 member 12a Tpm2 tropomyosin 2, beta2.3 BC024358 Tpm4 tropomyosin 4 3.5 AV122663 Tpx2 TPX2,microtubule-associated protein 3.9 AK011311 homolog (Xenopus laevis)Tpx2 TPX2, microtubule-associated protein 2.0 AK011311 homolog (Xenopuslaevis) Trip13 thyroid hormone receptor interactor 13 8.2 AK010336 Tuba1tubulin, alpha 1 3.8 NM_011653 Tubb2 /// tubulin, beta 2 /// RIKEN cDNA2410129E14 3.9 BC003475 2410129E14Rik gene /// similar to TUBULIN BETACHAIN /// LOC544939 (T BETA-15) Tubb5 tubulin, beta 5 3.7 NM_011655Tubb6 tubulin, beta 6 4.0 NM_026473 Tyrobp TYRO protein tyrosine kinasebinding 17.4 NM_011662 protein Uhrf1 ubiquitin-like, containing PHD andRING 9.5 BB702754 finger domains, 1 Vasp vasodilator-stimulatedphosphoprotein 3.1 BC015289 Vim vimentin 17.3 AV147875 Wisp1 WNT1inducible signaling pathway protein 1 2.9 NM_018865 Zwilch Zwilch,kinetochore associated, homolog 3.2 BC027435 (Drosophila) Zyx zyxin 2.2NM_011777

Other Embodiments

It is to be understood that while the invention has been described inconjunction with the detailed description thereof, the foregoingdescription is intended to illustrate and not limit the scope of theinvention, which is defined by the scope of the appended claims. Otheraspects, advantages, and modifications are within the scope of thefollowing claims.

1. A method for detecting tissue rejection, wherein said methodcomprises determining whether or not tissue transplanted into a mammalcontains cells that express at least two of the nucleic acids listed inTable 2 or Table 11 at elevated levels, wherein the presence of saidcells indicates that said tissue is being rejected.